Natural killer cells in hepatocellular carcinoma： current status and perspectives for future immunotherapeutic approaches
Natural killer cells in hepatocellular carcinoma： current status and perspectives for future immunotherapeutic approaches作者机构：State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Renji Hospital Shanghai Jiao Tong University School ofMedicine Shanghai 200032 China
出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)
年 卷 期：2017年第11卷第4期
页 面：509-521页
核心收录：
主 题：natural killer cell hepatocellular carcinoma immunotherapy
摘 要：Hepatocellular carcinoma （HCC） is currently the fifth most common malignancy and the third leading cause of cancer-related mortalities worldwide. In the last few years, treatments for HCC have significantly improved from a mere surgical resection to a series of minimally invasive therapies and targeted drugs. However, recurrence frequently occurs even upon curative therapeutics, and drug therapies generally produce disappointing results, with the overall prognosis dismal. This challenging clinical scenario warrants new effective and life-prolonging strategies for patients with HCC. Compelling evidence suggests that NK cells play a critical role in the immune function of the fiver and in the immune defenses against HCC, indicating that HCC might be an ideal target for NK cell-based immunotherapies. To obtain comprehensive insights into the putative influence of NK cells on HCC, this paper summarizes current knowledge on NK cells in HCC and discusses the usefulness and prospects of NK cell-based immunotherapies. Critical issues that require consideration for the successful clinical translation of NK cell-based therapies are also addressed. If appropriately used and further optimized, NK cell- based therapies could dominate important roles in the future immunotherapeutic market of HCC.
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