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Lithospheric thinning and ignition of a Cordilleran magmatic flare-up:Geochemical and O-Hf isotopic constraints from Cretaceous plutons in southern Korea

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Geoscience Frontiers 2023年第1期14卷 327-345页

作者： Albert Chang-sik Cheong min-ji jung Hui JeJo Jeongmin Kim Shinae Lee Youn-Joong Jeong Korea Basic Science Institute Ochang Center Cheongju 28119Republic of Korea Graduate School of Analytical Science and Technology Chungnam National UniversityDaejeon 34134Republic of Korea Korea Institute of Geoscience and mineral Resources Daejeon 34132Republic of Korea

Northeast Asian continental margins contain the products of magma emplacement driven by prolonged subduction of the(paleo-)Pacific *** observed in many Cordilleran arcs,magmatic evolution in this area was punctuated by high-volume pulses amid background *** present study investigates the early evolution of the Cretaceous magmatic flare-up using new and published geochronological,geochemical,and O-Hf isotope data from plutonic rocks in the southern Korean *** a long(~50 m.y.)magmatic hiatus and the development of the Honam Shear Zone through flat-slab subduction,the Cretaceous flare-up began with the intrusion of monzonites,granodiorites,and granites in the inboard Gyeonggi Massif and the intervening Okcheon *** to Jurassic granitoids formed during the former flare-up,Albian(~111 Ma)monzonites found in the Eopyeong area of the Okcheon Belt have distinctly higher zirconε_(Hf)(t)(-7.5±1.3)andδ^(18)O(7.78‰±0.25‰)values and lower wholerock La/Yb and Sr/Y *** voluminous coeval granodiorite and granite plutons in the Gyeonggi Massif are further reduced in Sr/Y and to a lesser extent,in La/Yb,and have higher zirconε_(Hf)(t)values(-13 to-19)than the Precambrian basement(ca.-30).These chemical and isotopic features indicate that Early Cretaceous lithospheric thinning,most likely resulting from delamination of tectonically and magmatically overthickened lithospheric keel that was metasomatized during prior subduction episodes,and consequent asthenospheric upwelling played vital roles in igniting the magmatic *** O-Hf isotopic ranges of synmagmatic zircons from the Albian plutons and their Paleoproterozoic and Jurassic inheritance attest to the involvement of lithospheric mantle and crustal basement in magma generation during this decratonization *** magmatism then migrated trenchward and culminated in the Late Cretaceous,yielding widespread granitoid rocks emplaced at shallow crustal *** early Late Cretaceous(94-8

关键词： Cordilleran arc Cretaceous flare-up Korean Peninsula Lithospheric thinning Crustal rejuvenation

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Self-assembled carbon monoxide nanoprodrug for chemiexcitationtriggered synergistic chemotherapy against breast cancer

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Science China Chemistry 2025年

作者： Shunfei Cui Yiyao Pan Chenzhe Ma Bin Qi Qingqiang min ming Li Huabing Chen Hengte Ke Xingyue ji jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development College of Pharmaceutical ScienceSoochow University

Carbon monoxide（CO） has recently been well-established as a promising therapeutic modality against cancer. The development of transition-metal-free and tumor-targeted delivery platforms for CO is highly demanded but remains very sporadic. Herein, we developed a polyprodrug system for the co-delivery of CO and a chemotherapeutic agent combretastin A-4（CA-4） to the tumor site based on a chemiexcitation mechanism. Such a poly-prodrug successfully achieved the co-activation of CO and CA-4 in response to H2O2at the tumor site both in vitro and in vivo. Importantly, a synergist effect between CO and CA-4 was observed in suppressing tumor growth in a mouse tumor model. It is anticipated that such a poly-prodrug system could be potentially adapted for the co-delivery of CO and another drug payload for combinational therapy for other indications.

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Tolerating Permanent State Transition Faults in Asynchronous Sequential Machines

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Journal of Computer Science & Technology 2016年第5期31卷 1028-1037页

作者： jung-min Yang School of Electronics Engineering Kyungpook National University Daegu 41566 Korea

Corrective control theory lays a novel foundation for the fault-tolerant control of asynchronous sequential machines. In this paper, we present a corrective control scheme for tolerating permanent state transition faults in the dynamics of asynchronous sequential machines. By a fault occurrence, the asynchronous machine may be stuck at a faulty state, not responding to the external input. We analyze the detectability of the considered faults and present the necessary and sufficient condition for the existence of a controller that overcomes any permanent transition faults. Fault tolerance is realized by using potential reachability and asynchronous mechanisms in the machine. A case study on an asynchronous counter is provided to illustrate the proposed fault detection and tolerance scheme.

