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Characteristics of Obesity and Its Related Disorders in china

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Biomedical and Environmental Sciences 2010年第1期23卷 4-11页

作者： WEI-ping JIA ,chen WANG,SHAN jiang,AND JIE-min PAN Department of Endocrinology and Metabolism,Shanghai Jiao Tong university Affiliated Sixth People’s Hospital,Shanghai Diabetes Institute,Shanghai Clinical center of Diabetes,Shanghai 200233,china Department of Endocrinology and Metabolism Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai Diabetes Institute Shanghai Clinical Center of Diabetes Shanghai 200233 China

Obesity is a medical condition with excess body fat accumulation to the extent which leads to serious health consequences. Abdominal obesity, also known as central obesity, refers to the presence of excess fat in the abdominal area. Obesity, especially abdominal obesity, contributes to many metabolic disorders including metabolic syndrome （MetS）, type 2 diabetes （T2DM） and cardiovascular diseases （CVD）. The incidence of obesity has increased dramaticaUy in recent yeats worldwide. In china, more than one-third of adults are overweight or obese and 10%-20% of all adults are affected by MetS. The pathogenesis underlying the abdominal obesity remains unclear. The ultimate health outcome of obesity and its related metabolic disorders have prompted physicians to take aggressive treatments （lifestyle changes, pharmacological interventions and surgical therapies） before a serious consequence becomes clinically apparent. In this review, we discuss the prevalence, pathogenesis and clinic features of obesity in china.

关键词： Obesity Metabolic syndrome Type 2 diabetes Cardiovascular disease

Design,synthesis,antitumor evaluations and molecular modeling studies of novel 3,5-substituted indolin-2-one derivatives

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Acta Pharmacologica Sinica 2007年第1期28卷 140-152页

作者： Hai-hong LI~2 Xiu-hua ZHANG~3 Jin-zhi TAN~2 Li-li chen~2 Hong LIU~(2,5) Xiao-min LUO~(2,5) Xu SHEN~(2,4) Li-ping LIN~(3,5) Kai-xian chen~2 Jian DING~3 Hua-liang jiang~(2,4)2 center for Drug Discovery and Design,State Key Laboratory of Drug research,Shanghai Institute of Materia Medica,Shanghai Institutes for Biological Sciences,and Graduate school,Chinese Academy of Sciences,Shanghai 201203,china 3 Division of Anti-tumor Pharmacology,Shanghai Institute of Materia Medica,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 201203,china 4 school of Pharmacy,East china university of Science and Technology,Shanghai 200237,china center for Drug Discovery and Design State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institutes for Biological Sciences and Graduate School Chinese Academy of Sciences Shanghai China Division of Anti-tumor Pharmacology Shanghai Institute of Materia Medica Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China school of Pharmacy East China University of Science and Technology Shanghai China

Aim:To design and synthesize a novel class of antitumor agents,featuring the 3,5-substituted indolin-2-one ***:Based on enzyme binding fea-tures of（Z）-SU5402,introducing a β-pyrrole group at the 3-position of the indolin-2-one core,a series of novel 3,5-substituted indolin-2-ones were designed *** human carcinoma cell lines of A-43l,A-549,MDA-MB-468,and Autosomal Dominant Polycystic Kidney disease were chosen for the cellproliferation ***:Twenty new compounds（1a-t）with E configurationhave been designed,synthesized and *** structural features weredetermined by nuclear magnetic resonance（NMR）spectra,low-and high-resolu-tion mass spectra,and confirmed by X-ray *** the enzymeassay showed a weak inhibition effect against the epidermal growth factor receptor,vascular endothelial growth factor receptor,fibroblast growth factor receptor andplatelet-derived growth factor receptor tyrosine kinases,the cell-based antitumoractivity was *** 1 g and lh showed higher inhibitory activitytoward the A-549 and MDA-MB-468 cell lines with IC50of 0.065-9.4 μmol/***:This study provides a new template for further development ofpotent antitumor drugs.

