检索结果-南通市图书馆

Nano-selenium alleviates cadmium-induced cerebellar injury by activating metal regulatory transcription factor 1 mediated metal response

引用

Animal Nutrition 2022年第4期11卷 402-412页

作者： Shao-Shuai Bi milton talukder Hai-Tao Jin Mei-Wei Lv Jing Ge Cong Zhang Jin-Long Li College of Veterinary Medicine Northeast Agricultural UniversityHarbin 150030China College of Biotechnology and Pharmaceutical Engineering of West Anhui University Lu’an 237012China Department of Physiology and Pharmacology Faculty of Animal Science and Veterinary MedicinePatuakhali Science and Technology UniversityBarishal8210Bangladesh Quality and Safety Institute of Agricultural Products Heilongjiang Academy of Agricultural SciencesHarbin 150010China College of Veterinary Medicine Henan Agricultural UniversityZhengzhou 450002China Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment Northeast Agricultural UniversityHarbin 150030China Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine Northeast Agricultural UniversityHarbin 150030China

This study aims to investigate the role of metal regulatory transcription factor 1(MTF1)-mediated metal response in cadmium(Cd)-induced cerebellar injury,and to evaluate the antagonistic effects of nanoselenium(Nano-Se)against Cd toxicity.A total of 80 chicks(1 d old,male,Hy-Line Variety White)were randomly allocated to 4 treatment groups for 3 months:the control group(fed with a basic diet,n=20),the Nano-Se group(basic diet with 1 mg/kg nano-Se 1 mg/kg Nano-Se in basic diet,n=20),the NanoSe+Cd group(basic diet with 1 mg/kg Nano-Se and 140 mg/kg Cd Cl_(2),n=20)and the Cd group(basic diet with 140 mg/kg Cd Cl_(2),n=20).The results of the experiment showed that the Purkinje cells were significantly decreased with their degradation and indistinct nucleoli after Cd ***,exposure to Cd caused a significant accumulation of Cd and ***,the contents of Se,iron,and zinc were decreased,thereby disturbing the metal homeostasis in the *** Cd exposure also resulted in high levels of malondialdehyde(MDA)and down regulation of selenoprotein ***,the expressions of MTF1,metallothionein 1(MT1),MT2,zinc transporter 3(ZNT3),ZNT5,ZNT10,zrt,irt-like protein 8(ZIP8),ZIP10,transferrin(TF),ferroportin 1(FPN1),ATPase copper transporting beta(ATP7B),and copper uptake protein 1(CTR1)were inhibited by Cd ***,all these changes were significantly alleviated by the supplementation of *** study proved that Cd could disorder metal homeostasis and induce oxidative stress,whereas Nano-Se could relieve all these negative effects caused by Cd via activating the MTF1-mediated metal response in the cerebellum of chicken.

关键词： Nano-selenium Cadmium Selenoprotein transcriptome MTF1-mediated metal response Cerebellar injury

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

饲料源重金属镉致鸡大脑神经毒性效应机制的研究进展

饲料源重金属镉致鸡大脑神经毒性效应机制的研究进展

引用

中国毒理学会第九次全国青年科技大会暨第二届生物技术药物毒理与安全评价委员会学术会议

作者：李雪楠许雅茹赵迎新李晨曦 milton talukder 李金龙东北农业大学动物医学学院

目的镉(Cadmium,Cd)是环境中广泛存在蓄积性强的重金属污染物,被美国毒物管理委员会列为第六位危及动物健康的有毒物质,已严重危害到了生态环境和人类健康。环境生态系统通过生物富集作用,将土壤中的镉通过食物链引入到动物体内,放大了... 详细信息