关键词： asynchronous sequential machine corrective control permanent fault fault tolerance

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Projective Dirichlet Boundary Condition with Applications to a Geometric Problem

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Acta Mathematica Sinica,English Series 2016年第1期32卷 11-24页

作者： min ji Academy of Mathematics and Systems Science Chinese Academy of Sciences

Given a domain Ω R^n, let λ 〉 0 be an eigenvalue of the elliptic operator L ：= ∑i,j^n= 1δ/δxi on Ω for Dirichlet condition. For a function f ∈ L2（Ω）, it is known that the linear resonance equation Lu ＋ λu = f in Ω with Dirichlet boundary condition is not always solvable. We give a new boundary condition Pλ（u｜δΩ） = g, called to be projective Dirichlet condition, such that the linear resonance equation always admits a unique solution u being orthogonal to all of the eigenfunctions corresponding to λ which satisfies ｜｜u｜｜2,2 ≤ C（｜｜f｜｜2 ＋｜｜g｜｜2,2） under suitable regularity assumptions on δΩ and L, where C is a constant depends only on n, Ω, and L. More a priori estimates, such as W^2~＇P-estimates and the C^2,α-estimates etc., are given also. This boundary condition can be viewed as a generalization of the Dirichlet condition to resonance equations and shows its advantage when applying to nonlinear resonance equations. In particular, this enables us to find the new indicatrices with vanishing mean （Cartan） torsion in minkowski geometry. It is known that the geometry of indicatries is the foundation of Finsler geometry.

关键词： Elliptic resonance equation nonlinear boundary condition convex indicatrix mean tor-sion

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The CONSTANS-like 4 transcription factor,AtCOL_4,positively regulates abiotic stress tolerance through an abscisic acid-dependent manner in Arabidopsis

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Journal of Integrative Plant Biology 2015年第3期57卷 313-324页

作者： ji-Hee min jung-Sung Chung Kyeong-Hwan Lee Cheol Soo Kim Department of Plant Biotechnology Chonnam National University Department of Agronomy Gyeongsang National University Department of Rural and Biosystems Engineering Chonnam National University

The precise roles of the B-box zinc finger family of transcription factors in plant stress are poorly *** analysis was performed on AtCOL4,an Arabidopsis thaliana ***-like 4 protein that is a putative novel transcription factor,and which contains a predicted transcriptional activation *** of an AtCOL4 promoter-b-glucuronidase（GUS） construct revealed substantial GUS activity in whole *** expression of AtCOL4 was strongly induced by abscisic acid（ABA）,salt,and osmotic *** in atcol4 resulted in increased sensitivity to ABA and salt stress during seed germination and the cotyledon greening *** contrast,AtCOL4-overexpressing plants were less sensitive to ABA and salt stress compared to the wild ***,in the presence of ABA or salt stress,the transcript levels of other ABA biosynthesis and stress-related genes were enhanced induction in AtCOL4-overexpressing and WT plants,rather than in the atcol4 ***,AtCOL4 is involved in ABA and salt stress response through the ABA-dependent signaling *** together,these findings provide compelling evidence that AtCOL4 is an important regulator for plant tolerance to abiotic stress.e

关键词： Abscisic acid B-box zinc finger family transcription factor salt stress

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Virtual Reality-Based Random Dot Kinematogram

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Computers, Materials & Continua 2021年第9期68卷 4205-4213页

作者： Jun Ma Hyo-jung Kim ji-Soo Kim Eek-Sung Lee min Hong Department of Software Convergence Soonchunhyang UniversityAsan31538Korea Research Administration Team Seoul National University Bundang HospitalSeongnam13620Korea Dizziness Center Clinical Neuroscience CenterDepartment of NeurologySeoul National University Bundang HospitalSeongnam13620Korea Department of Neurology Seoul National University College of MedicineSeoul03080Korea Department of Neurology College of MedicineSoonchunhyang UniversityBucheon14584Korea Department of Computer Software Engineering Soonchunhyang UniversityAsan31538Korea

This research implements a random dot kinematogram(RDK)using virtual reality(VR)and analyzes the results based on normal *** motion perception is one of visual functions localized to a specific cortical area,the human motion perception area(human analogue for the middle temporal/middle superior temporal area)located in the parieto–occipito–temporal junction of the human *** RDK measures visual motion perception *** stimuli in conventional RDK methods are presented using a monitor screen,so these devices require a spacious dark room for installation and ***,VR technology has been implemented in different medical *** test method proposed in this study include a VR-based RDK that can independently measure human motion perception abilities without any spatial constraints via a VR head-mounted ***,the VR-based RDK was implemented,and the visual perception abilities of the normal subjects were measured based on varying *** both screen-and VR-based RDK tests,the easier the stimulus is,the higher the correct answer rate and the shorter the reaction *** significant differences in coherence thresholds were observed between the two test *** VRbased RDK proposed in this study can be used as a diagnosis tool for visual motion perception and neurodegenerative disorders affecting the posterior region of the brain.

