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Chinese Journal of Chemistry 2017年第12期35卷 1808-1812页

作者： Rongrong Hui mina zhao Ming Chen Zhihui Ren Zhenghui Guan Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education Department of Chemistry & Materials Science Northwest University Xi'an Shaanxi 710127 China Shaanxi Key Laboratory of Phytochemistry College of Chemistry and Chemical Engineering Baoji University of Arts and Sciences Baoji Shaanxi 721013 China

A one-pot three-component reaction of aldehydes, nitroalkanes and NaN3 for the synthesis ofNH-1,2,3-triazoles has been developed. The reaction provides a safe, efficient and step-economic approach for the synthesis of... 详细信息

关键词： aldehydes sodium azide one-pot three-component reaction NH-1,2,3-triazoles

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通过环化反应构建多取代咪唑的最新研究进展

有机化学 2022年第1期42卷 111-128页

作者：赵咪娜杨梓墨杨得锁宝鸡文理学院化学化工学院陕西省植物化学重点实验室陕西宝鸡721013

咪唑是一类非常重要的五元含氮杂环化合物,在有机合成化学中具有广泛的用途,其广泛存在于天然产物、应用药物和材料等领域中,而且也是一类重要的有机合成中间体,因此合成咪唑的方法也倍受人们的关注.归纳总结了通过环化反应构建多取代... 详细信息

咪唑是一类非常重要的五元含氮杂环化合物,在有机合成化学中具有广泛的用途,其广泛存在于天然产物、应用药物和材料等领域中,而且也是一类重要的有机合成中间体,因此合成咪唑的方法也倍受人们的关注.归纳总结了通过环化反应构建多取代咪唑的最新研究进展,主要介绍了以肟酯、2H-氮杂环丙烯、酮类化合物、2-氨基吡啶、叠氮化合物、三唑类化合物、炔类化合物、异硫氰酸酯、芳胺类化合物、脒类化合物和腈类化合物等作为起始原料合成咪唑类化合物的方法及研究进展,并展望了它的发展前景.

关键词：咪唑环化合成研究进展

Observation of maximal intrinsic chirality empowered by dual quasi-bound states in the continuum in a planar metasurface

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Photonics Research 2024年第2期12卷 244-252页

作者： XIN QI JIAJU WU FENG WU SONG zhao CHAO WU YUEYANG MIN mina REN YUFEI WANG HAITAO JIANG YUNHUI LI ZHIWEI GUO YAPING YANG WANHUA ZHENG HONG CHEN YONG SUN MOE Key Laboratory of Advanced Micro-Structured Materials School of Physics Science and EngineeringTongji UniversityShanghai 200092China School of Optoelectronic Engineering Guangdong Polytechnic Normal UniversityGuangzhou 510665China l3 Shanghai Key Laboratory of Special Artificial Microstructure Materials and Technology School of Physics Science and EngineeringTongji UniversityShanghai 200092China Department of Electrical Engineering Tongji UniversityShanghai 201804China State Key Laboratory on Integrated Optoelectronics Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China

Metasurfaces with spin-selective transmission play an increasingly critical role in realizing optical chiral responses,especially for strong intrinsic chirality,which is limited to complex three-dimensional *** this paper,we propose a planar metasurface capable of generating maximal intrinsic chirality and achieving dual-band spinselective transmission utilizing dual quasi-bound states in the continuum(quasi-BICs)caused by the structural symmetry ***,the value of circular dichroism(CD)and the transmittance of two kinds of circular polarization states can be arbitrarily controlled by tuning the asymmetry *** CD approaching unity with the maximum transmittance up to 0.95 is experimentally achieved in the dual ***,assisted by chiral BICs,the application in polarization multiplexed near-field image display is also *** work provides a new avenue to flexibly control intrinsic chirality in planar structure and offers an alternative strategy to develop chiral sensing,multiband spin-selective transmission,and high-performance circularly polarized wave *** basic principle and design method of our experiments in the microwave regime can be extended to other bands,such as the terahertz and infrared wavelengths.

关键词： planar intrinsic quasi

奥氮平联合地西泮治疗精神分裂症急性兴奋的疗效及安全性评价

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西部医学 2017年第6期29卷 804-807页

作者：李娟赵米娜王瑜成都市第四人民医院急性精神科四川成都610000

目的探讨奥氮平联合地西泮治疗精神分裂症患者急性兴奋的疗效及安全性。方法选择2015年1月~2016年1月收治的精神分裂症患者120例,按照随机数字表法将其分为观察组和对照组各60例。对照组采用氟哌啶醇治疗,观察组给予奥氮平联合地西泮治... 详细信息

