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Advances in Active Suspension Systems for Road Vehicles

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Engineering 2024年第2期33卷 160-177页

作者： Min Yu Simos AEvangelou Daniele Dini Department of Mechanical Engineering Imperial College LondonLondon SW72AZUK Department of Electrical and Electronic Engineering Imperial College LondonLondon SW72AZUK

Active suspension systems(ASSs)have been proposed and developed for a few decades,and have now once again become a thriving topic in both academia and industry,due to the high demand for driving comfort and safety and the compatibility of ASSs with vehicle electrification and autonomy.Existing review papers on ASSs mainly cover dynamics modeling and robust control;however,the gap between academic research outcomes and industrial application requirements has not yet been bridged,hindering most ASS research knowledge from being transferred to vehicle companies.This paper comprehensively reviews advances in ASSs for road vehicles,with a focus on hardware structures and control strategies.In particular,state-of-the-art ASSs that have been recently adopted in production cars are discussed in detail,including the representative solutions of Mercedes active body control(ABC)and Audi predictive active suspension;novel concepts that could become alternative candidates are also introduced,including series active variable geometry suspension,and the active wheel-alignment system.ASSs with compact structure,small mass increment,low power consumption,high-frequency response,acceptable economic costs,and high reliability are more likely to be adopted by car manufacturers.In terms of control strategies,the development of future ASSs aims not only to stabilize the chassis attitude and attenuate the chassis vibration,but also to enable ASSs to cooperate with other modules(e.g.,steering and braking)and sensors(e.g.,cameras)within a car,and even with high-level decision-making(e.g.,reference driving speed)in the overall transportation system-strategies that will be compatible with the rapidly developing electric and autonomous vehicles.

关键词： Active suspension Vehicle dynamics Robust control Ride comfort Chassis attitude

Natural killer cells in hepatocellular carcinoma： current status and perspectives for future immunotherapeutic approaches

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Frontiers of Medicine 2017年第4期11卷 509-521页

作者： Min Yu Zonghai Li State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Renji Hospital Shanghai Jiao Tong University School ofMedicine Shanghai 200032 China

Hepatocellular carcinoma （HCC） is currently the fifth most common malignancy and the third leading cause of cancer-related mortalities worldwide. In the last few years, treatments for HCC have significantly improved from a mere surgical resection to a series of minimally invasive therapies and targeted drugs. However, recurrence frequently occurs even upon curative therapeutics, and drug therapies generally produce disappointing results, with the overall prognosis dismal. This challenging clinical scenario warrants new effective and life-prolonging strategies for patients with HCC. Compelling evidence suggests that NK cells play a critical role in the immune function of the fiver and in the immune defenses against HCC, indicating that HCC might be an ideal target for NK cell-based immunotherapies. To obtain comprehensive insights into the putative influence of NK cells on HCC, this paper summarizes current knowledge on NK cells in HCC and discusses the usefulness and prospects of NK cell-based immunotherapies. Critical issues that require consideration for the successful clinical translation of NK cell-based therapies are also addressed. If appropriately used and further optimized, NK cell- based therapies could dominate important roles in the future immunotherapeutic market of HCC.

关键词： natural killer cell hepatocellular carcinoma immunotherapy

Finite Difference Schemes for Time-Space Fractional Diffusion Equations in One-and Two-Dimensions

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Communications on Applied Mathematics and Computation 2023年第4期5卷 1674-1696页

作者： yu Wang min Cai Department of Mathematics Shanghai UniversityShanghai200444China

In this paper,finite difference schemes for solving time-space fractional diffusion equations in one dimension and two dimensions are proposed.The temporal derivative is in the Caputo-Hadamard sense for both cases.The spatial derivative for the one-dimensional equation is of Riesz definition and the two-dimensional spatial derivative is given by the fractional Laplacian.The schemes are proved to be unconditionally stable and convergent.The numerical results are in line with the theoretical analysis.

关键词： Time-space fractional diffusion equation Caputo-Hadamard derivative Riesz derivative Fractional Laplacian Numerical analysis

Bilateral U-Net semantic segmentation with spatial attention mechanism

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CAAI Transactions on Intelligence Technology 2023年第2期8卷 297-307页

作者： Guangzhe Zhao Yimeng Zhang Maoning Ge Min Yu Beijing University of Civil Engineering and Architecture College of Electrical and Information EngineeringBeijingChina Graduate School of Informatics Nagoya UniversityNagoyaJapan Department of General Surgery Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhouChina

