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Rock Mass Quality Rating Based on the Multi-Criteria Grey Metric Space

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2635-2664页

作者： miloš Gligoric Zoran Gligoric Saša Jovanovic Suzana Lutovac Dragan Pamucar Ivan Jankovic Faculty of Mining and Geology University of BelgradeBelgrade11000Serbia Faculty of Technical Sciences University of PrištinaKosovska Mitrovica38220Serbia Department of Operations Research and Statistics Faculty of Organizational SciencesUniversity of BelgradeBelgrade11000Serbia College of Engineering Yuan Ze UniversityTaoyuan City320315TaiwanChina

Assessment of rock mass quality significantly impacts the design and construction of underground and open-pit mines from the point of stability and *** study develops the novel Gromov-Hausdorff distance for rock quality(GHDQR)methodology for rock mass quality rating based on multi-criteria grey metric *** usually presents the quality of surrounding rock by classes(metric spaces)with specified properties and adequate interval-grey *** the distance between surrounding rock sample characteristics and existing classes represents the core of this *** Gromov-Hausdorff distance is an especially useful discriminant function,i.e.,a classifier to calculate these distances,and assess the quality of the surrounding *** efficiency of the developed methodology is analyzed using the Mean Absolute Percentage Error(MAPE)*** existing methods,such as the Gaussian cloud method,Discriminant method,Mutation series method,Artificial neural network(ANN),Support vector machine(SVM),Grey wolf optimizer and Support vector classification method(GWO-SVC)and Rock mass rating method(RMR)are used for comparison with the proposed GHDQR *** share of the highly accurate category of 85.71%clearly indicates compliance with actual values obtained by the compared *** results of comparisons showed that the model enables objective,efficient,and reliable assessment of rock mass quality.

关键词： Rock mass rating multi-criteria class metric space interval-grey numbers

Surface modifications of biometallic commercially pure Ti and Ti–13Nb–13Zr alloy by picosecond Nd:YAG laser

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International Journal of Minerals,Metallurgy and Materials 2021年第2期28卷 285-295页

作者： Slađana Laketić Marko Rakin milošMomčilović Jovan Ciganović Đorđe Veljović Ivana Cvijović-Alagić Vinča Institute of Nuclear Sciences University of BelgradeP.O.Box 52211001 BelgradeSerbia Faculty of Technology and Metallurgy University of BelgradeKarnegijeva 411120 BelgradeSerbia

The effects of picosecond Nd:YAG laser irradiation on chemical and morphological surface characteristics of the commercially pure titanium and Ti–13Nb–13Zr alloy in air and argon atmospheres were studied under different laser output energy *** the interaction of laser irradiation with the investigated materials,a part of the energy was absorbed on the target surface,influencing surface *** beam interaction with the target surface resulted in various morphological alterations,resulting in crater formation and the presence of microcracks and hydrodynamic ***,different chemical changes were induced on the target materials’surfaces,resulting in the titanium oxide formation in the irradiation-affected area and consequently increasing the irradiation energy *** the high energy absorption at the site of interaction,the dimensions of the surface damaged area ***,surface roughness *** appearance of surface oxides also led to the increased material hardness in the surface-modified *** chemical and morphological changes were pronounced after laser irradiation of the Ti–13Nb–13Zr alloy surface.

关键词： commercially pure titanium Ti-13Nb-13Zr alloy surface modification Nd:YAG laser laser-induced damage hard oxidized surface

Impact of Microstructural and Surface Modifications on the Ti-45Nb Alloy’s Response to Bio-Environment

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Acta Metallurgica Sinica(English Letters) 2024年第7期37卷 1215-1230页

作者： Ivana Cvijović-Alagić Slađana Laketić milošMomčilović Jovan Ciganović Jelena Bajat Vesna Kojić Vinča Institute of Nuclear Sciences-National Institute of the Republic of Serbia University of BelgradeMike Petrovića Alasa 12-1411000BelgradeSerbia Faculty of Technology and Metallurgy University of BelgradeKarnegijeva 411000BelgradeSerbia Oncology Institute of Vojvodina Faculty of MedicineUniversity of Novi SadPut Doktora Goldmana 4Sremska Kamenica21204Sremska KamenicaSerbia

The Ti-45Nb (mass%) alloy’s corrosive and biocompatible response in simulated physiological conditions was investigated before and after its additional high-pressure torsion (HPT) and laser irradiation processing. The grain size reduction from 2.76 µm to ~ 200 nm and the appearance of laser-induced morphologically altered and highly oxidized surface led to the significant improvement of alloy corrosion resistance and cell–implant interaction. Moreover, an additional increase of the laser pulse energy from 5 to 15 mJ during the alloy irradiation in the air led to an increase in the surface oxygen content from 13.64 to 23.89% accompanied by an increase of excellent cell viability from 127.18 to 134.42%. As a result of the controlled alloy microstructural and surface modifications, the formation of protective bi-modal mixed Ti- and Nb-oxide external scale was enabled. The presence of this surface oxide scale enhanced the alloy’s resistance to corrosion deterioration and simultaneously boosted cell viability and proliferation.