关键词： protein-tyrosine kinase indolin-2-one antitumor drug screening assays drug design molecular models

Recombinant aspartate aminotransferase-catalyzed synthesis of L-4-fluorophenylalanine

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Frontiers of Chemical Science and Engineering 2008年第2期2卷 220-223页

作者： Meijuan chen Honghua JIA Yongsheng chen min jiang ping WEI College of Life Science and Pharmacy Nanjing University of TechnologyNanjing 210009China

L-4-Fluorophenylalanine(FPhe)was prepared from 4-fluorophenylpyruvate(FPPA)catalyzed by aspartate aminotransferase(Asp-AT)of the recombinant *** BL21-pET/*** 12 h enzymatic reaction,the FPPA conversion was over 90%and the yield of FPhe could be above 85%under the following optimal conditions:37uC,pH value range of 5.0–8.0,5.5 mass ratio of cell to FPPA,0.6%(w/v)of Tween 80,7.08 g/L FPPA,and 1.6 of molar ratio of L-Asp to FPPA.

关键词： L-4-fluorophenylalanine 4-fluorophenylpyruvate aspartate aminotransferase

Cancer metabolism and tumor microenvironment:fostering each other?

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Science china(Life Sciences) 2022年第2期65卷 236-279页

作者： Yiyuan Yuan Huimin Li Wang Pu Leilei chen Dong Guo Hongfei jiang Bo He Siyuan Qin Kui Wang Na Li Jingwei Feng Jing Wen Shipeng cheng Yaguang Zhang Weiwei Yang Dan Ye Zhimin Lu Canhua Huang Jun Mei Hua-Feng Zhang ping Gao Peng jiang Shicheng Su Bing Sun Shi-min Zhao Obstetrics&Gynecology Hospital of Fudan university State Key Laboratory of Genetic EngineeringFudan UniversityShanghai 200438China State Key Laboratory of Cell Biology Center for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China Molecular and Cell Biology Lab Institutes of Biomedical Sciences and School of Life SciencesFudan UniversityShanghai 200032China Zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated Hospitaland Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China West china school of basic Medical Sciences&Forensic medicine Sichuan Universityand State Key Laboratory of Biotherapy and Cancer CenterWest China Hospitaland Collaborative Innovation Center for BiotherapyChengdu 610041China Department of Biochemistry and Molecular Cell Biology Shanghai Key Laboratory of Tumor Microenvironment and InflammationShanghai Jiao Tong University School of MedicineShanghai 200025China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Medical Research CenterSun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China school of Life Science and Technology ShanghaiTech UniversityShanghai 201210China CAS Centre for Excellence in Cell and Molecular Biology the CAS Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Basic Medical SciencesDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230027China school of medicine Institutes for Life SciencesSouth China University of TechnologyGuangzhou 510006China Tsinghua university school of Life Sciences and Tsinghua-Peking Center for Life SciencesBeijing 100084China

The changes associated with malignancy are not only in cancer cells but also in environment in which cancer cells *** reprogramming supports tumor cells’high demand of biogenesis for their rapid proliferation,and helps tumor cells to survive under certain genetic or environmental *** evidence suggests that metabolic alteration is ultimately and tightly associated with genetic changes,in particular the dysregulation of key oncogenic and tumor suppressive signaling *** cells activate HIF signaling even in the presence of oxygen and in the absence of growth factor *** cancer metabolic phenotype,described firstly by German physiologist Otto Warburg,ensures enhanced glycolytic metabolism for the biosynthesis of *** conception of metabolite signaling,i.e.,metabolites are regulators of cell signaling,provides novel insights into how reactive oxygen species(ROS)and other metabolites deregulation may regulate redox homeostasis,epigenetics,and proliferation of cancer ***,the unveiling of noncanonical functions of metabolic enzymes,such as the moonlighting functions of phosphoglycerate kinase 1(PGK1),reassures the importance of metabolism in cancer *** metabolic,microRNAs,and ncRNAs alterations in cancer cells can be sorted and delivered either to intercellular matrix or to cancer adjacent cells to shape cancer microenvironment via media such as *** them,cancer microenvironmental cells are immune cells which exert profound effects on cancer *** of all these processes is a prerequisite for the development of a more effective strategy to contain cancers.

