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Atmospheric and Oceanic Science Letters 2025年第1期18卷 6-11页

作者： Haoyu Zhou Pang-Chi Hsu Lin chen Yitian Qian Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environmental Change/Collaborative Innovation Center on Forecast and Evaluation of Meteorological DisastersNanjing University of Information Science and TechnologyNanjingChina

During the boreal summer,intraseasonal oscillations exhibit significant interannual variations in intensity over two key regions:the central-western equatorial Pacific(5°S-5°N,150°E-150°W)and the subtropical Northwestern Pacific(10°-20°N,130°E-175°W).The former is well-documented and considered to be influenced by the ENSO,while the latter has received comparatively less attention and is likely influenced by the Pacific Meridional Mode(PMM),as suggested by partial correlation analysis *** elucidate the physical processes responsible for the enhanced(weakened)intraseasonal convection over the subtropical northwestern Pacific during warm(cold)PMM years,the authors employed a moisture budget *** findings reveal that during warm PMM years,there is an increase in summer-mean moisture over the subtropical northwestern *** increase interacts with intensified vertical motion perturbations in the region,leading to greater vertical moisture advection in the lower troposphere and consequently resulting in convective *** a process is pivotal in amplifying intraseasonal convection *** observational findings were further verified by model experiments forced by PMM-like sea surface temperature patterns.

关键词： Boreal summer intraseasonal oscillation Interannual variability Pacific Meridional Mode Moisture budget analysis

Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegia

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Neural Regeneration Research 2025年第5期20卷 1397-1398页

作者： Zhenyu chen Xue-Jun Li Department of Biomedical Sciences University of Illinois College of Medicine RockfordRockfordILUSA Department of Bioengineering University of Illinois at ChicagoChicagoILUSA

Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower *** is one significant cause of chronic neurodisability due to the lack of effective treatments and a wide range of onset ages from early childhood to 70 years.

关键词： degeneration diseases hereditary

Autophagy-targeting modulation to promote peripheral nerve regeneration

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Neural Regeneration Research 2025年第7期20卷 1864-1882页

作者： Yan chen Hongxia Deng Nannan Zhang Department of Obstetrics and Gynecology West China Second HospitalSichuan UniversityChengduSichuan ProvinceChina Key Laboratory of Birth Defects and Women and Children’s Diseases Ministry of EducationSichuan UniversityChengduSichuan ProvinceChina Laboratory of Reproductive Endocrinology and Reproductive Regulation Sichuan UniversityChengduSichuan ProvinceChina National Center for Birth Defect Monitoring West China Second University HospitalSichuan UniversityChengduSichuan ProvinceChina

Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular *** studies have focused on factors that stimulate axonal outgrowth and myelin ***,recent studies have highlighted the pivotal role of autophagy in peripheral nerve regeneration,particularly in the context of traumatic ***,autophagy-targeting modulation has emerged as a promising therapeutic approach to enhancing peripheral nerve *** current understanding suggests that activating autophagy facilitates the rapid clearance of damaged axons and myelin sheaths,thereby enhancing neuronal survival and mitigating injury-induced oxidative stress and *** actions collectively contribute to creating a favorable microenvironment for structural and functional nerve regeneration.A range of autophagyinducing drugs and interventions have demonstrated beneficial effects in alleviating peripheral neuropathy and promoting nerve regeneration in preclinical models of traumatic peripheral nerve *** review delves into the regulation of autophagy in cell types involved in peripheral nerve regeneration,summarizing the potential drugs and interventions that can be harnessed to promote this *** hope that our review will offer novel insights and perspectives on the exploitation of autophagy pathways in the treatment of peripheral nerve injuries and neuropathies.

关键词： autophagy autophagy related genes Charcot–Marie–Tooth diseases diabetic peripheral neuropathy metformin myelination peripheral nerve injury Schwann cells sciatic nerve Wallerian degeneration

上海浦东新区良性前列腺增生合并膀胱过度活动症的流行病学调查

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现代泌尿外科杂志 2017年第10期22卷 732-737页

作者：伊庆同龚旻胡巍陈楚红陈长青顾建军祝凤明上海市浦东医院复旦大学附属浦东医院泌尿外科上海201399

目的调查上海浦东新区≥50岁人群良性前列腺增生(BPH)合并膀胱过度活动症(OAB)的患病率、相关危险因素及其对患者生活质量的影响。方法运用描述性流行病学多阶段随机抽样方法,在上海浦东新区一般人群中抽取≥50岁BPH患者1 632名,对下尿... 详细信息

