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Advances in the diagnosis and treatment of heterotopic pancreas

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World Journal of Clinical Cases 2024年第30期12卷 6349-6352页

作者： Li Lang Fa-Kun Yu Li-min kang Department of Outpatient Puer People's HospitalPuer 665000Yunnan ProvinceChina Department of Hepatobiliary and Pancreatic Surgery Puer People's HospitalPuer 665000Yunnan ProvinceChina

Heterotopic pancreas,a rare congenital malformation,manifests outside the normal *** suggests that abnormal embryonic development is linked to the presence of heterotopic *** prevailing theories explain its mechanism:Dislocation theory,metaplasia theory,and totipotent stem cell *** presentations of heterotopic pancreas are often nonspecific,with most patients being asymptomatic and incidentally discovered during unrelated surgeries or *** ultrasound,computed tomography,and magnetic resonance imaging are commonly employed diagnostic tools for heterotopic ***,the accuracy of diagnosis based on these methods is not consistently high,necessitating histopathological confirmation in many *** options for heterotopic pancreas typically involve endoscopic resection,surgical resection,or observation through follow-up.

关键词： Heterotopic pancreas Ultrasound endoscopy Enhanced computed tomography Endoscopic therapy Surgery

Heterogeneously elevated branched-chain/aromatic amino acids among new-onset type-2 diabetes mellitus patients are potentially skewed diabetes predictors

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World Journal of Diabetes 2024年第1期15卷 53-71页

作者： min Wang Yang Ou Xiang-Lian Yuan Xiu-Fang Zhu Ben Niu Zhuang kang Bing Zhang Anwar Ahmed Guo-Qiang Xing Heng Su School of Chemical Science and Technology Yunnan UniversityKunming 650091Yunnan ProvinceChina Department of Endocrinology The First People’s Hospital of Yunnan ProvinceKunming 650032Yunnan ProvinceChina Clinical Laboratory Nanchong Central Hospital&The Second Clinical Medical College of North Sichuan Medical UniversityNanchong 637000Sichuan ProvinceChina Department of Preventive Medicine and Biostatistics Uniformed Services University of the Health SciencesBethesdaMD 20814United States The Affiliated Hospital and Second Clinical Medical College North Sichuan Medical UniversityNanchong 637000Sichuan ProvinceChina Department of Research and Development Lotus *** LLCGaithersburgMD 20878United States

BACKGROUND The lack of specific predictors for type-2 diabetes mellitus(T2DM)severely impacts early intervention/prevention *** branched-chain amino acids(BCAAs:Isoleucine,leucine,valine)and aromatic amino acids(AAAs:Tyrosine,tryptophan,phenylalanine)show high sensitivity and specificity in predicting diabetes in animals and predict T2DM 10-19 years before T2DM onset in clinical ***,improvement is needed to support its clinical *** To evaluate the effects of body mass index(BMI)and sex on BCAAs/AAAs in new-onset T2DM individuals with varying body *** Ninety-seven new-onset T2DM patients(ming,China,were ***-way and 2-way ANOVAs were conducted to determine the effects of BMI and sex on BCAAs/*** Fasting serum AAAs,BCAAs,glutamate,and alanine were greater and high-density lipoprotein(HDL)was lower(Pminal adiposity,body weight and BMI,whereas isoleucine,leucine and phenylalanine were negatively correlated with *** Heterogeneously elevated amino acids,especially BCAAs/AAAs,across new-onset T2DM patients in differing BMI categories revealed a potentially skewed prediction of T2DM *** higher BCAA/AAA levels in obese T2DM patients would support T2DM prediction in obese individuals,whereas the lower levels of BCAAs/AAAs in NW-T2DM individuals may underestimate T2DM risk in NW *** potentially skewed T2DM prediction should be considered when BCAAs/AAAs are to

关键词： Hyperaminoacidemia Branched-chain/aromatic amino acids New-onset type-2 diabetes Predictor Obesity Sex

Natural marmatite photocatalyst for treatment of mineral processing wastewater to help zero wastewater discharge

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Journal of Environmental Sciences 2024年第8期142卷 83-91页

