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Gastric metastasis from primary lung adenocarcinoma mimicking primary gastric cancer

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World Journal of Gastrointestinal Oncology 2015年第3期7卷 12-16页

作者： min ji kim ji Hyung Hong Eun Su Park Jae Ho Byun Department of Internal Medicine Incheon St.Mary’s HospitalCollege of MedicineThe Catholic University of Korea Division of Medical Oncology Department of Internal MedicineIncheon St.Mary’s HospitalCollege of MedicineThe Catholic University of Korea Department of Hospital Pathology Incheon St.Mary’s HospitalCollege of MedicineThe Catholic University of Korea

Gastric metastases from lung adenocarcinoma are rare. Because gastric metastasis grossly resembles advanced gastric cancer, it is difficult to diagnose gastric metastasis especially when the histology of the primary lung cancer is adenocarcinoma. We describe a case of gastric metastasis from primary lung adenocarcinoma mimicking Borrmann type Ⅳ primary gastric cancer. A 68-year-old man with known lung adenocarcinoma with multiple bone metastases had been experiencing progressive epigastric pain and dyspepsia over one year. Esophagogastroduodenoscopy revealed linitis plasticalike lesions in the fundus of the stomach. Pathologic examination revealed a moderately differentiated adenocarcinoma with submucosal infiltration. Positive immunohistochemical staining for thyroid transcription factor-1(TTF-1) and napsin A(Nap-A) confirmed that the metastasis was pulmonary in origin. The patient had been treated with palliative chemotherapy for the lung cancer and had lived for over fifteen months after the diagnosis of gastric metastasis. Clinicians should be aware of the possibility of gastric metastasis in patients with primary lung adenocarcinoma, and additional immunohistochemical staining for Nap-A as well as TTF-1 may help in differentiating its origin.

关键词： Adenocarcinoma of lung Napsin-A Thyroidtranscription factor-1 Gastric metastasis

Chorioamnionitis caused by Serratia marcescens in a healthcare worker: A case report

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World Journal of Clinical Cases 2021年第20期9卷 5689-5694页

作者： Sue Youn Park min ji kim Sanghee Park Nah Ihm kim Hyung Hoon Oh Joungmin kim Department of Anesthesiology and Pain Medicine Chonnam National University Medical SchoolGwangju 61469South Korea Department of Pathology Chonnam National University Medical SchoolGwangju 61469South Korea Department of Internal Medicine Chonnam National University Medical SchoolGwangju 61469South Korea

BACKGROUND Healthcare workers(HCWs)are at an increased risk for exposure to *** marcescens(***)is a gram-negative,opportunistic and nosocomial pathogen belonging to the Enterobacterieae family.A few case reports have been published of chorioamnionitis caused by *** *** changes during pregnancy can also affect the risk of ***,few studies have examined hospital-acquired bacterial infection in pregnant *** SUMMARY A 33-year-old woman,a resident in anesthesiology,was admitted at 14 wk gestation for fever with *** had no medical history other than contact dermatitis of both hands that started from the beginning of the *** was no obvious infection focus and no bacterial growth in blood *** was discharged after 1 wk of empirical antibiotic *** three weeks before the fever started,she had a blister on the site of contact dermatitis on both hands,she applied antibiotic ointment for three days and the blisters had *** 19 wk gestation,she had a high fever and was *** examination and image studies were nonspecific and the patient had no other *** grew in blood cultures at 19 wk *** with intravenous antibiotics was ***,she suffered a miscarriage at 224/7 wk ***,the amniotic membrane showed chorioamnionitis with a focal ***,a placenta tissue culture grew *** HCWs can be exposed to pathogens that can cause opportunistic infections such as *** affects the immune system,making it susceptible to opportunistic ***,pregnant HCWs may require more preventive measures,including hand hygiene and avoid risk factors(*** the skin).

