Maternal serum level of resistin is associated with risk for gestational diabetes mellitus:A meta-analysis

作     者：Shi-Min Hu Meng-Shi Chen Hong-Zhuan Tan 

作者机构：Department of Epidemiology and Health Statistics Xiangya School of Public Health Central South University 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2019年第7卷第5期

页      面：585-599页

核心收录：

学科分类：10[医学] 

基　　金：Supported by the National Natural Science Foundation of China No.81373088 and No.81773535 

主　　题：Resistin Gestational diabetes mellitus Meta-analysis Gestational age 

摘      要：BACKGROUND Resistin is most likely involved in the pathogenesis of gestational diabetes mellitus(GDM), but the existing findings are *** To review the literature investigating the associations of the risk of GDM with serum level of *** A systematic literature search was performed using MEDLINE, EMBASE, and Web of Science(all databases). This meta-analysis included eligible studies that:(1) investigated the relationship between the risk of GDM and serum resistin;(2)included GDM cases and controls without GDM;(3) diagnosed GDM according to the oral glucose-tolerance test;(4) were performed in humans;(5) were published as full text articles in English; and(6) provided data with median and quartile range, median and minimum and maximum values, or mean and standard deviation. The pooled standardized mean difference(SMD) and 95%confidence interval(CI) were calculated to estimate the association between the risk of GDM and serum resistin. To analyze the potential influences of need for insulin in GDM patients and gestational age at blood sampling, we performed a subgroup analysis. Meta-regression with restricted maximum likelihood estimation was performed to assess the potentially important covariate exerting substantial impact on between-study *** The meta-analysis for the association between serum resistin level and GDM risk included 18 studies(22 comparisons) with 1041 cases and 1292 controls. The total results showed that the risk of GDM was associated with higher serum resistin level(SMD = 0.250, 95%CI: 0.116, 0.384). The after 28 wk subgroup, no need for insulin subgroup, and need for insulin subgroup indicated that higher serum resistin level was related to GDM risk(after 28 wk subgroup: SMD =0.394, 95%CI: 0.108, 0.680; no need for insulin subgroup: SMD = 0.177, 95%CI:0.018, 0.336; need for insulin subgroup: SMD = 0.403, 95%CI: 0.119, 0.687). Thebefore 14 wk subgroup, 14-28 wk subgroup, and no information