目的探讨奥氮平联合地西泮治疗精神分裂症患者急性兴奋的疗效及安全性。方法选择2015年1月~2016年1月收治的精神分裂症患者120例,按照随机数字表法将其分为观察组和对照组各60例。对照组采用氟哌啶醇治疗,观察组给予奥氮平联合地西泮治疗。治疗1、3、7d后,采用重复方差分析,比较两组阳性及阴性症状量表(PANSS)、兴奋因子(PANSS-EC)、治疗效果以及不良反应发生率。结果两组PANSS-EC评分差异具有统计学意义(F=13.32,P=0.003;F=5.42,P=0.035;F=7.43,P=0.024),治疗中进行两组PANSS-EC评分有所降低,但观察组降低程度明显大于对照组(P0.05),观察组静坐不能和便秘发生率明显低于对照组(P>0.05),观察组总不良反应发生率明显低于对照组(P<0.05)。结论奥氮平联合地西泮治疗精神分裂症患者能有效控制患者急性兴奋症状,并降低患者不良反应发生率。

关键词：奥氮平地西泮急性兴奋精神分裂症

New Genesis of Natural Coke around Magmatic Intrusion at the Shitai Coalmine of Huaibei City, North China

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Acta Geologica Sinica(English Edition) 2019年第4期93卷 1158-1159页

作者： zhao Meixia AN Yanfei WANG mina DING Min Chunkit LAI Key Laboratory of Ocean and Marginal Sea Geology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Innovation Academy of South China Sea Ecology and Environmental Engineering Chinese Academy of SciencesGuangzhou 510301China School of Resource and Environment Engineering Anhui UniversityHefei 230601China Faculty of Science University of Brunei DarussalamGadong BE1410Brunei Darussalam Centre for Excellence in Ore Deposits(CODES) University of TasmaniaHobart 7001Australia

Objective Studies on components of natural coke formed by the intrusion of sills into coals have attracted much attention,not only because the pyrolytic carbon in natural coke are associated with the magmatic events.

关键词： image New North

ChatGPT在护理学专业理论教学中的应用前景

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中国医学教育技术 2024年第3期38卷 276-280页

作者：姜兆权赵立成周诗雪于洋黄米娜锦州医科大学护理学院辽宁锦州121000 锦州医科大学马克思主义学院辽宁锦州121000 《锦州医科大学学报(社会科学版)》编辑部辽宁锦州121000

随着科技的迅猛发展,尤其是人工智能技术的不断进步,护理学领域也迎来了一系列新的机会和挑战。该研究从当前护理学专业课程理论教学现状、ChatGPT在护理学专业理论教学中的应用前景,以及如何在应用中进行不断完善并给予针对性的建议,... 详细信息

随着科技的迅猛发展,尤其是人工智能技术的不断进步,护理学领域也迎来了一系列新的机会和挑战。该研究从当前护理学专业课程理论教学现状、ChatGPT在护理学专业理论教学中的应用前景,以及如何在应用中进行不断完善并给予针对性的建议,助力人工智能在护理学专业教学中更好地应用,不断提高护理教学质量。

关键词： ChatGPT 理论教学护理学应用前景

Ultrasensitive electrolyte-assisted temperature sensor

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npj Flexible Electronics 2020年第1期4卷 203-209页

作者： mina Shiran Chaharsoughi Jesper Edberg Peter Andersson Ersman Xavier Crispin Dan zhao Magnus P.Jonsson Laboratory of Organic Electronics Department of Science and TechnologyLinköping UniversitySE-60174NorrköpingSweden RISE Research Institutes of Sweden Bio-and Organic ElectronicsBredgatan 3360221NorrköpingSweden

Heat sensors form an important class of devices that are used across multiple fields and *** applications such as electronic skin and health monitoring,it is particularly advantageous if the output electronic signals are not only high,stable,and reproducible,but also self-generated to minimize power ***,we present an ultrasensitive heat sensing concept that fulfills these criteria while also being compatible with scalable low-cost manufacturing on flexible *** concept resembles a traditional thermocouple,but with separated electrodes bridged by a gel-like electrolyte and with orders of magnitudes higher signals(around 11 mV K^(−1)).The sensor pixels provide stable and reproducible signals upon heating,which,for example,could be used for heat *** modification to plasmonic nanohole metasurface electrodes made the sensors capable of also detecting light-induced ***,we present devices on flexible substrates and show that they can be used to detect human touch.