作者： Meirong Wu Wei Sun Xiangsong Meng Jianhua kang Yue Yang School of minerals Processing and Bioengineering Central South UniversityChangsha 410083China Key Laboratory of Hunan Province for Clean and Efficient Utilization of Strategic Calcium-containing mineral Resources Central South UniversityChangsha 410083China

mineral processing wastewater(MPW)with large discharge and high toxicity affects environmental safety,and the realizing zero discharge of MPW is of great significance for reducing environmental pollution,saving water resources,and promoting the sustainable development of the mining *** this study,we reported natural marmatite(NM)as a low-cost and efficient photocatalyst for the treatment of MPW to help zero wastewater *** photocatalytic activity of NM was evaluated by the removal of total organic carbon(TOC)from MPW under visible-light illumination,and the optimal degradation conditions were *** showed that superoxide free radicals(^(·)O_(2)^(-))were the dominant active species responsible for organic pollutants degradation,and 74.25%TOC removal was obtained after 120 min reaction under the optimum treatment ***,the wastewater treated by NM photocatalysis can be reused in the flotation system without adverse impact on the product *** on these findings,a model of zero wastewater discharge for flotation with the help of photocatalytic treatment was established,it indicated that the water of the whole system can be balanced without affecting the ore dressing index,which showed that visible light-driven photocatalyst has a promising application prospect in the treatment and recycling of industrial wastewater.

关键词： Natural mineral Photocatalysis Industrial wastewater Wastewater recycling Water balance

Early proactive monitoring of DNA-thioguanine in patients with Crohn’s disease predicts thiopurine-induced late leucopenia in NUDT15/TPMT normal metabolizers

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World Journal of Gastroenterology 2024年第12期30卷 1751-1763页

作者： Ting Yang kang Chao Xia Zhu Xue-Ding Wang Sumyuet Chan Yan-Ping Guan Jing Mao Pan Li Shao-Xing Guan Wen Xie Xiang Gao min Huang School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006Guangdong ProvinceChina Institute of Clinical Pharmacology Sun Yat-sen UniversityGuangzhou 510006Guangdong ProvinceChina Department of Gastroenterology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655Guangdong ProvinceChina Department of Pharmacy The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina Center for Pharmacogenetics and Department of Pharmaceutical Sciences University of PittsburghPittsburghPA 15261United States

BACKGROUND Thiopurine-induced leucopenia significantly hinders the wide application of *** optimization guided by nudix hydrolase 15(NUDT15)has significantly reduced the early leucopenia rate,but there are no definitive biomarkers for late risk leucopenia *** To determine the predictive value of early monitoring of DNA-thioguanine(DNATG)or 6-thioguanine nucleotides(6TGN)for late leucopenia under a NUDT15-guided thiopurine dosing strategy in patients with Crohn’s disease(CD).METHODS Blood samples were collected within two months after thiopurine initiation for detection of metabolite *** leucopenia was defined as a leukocyte count<3.5×10^(9)/L over two *** Of 148 patients studied,late leucopenia was observed in 15.6%(17/109)of NUDT15/thiopurine methyltransferase(TPMT)normal and 64.1%(25/39)of intermediate *** patients suffering late leucopenia,early DNATG levels were significantly higher than in those who did not develop late leucopenia(P=4.9×10^(-13)).The DNATG threshold of 319.43 fmol/μg DNA could predict late leucopenia in the entire sample with an area under the curve(AUC)of 0.855(sensitivity 83%,specificity 81%),and in NUDT15/TPMT normal metabolizers,the predictive performance of a threshold of 315.72 fmol/μg DNA was much more remarkable with an AUC of 0.902(sensitivity 88%,specificity 85%).6TGN had a relatively poor correlation with late leucopenia whether in the entire sample(P=0.021)or NUDT15/TPMT normal or intermediate metabolizers(P=0.018,P=0.55,respectively).CONCLUSION Proactive therapeutic drug monitoring of DNATG could be an effective strategy to prevent late leucopenia in both NUDT15/TPMT normal and intermediate metabolizers with CD,especially the former.

关键词： Thiopurine-induced late leucopenia DNA-thioguanine 6-thioguanine nucleotide Proactive therapeutic drug monitoring Crohn’s disease

Lecithin-cholesterol acyltransferase is a potential tumor suppressor and predictive marker for hepatocellular carcinoma metastasis

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3651-3671页

作者： Yan Li Li-Na Jiang Bo-kang Zhao Mei-Ling Li Yi-Yun Jiang Yi-Si Liu Shu-Hong Liu Li Zhu Xin Ye Jing-min Zhao Department of Pathology and Hepatology The Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Department of Hepatology Center of Infectious Diseases and Pathogen BiologyThe First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina First Department of Liver Disease Center Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Savaid Medical School University of Chinese Academy of SciencesBeijing 100190China Department of Pathology The Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China