关键词： Ti-45Nb alloy High-pressure torsion Laser surface scanning Corrosion resistance Biocompatible properties

Cancer Cell：癌细胞如何在没有葡萄糖的条件下继续增殖扩张？

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现代生物医学进展 2017年第2期17卷 I0001-I0002页

作者： Stefan burén Structural Biology and Biocomputing Programme Spectroscopy and Nuclear Magnetic Resonance Unit Centro Nacional de Investigaciones Oncológicas CNIO Madrid 28029 Spain

肿瘤细胞最主要的目标就是生存，其甚至不惜破坏其所依附的有机体的健康也要达到生存的目的；为了生存肿瘤细胞会练就许多健康细胞没有的本领，包括在葡萄糖水平极低的情况下继续保持生长势头，而这或许就是常用的抗血管生成因子难以消... 详细信息

肿瘤细胞最主要的目标就是生存，其甚至不惜破坏其所依附的有机体的健康也要达到生存的目的；为了生存肿瘤细胞会练就许多健康细胞没有的本领，包括在葡萄糖水平极低的情况下继续保持生长势头，而这或许就是常用的抗血管生成因子难以消除癌症的主要原因，肿瘤细胞通常会通过妨碍提供常规的营养物质和葡萄糖的血管的发育来影响机体健康，

关键词：葡萄糖水癌细胞 Cell 血管生成因子增殖肿瘤细胞机体健康营养物质

Gender Differences in Acute Cadmium-Induced Systemic Inflammation in Rats

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Biomedical and Environmental Sciences 2009年第1期22卷 1-7页

作者： MILENA KATARANOVSKI SRDJA JANKOVic DRAGAN KATARANOVSKI JELENA STOic DESA BOGOJEVic Department of Ecology Institute for Biological Research"Sinia Stankovi"Bulevar Despota Stefana 14211060 BelgradeSerbia Department of Molecular Biology Institutefor Biological Research"Sinia Stankovi"Bulevar Despota Stefana 14211060 BelgradeSerbia

Objective To examine the presence of gender differences in pro-inflammatory potential of cadmium in rats by comparing systemic inflammatory response to acute cadmium intoxication in animals of the two sexes. Methods Basic aspects of this response were evaluated, including plasma levels of inflammatory cytokines tumor necrosis factor （TNF） and interleukin-6 （IL-6） and of major rat acute phase protein alpha 2-macroglobulin （alpba2-M）, as soluble indicators of inflammation, and the number and activity of peripheral blood leukocytes, as cellular indicators of inflammation. Results Differential increases of IL-6 and alpha 2-M （higher in males than in females） in peripheral blood cell counts and types （leukocytosis and shift in the ratio of granulocytes to lymphocytes more pronounced in males vs females） and in levels of neutrophil priming （higher in males vs females） were noted. Conclusion The data document a more intense inflammatory response to cadmium administration in males. The sex differences in inflammatory effects of cadmium might be taken into consideration in studying the toxicity of this heavy metal.

关键词： Cadmium Sex Rats Inflammation

Decomposition of multi-particle azimuthal correlations in Q-cumulant analysis

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Chinese Physics C 2023年第10期47卷 178-196页

作者： L.Nađđerđ J.milošević D.Devetak 王福强 Department of physics "VINČA"Institute of Nuclear Science-National Institute of the Republic of SerbiaUniversity of BelgradeMike Petrovića Alasa 12-14Vinča 11351BelgradeSerbia Strong coupling Physics International Research Laboratory Huzhou UniversityHuzhou 313000China College of Science Huzhou UniversityHuzhou 313000China Department of Physics and Astronomy Purdue UniversityIndiana 47907USA

The method of Q-cumulants is a powerful tool for studying the fine details of azimuthal anisotropies in high energy nuclear *** paper presents a new method,based on mathematical induction,to evaluate the analytical form of high-order *** capability of this method is demonstrated via a toy model that uses the elliptic power distribution to simulate the anisotropic emission of particles,quantified in terms of Fourier flow harmonics v_(n).The method can help in studying the large amount of event statistics that can be collected in the future and allow measurements of the very high central moments of the v_(2)*** can,in turn,facilitate progress in understanding the initial geometry,the input to the hydrodynamic calculations of medium expansion in high energy nuclear collisions,and the constraints on it.