目的镉(Cadmium,Cd)是环境中广泛存在蓄积性强的重金属污染物,被美国毒物管理委员会列为第六位危及动物健康的有毒物质,已严重危害到了生态环境和人类健康。环境生态系统通过生物富集作用,将土壤中的镉通过食物链引入到动物体内,放大了镉的毒害作用,特别对生态系统中的野生鸟类及家禽危害更为严重。目前研究表明,镉可通过血脑屏障,损伤神经系统,导致认知功能障碍等神经系统疾病发生,但机制尚不明确。本研究的目的是揭示镉暴露对禽类大脑毒性损伤机理。材料和方法本研究选用80只1日龄海兰白种鸡,随机分为4组:对照组、35 mg/kg CdC12、70mg/kg CdC12和140mg/kg CdC12组,饲养90天。观察大脑病理组织学变化,检测组织中金属元素含量及其转运蛋白的表达水平、氧化应激参数变化、MTF1金属反应、血脑屏障、Wnt/β-catenin信号通路、内质网应激、自噬和凋亡相关标志物水平。结果组织病理学评价和尼氏染色结果显示,镉暴露致大脑组织神经元肿胀变性、数量减少,轴突和树突缺失,细胞质空泡变性,纹状体损伤,毛细血管直径增宽,内质网和线粒体肿胀,自噬小体形成;镉暴露致大脑组织氧化还原稳态失衡,ROS、MDA和HO水平升高,GPX、CAT、T-SOD活性和T-AOC水平降低,引发氧化应激;镉暴露致大脑组织金属转运蛋白(DMT1、ZIP8、ZIP10、ZNT3、ZNT5和ZNT6)表达上调,转录因子MTF1及其下游靶点(MT1、MT2、FPN1、ATOX1和XIAP)的表达下调,导致大脑镉积累增加和其他金属(锌,铁,硒,铬,钼,铅)浓度的改变;转录组分析表明,Cx43可能是介导镉诱导星形胶质细胞向A1亚型的转化的潜在靶点;基因集富集分析显示Wnt/β-catenin信号转导轴减弱,降低Wnt7A、FZD 4和β-catenin的蛋白表达,上调TNF-α表达,抑制IL-10表达,诱导炎症的产生和BBB功能障碍,表现为受损的紧密连接和粘附连接的形成;镉暴露致大脑组织GRP78、PERK、eIF-2α表达上调,触发内质网应激;激活Mfn2、PINK1,促进自噬小体形成,Beclin1、LC3B、p62表达上调,诱导鸡脑组织自噬;镉暴露激活大脑神经元细胞Caspase依赖性凋亡信号通路,表明镉暴露诱导神经元凋亡。结论镉暴露会导致金属稳态失衡,鸡大脑组织形态和细胞器损伤,金属转运蛋白和MTF1相关因子异常表达,引发内质网应激、自噬、神经炎症应答和BBB功能障碍。本研究阐明了镉致鸡大脑毒性效应机理,为后续筛选缓解镉致鸡神经毒性作用靶点提供了理论依据。

关键词：镉鸡大脑金属稳态血脑屏障

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Oblique collisional effects of dust acoustic waves in unmagnetized dusty plasma

引用

Chinese Physics B 2020年第6期29卷 304-313页

作者： M S Alam M R talukder Department of Mathematics Chittagong University of Engineering and TechnologyChittagong-4349Bangladesh Plasma Science and Technology Laboratory Department of Electrical and Electronic EngineeringUniversity of RajshahiRajshahi-6205Bangladesh

Effects of oblique collisions of the dust acoustic(DA)waves in dusty plasma are studied by considering unmagnetized fully ionized *** plasma consists of inertial warm negatively charged massive dusts,positively charged dusts,superthermal kappa distributed electrons,and isothermal *** extended Poincaré–Lighthill–Kuo(e PLK)method is employed for the drivation of two-sided Korteweg–de Vries(KdV)equations(KdVEs).The Kd V soliton solutions are derived by using the hyperbolic secant *** effects of superthermality index of electrons,temperature ratio of isothermal ion to electron,and the density ratio of isothermal ions to negatively charged massive dusts on nonlinear coefficients are *** effects of oblique collision on amplitude,phase shift,and potential profile of right traveling solitons of DA waves are also *** study reveals that the new nonlinear wave structures are produced in the colliding region due to head-on collision of the two counter propagating DA *** nonlinearity is found to decrease with the increasing density ratio of ion to negative dust in the critical *** phase shifts decrease(increase)with increasing the temperature ratio of ion to electron(κe).The hump(compressive,κeκec)solitons are produced depending on the angle(θ)of oblique collision between the two waves.

关键词： ion acoustic wave dusty plasma kappa distribution ePLK method hyperbolic secant method

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Growth phase dependent changes in the structure and protein composition of nucleoid in Escherichia coli

引用

Science China(Life Sciences) 2015年第9期58卷 902-911页

作者： talukder AliAzam ISHIHAMA Akira Department of Microbiology Jahangirnagar University Micro-Nano Technology Research Center Hosei University Department of Molecular Genetics National Institute of Genetics

The genomic DNA of bacteria is highly compacted in a single or a few bodies known as nucleoids. Here, we have isolated Escherichia coli nucleoid by sucrose density gradient centrifugation. The sedimentation rates, structures as well as pro- tein/DNA composition of isolated nucleoids were then compared under various growth phases. The nucleoid structures were found to undergo changes during the cell growth; i. e., the nucleoid structure in the stationary phase was more tightly com- pacted than that in the exponential phase. In addition to factor for inversion stimulation （Fis）, histone-like nucleoid structuring protein （H-NS）, heat-unstable nucleoid protein （HU） and integration host factor （IHF） here we have identified, three new can- didates of E. coli nucleoid, namely DNA-binding protein from starved cells （Dps）, host factor for phage QJ3 （Hfq） and sup- pressor of taC phenotype A （StpA）. Our results reveal that the major components of exponential phase nucleoid are Fis, HU, H-NS, StpA and Hfq, while Dps occupies more than half of the stationary phase nucleoid. It has been known for a while that Dps is the main nucleoid-associated protein at stationary phase. From these results and the prevailing information, we propose a model for growth phase dependent changes in the structure and protein composition of nucleoid in E. coli.