关键词： electrolyte sensor heating

Functional analysis of the methyltransferase SMYD in the single-cell model organism Tetrahymena thermophila

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Marine Life Science & Technology 2020年第2期2卷 109-122页

作者： Xiaolu zhao Yuan Li Lili Duan Xiao Chen Fengbiao Mao mina Juma Yifan Liu Weibo Song Shan Gao Institute of Evolution and Marine Biodiversity Ocean University of ChinaQingdao 266003China Department of Pathology University of Michigan.Ann Arbor.MI 48109USA Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyQingdao 266003China

Lysine methylation of histones and non-histones plays a pivotal role in diverse cellular *** SMYD(SET and MYND domain)family methyltransferases can methylate various histone and non-histone substrates in mammalian systems,implicated in HSP90 methylation,myofilament organization,cancer inhibition,and gene transcription *** resolve controversies concerning SMYD's substrates and functions,we studied SMYD1(TTHERM_00578660),the only homologue of SMYD in the unicellular eukaryote Tetrahymena *** epitope-tagged SMYD1,and analyzed its localization and *** also characterized △SMYD1 cells,focusing on the replication and transcription *** results show that:(1)SMYD1 is present in both cytoplasm and transcriptionally active macronucleus and shuttles between cytoplasm and macronucleus,suggesting its potential association with both histone and non-histone substrates;(2)SMYD1 is involved in DNA replication and regulates transcription of metabolism-related genes;(3)HSP90 is a potential substrate for SMYD1 and it may regulate target selection of HSP90,leading to pleiotropic effects in both the cytoplasm and the nucleus.

关键词： Tetrahymena thennophila Methyltransferase SMYD DNA replication Transcription HSP90

Preparation and evaluation of PEGylated phospholipid membrane coated layered double hydroxide nanoparticles

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Asian Journal of Pharmaceutical Sciences 2016年第3期11卷 396-403页

作者： mina Yan zhaoguo Zhang Shengmiao Cui Xuefei Zhang Weijing Chu Ming Lei Ke Zeng Yunhui Liao Yihui Deng Chunshun zhao School of Pharmacy Shenyang Pharmaceutical University School of Pharmaceutical Sciences Sun Yat-sen University Guangzhou Higher Education Mega Center Guangdong Pharmaceutical University Guangzhou Higher Education Mega Center

The aim of the present study was to develop layered double hydroxide(LDH) nanoparticles coated with PEGylated phospholipid membrane. By comparing the size distribution and zeta potential, the weight ratio of LDH to lipid materials which constitute the outside membrane was identified as 2:1. Transmission electron microscopy photographs confirmed the core-shell structure of PEGylated phospholipid membrane coated LDH(PEG-PLDH)nanoparticles, and cell cytotoxicity assay showed their good cell viability on Hela and BALB/C-3 T3 cells over the concentration range from 0.5 to 50 μg/mL.

关键词： Preparation In vitro evaluation Layered double hydroxides Phospholipid membrane Size distribution Zeta potential

Multifunctional bioactive core-shell electrospun membrane capable to terminate inflammatory cycle and promote angiogenesis in diabetic wound

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Bioactive Materials 2021年第9期6卷 2783-2800页

作者： Atta ur Rehman Khan Kai Huang mina Shahriari Khalaji Fan Yu Xianrui Xie Tonghe Zhu Yosry Morsi zhao Jinzhong Xiumei Mo State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai201620PR China Department of Sports Medicine Department of OrthopedicsShanghai Jiao Tong University Affiliated Sixth People’s HospitalNo.600 Yishan RoadShanghai200233PR China Microbiological Engineering and Industrial Biotechnology Group College of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai201620PR China Multidisciplinary Centre for Advanced Materials of Shanghai University of Engineering Science College of Chemistry and Chemical EngineeringShanghai University of Engineering ScienceNo.333 Longteng RoadShanghai201620PR China Faculty of Engineering and Industrial Sciences Swinburne University of TechnologyBoroondaraVIC3122Australia

Diabetic wound(DW)healing is a major clinical challenge due to multifactorial complications leading to prolonged *** nanofibrous(NF)membranes,due to special structural features,are promising biomaterials capable to promote DW healing through the delivery of active agents in a controlled ***,we report a multifunctional composite NF membrane loaded with ZnO nanoparticles(NP)and oregano essential oil(OEO),employing a new loading strategy,capable to sustainedly co-deliver bioactive *** characterization revealed the successful fabrication of loaded nanofibers with strong in vitro anti-bacterial and anti-oxidant ***,in vivo wound healing confirmed the potential of bioactive NF membranes in epithelialization and granulation tissue *** angiogenesis was greatly prompted by the bioactive NF membranes through expression of vascular endothelial growth factor(VEGF).Moreover,the proposed NF membrane successfully terminated the inflammatory cycle by downregulating the pro-inflammatory cytokines interleukin􀀀6(IL-6)and matrix metalloproteinases-9(MMP-9).In vitro and in vivo studies revealed the proposed NF membrane is a promising dressing material for the healing of DW.

关键词： Bioactive NF membrane Diabetic wound healing Antibacterial Antioxidant Anti-inflammatory Angiogenesis