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3D imaging of the mitochondrial redox state of rathearts under normal and fasting conditions

Journal of Innovative Optical Health Sciences 2014年第2期7卷 60-69页

作者： He n.Xu Rong Zhou Lily Moon min Feng Lin Z.Li Department of Radiology Universityof PennsyluaniaPhilade lphia PA 19104USA Briton Chance Laboratory of Redor Imaging Johnson Research Foundation Department of Biochemistry and Biophysics University of Pennsyluania Philade lphiaPA 19104USA Institute of Translational Medicine and Therapeutics Perelman School of Medicine University of Pennsylvania Philadelphia PA 19104USA

The heart requires continuous ATP availability that is generated in the *** using the cell culture and perfiused organ models have been carried out to investigate thebiochemistry in the mitochondria in response to a change in substrate supply,mitochondrialbioenergetics of heart under normal feed or fasting conditions has not been studied at the tissuelevel with a sub-millimeter spatial resolution either in vivo or er *** of many food-derived metabolites to generate ATP in the mitochondria is realized through the nADH/nAD+couple acting as a central electron *** employed the Chance redox scanner thelow-temperat ure fluorescence scanner to image the three-dimensional(3D)spatial distribution of themitochondrial redox states in heart tissues of rats under normai feeding or an overnight star-vation for 14.5 *** consecutive sections of each heart were imaged to map three redoxindices,i.e,nADH,oxidized favoproteins Fp,including flavin adenine dinucleotide(FAD)andthe redox ratio nADH/*** imaging results revealed the micro-heterogeneity and the spatial distribution of these redox *** quantitative analysis showed that in the fasted hearts thestandard deviation of both nADH and Fp,ie.,SD nADH and SDFp,significantly decreasedwith a p value of 0.032 and 0.045,respectively,indicating that the hearts become relatively morehomogeneous after *** fasted hearts contained 28.6%less nADH(p=0.038).no *** change in Fp was foumnd(p=0.4).The nADH/Fp ratio decreased with a marginalP value(0.076).The decreased nADH im the fasted hearts is consistent with the cardiac celsreliance of fatty acids consumption for energy metabolism when glucose becomes *** o bservation of n ADH decrease induced by dietary restriction in the heart at tissuelevel has not been reported to our best *** Chance redox scanner demonstrated thefeasibility of 3D imaging of the mitochondrial redox st ate in the heart and

关键词： Mitochondion metabolism bioenergetics cardiomyocyte nADH flavoproteins Fp FAD caloric restriction food deprivation.

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Effect of internal sloshing on added resistance of ship

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Journal of Hydrodynamics 2017年第1期29卷 13-26页

作者： min-Guk Seo y.nghwan Kim Dong-min Park Korea Research Institute of Ships and Ocean Engineering DaejeonKorea Department of naval Architecture and Ocean Engineering Seoul National UniversitySeoulKorea

The motion responses of ships carry.ng liquid cargo are affected not only by external wave excitation, but also by internal sloshing-induced forces and moments. Sloshing flow is coupled with the ship motion. This means the added resistance in waves may change when sloshing occurs inside the tank of the ship. In this study, the motion responses and added resistance of a ship, coupled with the sloshing-induced internal forces and moments are considered by using the linear potential theory. The three-dimensional Rankine panel method, in which the physical quantities are represented by using B-spline basis function, is applied. The sloshing flow of inner tanks is also simulated by Using the Rankine panel method and linearized boundary value problem. To study the added resistance, a near-field method, which integrates the second-order pressure on a body surface, is applied. The model ship is a blunt modified Wigley model with two inner tanks. numerical results obtained without inner tanks are compared with the experimental data, and then the effect of filling ratio of inner tanks on ship motion and added resistance are observed. The components that induce added resistance are examined, and the effects of surge motion on sloshing flow and added resistance are briefly considered. This study shows that the sloshing flow inside the inner tanks may significantly influence not only the motion responses, but also added resistance, especially, when the incident wave frequency approaches the resonance frequency of the sloshing flow.

关键词： Added resistance sloshing seakeeping coupled effect Rankine panel method

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FUnCTIOnAL COEFFICIEnT AUTOREGRESSIVE COnDITIOnAL ROOT MODEL

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Journal of Systems Science & Complexity 2012年第5期25卷 998-1013页

作者： Jianjun ZHOU min CHEn School of Mathematics and Statistics Yunnan University Academy of Mathematics and Systems Science Chinese Academy of Sciences

This paper proposes an extended model based on ACR nmdel： Functional coefficient autoregressive conditional root model （FCACR）. Under some assumptions, the authors show that the process is geometrically ergodic, stationary and all moments of the process exist. The authors use the polynomial spline function to approximate the functional coefficient, and show that the estimate is consistent with the rate of convergence Op（hv＋1 ＋ n-1/3）. By simulation study, the authors discover the proposed method can approximate well the real model. Furthermore, the authors apply the model to real exchange rate data analysis.

