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信仰与欢娱:徽州忠义神崇拜的形成与发展——以汪王神、世忠庙神、双忠庙神为中心

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黑河学院学报 2024年第2期15卷 154-159页

作者：施莉莉颜莉吴杰安徽农业大学马克思主义学院安徽合肥230061 安徽大学安徽合肥230601

徽州忠义神信仰是其民间信仰的重要组成部分,作为一种带有儒家价值观的神灵崇拜,其形成与发展经历了长期而漫长的过程。从现实人物到忠义神灵,从小范围的民间祭祀到整个徽州的信仰活动,忠义神信仰发生了量到质的蜕变,这些变化离不开民... 详细信息

徽州忠义神信仰是其民间信仰的重要组成部分,作为一种带有儒家价值观的神灵崇拜,其形成与发展经历了长期而漫长的过程。从现实人物到忠义神灵,从小范围的民间祭祀到整个徽州的信仰活动,忠义神信仰发生了量到质的蜕变,这些变化离不开民众和政府的双向推动,而徽州社会对忠义神信仰的实践也构成了其独特的民间信仰图景。

关键词：忠义神信仰汪华程灵洗张巡许远

An MPXV mRNA-LNP vaccine candidate elicits protective immune responses against monkeypox virus

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Chinese Chemical Letters 2024年第8期35卷 466-470页

作者： Yuxin Tian Mengjun Li Yang Yang Chunhui Li Yun Peng Haiyin Yang Mengyuan Zhao Pengfei wu Shaobo Ruan Yuanyu Huang Chenguang Shen minghui Yang Advanced Research Institute of Multidisciplinary Science School of Life ScienceKey Laboratory of Molecular Medicine and BiotherapyBeijing Institute of TechnologyBeijing 100081China BSL-3 Laboratory(Guangdong) Guangdong Provincial Key Laboratory of Tropical Disease ResearchSchool of Public HealthDepartment of Laboratory MedicineZhujiang HospitalSouthern Medical UniversityGuangzhou 510280China National Clinical Research Center for infectious disease Shenzhen Third People’s HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518112China

The monkeypox virus(MPXV)outbreak,declared a Public Health Emergency of International Concern(PHEIC)by the World Health Organization(WHO)in 2022,continues to pose a significant threat due to the absence of vaccines or drugs for MPXV *** this study,we developed an mRNA vaccine that expressing the A29L antigen,a specific protein of the intracellular mature *** vaccine utilizes a thermostable ionizable lipid nanoparticle(iLNP)platform and has been administered to *** find-ings demonstrate that the MPXV A29L mRNA vaccine candidate induces robust cross-neutralizing immune responses against both vaccinia virus(VACV)and MPXV live ***,immunization with the vaccine candidate provided protection against the VACV challenge in *** findings underscore the potential of mRNA-LNP vaccines as safe and effective candidates against monkeypox *** the current absence of specific interventions for MPXV infection,our study represents a significant step forward in developing a viable solution to combat this ongoing public health threat.

关键词： Monkeypox virus mRNA vaccine Lipid-nano particle A29L VACV

A combined nanotherapeutic approach targeting farnesoid X receptor,ferroptosis,and fibrosis for nonalcoholic steatohepatitis treatment

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2228-2246页

作者： Jiangtao Fu Pingping Zhang Zhiguo Sun Guodong Lu Qi Cao Yiting Chen Wenbin wu Jiabao Zhang Chunlin Zhuang Chunquan Sheng Jiajun Xu Ying Lu Pei Wang The Center for Basic Research and Innovation of Medicine and Pharmacy(MOE) School of PharmacyNaval Medical UniversityShanghai 200433China National Demonstration Center for Experimental Pharmaceutical Education Naval Medical University/Second Military Medical UniversityShanghai 200433China Department of Diving and Hyperbaric Medicine Naval Special Medical CenterNaval Medical UniversityShanghai 200433China