关键词： Random dot kinematogram virtual reality visual psychophysics diagnostic device

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Critical role of corrosion inhibitors modified by silyl ether functional groups on electrochemical performances of lithium manganese oxides

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Journal of Energy Chemistry 2020年第12期29卷 425-433页

作者： min ji Seong Taeeun Yim Department of Chemistry Incheon National UniversityYeonsu-gu 22012IncheonRepublic of Korea Research Institute of Basic Sciences College of Natural ScienceIncheon National UniversityYeonsu-gu 22012IncheonRepublic of Korea

Lithium manganese oxides(Li Mn2 O4, LMO) have attracted significant attention as important cathode materials for lithium-ion batteries(LIBs), which require fast charging based on their intrinsic electrochemical properties. However, these properties are limited by the rapid fading of cycling retention, particularly at high temperatures, because of the severe Mn corrosion triggered by the chemical reaction with fluoride(F-) species existing in the cell. To alleviate this issue, three types of silyl ether(Si–O)-functionalized task-specific additives are proposed, namely methoxytrimethylsilane, dimethoxydimethylsilane, and trimethoxymethylsilane. Ex-situ NMR analyses demonstrated that the Si-additives selectively scavenged the F-species as Si forms new chemical bonds with F via a nucleophilic substitution reaction due to the high binding affinity of Si with F-, thereby leading to a decrease in the F concentration in the cell. Furthermore, the addition of Si-additives in the electrolyte did not significantly affect the ionic conductivity or electrochemical stability of the electrolyte, indicating that these additives are compatible with conventional electrolytes. In addition, the cells cycled with Si-additives exhibited improved cycling retention at room temperature and 45 °C. Among these candidates, a combination of MTSi and the LMO cathode was found to be the most suitable choice in terms of cycling retention(71.0%), whereas the cell cycled with the standard electrolyte suffered from the fading of cycling retention triggered by Mn dissolution(64.4%). Additional ex-situ analyses of the cycled electrodes using SEM, TEM, EIS, XPS, and ICP-MS demonstrated that the use of Si-additives not only improved the surface stability of the LMO cathode but also that of the graphite anode, as the Si-additives prevent Mn corrosion. This inhibits the formation of cracks on the surface of the LMO cathode, facilitating the formation of a stable solid electrolyte interphase layer on the su

关键词： Lithium-ion batteries Lithium manganese oxide cathode Electrolyte additive Corrosion Silyl ether Fluoride scavenger

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Protective effect of decursin and decursinol angelate-rich Angelica gigas Nakai extract on dextran sulfate sodium-induced murine ulcerative colitis

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Asian Pacific Journal of Tropical Medicine 2017年第9期10卷 864-870页

作者： Sa-Rang Oh Seon Ok Tae-Sung jung Sang-Ok Jeon ji-min Park ji-wook jung Deok-Seon Ryu Department of Wellbeing Products Co. LtdGimhaeGyeongnam 50969Republic of Korea Department of Herbal Medicinal Pharmacology College of Herbal Bio-industryDaeguHaany UniversityKyungsanRepublic of Korea Department of Biomedical Laboratory Science College of Medical SciencesSoonchunhyang UniversityAsanRepublic of Korea

Objective: To investigate the anti-inflammatory effects of decursin and decursinol angelate-rich Angelica gigas Nakai(AGNE) on dextran sulfate sodium(DSS)-induced murine ulcerative colitis(UC).Methods: The therapeutic effect of an AGNE was analyzed in a mouse model of UC induced by DSS. Disease activity index values were measured by clinical signs such as a weight loss, stool consistency, rectal bleeding and colon length. A histological analysis was performed using hematoxylin and eosin staining. Key inflammatory cytokines and mediators including IL-6, TNF-a, PGE2, COX-2 and HIF-1 a were assayed by enzymelinked immunosorbent assay or western ***: Treatment with the AGNE at 10, 20, and 40 mg/kg alleviated weight loss,decreased disease activity index scores, and reduced colon shortening in mice with DSSinduced UC. AGNE inhibited the production of IL-6 and TNF-a in serum and colon tissue. Moreover, AGNE suppressed the increased expression of COX-2 and HIF-1 a and the increased production of PGE2 in colon tissue were observed in mice with DSSinduced UC. Additionally, histological damage was also alleviated by AGNE ***: The findings of this study verified that AGNE significantly improves clinical symptoms and reduces the activity of various inflammatory mediators. These results indicate the AGNE has the therapeutic potential in mice with DSS-induced UC.