关键词： Ergodicity functional coefficient polynomial spline function.

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yersinia pestis: examining wildlife plague surveillance in China and the USA

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Integrative Zoology 2012年第1期7卷 99-109页

作者： Sarah n.BEVInS John A.BAROCH Dale L.nOLTE min ZHAnG Hongxuan HE US Department of Agriculture Wildlife ServicesNational Wildlife Disease ProgramFort CollinsColoradoUSA Chinese Academy of Sciences Institute of ZoologyBeijingChina

Plague is a zoonotic disease caused by the bacterium yersinia pestis Lehmann and neumann,*** it is essentially a disease of rodents,plague can also be transmitted to ***,plague has caused mas-sive morbidity and mortality events in human populations,and has recently been classified as a reemerging dis-ease in many parts of the *** public health threat has led many countries to set up wild and domestic an-imal surveillance programs in an attempt to monitor plague activity that could potentially spill over into human *** China and the USA have plague surveillance programs in place,but the disease dynamics dif-fer in each *** present data on plague seroprevalence in wildlife and review different approaches for plague surveillance in the 2 *** need to better comprehend plague dynamics,combined with the fact that there are still several thousand human plague cases per year,make well-designed wildlife surveillance pro-grams a critical part of both understanding plague risks to humans and preventing disease outbreaks in the future.

关键词： plague sentinel species surveillance yersinia pestis

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Ligand-controlled niH-catalyzed regiodivergent hydroalkylation of 2-alkenylazaarenes

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Science China Chemistry 2024年第6期67卷 1935-1940页

作者： ya-Ping Shao Zhuo-min Chi y.ng-min Liang State Key Laboratory of Applied Organic Chemistry School of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou730000China

A nickel-hydride(ni H)-catalyzed migratory and nonmigratory hydroalkylation reaction of 2-alkenyl azaarenes with alkyl iodines has been established through strategic modulation of n-or P-donor *** method enables the synthesis of diverseβ-orγ-branched aromatic *** mild regiodivergent protocols exhibit wide substrate scope,excellent functional tolerance,and great reaction yield with remarkable ***,deuterium labeling studies reveal ni H-catalyzed interrupted chain-walking mode as the mechanism behind remotedβ-selective hydroalkylation reaction—an interesting phenomenon mediated through aromatic imine directing groups.

关键词： niH regiodivergent hydroalkylation azaarenes interrupted chain-walking

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Projective Dirichlet Boundary Condition with Applications to a Geometric Problem

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Acta Mathematica Sinica,English Series 2016年第1期32卷 11-24页

作者： min JI Academy of Mathematics and Systems Science Chinese Academy of Sciences

Given a domain Ω R^n, let λ 〉 0 be an eigenvalue of the elliptic operator L ：= ∑i,j^n= 1δ/δxi on Ω for Dirichlet condition. For a function f ∈ L2（Ω）, it is known that the linear resonance equation Lu ＋ λu = f in Ω with Dirichlet boundary condition is not always solvable. We give a new boundary condition Pλ（u｜δΩ） = g, called to be projective Dirichlet condition, such that the linear resonance equation always admits a unique solution u being orthogonal to all of the eigenfunctions corresponding to λ which satisfies ｜｜u｜｜2,2 ≤ C（｜｜f｜｜2 ＋｜｜g｜｜2,2） under suitable regularity assumptions on δΩ and L, where C is a constant depends only on n, Ω, and L. More a priori estimates, such as W^2~＇P-estimates and the C^2,α-estimates etc., are given also. This boundary condition can be viewed as a generalization of the Dirichlet condition to resonance equations and shows its advantage when apply.ng to nonlinear resonance equations. In particular, this enables us to find the new indicatrices with vanishing mean （Cartan） torsion in minkowski geometry. It is known that the geometry of indicatries is the foundation of Finsler geometry.

关键词： Elliptic resonance equation nonlinear boundary condition convex indicatrix mean tor-sion

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Edge-Pancyclicity and Hamiltonian Connectivity of Twisted Cubes

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Acta Mathematica Sinica,English Series 2010年第7期26卷 1315-1322页

作者： min XU School of Mathematical Sciences Beijing Normal UniversityLaboratory of Mathematics and Complex Systems Ministry of Education Beijing 100875 P. R. China

The twisted cube TQn is a variant of the hypercube Qn. It has been shown by Chang, Wang and Hsu [Topological properties of twisted cube. Information Science, 113, 147-167 （1999）] that TQn contains a cycle of every length from 4 to 2^n. In this paper, we improve this result by showing that every edge of TQn lies on a cycle of every length from 4 to 2^n inclusive. We also show that the twisted cube are Hamiltonian connected.