关键词： growth phase sucrose gradient bacterial nucleoid DNA binding protein DNA compaction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Head-on collision between single-and multi-soliton heavy ion acoustic waves in multi-ion plasmas

引用

Plasma Science and Technology 2019年第9期21卷 58-72页

作者： M S ALAM M R talukder Department of Mathematics Chittagong University of Engineering and Technology Chittagong-4349 Bangladesh Plasma Science and Technology Lab Department of Electrical and Electronic Engineering University of Rajshahi Rajshahi-6205 Bangladesh

Head-on collisions among the single-and multi-soliton’s heavy ion acoustic waves(HIAWs) of multi-ion plasma are studied. The plasma consists of adiabatic positively charged inertial heavy ions, Boltzmann energy distributed light ions and kappa energy distributed electrons. The extended poincaré-Lighthill-Kuo(e PLK) method is applied for the derivation of two-sided Korteweg–de Vries(KdV) equations(KdVEs). The KdV single-soliton solutions(KdVSSs) are determined using the hyperbolic secant method and the KdV multi-soliton solutions(KdVMSs)are obtained using the Hirota method. The effects of superthermality of electrons, temperature ratios of electron to light ion and heavy ion to electron, and the density ratio of electron to heavy ion on phase shifts are investigated for the head-on collisions between two-soliton HIAWs. The effects of plasma parameters on angular frequency, phase speed, production of multi-soliton structures, and the head-on collisions among single-, double-, triple-, quadruple-, and quintuplesolitons are also studied.

关键词： HIAWs multi-soliton kappa-distribution ePLK method Hirotta's method multi-ion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Methodology of Probe Design with Better Resolution and Less Resistive Donut Probe to Achieve the Best Performance

引用

Journal of Bionic Engineering 2009年第3期6卷 239-245页

作者： Mohammad Ismail talukder Pepe Siy Gregory Auner Department of Electrical and Computer Engineering Wayne State University

Probes are the interface between microsystems and *** ideal interface is one-to-one *** various research groups have been able to establish some sort of interfaces after many years of research,they are very *** are millions in numbers,whereas the prostheses successfully built so far have only a few hundred probes at *** an ef- fective interface is still far *** we have micro-and nano-technologies,we couldn't build a prosthesis with an effective *** reasons behind it are the type of probe being used and the poor design of the *** address this problem,we developed a methodology to design a probe and an array of probes with better resolution and less resistive donut *** methodology helps us to design a probe optimizing all the *** presented our methodology through a design that is capable of 70 μm penetration inside the *** tissue heating by our designed probe is only 0.411 °*** also characterized the donut probe,which could be used by any research group to design a donut probe of their specific need.

关键词： donut probe resolution methodology retina prosthesis probe design

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

OH and O radicals production in atmospheric pressure air/Ar/H_2O gliding arc discharge plasma jet

引用

Plasma Science and Technology 2017年第12期19卷 71-80页

作者： N C ROY M R talukder A N CHOWDHURY Plasma Science and Technology Laboratory Department of Applied Physics and Electronic EngineeringUniversity of RajshahiRajshahi 6205Bangladesh Bangladesh Council of Scientific and Industrial Research Laboratory Rajshahi Rajshahi 6206Bangladesh

Atmospheric pressure air/Ar/H_2O gliding arc discharge plasma is produced by a pulsed dc power supply. An optical emission spectroscopic（OES） diagnostic technique is used for the characterization of plasmas and for identifications of OH and O radicals along with other species in the plasmas. The OES diagnostic technique reveals the excitation Tx？≈？5550–9000 K, rotational Tr？≈？1350–2700 K and gas Tg？≈？850–1600 K temperatures, and electron density n？（1.1-1.9） ′101 4 cm^（-3） e under different experimental conditions. The production and destruction of OH and O radicals are investigated as functions of applied voltage and air flow rate. Relative intensities of OH and O radicals indicate that their production rates are increased with increasing Ar content in the gas mixture and applied voltage. nereveals that the higher densities of OH and O radicals are produced in the discharge due to more effective electron impact dissociation of H_2O and O_2 molecules caused by higher kinetic energies as gained by electrons from the enhanced electric field as well as by enhanced n *** productions of OH and O are decreasing with increasing air flow rate due to removal of Joule heat from the discharge region but enhanced air flow rate significantly modifies discharge maintenance properties. Besides, Tgsignificantly reduces with the enhanced air flow rate. This investigation reveals that Ar plays a significant role in the production of OH and O radicals.