Aiming at the problem that the existing models have a poor segmentation effect on imbalanced data sets with small-scale samples,a bilateral U-Net network model with a spatial attention mechanism is designed.The model uses the lightweight MobileNetV2 as the backbone network for feature hierarchical extraction and proposes an Attentive Pyramid Spatial Attention(APSA)module compared to the Attenuated Spatial Pyramid module,which can increase the receptive field and enhance the information,and finally adds the context fusion prediction branch that fuses high-semantic and low-semantic prediction results,and the model effectively improves the segmentation accuracy of small data sets.The experimental results on the CamVid data set show that compared with some existing semantic segmentation networks,the algorithm has a better segmentation effect and segmentation accuracy,and its mIOU reaches 75.85%.Moreover,to verify the generality of the model and the effectiveness of the APSA module,experiments were conducted on the VOC 2012 data set,and the APSA module improved mIOU by about 12.2%.

关键词： attention mechanism receptive field semantic fusion semantic segmentation spatial attention module U-Net

Chidamide,Decitabine,Cytarabine,Aclarubicin,and Granulocyte Colony-stimulating Factor Therapy for Patients with Relapsed/Refractory Acute Myeloid Leukemia:A Retrospective Study from a Single-Center

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Current Medical Science 2023年第6期43卷 1151-1161页

作者： Fan-cong KONG Ling QI yu-lan ZHOU Min Yu Wen-feng HUANG Fei LI Center of Hematology The First Affiliated Hospital of Nanchang UniversityNanchang330006China Jiangxi Clinical Research Center for Hematologic Diseases Nanchang330006China

Objective Preclinical evidence and clinical trials have suggested synergistic effects of epigenetic modifiers in combination with cytotoxic agents for the treatment of leukemia.However,their efficacy in patients with relapsed/refractory acute myeloid leukemia(R/R AML)remains unclear.Methods Clinical data of R/R AML patients who received a CDCAG regimen(chidamide,decitabine,cytarabine,aclarubicin,and granulocyte colony-stimulating factor)from July 1,2018 to October 31,2021 at our center were retrospectively assessed,and the safety and efficacy of the CDCAG regimen were evaluated.Patients were followed up until November 30,2021,with a median follow-up of 21.6 months(95%CI:10.0–33.2 months).Results A total of 67 patients were enrolled.Two patients died within 3 weeks after the initiation,and therefore only 65 patients underwent the assement for clinical response and survival.It was found that 56.9%patients achieved complete remission with a median overall survival(OS)of 9.6 months.The median OS of responders was 25.9 months,while that of non-responders was 5.0 months(P<0.0001).Patients with gene mutations had a superior overall response rate(ORR)(80.4%vs.45.5%,P=0.043)compared to those without gene mutations.The presence of DNA methyltransferase 3 A(DNMT3A),ten-eleven translocation-2(TET2),and isocitrate dehydrogenase 1/2(IDH1/2)mutations did not affect the response rate(88.2%vs.68.9%,P=0.220)and reflected a better OS(not attained vs.9.0 months,P=0.05).The most common non-hematologic adverse events were pulmonary infection(73.1%),followed by febrile neutropenia(23.9%)and sepsis(19.4%).Conclusions The CDCAG regimen was effective and well-tolerated in R/R AML patients,increasing the potential for allogeneic hematopoietic stem cell transplantation.Moreover,patients with DNMT3A,TET2,and IDH1/2 mutations might benefit from this regimen.

关键词： relapsed/refractory acute myeloid leukemia histone deacetylase inhibitor DNA methyltransferase inhibitor salvage therapy

Experimental Studies on Sloshing Mitigation Using Dual Perforated Floating Plates in A Rectangular Tank

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China Ocean Engineering 2021年第2期35卷 301-307页

作者： yu yue-min College of Civil Engineering and Architecture Hainan UniversityHaikou 570228China State Key Laboratory of Marine Resource Utilization in South China Sea Hainan UniversityHaikou 570228China

The performance of dual perforated floating plates in a rectangular tank is investigated based on the model tests under different external excitations for different filling rates.It is found that dual perforated floating plates in the tank can remarkably mitigate violent resonant sloshing responses compared with the clean tank,especially when the external excitation frequency is in the vicinity of the first-order resonant frequency.Next,the parametric studies based on different filling rates and external excitation amplitudes are performed for the first-order resonant frequencies.The presence of dual perforated floating plates seldom shifts the sloshing natural frequencies.Further,dual perforated floating plates change the sloshing modes from the standing-wave mode in the clean tank to the Utube mode,which can arise from the sloshing reduction to some extent.