关键词： cancer metabolism cancer microenvironment epigenetics cancer immunology

Value of early diagnosis of sepsis complicated with acute kidney injury by renal contrast-enhanced ultrasound

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World Journal of Clinical Cases 2019年第23期7卷 3934-3944页

作者： Xiu-Yan Wang Yan-ping Pang Tian jiang Shuo Wang jiang-Tao Li Bao-min Shi chen Yu Department of Ultrasound Tongji Hospital of Tongji UniversityShanghai 200065China Department of Nephrology Tongji Hospital of Tongji UniversityShanghai 200065China Department of General Surgery Tongji Hospital of Tongji UniversityShanghai 200065China

BACKGROUND The incidence of acute kidney injury(AKI)in patients with sepsis is high,and the prognosis of patients with septic AKI is *** early diagnosis and treatment of septic AKI is of great significance in improving the prognosis of patients with *** To explore the value of contrast-enhanced ultrasound(CEUS),serum creatinine(Scr),and other indicators in the early diagnosis of septic *** Ninety patients with sepsis during hospitalization at Tongji Hospital of Tongji university were recruited as *** patient was recorded with relevant basic data,clinical indicators,and CEUS *** patients were divided into AKI group and non-AKI group according to the results of renal function diagnosis after 48 *** the 7th day,the renal function of the non-AKI group was re-evaluated and the patients were further divided into AKI subgroup and non-AKI *** differences of the indicators in different groups were compared,and the diagnostic value of each indicator and their combination for septic AKI was *** Systemic inflammatory response score(2.58±0.75),blood lactic acid(3.01±1.33 mmol/L),Scr(141.82±27.19μmol/L),blood urea nitrogen(4.41±0.81mmol/L),and rise time(10.23±2.63 s)in the AKI group were higher than those in the non-AKI *** intensity(PI)(10.78±3.98 dB)and wash in slope(WIS)(1.07±0.53 dB/s)were lower than those in the non-AKI *** differences were statistically significant(P2.83±3.77 dB)and WIS(1.22±0.68 dB/s)in the AKI subgroup were lower than those in the non-AKI subgroup,and the differences were statistically significant(P25 with a sensitivity of 56.76% and a specificity of 100%.The AUCs of WIS and PI(0.928 and 0.912)were higher than those of *** sensitivities were 100%,but the specificities were 71.70% and 75.47%.The AUC of the combination of three indicators for the diagnosis of septic AKI was 0.943,which w

关键词： Sepsis Acute kidney injury Serum creatinine Contrast-enhanced ultrasound Peak intensity Wash in slope

Epigenome-wide DNA methylation analysis reveals differentially methylation patterns in skeletal muscle between Chinese chenghua and Qingyu pigs

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Journal of Integrative Agriculture 2022年第6期21卷 1731-1739页

作者： WANG Kai WU ping-xian WANG Shu-jie JI Xiang chen Dong jiang An-an XIAO Wei-hang jiang Yan-zhi ZHU Li ZENG Yang-shuang XU Xu QIU Xiao-tian LI ming-zhou LI Xue-wei TANG Guo-qing Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province Sichuan Agricultural UniversityChengdu 611130P.R.China College of Life Science Sichuan Agricultural UniversityYa’an 625014P.R.China Sichuan Animal Husbandry Station Chengdu 610041P.R.China National Animal Husbandry Service Beijing 100125P.R.China Chongqing Academy of Animal Science Chongqing 402460P.R.China

chenghua(CH)pig and Qingyu(QY)pig are typical Chinese native fatty *** pig is mainly distributed in chengdu Plain,while QY pig is widely distributed throughout the mountain areas around the Sichuan *** are significant differences in their phenotypic traits,including body image,growth performance,and meat *** study compared several meat quality traits of CH and QY pigs and conducted a genome-wide DNA methylation analysis using reduced representation bisulfite sequencing(RRBS).It was observed that the pH at 45 min(pH_(45min),P=5.22e-13),lightness at 45 min(L^(*)_(45min),P=4.85e-5),and lightness at 24 h(L^(*)_(24h),P=3.57e-5)of CH pigs were higher than those of QY *** detected 10699 differentially methylated cytosines(DMCs)and 2760 differentially methylated genes(DMGs)associated with these *** analysis showed that these DMGs were mainly enriched in the AMPK signaling pathway,Type II diabetes mellitus,Insulin signaling pathway,mTOR signaling pathway,and Insulin ***,15 DMGs were associated with fat metabolism(ACACA,CAB39,CRADD,CRTC2,FASN,and GCK),muscle development(HK2,IKBKB,MTOR,PIK3CD,PPARGC1A,and RPTOR),or meat quality traits(PCK1,PRKAG2,and SLC2A4).The findings may help to understand further the epigenetic regulation mechanisms of meat quality traits in pigs and provide new basic data for the study of local pigs.

