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Small extracellular vesicles derived from h.man induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong Li h.i-min Xing h.i-Dong Qian Qiao Gao Sh.ng-Lan Xu h.a Ma Zai-Long Ch. State Key Laboratory of Oph.h.lmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research.Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies h.ve found th.t transplantation of neural progenitor cells(NPCs)promotes th. survival of injured ***,a poor integration rate and h.gh.risk of tumorigenicity after cell transplantation limits th.ir clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies h.ve sh.wn th.t stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and oth.r eye *** th.s study,we intravitreally transplanted sEVs derived from h.man induced pluripotent stem cells(h.PSCs)and h.PSCs-differentiated NPCs(h.PSC-NPC)in a mouse model of optic nerve *** results sh.w th.t th.se intravitreally injected sEVs were ingested by retinal cells,especially th.se localized in th. ganglion cell *** with.h.PSC-NPC-derived sEVs mitigated optic nerve crush.induced retinal ganglion cell degeneration,and regulated th. retinal microenvironment by inh.biting excessive activation of *** analysis furth.r revealed th.t h.PSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,wh.ch.h.d protective effects on RGCs after optic nerve *** findings suggest th.t sEVs derived from h.PSC-NPC are a promising cell-free th.rapeutic strategy for optic neuropath..

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropath. retinal ganglion cell small extracellular vesicles

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Ph.toph.sical,optical,and ph.tocatalytic h.drogen production properties of layered-type BaNb_(2-x)Ta_(x)P_(2)O_(11)(x=0,0.5,1.0,1.5,and 2.0)compounds

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Journal of Materials Science & Tech.ology 2022年第3期98卷 26-32页

作者： min Je kang Gill Sang h.n In Sun Ch. Department of Materials Science and Engineering Ajou UniversitySuwon 16499Republic of Korea Department of Energy Systems Research Ajou UniversitySuwon 16499Republic of Korea Sch.ol of Advanced Materials Science and Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea

Layered-type metal ph.sph.tes of BaNb_(2-x)Ta_(x)P_(2)O_(11)(x=0,0.5,1.0,1.5,and 2.0)were synth.sized using a solid-state reaction *** ph.toph.sical,optical,and ph.tocatalytic h.drogen production properties of th. resulting powders were investigated for th. first ***-pure and h.mogeneous powders with.irregular morph.logies were obtained at a calcination temperature of 1200℃.As th. Ta content increased,th. interlayer distance along th. c-axis increased by up to 0.14%.Additionally,th. optical bandgap values increased from 3.32 to 3.59 *** energy band positions were estimated from th. Mott–Sch.ttky ***_(2)P_(2)O_(11)(x=0)exh.bited th. lowest conduction band edge position(-0.14 V *** normal h.drogen electrode,Nh.),wh.ch.is located above th. water reduction potential(0.0 V ***).In comparison,BaTa_(2)P_(2)O_(11)(x=2.0)exh.bited th. h.gh.st conduction band edge position(-0.29 V ***),comparable to th.t of TiO_(2).Th. ph.tocatalytic activity for h.drogen produced from splitting water was measured under ultraviolet ligh. ***,BaTa_(2)P_(2)O_(11)exh.bited th. h.gh.st activity(7.3μmol/h.,wh.ch.was 15 and 10 times larger th.n BaNb_(2)P_(2)O_(11)(0.5μmol/h.and nano-TiO_(2)(0.7μmol/h.,*** activity of BaTa_(2)P_(2)O_(11)increased to 24.4μmol/h.after deposition of th. NiO_(x)co-catalyst(1 wt.%),wh.ch.remained stable during continuous operation(~35 h..

关键词： BaNb_(2)P_(2)O_(11) BaTa_(2)P_(2)O_(11) Layered crystal structure Bandgap Band edge positions Ph.tocatalytic h.drogen production

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Development of a novel electrolytic process for producing h.gh.purity magnesium metal from magnesium oxide using a liquid tin cath.de

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Journal of Magnesium and Alloys 2021年第5期9卷 1661-1672页

作者： Tae-h.uk Lee Toru h.Okabe Jin-Young Lee Young min Kim Jungsh.n kang Korea Institute of Geoscience and mineral Resources 124 Gwahak-ro Yuseong-guDaejeon 34132Republic of Korea Institute of Industrial Science The University of Tokyo4-6-1 KomabaMeguro-kuTokyo 153-8505Japan University of Science and Tech.ology 217 Gajeong-ro Yuseong-guDaejeon 34113Republic of Korea Korea Institute of Materials Science 797 Changwondae-roSeongsan-guChangwonGyeongnam51508Republic of Korea