Obeticholic acid(OCA),a farnesoid X receptor(FXR)agonist with favorable effects on fatty and glucose metabolism,has been considered the leading candidate drug for nonalcoholic steatohepatitis(NASH)***,its limited effectiveness in resolving liver fibrosis and lipotoxicity-induced cell death remains a major ***,a newly recognized form of cell death characterized by uncontrolled lipid peroxidation,is involved in the progression of *** oxide(NO)is a versatile biological molecule that can degrade extracellular *** this study,we developed a PEGylated thiolated hollow mesoporous silica nanoparticles(MSN)loaded with OCA,as well as a ferroptosis inhibitor liproxsatin-1 and a NO donor S-nitrosothiol(ONL@MSN).Biochemical analyses,histology,multiplexed flow cytometry,bulk-tissue RNA sequencing,and fecal 16S ribosomal RNA sequencing were utilized to evaluate the effects of the combined nanoparticle(ONL@MSN)in a mouse NASH *** with the OCA-loaded nanoparticles(O@MSN),ONL@MSN not only protected against hepatic steatosis but also greatly ameliorated fibrosis and ***@MSN also displayed enhanced therapeutic actions on the maintenance of intrahepatic macrophages/monocytes homeostasis,inhibition of immune response/lipid peroxidation,and correction of microbiota *** findings present a promising synergistic nanotherapeutic strategy for the treatment of NASH by simultaneously targeting FXR,ferroptosis,and fibrosis.

关键词： Nonalcoholic steatohepatitis Nanotherapy Farnesoid X receptor Ferroptosis Fibrosis Obeticholic acid S-Nitrosothiol Liproxstatin-1

Grading severity of microscopic vascular invasion was independently associated with recurrence and survival following hepatectomy for solitary hepatocellular carcinoma

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Hepatobiliary Surgery and Nutrition 2024年第1期13卷 16-28页

作者： Lan-Qing Yao Chao Li Yong-Kang Diao Lei Liang Hang-Dong Jia Shi-Chuan Tang Yong-Yi Zeng Han wu ming-Da Wang Li-Hui Gu Timothy MPawlik Wan Yee Lau Cheng-wu Zhang Feng Shen Kui Wang Tian Yang Department of Hepatobiliary Surgery Eastern Hepatobiliary Surgery HospitalSecond Military Medical University(Navy Medical University)ShanghaiChina Department of General Surgery Cancer CenterDivision of Hepatobiliary and Pancreatic SurgeryZhejiang Provincial People’s HospitalAffiliated People’s HospitalHangzhou Medical CollegeHangzhouChina Department of Hepatobiliary Surgery Mengchao Hepatobiliary HospitalFujian Medical UniversityFuzhouChina Department of Surgery Ohio State UniversityWexner Medical CenterColumbusOHUSA Faculty of Medicine the Chinese University of Hong KongShatinNew TerritoriesHong KongChina Eastern Hepatobiliary Clinical Research Institute Third Affiliated Hospital of Navy Medical UniversityShanghaiChina

Background:Hepatectomy is the preferred treatment for solitary hepatocellular carcinoma(HCC)without macrovascular invasion and distant metastasis,but long-term survival remains unsatisfactory in certain *** sought to identify whether the grading severity of microscopic vascular invasion(MVI)was associated with recurrence and survival among patients with solitary ***:Consecutive patients who underwent hepatectomy for solitary HCC were identified from a multicenter prospectively-collected *** were categorized into three groups according to the MVI grading system proposed by the Liver Cancer Pathology Group of China:M0(no MVI),M1(1-5 sites of MVI occurring≤1.0 cm away from the tumor),and M2(>5 sites occurring≤1.0 cm or any site occurring>1 cm away from the tumor).Recurrence-free survival(RFS)and overall survival(OS)were compared among the ***:Among 227 patients,97(42.7%),83(36.6%),and 47(20.7%)patients had M0,M1,and M2,*** RFS rates among patients with M0,M1,and M2 were 38.3,35.1,11.6 months,respectively,while OS rates were 66.8,62.3,30.6 months,respectively(both P<0.001).Multivariate Cox-regression analyses demonstrated that both M1 and M2 were independent risk factors for RFS(hazard ratio 1.20,95%CI:1.03-1.89,P=0.040;and hazard ratio 1.67,95%CI:1.06-2.64,P=0.027)and OS(hazard ratio 1.28,95%CI:1.05-2.07,P=0.035;and hazard ratio 1.97,95%CI:1.15-3.38,P=0.013).Conclusions:Grading severity of MVI was independently associated with RFS and OS after hepatectomy for solitary *** surveillance for recurrence and potentially adjuvant therapy may be considered for patients with MVI,especially individuals with more severe MVI grading(M2).

