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Enhancement of porcine in vitro embryonic development through luteolin‑mediated activation of the Nrf2/Keap1 signaling pathway

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Journal of Animal Science and Biotechnology 2024年第2期15卷 600-613页

作者： Se-Been Jeon Pil-Soo Jeong min Ju Kim Hyo-Gu Kang Bong-seok Song Sun-Uk Kim Seong-Keun cho Bo-Woong Sim Futuristic Animal Resource&Research Center(FARRC) Korea Research Institute of Bioscience and Biotechnology(KRIBB)Cheongju 28116Republic of Korea Department of Animal Science College of Natural Resources&Life SciencePusan National UniversityMiryang 50463Republic of Korea Department of Animal Science and Biotechnology College of Agriculture and Life ScienceChungnam National UniversityDaejeon 34134Republic of Korea Department of Functional Genomics University of Science and TechnologyDaejeon 34113Republic of Korea Department of Animal Science Life and Industry Convergence Research Institute(RICRI)College of Natural Resources&Life SciencePusan National UniversityMiryang 50463Republic of Korea

Background Oxidative stress,caused by an imbalance in the production and elimination of intracellular reactive oxygen species(ROS),has been recognized for its detrimental effects on mammalian embryonic ***(Lut)has been documented for its protective effects against oxidative stress in various ***,its specific role in embryonic development remains *** study aims to investigate the influence of Lut on porcine embryonic development and to elucidate the underlying *** After undergoing parthenogenetic activation(PA)or in vitro fertilization,embryos supplemented with 0.5μmol/L Lut displayed a significant enhancement in cleavage and blastocyst formation rates,with an increase in total cell numbers and a decrease in the apoptosis rate compared to the *** on D2 and D6 revealed that embryos with Lut supplementation had lower ROS levels and higher glutathione levels compared to the ***,Lut supplementation significantly augmented mitochondrial content and membrane ***,activation of the Nrf2/Keap1 signaling pathway was observed in embryos supplemented with Lut,leading to the upregulation of antioxidant-related gene transcription *** further validate the relationship between the Nrf2/Keap1 signaling pathway and effects of Lut in porcine embryonic development,we cultured PA embryos in a medium supplemented with brusatol,with or without the inclusion of *** positive effects of Lut on developmental competence were negated by brusatol *** Our findings indicate that Lut-mediated activation of the Nrf2/Keap1 signaling pathway contributes to the enhanced production of porcine embryos with high developmental competence,and offers insight into the mechanisms regulating early embryonic development.

关键词： Luteolin Mitochondrial function Nrf2/Keap1 signaling pathway Oxidative stress Porcine embryo development

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Nomogram for prediction of pathologic complete remission using biomarker expression and endoscopic finding after preoperative chemoradiotherapy in rectal cancer

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Chinese Journal of Cancer Research 2020年第2期32卷 228-241页

作者： Hyuk Hur min Soo cho Woong Sub Koom Joon seok Lim Tae Il Kim Joong Bae Ahn Hoguen Kim Nam Kyu Kim Division of Colon and Rectal Surgery Department of SurgerySeverance HospitalYonsei University College of MedicineSeoul 03722Korea Department of Radiation Oncology Severance HospitalYonsei University College of MedicineSeoul 03722Korea Departm ent of Radiology Research Institute of Radiological ScienceSeverance HospitalYonsei University College of MedicineSeoul 03722Korea Department of Internal Medicine Institute of Gastroenterology Department of Medical Oncology Severance HospitalYonsei University College of MedicineSeoul 03722Korea Department of Pathology Severance HospitalYonsei University College of MedicineSeoul 03722Korea

