Crystal structure of RNA helicase from Saint Louis encephalitis virus and discovery of its inhibitors
作者机构：Key Laboratory of Cellular Physiology at Shanxi Medical UniversityMinistry of EducationAnd the Department of PhysiologyShanxi Medical UniversityTaiyuanShanxi 030001China College of Life SciencesChongqing Medical UniversityChongqing 400016China Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesTianjin Medical UniversityTianjin 300070China Department of RheumatologyThe Second Hospital of Shanxi Medical UniversityTaiyuanShanxi 030001China
出 版 物：《Genes & Diseases》 (基因与疾病（英文）)
年 卷 期：2023年第10卷第2期
页 面：389-392页
核心收录：
学科分类：0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学]
基 金：supported by Key Medical Science and Technology Program of Shanxi Province(No.2020XM01) Shanxi“1331”Project Quality and Efficiency Improvement Plan(No.1331KFC) National Natural Science Foundation(NSFC)of China(No.82170523)
主 题：encephalitis invasion clinical
摘 要：St. Louis encephalitis virus (SLEV) was first recognized in 1933 and caused a major encephalitis epidemic with 1095 clinical cases and 201 deaths in St. Louis, Missouri.1 According to the median values from 2014 to 2018, the percentage of neuroinvasion by SLEV was 62% and the fatality rate was 9% in the United States.2 The clinical symptoms of SLEV infection include neurological abnormalities such as memory loss, disorientation, and meningoencephalitis. Till now, specific treatments including vaccine and drug are unavailable for SLEV infection. It is of particular importance to get prepared for SLEV infection, especially given the currently raging global COVID-19 epidemic.
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