关键词： Serratia marcescens Chorioamnionitis Healthcare workers Pregnancy Case report

Efficacy of chemotherapy containing bevacizumab in patients with metastatic colorectal cancer according to programmed cell death ligand 1

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3521-3528页

作者： Shin Woo Kang Sung Hee Lim min-ji kim Jeeyun Lee Young Suk Park Ho Yeong Lim Won Ki Kang Seung Tae kim Division of Hematology Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Samsung Biomedical Research Institute Samsung Medical CenterSeoul 06351South Korea

BACKGROUND Bevacizumab,an anti-vascular endothelial growth factor(VEGF)monoclonal antibody,inhibits angiogenesis and reduces tumor *** VEGF-C,lactate dehydrogenase,and inflammatory markers have been reported as predictive markers related to bevacizumab *** cell death ligand 1(PD-L1)could act upon VEGF receptor 2 to induce cancer cell angiogenesis and *** To investigate the efficacy of bevacizumab-containing chemotherapy in patients with metastatic colorectal cancer(CRC)according to the expression of *** This analysis included CRC patients who received bevacizumab plus FOLFOX or FOLFIRI as first-line therapy between June 24,2014 and February 28,2022,at Samsung Medical Center(Seoul,South Korea).Analysis of patient data included evaluation of PD-L1 expression by the combined positive score(CPS).We analyzed the efficacy of bevacizumab according to PD-L1 expression status in patients with *** A total of 124 patients was included in this *** all patients were treated with bevacizumab plus FOLFIRI or FOLFOX as the first-line *** 77%of patients received FOLFOX,23%received FOLFIRI as backbone first-line *** numbers of patients with a PD-L1 CPS of 1 or more,5 or more,or 10 or more were 105(85%),64(52%),and 32(26%),*** results showed no significant difference in progression-free survival(PFS)and overall survival(OS)with bevacizumab treatment between patients with PDL1 CPS less than 1 and those with PD-L1 CPS of 1 or more(PD-L1<1%vs PD-L1≥1%;PFS:P=0.93,OS:P=0.33),between patients with PD-L1 CPS less than 5 and of 5 or more(PD-L1<5%vs PD-L1≥5%;PFS:P=0.409,OS:P=0.746),and between patients with PD-L1 CPS less than 10 and of 10 or more(PD-L1<10%vs PD-L1≥10%;PFS:P=0.529,OS:P=0.568).CONCLUSION Chemotherapy containing bevacizumab can be considered as first-line therapy in metastatic CRC irrespective of PD-L1 expression.

关键词： Bevacizumab Colorectal cancer Programmed cell death ligand 1 expression First-line chemotherapy Metastatic colorectal cancer

Intravenous Suitability Studies of Commonly Used Oxacillin Sodium Solutions in the Accufuser^(■) Infusion Device

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Pharmacology & Pharmacy 2011年第3期2卷 189-193页

作者： min-Jeong kim Ga-Young Lee Yoo-Sin Park Shin-Hee kim Sang-Yeon kim min-A.Kang min-ji kim Ju-Seop Kang Korean minjok Leadership Academy Gangwon-doSouth Korea Gimpo Foreign Language High School GimpoSouth Korea Department of Pharmacology&Clinical Pharmacology Lab College of Medicine and Division of Molecular Therapeutics DevelopmentHanyang Biomedical Research InstituteHanyang UniversitySeoulSouth Korea Department of Nursing College of NursingYonsei UniversitySeoulSouth Korea 5Korean International School in Beijing BeijingChina

Our study compares two commonly used solutions of oxacillin sodium, 5.0 mg/mL in either 0.9% sodium chloride (NS) or 5% dextrose water (D5W), for their continued suitability for IV usage, and stability of active compound over time, when stored at two different controlled temperatures for six weeks. Both solutions were stored in an intravenous infusion device commercially available as Accufuser? and kept at a continuously maintained temperature of either 4 ± 2?C (CT) or 25 ± 2?C (RT). Suitability for IV administration was assessed by measuring changes in macrographical transparency and pH over time, and drug stability was assessed by measuring changes in oxacillin concentration over time using high-performance liquid chromatography (HPLC). After 6 weeks, concentrations of oxacillin were unchanged in the CT solutions, while both RT solutions showed significant decreases in the concentration of oxacillin after only two weeks. Final concentration compared to starting concentrations after 6 weeks at RT, were 36.57% in NS, while virtually no oxacillin was detectable in D5W. Also pH measurements showed a slight decrement at 2 weeks with RT, and at 6 weeks, there was a significant change in pH in both NS and D5W at RT. There was no significant change in color, transparency or appearance after 6 weeks in any of the oxacillin solutions stored in the Accufuser? infusion device. In summary, two commonly used IV solutions for oxacillin administration(5 mg/mL in NS or D5W) stored ready to use in the Accufuser? showed significant changes over time when maintained at RT, that would make the solutions inappropriate for therapeutic use. Both solutions when maintained in CT were not significantly altered and continued to be appropriate in pH and drug concentration for IV therapy. This suggests that ready-to-use solutions of oxacillin sodium in the Accufuser? infusion device can be kept at CT for up to 6 weeks safely but should not be stored at RT due to loss of potency and changes in