Objective:The aim of this study is to develop a nomogram for prediction of pathologic complete remission(p CR)after preoperative chemoradiotherapy(CRT)for rectal ***:m RNA expression levels of seven molecular markers[p53,p21,Ki-67,vascular endothelial growth factor(VEGF),CD133,CD24,CD44]were measured by reverse transcriptase polymerase chain reaction(RTPCR)in 120 rectal *** findings of clinical complete remission(c CR)and biologic variables were used to construct nomogram in the training group(n=80),which was validated in the validation group(n=40).Results:m RNA expression levels of four markers(p53,p21,Ki67,CD133)correlated with p CR(24/80,30.0%)in the training *** expression of p53 and/or high expression of p21,Ki67 and CD133 showed greater p CR rate.p CR was shown in 18(69.2%)of 26 cases showing endoscopic c CR in the training *** p CR rate was demonstrated in lower tumor location than middle tumor(19/49,38.8%vs.5/31,16.1%).A nomogram for prediction of p CR was developed from the multivariate prediction model using these six variables,which showed good discrimination ability in the training group[area under the curve(AUC)=0.945]and validation group(AUC=0.922).The calibration plot showed good agreement between actual and predicted p CR in both patient ***:Nomogram for assessment of p CR can be useful for making treatment decisions after CRT according to predicted responses.

关键词： Rectal cancer chemoradiotherapy treatment response molecular marker endoscopy nomogram

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Strong contact coupling of neuronal growth cones with height-controlled vertical silicon nanocolumns

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Nano Research 2018年第5期11卷 2532-2543页

作者： Seong-min Kim Seyeong Lee Dongyoon Kim Dong-Hee Kang Kisuk Yang Seung-Woo cho Jin seok Lee Insung S. choi Kyungtae Kang Myung-Han Yoon School of Materials Science and Engineering Gwangju Institute of Science and Technology Gwongju 61005 Republic of Korea Department of Biotechnology Yonsei University 50 Yonsei-ro Seodaemun-gu Seoul 03722 Republic of Korea Department of Chemistry Sookmyung Women's University Seoul 04310 Republic of Korea Center for Cell-Encapsulation Research Department of Chemistry KAIST Daejeon 34141 Republic of Korea Department of Applied Chemistry Kyung Hee University Yongin Gyeonggi 17104 Republic of Korea

In this study, we report that height-controlled vertically etched silicon nano- column arrays （vSNAs） induce strong growth cone-to-substrate coupling and accelerate in vitro neurite development while preserving the essential features of initial neurite formation. Large-scale preparation of vSNAs with flat head morphology enabled the generation of well-controlled topographical stimulation without cellular impalement. A systematic analysis on topography- induced variations on cellular morphology and cytoskeletal dynamics was conducted. In addition, neurite development on the grid-patterned vSNAs exhibited preferential adhesion to the nanostructured region and outgrowth directionality. The arrangement of cytoskeletal proteins and the expression of a focal adhesion complex indicated that a strong coupling existed between the underlying nanocolumns and growth cones. Furthermore, the height-controlled nanocolumn substrates differentially modulated neurite polarization and elongation. Our findings provide an important insight into neuron-nanotopography interactions and their role in cell adhesion and neurite development.

关键词： vertical silicon nanostructures metal-assisted chemical etching primary hippocampal neurons neurite outgrowth cytoskeletal dynamics

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Practical Privacy-Preserving ROI Encryption System for Surveillance Videos Supporting Selective Decryption

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Computer Modeling in Engineering & Sciences 2024年第12期141卷 1911-1931页

作者： Chan Hyeong cho Hyun min Song Taek-Young Youn Department of Cyber Security Dankook UniversityYonginGyeonggi-Do16890Republic of Korea

With the advancement of video recording devices and network infrastructure,we use surveillance cameras to protect our valuable *** paper proposes a novel system for encrypting personal information within recorded surveillance videos to enhance efficiency and *** proposed method leverages Dlib’s CNN-based facial recognition technology to identify Regions of Interest(ROIs)within the video,linking these ROIs to generate unique *** IDs are then combined with a master key to create entity-specific keys,which are used to encrypt the ROIs within the *** system supports selective decryption,effectively protecting personal information using surveillance ***,the system overcomes the limitations of existing ROI recognition technologies by predicting unrecognized frames through *** research validates the proposed technology through experimental evaluations of execution time and post-processing techniques,ensuring comprehensive personal information *** for setting the thresholds used in this process are also *** the proposed method could serve as an effective solution to security vulnerabilities that traditional approaches fail to address.