目的调查上海浦东新区≥50岁人群良性前列腺增生(BPH)合并膀胱过度活动症(OAB)的患病率、相关危险因素及其对患者生活质量的影响。方法运用描述性流行病学多阶段随机抽样方法,在上海浦东新区一般人群中抽取≥50岁BPH患者1 632名,对下尿路症状(LUTS)情况采用国际前列腺症状评分(IPSS)和生活质量评分(QoL)进行评估;应用国际勃起功能指数问卷-5(IIEF-5)记录患者的阴茎勃起功能情况;对合并OAB患者采用膀胱过度活动症症状评分(OABSS)和King健康问卷评分(KHQ)调查;评估BPH合并OAB对患者生活质量的影响。结果共获得有效问卷1 476份。BPH合并OAB的总患病率为39.6%,50岁~、60岁~、70岁~、80岁~及≥90岁年龄组的患病率分别为28.1%、34.2%、44.6%、48.2%、51.5%。年龄、前列腺体积及焦虑抑郁是BPH合并OAB的危险因素。随着年龄与前列腺体积的增加,BPH合并OAB患病率升高,患者LUTS加重,IPSS、QoL、OABSS、KHQ评分增加,IIEF-5评分下降。KHQ评分较高的项目有一般健康状况(26.9±7.4)分、排尿问题严重程度(29.6±8.2)分和睡眠/精力(32.5±8.3)分。结论浦东新区≥50岁人群BPH合并OAB患病率为39.6%,其患病率与年龄、前列腺体积及焦虑抑郁程度呈正相关;BPH可能是男性OAB的患病危险因素之一,而BPH合并OAB可严重影响患者生活质量。

关键词：良性前列腺增生膀胱过度活动症流行病学调查

Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

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Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin Su Taiqi huang Meiyu Zhang Yanyu Zhang Yan Zeng Xingxing chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

Radiometric Cross-Calibration for Multiple Sensors with the Moon as an Intermediate Reference

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Journal of Meteorological Research 2019年第5期33卷 925-933页

作者： Lu ZHANG Peng ZHANG Xiuqing hu Lin chen min min Na XU Ronghua WU Nanjing University of Information Science&Technology Nanjing 210044 Chinese Academy of Meteorological Sciences China Meteorological AdministrationBeijing 100081 Key Laboratory of Radiometric Calibration and Validation for Environmental Satellites National Satellite Meteorological CenterChina Meteorological AdministrationBeijing 100081

The instrument cross-calibration is an effective way to assess the quality of satellite data. In this study, a new method is proposed to cross-calibrate the sensors among satellite instruments by using a RObotic Lunar Observatory(ROLO) model and Apollo sample reflectance in reflective solar bands(RSBs). The ROLO model acts as a transfer radiometer to bridge between the instruments. The reflective spectrum of the Apollo sample is used to compensate for the difference in the instrument's relative spectral responses(RSRs). In addition, the double ratio between the observed lunar irradiance and the simulated lunar irradiance is used to reduce the difference in instrument lunar viewing and illumining geometry. This approach is applied to the Moderate Resolution Imaging Spectroradiometer(MODIS), the Sea-Viewing Wide Field-of-View Sensor(Sea Wi FS), and the Advanced Land Imager(ALI) on board three satellites, respectively. The mean difference between MODIS and Sea Wi FS is less than 3.14%, and the difference between MODIS and ALI is less than 4.75%. These results indicate that the proposed cross-calibration method not only compensates for the RSR mismatches but also reduces the differences in lunar observation geometry. Thus,radiance calibration of any satellite instrument can be validated with a reference instrument bridged by the moon.

关键词： radiometric cross-calibration multiple sensors calibration reference

Preparation and Catalytic Activity of SO42-/TiO2-La2O3 in Synthesis of Butyl Butyrate

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合成化学 2004年第S1期 154-154页

作者： YANG Shui-jin*, LUO Yi, BAI Ai-min, hu Zhen-zhu, chen Fang Department of Chemistry and Environmental Engineering, hubei Normal University, huangshi 435002, China

Maternal serum level of resistin is associated with risk for gestational diabetes mellitus:A meta-analysis

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World Journal of Clinical Cases 2019年第5期7卷 585-599页

作者： Shi-min hu Meng-Shi chen Hong-Zhuan Tan Department of Epidemiology and Health Statistics Xiangya School of Public Health Central South University