Th. current electrolytic processes for magnesium(Mg)metal h.ve several disadvantages,such.as anh.drous magnesium ch.oride(MgCl_(2))preparation and generation of h.rmful ch.orine(Cl_(2))*** overcome th.se drawbacks,a novel Mg production process to produce h.gh.purity Mg metal directly from magnesium oxide(MgO)was investigated in th.s *** electrolysis of MgO was conducted using a liquid tin(Sn)cath.de and a carbon(C)anode in th. eutectic composition of a magnesium fluoride(MgF_(2))-lith.um fluoride(LiF)molten salt under an applied voltage of 2.5 V at 1053-1113 *** certain conditions,th. Mg-Sn alloys with.Mg_(2)Sn and Mg(Sn)ph.ses were obtained with.a current efficiency of 86.6%at 1053 *** produce h.gh.purity Mg metal from th. Mg-Sn alloy,vacuum distillation was conducted at 1200-1300 K for a duration of 5-10 *** th. vacuum distillation,th. concentration of Mg in th. Mg-Sn alloy feed decreased from 34.1 to 0.17 mass%,and Mg metal with.a purity of 99.999%was obtained at 1200 ***,th. electrolytic process developed h.re is feasible for th. production of h.gh.purity Mg metal from MgO using an efficient meth.d.

关键词： Magnesium Magnesium oxide Electrolytic process Liquid tin cath.de Vacuum distillation

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Preparation of SnO Nanosh.ets and SnO_2 Fine Powders by h.drazine Meth.d

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稀有金属材料与工程 2006年第A03期35卷 43-46页

作者： kang-min Kim Jong-h.un Lee Department of Materials Science & Engineering Korea UniversitySeoul 136-713Korea

SnO nanosh.ets and SnO_2 nanopowder were prepared by h.drazine (N_2h.4)-based ch.mical routes and th.ir gas sensing ch.racteristics were investigated.A SnCl_2-h.drazine complex (Sn[ N_2h.4)_x]·yh.2O) was formed by a reaction between a SnCl_2 aqueous solution and N_2h.4·h.*** th.s complex was h.at-treated at 450℃,SnO_2 nanopowders were prepared by th. decomposition of th. *** sensor fabricated from th. SnO_2 nano powders sh.wed a good recovery,fast response and h.gh.sensitivity for CO 50μg/g (R_a/R_g=1.87),C_2h.5Oh.100μg/g (R_a/R_g=4.80),and acetone 100μg/g (R_a/R_g=1.50).SnO nano- sh.ets could be prepared wh.n a NaOh.solution was added to th. solution containing th. ***_2 nano sh.ets prepared by th. oxidation of SnO nanosh.ets at 700℃in air atmosph.re also sh.wed a good sensitivity R_a/R_g=1.79) for CO 50μg/g at 400℃.Th. h.drazine meth.d provided an effective tool to controlling th. morph.logy and oxidation state of th. tin oxide powders.

关键词： SnO2 SnO h.drazine meth.d gas sensor nanosh.ets nanopowders

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Effect of Microstructures on Elevated-Temperature Wear Resistance of a h.t Working Die Steel

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Journal of Iron and Steel Research.International 2011年第10期18卷 47-53页

作者： WEI min-xian WANG Sh.-qi WANG Lan Ch.N kang-min Sch.ol of Materials Science and Engineering Jiangsu University Zhenjiang 212013 Jiangsu China

Elevated-temperature wear tests under atmosph.ric conditions at 400 ℃ were performed for a h.t working die steel h.1 on a pin-on-disk wear tester. Th. ph.se and morph.logy of worn surfaces were examined using XRD and SEM, and th. relation of wear resistance to tempered microstructures was studied for h.1 steel. XRD patterns exh.bit th.t oxidative wear is a predominated wear mech.nism with.Fe3O4 and Fe2O3 on worn surfaces. It is found th.t with.increasing normal load, obvious plastic deformation of substrate appears on worn surfaces. Microstructures start to affect apparently wear resistance of th. steel with.an increase of load. Under loads of 50--100 N, wear losses of steel retain low values and relatively approach.for steels with.various microstructures. As loads are increased to 150--200 N, wear losses of steel start to increase obviously and present apparent difference for steel with.various microstructures. Wear resistance is found to increase in th. sequence as follows., tempered sorbite, tempered martensite, tempered troostite with.ut secondary h.rdening and tempered troostite with.secondary h.rdening or upcoming one. h.gh.r strength.and microstructural stability are required for steels with.excellent wear resistance.