关键词： suppressing sloshing experiment dual perforated floating plates the lowest natural frequency sloshing mode

Fusion Model for Tentative Diagnosis Inference Based on Clinical Narratives

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清华大学学报:自然科学版(英文版) 2023年第4期28卷 686-695页

作者： Ying yu Junwen Duan min Li School of Computer Science and Engineering Central South UniversityChangsha 410083Chinaand also with the School of Computer ScienceUniversity of South ChinaHengyang 421001China Hunan Provincial Key Lab on Bioinformatics School of Computer Science and EngineeringCentral South UniversityChangsha 410083China

In general,physicians make a preliminary diagnosis based on patients’admission narratives and admission conditions,largely depending on their experiences and professional knowledge.An automatic and accurate tentative diagnosis based on clinical narratives would be of great importance to physicians,particularly in the shortage of medical resources.Despite its great value,little work has been conducted on this diagnosis method.Thus,in this study,we propose a fusion model that integrates the semantic and symptom features contained in the clinical text.The semantic features of the input text are initially captured by an attention-based Bidirectional Long Short-Term Memory(BiLSTM)network.The symptom concepts,recognized from the input text,are then vectorized by using the term frequency-inverse document frequency method based on the relations between symptoms and diseases.Finally,two fusion strategies are utilized to recommend the most potential candidate for the international classification of diseases code.Model training and evaluation are performed on a public clinical dataset.The results show that both fusion strategies achieved a promising performance,in which the best performance obtained a top-3 accuracy of 0.7412.

关键词： tentative diagnosis clinical narrative Bidirectional Long Short-Term Memory(BiLSTM) Term FrequencyInverse Document Frequency(TF-IDF) fusion strategy

A review on food oral tribology

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Friction 2022年第12期10卷 1927-1966页

作者： Wenhu XU Shuaike yu min ZHONG School of Mechatronics Engineering Key Laboratory of TribologyNanchang UniversityNanchang 330031China

Food entering the oral cavity undergoes a series of complex processing behaviors.It is subjected to compression and shearing by the teeth,tongue,and palate to reduce its size and mix with saliva until it is swallowed.The oral processing behaviors are thought to be closely related to both food and oral frictional properties.Much effort has been made in recent decades about food oral tribology to explore this complicated lubrication behavior.Understanding the lubrication mechanism of food in the mouth is important for improving the consumption experience and developing the novel food.This paper provides a new perspective on the effects of composition,texture,structure,and saliva-food component interactions on lubrication properties of different foods,the relationship between sensory perception and oral frictional behavior,and the mechanism and pattern of lubrication categorized by common food types.The roles of tribology in the improvement of food taste,the search for healthier ingredient substitutes,functional foods,and the development of green foods are analyzed.Conceptual and numerical prediction models among physical properties,sensory perception,and frictional behavior of food are discussed.Studies of simulating oral processing,such as the selection of friction pair materials,physical modification of contact surfaces,addition of saliva,different modes of motion,and contact forms are concluded and classified.The progress of commercial friction apparatus as well as customized friction devices applied to the food sector in recent years are described.The characteristics,performances,and applications of these tribological instruments are analyzed and compared.In addition,the results achieved by oral tribology in identifying adulterated foods and ensuring food safety are presented.Finally,some suggestions are put forward for the current challenges and future development of food oral tribology.

关键词： food oral tribology in vitro friction tests lubrication behavior Stribeck curve sensory perception food development and detection

Motion Control of Capsule-like Underwater Robot Utilizing the Swing Properties of Ionic Polymer Metal Composite Actuators

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Journal of Bionic Engineering 2020年第2期17卷 281-289页

作者： Hongkai Li min Fan Yinghao yue Guoliang Hu Qingsong He Min Yu Key Laboratory of Bionic Functional Materials of Jiangsu Province Nanjing University of Aeronautics and AstronauticsNanjing 210016China College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China Science and Technology on Electro-optic Control Laboratory Luoyang 471000China

Ionic Polymer Metal Composite(IPMC)is a novel electrically actuated intelligent material with the advantages of big bending displacement,low driving voltage,flexible and so on.It has been recognized as one of the most attractive actuators with prospective applications for underwater robots and bionic organs.In this work,a capsule-like robot was introduced with the pectoral and caudal fins made of IPMC.By analyzing the properties of displacement response to square waves with different frequencies and low level voltages,it was found that performance of IPMC are frequency sensitive.Besides,when the absolute value of low level voltage decreases,IPMC could swing on one side with the decrease in amplitudes,whereas the amplitude at high level voltage fluctuates within small ranges at low frequencies.IPMC tip can approximately maintain when the frequency of driving signal around 30 Hz.Such properties were employed to control the locomotion of robot combining the motions of pectoral and caudal fin.Thus,the locomotions of swimming forward,turning and positioning were realized.

关键词： underwater robot open-loop control IPMC swing property displacement response