关键词： Intravenous suitability Oxacillin sodium Accufuser^(■) Infusion Device HPLC

Aligned Ion Conduction Pathway of Polyrotaxane‑Based Electrolyte with Dispersed Hydrophobic Chains for Solid‑State Lithium–Oxygen Batteries

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Nano-Micro Letters 2025年第2期17卷 169-186页

作者： Bitgaram kim Myeong‑Chang Sung Gwang‑Hee Lee Byoungjoon Hwang Sojung Seo ji‑Hun Seo Dong‑Wan kim Department of Materials Science and Engineering Korea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea School of Civil Environmental and Architectural EngineeringKorea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea Materials Science and Chemical Engineering Center Institute for Advanced Engineering(IAE)Yongin 17180Republic of Korea

A critical challenge hindering the practical application of lithium–oxygen batteries(LOBs)is the inevitable problems associated with liquid electrolytes,such as evaporation and safety *** study addresses these problems by proposing a modified polyrotaxane(mPR)-based solid polymer electrolyte(SPE)design that simultaneously mitigates solvent-related problems and improves ***-SPE exhibits high ion conductivity(2.8×10^(−3)S cm^(−1)at 25℃)through aligned ion conduction pathways and provides electrode protection ability through hydrophobic chain *** this mPR-SPE into solid-state LOBs resulted in stable potentials over 300 *** situ Raman spectroscopy reveals the presence of an LiO_(2)intermediate alongside Li_(2)O_(2)during oxygen *** situ X-ray diffraction confirm the ability of the SPE to hinder the permeation of oxygen and moisture,as demonstrated by the air permeability *** present study suggests that maintaining a low residual solvent while achieving high ionic conductivity is crucial for restricting the sub-reactions of solid-state LOBs.

关键词： Solid polymer electrolyte Lithium-oxygen batteries Polyrotaxane ion conductivity Hydrophobic chain

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Optimization of an Artificial Intelligence Database and Camera Installation for Recognition of Risky Passenger Behavior in Railway Vehicles

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Computers, Materials & Continua 2025年第1期82卷 1277-1293页

作者： min-kyeong kim Yeong Geol Lee Won-Hee Park Su-hwan Yun Tae-Soon Kwon Duckhee Lee Railroad Test&Certification Division Korea Railroad Research Institute(KRRI)Cheoldo BangmulgwanroUiwang-si16105Republic of Korea Railroad Safety Division Korea Railroad Research Institute(KRRI)Cheoldo BangmulgwanroUiwang-si16105Republic of Korea

Urban railways are vital means of public transportation in *** than 30%of metropolitan residents use the railways,and this proportion is expected to *** enhance safety,the government has mandated the installation of closed-circuit televisions in all carriages by ***,cameras still monitored *** address this limitation,we developed a dataset of risk factors and a smart detection system that enables an immediate response to any abnormal behavior and intensive monitoring *** created an innovative learning dataset that takes into account seven unique risk factors specific to Korean railway *** data collection was conducted across the Shinbundang Line of the Incheon Transportation Corporation,and the Ui-Shinseol *** observed several behavioral characteristics and assigned unique annotations to *** also considered carriage *** performance was evaluated by camera placement and *** the camera installation plan was *** dataset will find immediate applications in domestic railway *** artificial intelligence algorithms will be verified shortly.