关键词： cycles twisted cubes hypercubes edge-pancyclicity hamiltonian connectivity

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Double minimum creep processing and mechanism forγ'strengthened cobalt-based superalloy

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Journal of Materials Science & Technology 2022年第17期112卷 123-129页

作者： Jia Chen min Guo min y.ng Lin Liu Jun Zhang State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China

The double minimum creep,characterized by two creep rate minima,in Co-based superalloy is investigated using a phase-field model coupled with a crystal plasticity *** constitutive modeling,based on the dislocation slip theory considering dislocation interaction,is applied to simulate microstructural evolution and deformation *** process commences at the beginning of creep until the global minimum of creep rate is reached,demonstrating a strengthening effect from n-type rafts under compressive *** high shear strain rate of(111)[011]slip system in the intersections of horizontal and verticalγchannels leads to a slight increase of creep rate after the first local *** evolution of stress field shows that the softening effect is the combined effect of the increase of resolved shear stress and the decrease of hardening stress in the ***,these changes in stress are primarily caused by the dislocation annihilation and the inhomogeneous plastic *** study indicates that the intermediate local softening stage during creep may be eliminated if the initial inter-distance betweenγ’precipitates is decreased.

关键词： Cobalt-based superalloy Phase-field simulation Creep γ’precipitates Slip system

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Film cooling effects on the tip flow characteristics of a gas turbine blade

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Propulsion and Power Research 2015年第1期4卷 9-22页

作者： Jin Wang Bengt Sundén min Zeng Qiuwang Wang Key Laboratory of Thermo-Fluid Science and Engineering Ministry of EducationXi’an Jiaotong UniversityXi’anShaanxi 710049China School of Energy and Environmental Engineering Hebei University of TechnologyTianjin 300401China Department of Energy Sciences Division of Heat TransferLund UniversityLund SE-22100Sweden

An experimental investigation of the tip flow characteristics between a gas turbine blade tip and the shroud was conducted by a pressure-test system and a particle image velocimetry(PIV)system.A three-times scaled profile of the GE-E3 blade with five film cooling holes was used as *** effects on flow characteristics by the rim width and the groove depth of the squealer tip were *** rim widths were(a)0.9%,(b)2.1%,and(c)3.0%of the axial chord,and the groove depths were(a)2.8%,(b)4.8%,and(c)10%of the blade *** pressure taps on the top plate above the blades were connected to pressure *** a CCD camera the PIV system recorded the velocity field around the leading edge zone including the five cooling *** flow distributions both in the tip clearance and in the passage were revealed,and the influence of the inlet velocity was *** this work,the tip flow characteristics with and without film cooling were *** effects of different global blowing ratios of M=0.5,1.0,1.3 and 2.5 were *** was found that decreasing the rim width resulted in a lower mass flow rate of the leakage flow,and the pressure distributions from the leading edge to the trailing edge showed a linearly increasing *** was also found that if the inlet velocity was less than 1.5 m/s,the flow field in the passage far away from the suction side appeared as a stagnation zone.

关键词： Film cooling Squealer tip Rim Vorticity Particle image velocimetry(PIV)

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Singular Supercritical Trudinger-Moser Inequalities and the Existence of Extremals

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Acta Mathematica Sinica,English Series 2020年第8期36卷 873-888页

作者： Xu min WAnG School of Mathematical Sciences Beijing Normal UniversityBeijing 100875P.R.China

In this paper,we present the singular supercritical Trudinger-Moser inequalities on the unit ball B in Rn,where n≥*** precisely,we show that for any given α>0 and 0n,then the following two inequalities hold for ∀u∈W^1,n0,r(B),∫Bsup∣▽u∣^ndx≤1∫Bexp((αn,t+∣x∣^α∣)u∣^n/n-1)/∣x∣^tdxnd ∫Bsup∣▽u∣^ndx≤1∫Bexp(αn,t+∣u∣^n/n-1+∣x∣^α)/∣x∣^tdxnsider the problem of the sharpness of the constantαn,***,by employ.ng the method of estimating the lower bound and using the concentration-compactness principle,we establish the existence of *** results extend the known results when t=0 to the singular version for 0n.

关键词： Singular supercritical Trudinger-Moser inequality radial lemma concentration-compactness principle extremal functions

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