关键词： Hepatocellular carcinoma microscopic vascular invasion recurrence survival hepatectomy

基于加速度计测量幼儿身体活动的国内研究热点与趋势分析

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科技资讯 2024年第1期22卷 246-252页

作者：杨杰吴华周文龙海南师范大学海南省儿童认知与行为发展重点实验室琼台师范学院海南海口571127

采用科学文献分析工具——CiteSpace软件分析中国知网数据库中2012—2022年运用加速计测量幼儿身体活动的研究热点及趋势,为后续开展相关研究,解决我国幼儿卫生与健康问题提供支持。结果显示研究热点包括“体质健康、执行功能、静坐行... 详细信息

采用科学文献分析工具——CiteSpace软件分析中国知网数据库中2012—2022年运用加速计测量幼儿身体活动的研究热点及趋势,为后续开展相关研究,解决我国幼儿卫生与健康问题提供支持。结果显示研究热点包括“体质健康、执行功能、静坐行为、活动强度、认知能力”等,我国该领域相关研究尚处于发展阶段,部分关系研究已指出良好的身体活动对幼儿身体健康具有促进作用。未来幼儿身体活动的研究还需深挖根因、探索新策,切实促进幼儿健康成长。

关键词：幼儿卫生与健康身体活动加速度计可视化分析

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Design of high-performance and sustainable Co-free Ni-rich cathodes for next-generation lithium-ion batteries

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SusMat 2024年第1期4卷 48-71页

作者： Hao Ge Zhiwen Shen Yanhong Wang Zhijia Sun Xiaoman Cao Chaoyue Wang Xinyue Fan Jinsong Bai Rundong Li Tianhua Yang Gang wu School of Energy and Environment Shenyang Aerospace UniversityShenyangP.R.China Shenyang Aircraft Airworthiness Certification Center of CAAC ShenyangP.R.China College of Chemistry and Materials Engineering Bohai UniversityJinzhouP.R.China Liaoning General Aviation Academy ShenyangP.R.China Department of Chemical and Biological Engineering University at BuffaloState University of New YorkBuffaloNew YorkUSA

Great attention has been given to high-performance and inexpensive lithiumion batteries(LIBs)in response to the ever-increasing demand for the explosive growth of electric vehicles(EVs).High-performance and low-cost Co-freeNi-rich layered cathodes are considered one of the most favorable candidates for nextgeneration LIBs because the current supply chain of EVs relies heavily on scarce and expensive ***,we review the recent research progress on Co-free Nirich layered cathodes,emphasizing on analyzing the necessity of replacing Co and the popular improvment *** current advancements in the design strategies of Co-free Ni-rich layered cathodes are summarized in *** considerable improvements achieved so far,the main technical challenges contributing to the deterioration of Co-free Ni-rich cathodes such as detrimental phase transitions,crack formation,and severe interfacial side reactions,are difficult to resolve by a single *** cooperation of multiple modification strategies is expected to accelerate the industrialization of Co-free Ni-rich layered cathodes,and the corresponding synergistic mechanisms urgently need to be *** effects will be aroused to explore high-performance Co-free Ni-rich layered cathodes to promote the sustainable development of LIBs.