关键词： AI railway vehicle risk factor smart detection AI training data

Self-assembled carbon monoxide nanoprodrug for chemiexcitationtriggered synergistic chemotherapy against breast cancer

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Science China Chemistry 2025年

作者： Shunfei Cui Yiyao Pan Chenzhe Ma Bin Qi Qingqiang min ming Li Huabing Chen Hengte Ke Xingyue ji jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development College of Pharmaceutical ScienceSoochow University

Carbon monoxide（CO） has recently been well-established as a promising therapeutic modality against cancer. The development of transition-metal-free and tumor-targeted delivery platforms for CO is highly demanded but remains very sporadic. Herein, we developed a polyprodrug system for the co-delivery of CO and a chemotherapeutic agent combretastin A-4（CA-4） to the tumor site based on a chemiexcitation mechanism. Such a poly-prodrug successfully achieved the co-activation of CO and CA-4 in response to H2O2at the tumor site both in vitro and in vivo. Importantly, a synergist effect between CO and CA-4 was observed in suppressing tumor growth in a mouse tumor model. It is anticipated that such a poly-prodrug system could be potentially adapted for the co-delivery of CO and another drug payload for combinational therapy for other indications.

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Projective Dirichlet Boundary Condition with Applications to a Geometric Problem

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Acta Mathematica Sinica,English Series 2016年第1期32卷 11-24页

作者： min ji Academy of Mathematics and Systems Science Chinese Academy of Sciences

Given a domain Ω R^n, let λ 〉 0 be an eigenvalue of the elliptic operator L ：= ∑i,j^n= 1δ/δxi on Ω for Dirichlet condition. For a function f ∈ L2（Ω）, it is known that the linear resonance equation Lu ＋ λu = f in Ω with Dirichlet boundary condition is not always solvable. We give a new boundary condition Pλ（u｜δΩ） = g, called to be projective Dirichlet condition, such that the linear resonance equation always admits a unique solution u being orthogonal to all of the eigenfunctions corresponding to λ which satisfies ｜｜u｜｜2,2 ≤ C（｜｜f｜｜2 ＋｜｜g｜｜2,2） under suitable regularity assumptions on δΩ and L, where C is a constant depends only on n, Ω, and L. More a priori estimates, such as W^2~＇P-estimates and the C^2,α-estimates etc., are given also. This boundary condition can be viewed as a generalization of the Dirichlet condition to resonance equations and shows its advantage when applying to nonlinear resonance equations. In particular, this enables us to find the new indicatrices with vanishing mean （Cartan） torsion in minkowski geometry. It is known that the geometry of indicatries is the foundation of Finsler geometry.

关键词： Elliptic resonance equation nonlinear boundary condition convex indicatrix mean tor-sion

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Optimization of thermoelectric properties of n-type Bi_2(Te,Se)_3 with optimizing ball milling time

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Rare Metals 2018年第4期37卷 351-359页

作者： ji-Hee Son min-Wook Oh Bong-Seo kim Su-Dong Park Thermoelectric Conversion Research Center Korea Electrotechnology Research Institute Department of Materials Science and Engineering Hanbat National University

The thermoelectric properties at elevated temperature were investigated for n-type Bi2（Te,Se）3 which is obtained from ball milling processed powder with various milling times. Electrical properties such as electrical resistivity and Seebeck coefficient are clearly dependent on milling time, in which the carrier concentration is attributed to the change of the electrical properties. The concentrations of the defects are also varied with the ball milling time, which is the origin of the carrier concentration variation. Even though finer grain sizes are obtained after the long ball milling time, the temperature dependence of the thermal conductivity is not solely understood with the grain size, whereas the electrical contribution to the thermal conductivity should be also considered. The highest figure of merit value of ZT = 0.83 is achieved at 373 K for the optimized samples, in which ball milling time is 10 h. The obtained ZT value is 48% improvement over that of the 0.5-h sample at 373 K.

关键词： Thermoelectric properties Ball milling Bi2Te3 Seebeck coefficient Grain size Thermalconductivity

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