关键词： Privacy de-identification selective decryption surveillance video

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Microalgae Scenedesmus obliquus as renewable biomass feedstock for electricity generation in microbial fuel cells （MFCs）

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Frontiers of Environmental Science & Engineering 2014年第5期8卷 784-791页

作者： Sanath KONDAVEETI Kwang Soon cho Ramesh KAKARLA Booki min Department of Environmental Science and Engineering Kyung Hee University Gyeonggi-do 446-701 Republic of Korea

Renewable algae biomass, Scenedesmus obliquus, was used as substrate for generating electricity in two chamber microbial fuel cells （MFCs）. From polarization test, maximum power density with pretreated algal biomass was 102mW·m^2 （951mW·m^3） at current generation of 276mA·m^-2. The individual electrode potential as a function of current generation suggested that anodic oxidation process of algae substrate had limitation for high current generation in MFC. Total chemical oxygen demand （TCOD） reduction of 74% was obtained when initial TCOD concentration was 534mg · L^-1 for 150 h of operation. The main organic compounds of algae oriented biomass were lactate and acetate, which were mainly used for electricity generation. Other byproducts such as propionate and butyrate were formed at a negligible amount. Electrochemical Impedance Spectroscopy （EIS） analysis pinpointed the charge transfer resistance （112Ω ） of anode electrode, and the exchange current density of anode electrode was 1214 nA·cm^-2.

关键词： microbial fuel cell (MFC) algae bioelectricity substrate volatile fatty acid biomass COD removalefficiency

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Simultaneous surface modification method for 0.4Li2MnO3-0.6LiNi1/3Co1/3Mn1/3O2 cathode material for lithium ion batteries： Acid treatment and LiCoPO4 coating

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Nano Research 2017年第12期10卷 4210-4220页

作者： min-Joon Lee Eunsol Lho Pilgun Oh Yoonkook Son Jaephil cho Department of Energy Engineering School of Energy and Chemical Engineering Ulsan National Institute of Science and Technology(UNIST) Ulsan 44919 Republic of Korea

Li-rich layered cathode materials have been considered the most promising candidates for large-scale Li-ion batteries due to their low cost and high reversible capacity. However, these materials have many drawbacks that hinder commercialization, such as low initial efficiency and cyclability at elevated temperatures. To overcome these barriers, we propose an efficient and effective surface modification method, in which chemical activation （acid treatment） and LiCoPO4 coating were carried out simultaneously. During the synthesis, the lithium ions were extracted from the lattice, leading to improved Columbic efficiency, and these ions were used for the formation of LiCoPO4. The Ni and Co doped spinel phase was formed at the surface of the host material, which gives rise to the facile pathway for lithium ions. The LiCoPO4 and highly doped spinel on the surface acted as double protection layers that effectively prevented side reactions on the surface at 60℃. Moreover, the transition metal migration of the modified cathode was weakened, due to the presence of the spinel structure at the surface. Consequently, the newly developed Li-rich cathode material exhibited a high 1st efficiency of 94%, improved capacity retention of 82% during 100 cycles at 60℃, and superior rate capability of 62% at 12C （1C = 200 mA/g） rate at 24℃. In addition, the thermal stability of the modified cathode was significantly improved as compared to that of a bare counterpart at 4.6 V, showing a 60% decrease in the total heat generation.