BACKGROUND Resistin is most likely involved in the pathogenesis of gestational diabetes mellitus(GDM), but the existing findings are *** To review the literature investigating the associations of the risk of GDM with serum level of *** A systematic literature search was performed using MEDLINE, EMBASE, and Web of Science(all databases). This meta-analysis included eligible studies that:(1) investigated the relationship between the risk of GDM and serum resistin;(2)included GDM cases and controls without GDM;(3) diagnosed GDM according to the oral glucose-tolerance test;(4) were performed in humans;(5) were published as full text articles in English; and(6) provided data with median and quartile range, median and minimum and maximum values, or mean and standard deviation. The pooled standardized mean difference(SMD) and 95%confidence interval(CI) were calculated to estimate the association between the risk of GDM and serum resistin. To analyze the potential influences of need for insulin in GDM patients and gestational age at blood sampling, we performed a subgroup analysis. Meta-regression with restricted maximum likelihood estimation was performed to assess the potentially important covariate exerting substantial impact on between-study *** The meta-analysis for the association between serum resistin level and GDM risk included 18 studies(22 comparisons) with 1041 cases and 1292 controls. The total results showed that the risk of GDM was associated with higher serum resistin level(SMD = 0.250, 95%CI: 0.116, 0.384). The "after 28 wk" subgroup, "no need for insulin" subgroup, and "need for insulin" subgroup indicated that higher serum resistin level was related to GDM risk("after 28 wk" subgroup: SMD =0.394, 95%CI: 0.108, 0.680; "no need for insulin" subgroup: SMD = 0.177, 95%CI:0.018, 0.336; "need for insulin" subgroup: SMD = 0.403, 95%CI: 0.119, 0.687). The"before 14 wk" subgroup, "14-28 wk" subgroup, and "no information

关键词： Resistin Gestational diabetes mellitus Meta-analysis Gestational age

Topographic Characteristics for the Geomorphologic Zones in the Northwestern Edge of the Qinghai-Tibet Plateau

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Journal of Mountain Science 2013年第6期10卷 1039-1049页

作者： chenG Wei-ming ZHAO Shang-min ZHOU cheng-hu chen Xi State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Department of Surveying and Mapping College of Mining Technology Taiyuan University of Technology Xinjiang Institute of Ecology and Geography Chinese Academy of Sciences

Based on geomorphologic and digital elevation model(DEM) data, the topographic characteristics of the northwestern edge of the Qinghai-Tibet Plateau are analyzed. Five representative peaks are first determined according to the topographic profile maps for the ridge and piedmont lines, and then the topographic gradient characteristics are analyzed according to the representative topographic profile acquisition *** on the geomorphologic database data, the regions between the ridge and the piedmont lines are divided into four geomorphologic zones; and the topographic characteristics are finally analyzed for the different geomorphologic zones regions using the DEM data. The research results show that from the piedmont to the ridge, there exist four geomorphologic zones: arid, fluvial, periglacial and glacial. The arid has the lowest elevation, topographic gradient, relief and slope characteristics. The fluvial has lower elevation and the highest topographic gradient, but with lower relief and slope characteristics. With higher elevation, the periglcial has lower topographic gradient, but the highest relief and slope characteristics. The glacial has the highest elevation with higher topographic gradient, relief and slope characteristics.

关键词： Topographic characteristics Geomorphologic zone Topographic gradient Topographic profile map Qinghai-Tibet Plateau

Romipeptides A and B, two new romidepsin derivatives isolated from Chromobacterium violaceum No.968 and their antitumor activities in vitro

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Chinese Journal of Natural Medicines 2019年第2期17卷 155-160页

作者： XIONG Lei chen Chang-Fa min Tao-Ling hu Hai-Feng State Key Lab of New Drug&Pharmaceutical Process Shanghai Institute of Pharmaceutical Industry China State Institute of Pharmaceutical Industry

Romipeptides A and B(1 and 2),two new romidepsin derivatives,and three known compounds,chromopeptide A(3),romidepsin(4)and valine-leucine dipeptide(5)were isolated from the fermentation broth of Chromobacterium violaceum *** structures were elucidated by interpretation of their UV,HR-ESI-MS and NMR *** absolute configuration of compound 1 and 2 were established by single crystal X-ray diffraction *** 1–5 were evaluated for their anti-proliferative activities against three human cancer cell lines,SW620,HL60,and *** results showed most of these compounds exhibited antitumor activities in vitro,in which compound 2 displayed potent cytotoxicity to SW620,HL60 and A549 cell lines,with IC_(50) of 12.5,6.7 and 5.7 nmol·L^(–1),respectively.

关键词： Chromobacterium violaceum Romidepsin derivatives Cytotoxicity