BACKGROUND Hepatocellular carcinoma(HCC)is a major cause of cancer mortality worldwide,and metastasis is the main cause of early recurrence and poor ***,the mechanism of metastasis remains poorly *** To determine the possible mechanism affecting HCC metastasis and provide a possible theoretical basis for HCC *** The candidate molecule lecithin-cholesterol acyltransferase(LCAT)was screened by gene microarray and bioinformatics *** expression levels of LCAT in clinical cohort samples was detected by quantitative realtime polymerase chain reaction and western *** proliferation,migration,invasion and tumor-forming ability were measured by Cell Counting Kit-8,Transwell cell migration,invasion,and clonal formation assays,*** formation was detected in nude mice after LCAT gene knockdown or *** immunohistochemistry for Ki67,E-cadherin,N-cadherin,matrix metalloproteinase 9 and vascular endothelial growth factor were performed in liver tissues to assess the effect of LCAT on *** set enrichment analysis(GSEA)on various gene signatures were analyzed with GSEA version *** machine-learning algorithms(random forest,support vector machine,and logistic regression)were applied to predict HCC metastasis in The Cancer Genome Atlas and GEO *** LCAT was identified as a novel gene relating to HCC metastasis by using gene microarray in HCC *** was significantly downregulated in HCC tissues,which is correlated with recurrence,metastasis and poor outcome of HCC *** analysis indicated that LCAT inhibited HCC cell proliferation,migration and invasion both in vitro and in *** data showed that LCAT was negatively associated with HCC size and metastasis(HCC size≤3 cm vs 3-9 cm,P9 cm,P<0.01;metastatic-free HCC vs extrahepatic metastatic HCC,P<0.05).LCAT suppressed the growth,migration and invasion of HCC cell lines via PI3K/A

关键词： Lecithin-cholesterol acyltransferase Tumor suppressor gene Hepatocellular carcinoma PI3K/AKT/mTOR Predicting model

Anti-obesity effects of fucoidan from Sargassum thunbergii in adipocytes and high fat diet induced obese mice through inhibiting adipogenic specific transcription factor

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Food Science and Human Wellness 2024年第3期13卷 1608-1616页

作者： Hyo-Geun Lee H.H.A.C.K.Jayawardhana Fengqi Yang D.P.Nagahawaththa N.M.Liyanage Kyung-Mo Song Yun-Sang Choi Seung-Hong Lee You-Jin Jeon min-Cheol kang Department of Marine Life Sciences Jeju National UniversityJeju 63243Republic of Korea Marine Science Institute Jeju National UniversityJeju 63333Republic of Korea Research Group of Food Processing Korea Food Research InstituteWanju 55365Republic of Korea Department of Pharmoceutical Engineering Soonchunhyang UniversityAsan 31538Republic of Korea

The prevalence of obesity has increased and is a health concern *** to the concerns regarding synthetic anti-obesity treatments,nowadays natural products become a *** studies proved that there is a potential to use marine algae as anti-obesity ***,in this study,the lipid inhibitory effect of crude polysaccharide of amyloglucosidase-assisted hydrolysate from Sargassum thunbergii(STAC)and its fucoidan fractions(STAFs)on 3T3-L1 cells and high-fat diet(HFD)-induced obese mice were *** to the results,the STAF3,showed the highest xylose content and exhibited significant inhibitory effects on lipid accumulation by downregulating adipogenic and lipogenic proteins in 3T3-L1 ***,oral supplementation with STAC significantly declined gain in body weight and fat weight,and serum lipid contents in an HFD-induced obesity mouse *** and chemical characterizations demonstrated that puritied STAF3 has consistent surface morphology and small particle size,with similar structural characteristics as commercial ***,these results indicate that STAC and purified STAF3 from Sargassum thunbergia is a potent source to develop as ananti-obesity agents or functional food products to counter obesity.