关键词： Co-free cathodes electrochemical performance lithium-ion batteries modification strategies Ni-rich layered cathodes

社区糖尿病患者对科普系列短视频的满意度与传播意愿分析

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上海医药 2024年第8期45卷 19-25页

作者：许开彦王涛吴洁上海市奉贤区西渡街道社区卫生服务中心全科上海201400

目的:分析社区糖尿病患者对短视频的满意度与传播意愿,为提升糖尿病患者的相关知识掌握与自我健康管理能力提供参考。方法:于2023年3—10月采用单纯随机抽样方法选取上海市奉贤区西渡街道社区卫生服务中心的600名糖尿病患者作为调查对... 详细信息

目的:分析社区糖尿病患者对短视频的满意度与传播意愿,为提升糖尿病患者的相关知识掌握与自我健康管理能力提供参考。方法:于2023年3—10月采用单纯随机抽样方法选取上海市奉贤区西渡街道社区卫生服务中心的600名糖尿病患者作为调查对象开展问卷调查,问卷内容包括一般资料、短视频观看情况、短视频满意度与传播意愿、糖尿病知识水平测试题与糖尿病自我管理能力评估表。结果:195名(33.9%)糖尿病患者表示看过1~4集短视频,195名(33.9%)表示看过5~9集短视频,185名(32.2%)表示看过全部10集短视频。二元Logistic回归分析结果显示,年龄(≥51岁)、学历、病程(≥16年)、糖化血红蛋白水平(≥9.1%)、对饮食方面科普内容感兴趣、糖尿病知识水平、糖尿病自我管理能力是对糖尿病患者短视频满意度与传播意愿具有统计学意义的影响因素(P<0.05)。结论:“许阿姨的降糖之路”短视频在西渡社区糖尿病患者中具有较好的满意度与传播效果,患者能够通过观看短视频进一步提升自身相关知识掌握水平与自我健康管理能力。

关键词：糖尿病健康教育短视频满意度传播意愿

基于Django的小水库雨水工情一体化监测平台研究与开发

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中国水能及电气化 2024年第4期 65-70页

作者：武学毅刘杰张永嵩中国水利水电科学研究院北京100048 北京中水科工程集团有限公司北京100048 内蒙古自治区水利事业发展中心内蒙古呼和浩特010020 辽宁水利土木工程咨询有限公司辽宁沈阳110003

文章基于Django的开发框架,研究开发了小型水库雨水工情一体化监测信息管理平台,解决了平台开发过程中Web应用扩展开发困难、表单处理能力不足、数据库开发要求较高等问题,可实现小型水库雨量、水位、大坝渗压自动监测和信息综合展示功... 详细信息

文章基于Django的开发框架,研究开发了小型水库雨水工情一体化监测信息管理平台,解决了平台开发过程中Web应用扩展开发困难、表单处理能力不足、数据库开发要求较高等问题,可实现小型水库雨量、水位、大坝渗压自动监测和信息综合展示功能。工程数据试验表明,该平台可靠、可高速运行。

关键词： Django 雨水情安全监测小水库

浅析新版水电工程设计概算编制规定和费用标准调整变化

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建筑经济 2024年第7期45卷 32-38页

作者：邓子谦吴洁王秦川中国电建集团成都勘测设计研究院有限公司四川成都610072

2023年12月28日,国家能源局以2023年第8号公告批准发布《水电工程设计概算编制规定》(NB/T 11408-2023)等5项能源行业技术经济类标准,并于2024年6月28日起正式实施。本文简要对比分析2023版水电工程设计概算编制规定和费用标准与2013版... 详细信息

2023年12月28日,国家能源局以2023年第8号公告批准发布《水电工程设计概算编制规定》(NB/T 11408-2023)等5项能源行业技术经济类标准,并于2024年6月28日起正式实施。本文简要对比分析2023版水电工程设计概算编制规定和费用标准与2013版调整变化之处,旨在为水电工程业主、设计、施工、监理等参建各方更好地使用新版编制规定和费用标准提供参考。

关键词：水电工程概算编制规定费用标准新版