关键词： steel h.at treatment microstructure wear wear resistance

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Melt film formation and disintegration during novel atomization process

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中国有色金属学会会刊：英文版 2007年第6期17卷 1276-1281页

作者：刘允中 K. min agawa h. Kakisawa K. h.lada Sch.ol of Mech.nical Engineering South China University of Technology Ecomaterials Research.Center National Institute for Materials Science 1-2-1 Sengen Tsukuba Cit y Ibaraki 305-0047 Japan

h.brid atomization is a new powder-making meth.d and can produce economically very fine, clean, sph.rical tin alloy powders with.average particle size about 10μm and narrow size distributions. Th. key concept of h.brid atomization is to control th. liquid film formation on disk for fine powder production. Low-pressure gas atomization was utilized to promote th. formation of a very th.n stable liquid film before centrifugal breakup and give a better preparation for th. final disintegration of melts. Besides th. breakup ability of th. rotating atomizer, th. ch.racteristics of liquid film on rotating disk affect th. atomization mech.nism and results remarkably. Th. main disintegration mode of melt is th. breakup type of liquid film, wh.ch.depends on th. film instability and th. atomization ability of th. rotating disk. On th. oth.r h.nd, th. mean powder size relates closely to th. film th.ckness. Th. powder size distribution is mainly controlled by th. atomization mode and th. stability, flow type of liquid film on th. rotating disk. A very th.n, stable liquid film with.long ligaments and a small pitch.in LF mode results in very fine uniform tin alloy powders.

关键词：混合雾化薄膜雾化模式合金

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Self-assembled carbon monoxide nanoprodrug for ch.miexcitationtriggered synergistic ch.moth.rapy against breast cancer

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Science Ch.na Ch.mistry 2025年

作者： Sh.nfei Cui Yiyao Pan Ch.nzh. Ma Bin Qi Qingqiang min ming Li h.abing Ch.n h.ngte Ke Xingyue Ji Jiangsu Province Engineering Research.Center of Precision Diagnostics and Th.rapeutics Development College of Pharmaceutical ScienceSoochow University

Carbon monoxide（CO） h.s recently been well-establish.d as a promising th.rapeutic modality against cancer. Th. development of transition-metal-free and tumor-targeted delivery platforms for CO is h.gh.y demanded but remains very sporadic. h.rein, we developed a polyprodrug system for th. co-delivery of CO and a ch.moth.rapeutic agent combretastin A-4（CA-4） to th. tumor site based on a ch.miexcitation mech.nism. Such.a poly-prodrug successfully ach.eved th. co-activation of CO and CA-4 in response to h.O2at th. tumor site both.in vitro and in vivo. Importantly, a synergist effect between CO and CA-4 was observed in suppressing tumor growth.in a mouse tumor model. It is anticipated th.t such.a poly-prodrug system could be potentially adapted for th. co-delivery of CO and anoth.r drug payload for combinational th.rapy for oth.r indications.

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Stable metal-organic frameworks with.h.gh.catalytic performance in th. cycloaddition of CO_2 with.aziridines

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Science Ch.na Ch.mistry 2019年第5期62卷 622-628页

作者： Xiao-min kang Ying Sh. Ch.n-Sh.ai Cao Bin Zh.o College of Ch.mistry and Key Laboratory of Advanced Energy Material Ch.mistry Nankai University

Based on th. mixed ligands XN(4′-(4-pyridine)4,2′:2′,4′′-terpyridine) and isoph.h.lic acid(IPA), th.ee new metal-organic frameworks(MOFs) {[M_2(XN)_2(IPA)_2]·2 h.2O}_n(M=Co(1), Mn(2), Ni(3)) were assembled and structurally ch.racterized,presenting 3 D pillar-ch.in feature structures. Stability measurements demonstrate th.t th.se compounds possess h.gh.th.rmostability and can endure different organic solvents as well as various acid/base solutions with.ph.range of 1 to 14. Importantly,compounds 1–3 can serve as h.gh.efficiency catalysts for th. transformation of CO_2 and aziridines to form h.gh.value oxazolidinones under mild conditions, exh.biting excellent cyclicity at least five times.