关键词： reactive oxygen species(ROS) optical emission spectroscopy(OES) gliding arc discharge plasma kinetics broadening mechanism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Rice plant growth and yield: foliar application of plasma activated water

引用

Plasma Science and Technology 2021年第7期23卷 134-143页

作者： M M RASHID Mamunur RASHID M M HASAN M R talukder Plasma Science and Technology Lab Department of Electrical and Electronic EngineeringUniversity of RajshahiRajshahi 6205Bangladesh Plant Pathology and Mycology Lab Department of BotanyUniversity of RajshahiRajshahi 6205Bangladesh Plant Pathology Lab Department of Agronomy and Agricultural ExtensionUniversity of RajshahiRajshahi 6205Bangladesh

Plasma activated water(PAW)was prepared for 10 min to be applied one toﬁve times as a foliar spray to rice plants,to investigate plant growth,yield and the concentrations of total soluble protein and sugar in the rice grains *** results reveal that(1)the plant height,stem diameter,dry weight,chlorophyll and total carotene concentrations were improved by∼15%,∼25%,∼24%,∼47%and∼45%,respectively,with respect to control,(2)defense mechanisms of the plants treated with PAW were improved,(3)concentrations of total soluble protein and sugar were enhanced in the rice grains of PAW treated plants and(4)yield was increased by∼14%.

关键词： plasma agriculture plasma activated water rice plant growth rice yield total soluble protein

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ion acoustic shock and periodic waves through Burgers equation in weakly and highly relativistic plasmas with nonextensivity

引用

Plasma Science and Technology 2017年第1期19卷 7-19页

作者： M G HAFEZ N C ROY M R talukder M HOSSAIN ALI Department of of Applied Mathematics University of Rajshahi Rajshahi-6205 Bangladesh Department of Mathematics Chittagong University of Engineering and Technology Chittagong-4349Bangladesh Plasma Science and Technology Lab Department of Applied Physics and Electronic EngineeringUniversity of Rajshahi Rajshahi-6205 Bangladesh

A comparative study is carried out for the nonlinear propagation of ion acoustic shock waves both for the weakly and highly relativistic plasmas consisting of relativistic ions and qdistributed electrons and *** Burgers equation is derived to reveal the physical phenomena using the well known reductive perturbation *** integration of the Burgers equation is performed by the（G￠/G）-expansion *** effects of positron concentration,ion–electron temperature ratio,electron–positron temperature ratio,ion viscosity coefficient,relativistic streaming factor and the strength of the electron and positron nonextensivity on the nonlinear propagation of ion acoustic shock and periodic waves are presented graphically and the relevant physical explanations are provided.

关键词： electron-positron-ion plasmas ion acoustic shock and periodic waves weakly and highly relativistic effects Burgers equation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Interactions of ion acoustic multi-soliton and rogue wave with Bohm quantum potential in degenerate plasma

引用

Chinese Physics B 2017年第9期26卷 301-309页

作者： M S Alam M G Hafez M R talukder M Hossain Ali Department of Applied Mathematics University of RajshahiRajshahi-6205Bangladesh Plasma Science and Technology Lab Department of Applied Physics and Electronic EngineeringUniversity of RajshahiRajshahi-6205Bangladesh Department of Mathematics Chittagong University of Engineering and TechnologyChittagong-4349Bangladesh

This work investigates the interactions among solitons and their consequences in the production of rogue waves in an unmagnetized plasmas composing non-relativistic as well as relativistic degenerate electrons and positrons, and inertial non-relativistic helium ions. The extended Poincare′–Lighthill–Kuo（PLK） method is employed to derive the two-sided Korteweg–de Vries（KdV） equations with their corresponding phase shifts. The nonlinear Schrodinger equation（NLSE） is obtained from the modified Kd V（mKdV） equation, which allows one to study the properties of the rogue waves. It is found that the Fermi temperature and quantum mechanical effects become pronounced due to the quantum diffraction of electrons and positrons in the plasmas. The densities and temperatures of the helium ions, degenerate electrons and positrons, and quantum parameters strongly modify the electrostatic ion acoustic resonances and their corresponding phase shifts due to the interactions among solitons and produce rogue waves in the plasma.

关键词： wave-wave interaction rogue waves degenerate plasmas Bohm potential

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：