关键词： DNA methylation reduced representation bisulfite sequencing(RRBS) chenghua pig Qingyu pig

A novel biosynthetic hybrid scaffold seeded with olfactory ensheathing cells for treatment of spinal cord injuries

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Chinese Medical Journal 2009年第17期122卷 2032-2040页

作者： QIAN Lei-min ZHANG Zhi-jian GONG Ai-hua QIN Ru-juan SUN Xiang-lan CAO Xu-dong LIU Jin-bo jiang ping chen Yong-chang Department of Gastroenterology People's Hospital of JiangyinWuxi Jiangsu 214400 China Department of Histology and Embryology School of MedicineJiangsu University Zhenjiang Jiangsu 212001 China Institute of Molecular and Cellular Biology Academy of ScienceJiangsu University Zhenjiang Jiangsu 212001 China Department of Chemical Engineering University of Ottawa 161Louis Pasteur Ottawa Ontario Canada

Background Implantation of tissue-engineered scaffolds is one of the most promising therapeutic strategies for inducing nerve regenerations following spinal cord injuries. In this paper, we report a novel bioengineered hybrid scaffold comprised of three major extracellular matrix （ECM） proteins. Methods ECM-scaffolds （ECM-S） were prepared by gelling fibrinogen, fibronectin and laminin using fresh rat plasma. Olfactory ensheathing cells （OECs） were isolated from fresh rat olfactory mucosa, purified under differential adhesion, and assessed by immunofluorescent staining. OECs were seeded onto ECM-S and cultured. The effects of the scaffolds on the seeded cells were detected using the immunofluorescent staining, Western blotting, scanning electron microscopy and transmission electron microscopy. Results Tissue-engineered ECM-S could be easily molded into mat-like or cylindrical shapes and gelled by addition of fresh plasma. Observations by electron microscopy show that the ECM-S forms a stable three-dimensional porous network. Studies on the effects of the ECM-S on the biological behaviors of OECs in vitro indicate that the scaffold can promote OEC adhesion, proliferation and process extensions. Additionally, OECs seeded on the scaffold maintained the expression of nerve growth factor, matrix metalloproteinase-3 and matrix metalloproteinase-9. Conclusion We developed a biosynthetic hybrid gel which could be used as a scaffold for OEC transplantation; this gel can promote nerve regeneration following spinal cord injuries. Chin Med J 2009; 122（17）：2032-2040

关键词： tissue-engineering scaffold biological behaviors extracellular matrix olfactory ensheathing cells

Measurement of the ^(232)Th(n,f)cross section in the 1-200 MeV range at the CSNS Back-n

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Nuclear Science and Techniques 2023年第8期34卷 142-153页

作者： Zhi-Zhou Ren Yi-Wei Yang Yong-Hao chen Rong Liu Bang-Jiao Ye Jie Wen Hai-Rui Guo Zi-Jie Han Qi-ping chen Zhong-Wei Wen Wei-Li Sun Han Yi Xing-Yan Liu Tao Ye jiang-Bo Bai Qi An Jie Bao Yu Bao ping Cao Hao-Lei chen Zhen chen Zeng-Qi Cui Rui-Rui Fan Chang-Qing Feng Ke-Qing Gao Xiao-Long Gao min-Hao Gu Chang-Cai Han Guo-Zhu He Yong-cheng He Yang Hong Yi-Wei Hu Han-Xiong Huang Xi-Ru Huang Hao-Yu jiang Wei jiang Zhi-Jie jiang Han-Tao Jing Ling Kang Bo Li Chao Li Jia-Wen Li Qiang Li Xiao Li Yang Li Jie Liu Shu-Bin Liu Ze Long Guang-Yuan Luan Chang-Jun Ning Meng-chen Niu Bin-Bin Qi Jie Ren Xi-Chao Ruan Zhao-Hui Song Kang Sun Zhi-Jia Sun Zhi-Xin Tan Jing-Yu Tang Xin-Yi Tang Bin-Bin Tian Li-Jiao Wang Peng-cheng Wang Zhao-Hui Wang Xiao-Guang Wu Xuan Wu Li-Kun Xie Xiao-Yun Yang Li Yu Tao Yu Yong-Ji Yu Guo-Hui Zhang Lin-Hao Zhang Qi-Wei Zhang Xian-Peng Zhang Yu-Liang Zhang Zhi-Yong Zhang Lu-ping Zhou Zhi-Hao Zhou Ke-Jun Zhu Department of Modern Physics University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science center Dongguan 523803China Institute of Applied Physics and Computational Mathematics Beijing 100088China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230027China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China school of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijingChina Northwest Institute of Nuclear Technology Xi’an 710024China university of Chinese Academy of Sciences Beijing 100049China Department of Engineering and Applied Physics University of Science and Technology of ChinaHefei 230026China