关键词： MOFs stability catalysis oxazolidinones CO2 conversion

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Textural and compositional variation of mica from th. Dexing porph.ry Cu deposit:constraints on th. beh.vior of h.logens in porph.ry systems

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Acta Geoch.mica 2023年第2期42卷 221-240页

作者： Yan Liu Jian-Feng Gao Liang Qi kang min State Key Laboratory of Ore Deposit Geoch.mistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China University of Ch.nese Academy of Sciences Beijing 100049China

Th. Dexing porph.ry deposit is th. largest porph.ry Cu–Mo–Au deposit in South.*** composition can record th. ph.sicoch.mical conditions and evolution h.story of magmatic-h.droth.rmal *** from th. Dexing porph.ry deposit could be divided to th.ee types:primary magmatic biotite(Bi-M),h.droth.rmal altered magmatic biotite(Bi-A)and h.droth.rmal biotite(Bi-h..Th. temperature of Bi-M and Bi-h.range from 719 to 767℃ and 690 to 727℃,*** magmatic and h.droth.rmal biotite h.ve h.gh.Fe^(3+)/Fe^(2+)ratios(from 0.18 to 0.24)and XMgvalues(from 0.57 to 0.66),indicating a h.gh.oxygen *** h.s F lower th.n Bi-A and Bi-h.up to 0.26 wt%),but h.s Cl(Cl=0.18–0.30 wt%)similar to Bi-A and Bi-h.Cl=0.21–0.35 wt%),suggesting th.t h.gh.Cl/F ratios of early h.droth.rmal fluid may result from th. exsolution from h.gh.Cl *** potassic alteration zone to ph.llic and propylitic alteration zones,Cl decreases with.increasing Cu,wh.reas F increases ***,Cl mostly originate from magma,but enrich.ent of F possibly results from reaction of fluids and Neoproterozoic *** correlation between Cl and Cu indicates th.t Cl migh. act as an important catalyst during Cu mineralization *** from Dexing h.s similar h.logen compositions to oth.r porph.ry Cu-/Mo deposits in th. *** contents of h.droth.rmal fluid may be critical for Cu transportation and enrich.ent,wh.le consumption of Cl would promote Cu deposition.

关键词： h.logen Dexing porph.ry deposit Biotite Geoch.mistry Porph.ry Cu deposit

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Engineering h.gh.performance ch.miluminescent probes via enzymatic pocket targeting: h.gh.th.ough.ut screening for ultralong afterglow imaging of orth.topic h.patocellular carcinoma

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Science Ch.na Ch.mistry 2025年

作者： Sh.ai h.ang Sh.aige Bai Ting Luo Bin Feng min Liu Fan Zh.ng Sh.ang h.ang Yanpeng Fang Dan Ding Wenbin Zeng Xiangya Sch.ol of Ph.rmaceutical Sciences Central South University College of Life Sciences Nankai University

h.patocellular carcinoma （h.C） is a h.gh.y aggressive liver malignancy and th. main form of liver cancer. Early diagnosis and treatment of h.C can effectively reduce mortality. Carboxylesterase （CE）-specific detection and imaging can be used for early diagnosis and image-guided surgical of h.C. h.wever, traditional optical probes suffer from poor selectivity and low imaging signal-to-noise ratio. h.re, we h.ve constructed a series of ch.miluminescent probes for carboxylesterase detection based on th. strategy of enzymatic pocket-oriented steric tailoring tech.iques. Th. probes with.different unique and excellent properties h.ve been obtained th.ough.th. structure-based steric h.ndrance adjustment on th. recognition site. h.re, CE-2 h.s been successfully used for h.gh.th.ough.ut screening of rapid carboxylesterase inh.bitors due to its extremely low detection limit (2.5×10-4U mL-1) and fast recognition ability. CE-3 h.s been successfully used for image-guided surgery of orth.topic h.patocellular carcinoma due to its ultra-long ch.miluminescence imaging （over 12 h. of h.patocellular carcinoma. Th.s study may promote advances in th. rapid detection and screening of inh.bitory drugs for CE and th. field of surgical navigation in h.C.

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