关键词： lithium ion battery cathode material Li-rich material electrochemistry surface modification

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Anethole improves the developmental competence of porcine embryos by reducing oxidative stress via the sonic hedgehog signaling pathway

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Journal of Animal Science and Biotechnology 2023年第4期14卷 1395-1407页

作者： Ye Eun Joo Pil-Soo Jeong Sanghoon Lee Se-Been Jeon min-Ah Gwon min Ju Kim Hyo-Gu Kang Bong-seok Song Sun-Uk Kim Seong-Keun cho Bo-Woong Sim Futuristic Animal Resource and Research Center Korea Research Institute of Bioscience and BiotechnologyCheongjuSouth Korea Department of Animal Science College of Natural Resources and Life SciencePusan National UniversityMiryangSouth Korea Laboratory of Theriogenology College of Veterinary MedicineChungnam National UniversityDaejeonSouth Korea Department of Biotechnology College of EngineeringDaegu UniversityGyeongsanSouth Korea Department of Animal Science and Biotechnology College of Agriculture and Life ScienceChungnam National UniversityDaejeonSouth Korea Department of Functional Genomics University of Science and TechnologyDaejeonSouth Korea Department of Animal Science College of Natural Resources and Life ScienceLife and Industry Convergence Research InstitutePusan National UniversityMiryangSouth Korea

Background Anethole(AN)is an organic antioxidant compound with a benzene ring and is expected to have a positive impact on early embryogenesis in ***,no study has examined the effect of AN on porcine embryonic ***,we investigated the effect of AN on the development of porcine embryos and the underlying *** We cultured porcine in vitro-fertilized embryos in medium with AN(0,0.3,0.5,and 1 mg/mL)for 6 *** at 0.5 mg/mL significantly increased the blastocyst formation rate,trophectoderm cell number,and cellular survival rate compared to the ***-supplemented embryos exhibited significantly lower reactive oxygen species levels and higher glutathione levels than the ***,AN significantly improved the quantity of mitochondria and mitochondrial membrane potential,and increased the lipid droplet,fatty acid,and ATP ***,the levels of proteins and genes related to the sonic hedgehog(SHH)signaling pathway were significantly increased by *** These results revealed that AN improved the developmental competence of porcine preimplantation embryos by activating SHH signaling against oxidative stress and could be used for large-scale production of high-quality porcine embryos.

关键词： Anethole Lipid metabolism Mitochondrial function Porcine embryo development Sonic hedgehog signaling pathway

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Influence of different nitrogen application on flour properties,gluten properties by HPLC and end-use quality of Korean wheat

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Journal of Integrative Agriculture 2018年第5期17卷 982-993页

作者： Seong-Woo cho chon-Sik Kang Taek-Gyu Kang Kwang-min cho Chul Soo Park Department of Crop Science and Biotechnology Chonbuk National University National Institute of Crop Science Rural Development Administration Research Center of Bioactive Materials Chonbuk National University

This study was performed to identify how the different levels of nitrogen application affected the variances of gluten properties and end-use qualities and the differences of variances among Korean wheat cultivars. Protein and dry gluten content, SDS sedimentation volume and water absorption of Mixolab increased as nitrogen application increased. This ratio of the increase was higher in Korean wheat cultivars for bread than in Korean wheat cultivars for noodles and cookies. The proportion of（α＋β）-gliadin measured by reversed-phase high-performance liquid chromatography（RP-HPLC） increased, but the proportion of ω-and γ-gliadin decreased as the protein content increased. The Korean wheat cultivars for bread showed a high proportion of（α＋β）-gliadin increase, the Korean cultivars for noodles had a high proportion of γ-gliadin decrease and the Korean wheat cultivars for cookies had a high proportion of ω-gliadin decrease. However, there was no variation of the component in the proportion of glutenin component measured by RP-HPLC, even though the protein content was increased, but all of the protein fractions measured by size exclusion（SE）-HPLC were increased. The soluble monomeric protein showed a high proportion of Korean wheat cultivars for bread by the increase of protein content. Bread loaf volume increased by the increase of protein content but there were no variances in the ratio of increase among Korean wheat cultivars. The cookie diameter decreased with the increase of protein content, and this ratio of decrease was the highest in Korean wheat cultivars for cookies. The hardness of cooked noodles also increased by the increase of protein content but there were no variations in springiness and cohesiveness. The decrease proportion of ω-gliadin affected the increase of bread loaf volume, the hardness of cooked noodles, and the decrease of cookie diameter.