关键词： Sargassum thunbergii Fucoidan Anti-obesity Anti-steatosis

Development and validation of a nomogram for predicting in-hospital mortality of intensive care unit patients with liver cirrhosis

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World Journal of Hepatology 2024年第4期16卷 625-639页

作者： Xiao-Wei Tang Wen-Sen Ren Shu Huang kang Zou Huan Xu Xiao-min Shi Wei Zhang Lei Shi Mu-Han Lü Department of Gastroenterology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646099Sichuan ProvinceChina Nuclear Medicine and Molecular Imaging Key Laboratory The Affiliated Hospital of Southwest Medical UniversityLuzhou 646099Sichuan ProvinceChina Department of Gastroenterology Lianshui People’Hospital of Kangda College Affiliated to Nanjing Medical UniversityHuaian 223499Jiangsu ProvinceChina

BACKGROUND Liver cirrhosis patients admitted to intensive care unit(ICU)have a high mortality *** To establish and validate a nomogram for predicting in-hospital mortality of ICU patients with liver *** We extracted demographic,etiological,vital sign,laboratory test,comorbidity,complication,treatment,and severity score data of liver cirrhosis patients from the Medical Information Mart for Intensive Care IV(MIMIC-IV)and electronic ICU(eICU)collaborative research database(eICU-CRD).Predictor selection and model building were based on the MIMIC-IV *** variables selected through least absolute shrinkage and selection operator analysis were further screened through multivariate regression analysis to obtain final *** final predictors were included in the multivariate logistic regression model,which was used to construct a ***,we conducted external validation using the *** area under the receiver operating characteristic curve(AUC),decision curve,and calibration curve were used to assess the efficacy of the *** Risk factors,including the mean respiratory rate,mean systolic blood pressure,mean heart rate,white blood cells,international normalized ratio,total bilirubin,age,invasive ventilation,vasopressor use,maximum stage of acute kidney injury,and sequential organ failure assessment score,were included in the multivariate logistic *** model achieved AUCs of 0.864 and 0.808 in the MIMIC-IV and eICU-CRD databases,*** calibration curve also confirmed the predictive ability of the model,while the decision curve confirmed its clinical *** The nomogram has high accuracy in predicting in-hospital *** the included predictors may help improve the prognosis of patients.

关键词： Liver cirrhosis Intensive care unit Nomogram Predicting model Mortality

Pay attention to the application of indocyanine green fluorescence imaging technology in laparoscopic liver cancer resection

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World Journal of Clinical Cases 2024年第23期12卷 5288-5293页

作者： Li-min kang Fu-Wei Zhang Fa-Kun Yu Lei Xu Department of Hepatobiliary and Pancreatic Surgery Puer People's HospitalPuer 665000Yunnan ProvinceChina

Traditional laparoscopic liver cancer resection faces challenges,such as difficultiesin tumor localization and accurate marking of liver segments,as well as theinability to provide real-time intraoperative *** approach falls shortof meeting the demands for precise and anatomical liver *** introductionof fluorescence imaging technology,particularly indocyanine green,hasdemonstrated significant advantages in visualizing bile ducts,tumor localization,segment staining,microscopic lesion display,margin examination,and lymphnode *** technology addresses the inherent limitations oftraditional laparoscopy,which lacks direct tactile feedback,and is increasinglybecoming the standard in laparoscopic *** by fluorescenceimaging technology,laparoscopic liver cancer resection is poised to become thepredominant technique for liver tumor removal,enhancing the accuracy,safetyand efficiency of the procedure.

关键词： Indocyanine green Fluorescence imaging technology Laparoscopy Hepatectomy Liver tumor

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一种新的模糊滑模控制器设计方法

控制与决策 2024年第6期39卷 1909-1917页

作者：康庄贾利民秦勇北京交通大学轨道交通控制与安全国家重点实验室北京100044 北京交通大学交通运输学院北京100044

针对具有较大且不可观测外界干扰的一类不确定系统,提出一种新的模糊滑模控制器设计方法.首先基于模糊滑模控制原理,引入全局快速终端滑模控制,使系统在有限时间内达到稳态;然后构造以李雅普诺夫函数导数的绝对值为补偿的自适应干扰估计... 详细信息

针对具有较大且不可观测外界干扰的一类不确定系统,提出一种新的模糊滑模控制器设计方法.首先基于模糊滑模控制原理,引入全局快速终端滑模控制,使系统在有限时间内达到稳态;然后构造以李雅普诺夫函数导数的绝对值为补偿的自适应干扰估计项,对外界干扰进行准确估计,进而提出一种双层递阶指数趋近全局快速终端模糊滑模控制器,通过指数趋近率来调节滑模面的动态品质,该控制器能快速收敛到稳定状态,且有效消除控制器的抖振情况;最后通过仿真算例验证所提方法的有效性.

关键词：滑模控制模糊系统滑模面全局快速终端滑模控制指数趋近率外界干扰