The ^(232)Th(n,f)cross section is very important in basic nuclear physics and applications based on the Th/U fuel *** the time-of-flight method and a multi-cell fast-fission ionization chamber,a novel measurement of the^(232)Th(n,f)cross sec-tion relative to^(235)U in the 1–200 MeV range was performed at the china Spallation Neutron Source Back-n white neutron source(Back-n).The fission event-neutron energy spectra of^(232)Th and^(235)U fission cells were measured in the single-bunch *** 232Th/235U fission cross-sectional ratios were obtained,and the measurement uncertainties were 2.5–3.7%for energies in the 2–20 MeV range and 3.6–6.2%for energies in the 20–200 MeV ***^(232)Th(n,f)cross section was obtained by introducing the standard cross section of^(235)U(n,f).The results were compared with those of previous theoreti-cal calculations,measurements,and *** measured 232Th fission cross section agreed with the main evaluation results in terms of the experimental uncertainty,and 232Th fission resonances were observed in the 1–3 MeV *** present results provide^(232)Th(n,f)cross-sectional data for the evaluation and design of Th/U cycle nuclear systems.

关键词： 232Th(n f)cross section Fast-fission ionization chamber Back-n white neutron source

Serum Low-Density Lipoprotein and Heart Rate Related to the Effectiveness in the Treatment of Angina Pectoris with Two Similar Chinese medicine Herbal Formulae

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Chinese Journal of Integrative medicine 2011年第12期17卷 903-907页

作者： YAN Shi-yan yAO chen DING Xiao-rong jiang Miao LU Ai-ping Institute of basic research in Clinical medicine China Academy of Chinese Medical Sciences Beijing （100700） China Peking university First Hospital Beijing （100034） China E-Institute of Shanghai Municipal Education Commission Shanghai University of Traditional Chinese Medicine Shanghai （201203） China

Objective： To explore the effectiveness related indicators which might help identify the indications of Tongxinluo Capsule （通心络胶囊） and Kangxin Capsule （康欣胶囊） targeting on qi deficiency and blood stasis pattern in Chinese medicine （CM） in the treatment of angina pectoris. Methods： The data from a multicenter, randomized and double-blinded study conducted at 5 centers in china were obtained for the analysis. A total of 239 patients with angina pectoris and CM syndrome of qi deficiency and blood stasis were randomly assigned in a 1：1 ratio to Tongxinluo Capsule group （119 cases） and Kangxin Capsule group （120 cases）. Angina effectiveness and electrocardiogram （ECG） improvement were selected as the therapeutic outcomes. Results： After a 4-week treatment, the effective rates of Tongxinluo Capsule and Kangxin Capsule were 43.70% and 25.00%, respectively （P〈0.05）. Serum low-density lipoprotein （LDL） level was found to influence the effectiveness of Tongxinluo Capsule which had higher effective rate in the patients with lower level of LDL. Heart rate was found to influence the effectiveness in the patients treated with Kangxin Capsule which had higher effective rate in the patients with heart rate ≤80 beats/min. Conclusion： LDL level and heart rate were the indicators which help indentify the indications of Tongxinluo Capsule and Kangxin Capsule, respectively, in the treatment of angina pectoris with CM syndrome of qi deficiency and blood stasis.

关键词： angina pectoris qi deficiency and blood stasis syndrome Chinese medicine low-densitylipoprotein heart rate