关键词： wheat gluten end-use quality cultivar nitrogen application

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Value of temporary stents for the management of perivaterian perforation during endoscopic retrograde cholangiopancreatography

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World Journal of Clinical Cases 2014年第11期2卷 689-697页

作者： Sang min Lee Kwang Bum cho Department of Internal Medicine and Institute for Medical Science Keimyung University School of Medicine Daegu 700-712 South Korea

Endoscopic retrograde cholangiopancreatography(ERCP) has become the mainstay of treatment in hepato-pancreato-biliary disease. However, ERCP requires a high level of technical skills and experience in therapeutic endoscopy, there is always a risk of complications. Especially, the perforation per se affects the patient adversely, and the clinical course may lead to a poor prognosis, even with appropriate management. The treatments for ERCPrelated perforation are diverse, depending on the location and mechanism of the bowel perforation and the time of diagnosis. Thus, we reviewed the appropriate surgical and non-surgical management options for therapeutic ERCP-related perforations, especially, evaluating metallic stenting as a treatment modality in perivaterian perforation.

关键词： Endoscopic retrograde cholangiopancreatography Perforation Self-expandable metallic stent Duodenum Perivaterian

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A conformal titanyl phosphate amorphous overlayer for enhancing photoelectrochemical hydrogen peroxide production

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Journal of Energy Chemistry 2023年第11期86卷 399-408,I0009页

作者： Jaekyum Kim Young Eun Kim minyeong Je Won Tae Hong Chang-Lyoul Lee Tae-Hoon Kim Sung min cho Chang Hyuck choi Heechae choi Woo-seok choe Jung Kyu Kim School of Chemical Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea SKKU Advanced Institute of Nano Technology(SAINT) Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Theoretical Materials&Chemistry Group Institute of Inorganic ChemistryUniversity of CologneGreinstr.650939CologneGermany Advanced Photonics Research Institute(APRI) Gwangju Institute of Science and Technology(GIST)Gwangju 61005Republic of Korea Department of Materials Science and Engineering Chonnam National UniversityGwangju 61186Republic of Korea Department of Chemistry Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea Institute for Convergence Research and Education in Advanced Technology(I-CREATE) Yonsei UniversitySeoul 03722Republic of Korea Department of Chemistry Xi’an Jiaotong-Liverpool UniversitySuzhou 215123JiangsuChina

Photoelectrochemical(PEC)H_(2)O_(2)production through water oxidation reaction(WOR)is a promising strategy,however,designing highly efficient and selective photoanode materials remains challenging due to competitive reaction ***,for highly enhanced PEC H_(2)O_(2)production,we present a conformal amorphous titanyl phosphate(a-TP)overlayer on nanoparticulate TiO_(2)surfaces,achieved via lysozyme-molded in-situ surface *** a-TP overlayer modulates surface adsorption energies for reaction intermediates,favoring WOR for H_(2)O_(2)production over the competing O_(2)evolution *** density functional theory calculations reveal that a-TP/TiO_(2)exhibits a substantial energy uphill for the O·*formation pathway,which disfavors O_(2)evolution but promotes H_(2)O_(2)***,the a-TP overlayer strengthens the built-in electric field,resulting in favorable ***,a-TP/TiO_(2)exhibits 3.7-fold higher Faraday efficiency(FE)of 63%at 1.76 V *** hydrogen electrode(RHE)under 1 sun illumination,compared to bare TiO_(2)(17%),representing the highest FE among TiO_(2)-based WOR H_(2)O_(2)production *** the a-TP overlayer constitutes a promising strategy for controlling reaction pathways and achieving efficient solar-to-chemical energy conversion.

关键词： Solar H_(2)O_(2) production In-situ surface reforming Titanyl phosphate Amorphous overlayer Reaction pathway control

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