关键词： Angelica gigas Nakai Ulcerative colitis Dextran sulfate sodium Anti-inflammatory effects Cytokine

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Phytoglycoprotein isolated from Dioscorea batatas Decne promotes intestinal epithelial wound healing

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Chinese Journal of Natural Medicines 2020年第10期18卷 738-748页

作者： KIM ji-Yun LEE Young-min PARK Jong-Pil LIM Kye-Taek LEE Sei-jung Department of Pharmaceutical Engineering Daegu Haany UniversityGyeongsan 38610Republic of Korea Department of Food Science and Technology Chung-Ang UniversityAnseong 17546Republic of Korea Division of Animal Science Chonnam National UniversityGwangju61186Republic of Korea

Dioscorea batatas Decne(DBD)has been used to heal various illnesses of the kidney and intestine as an herbal medicine in *** a source of therapeutic agents,many glycoproteins have been isolated from mushrooms and plants,but the functional role of glycoprotein in intestinal epithelial wound healing has not been understood *** the present study,we investigated the wound healing potentials of the 30 kDa glycoprotein(DBD glycoprotein)isolated from DBD in human intestinal epithelial(INT-407)*** found that DBD glycoprotein(100μg·mL^-1)significantly increased the motility of INT-407 cells for 24 h by activating protein kinase C(PKC).DBD glycoprotein stimulated the activation of p38 mitogen-activated protein kinase(MAPK),which is responsible for the phosphorylation of NF-κB inhibitorα(IκBα).DBD glycoprotein increased the level of profilin-1(PFN1),α-actinin and F-actin expression via activation of transcription factor,nuclear factor-kappa B(NF-κB)during its promotion of cell *** mouse colitis was induced by adding dextran sulfate sodium(DSS)to the drinking water at a concentration of 4%(W/V)for 7 *** figured out that administration of DBD glycoprotein(10 and 20 mg·kg-1)lowers the levels of disease activity index and histological inflammation in DSS-treated ICR *** this regard,we suggest that DBD glycoprotein has ability to promote the F-actin-related migration signaling events via activation of PKC and NF-κB in intestinal epithelial cells and prevent inflammatory bowel disease.

关键词： Cell migration Dioscorea batatas Decne(DBD)glycoprotein Intestinal epithelial cells p38 MAPK F-actin Mouse colitis

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Effects of different Ca^(2+) behavior patterns in the electric field on membrane fouling formation and removal of trace organic compounds

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Journal of Environmental Sciences 2022年第1期34卷 292-300页

作者： Zhen Du min ji Ruying Li School of Environmental Science and Engineering Tianjin UniversityTianjin 300350China

The effects of Ca^(2+) on membrane fouling and trace organic compounds(TrOCs)removal in an electric field-assisted microfiltration system were investigated in the presence of Na^(+) alone for *** the electric field,negatively charged bovine serum albumin(BSA)migrated towards the anode far away from the membrane surface,resulting in a 42.9%transmembrane pressure(TMP)reduction in the presence of Na^(+) at 1.5 *** contrast,because of the stronger charge shielding of Ca^(2+),the electrophoretic migration of BSA was limited and led to a neglectable effect of the electric field(1.5 V)on membrane ***,under 3 V applied voltage,the synergistic effects of electrochemical oxidation and bridging interaction between Ca^(2+) and BSA promoted the formation of denser settleable flocs and a thinner porous cake layer,which alleviated membrane fouling with a 64.5%decrease in TMP and nearly 100%BSA *** Tr OCs elimination increased with voltage and reached29.4%–80.4%at 3 *** electric field could prolong the contact between Tr OCs and strong oxidants generated on the anode,which enhanced the Tr OCs ***,a stronger charge shielding ability of Ca^(2+) weakened the electric field force and thus lowered the Tr OCs removal.

关键词： Electric field Membrane fouling Ca^(2+) Flocs formation Trace organic compounds

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