关键词： quark gluon plasma azimuthal anisotropies Q-cumulants Pfaff transformation

Sparse and hybrid modelling of relative humidity: the Krsˇ ko basin case study

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CAAI Transactions on Intelligence Technology 2020年第1期5卷 42-48页

作者： Jus Kocijan Matija Perne Bostjan Gras ic Marija Zlata Boznar Primoz Mlakar Department of Systems and Control Jozef Stefan InstituteJamova 39LjubljanaSlovenia Centre for Information Technologies and Applied Mathematics University of Nova GoricaVipavska 13Nova GoricaSlovenia MEIS d.o.o. Mali Vrh pri Smarju 78Smarje-SapSlovenia

This study describes an application of hybrid modelling for an atmospheric variable in the Krsko *** hybrid model is a combination of a physics-based and data-driven model and has some properties of both modelling *** the authors’case,it is used for the modelling of an atmospheric variable,namely relative humidity in a particular location for the purpose of using the predictions of the model as an input to the air-pollution-dispersion model for radiation *** presented hybrid model is a combination of a physics-based atmospherical model and a Gaussian-process(GP)regression *** GP model is a probabilistic kernel method that also enables evaluation of prediction *** problem of poor scalability of GP modelling was solved using sparse GP modelling;in particular,the fully independent training conditional method was *** different approaches to dataset selection for empirical model training were used and multiple-step-ahead predictions for different horizons were *** is shown in this study that the accuracy of the predicted relative humidity in the Krsko basin improved when using hybrid models over using the physics-based model alone and that predictions for a considerable length of horizon can be used.

关键词： humidity horizon modelling

Simulation-based correction of dose enhancement factor values in photon brachytherapy with metal nanoparticle targeting

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Nuclear Science and Techniques 2020年第11期31卷 93-106页

作者： Slobodan Milutinovic milos Vujisic School of Electrical Engineering University of BelgradeBelgradeSerbia Vinca Institute of Nuclear Sciences-National Institute of tht Republic of Serbia University of BelgradeBelgradeSerbia

The purpose of this study is to investigate and quantify the influence of nanoparticle composition,size,and concentration on the difference between dose enhancement values derived from Monte Carlo simulations with homogeneous and structured geometrical representations of the target region in metal nanoparticle-enhanced photon *** of the dose enhancement factor(DEF)were calculated for Pd-103,I-125,and Cs-131 brachytherapy sources with gold,silver,or platinum nanoparticles acting as targeting *** were performed using the Geant4 toolkit with condensed history models of electron *** limits were imposed on adjustable parameters that define secondary electron histories,so that simulations came closest to true event-byevent electron tracking,thereby allowing part of the nanoparticle-laden volume used for calculating the dose to be represented as a structured region with uniformly distributed discrete ***-tuned physical models of secondary radiation emission and propagation,along with the discrete geometrical representation of nanoparticles,result in a more realistic assessment of dose *** DEF correction coefficient is introduced as a metric that quantifies the absorption of secondary radiation inside the nanoparticles themselves,a phenomenon disregarded when the target region is treated as a homogeneous metal–tissue mixture,but accounted for by discrete nanoparticle *** approach applied to correcting DEF values both draws from and expands upon several related investigations published *** of the obtained results to those found in relevant references shows both agreement and deviation,depending on nanoparticle properties and photon energy.

关键词： Monte Carlo Brachytherapy Nanoparticles Dose enhancement Geant4

Cancer stem cells,epithelial-mesenchymal transition,ATP and their roles in drug resistance in cancer

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Cancer Drug Resistance 2021年第3期4卷 684-709页

作者： Haiyun Zhang Alexander Steed milo Co Xiaozhuo Chen Department of Biological Science Ohio UniversityAthensOH 45701USA Edison Biotechnology Institute Ohio UniversityAthensOH 45701USA Interdisciplinary Graduate Program in Molecular and Cellular Biology Ohio UniversityAthensOH 45701USA Heritage College of Osteopathic Medicine Ohio UniversityAthensOH 45701USA Department of Biomedical Sciences Ohio UniversityAthensOH 45701USA.

The cancer stem cell(CSC)state and epithelial-mesenchymal transition(EMT)activation are tightly *** cells that acquire the EMT/CSC phenotype are equipped with adaptive metabolic changes to maintain low reactive oxygen species levels and stemness,enhanced drug transporters,anti-apoptotic machinery and DNA repair *** present in the tumor microenvironment such as hypoxia and the communication with non-cancer stromal cells also promote cancer cells to enter the EMT/CSC state and display related ***,particularly the high levels of intratumoral extracellular ATP functioning through both signaling pathways and ATP internalization,induces and regulates EMT and *** three of them work together to enhance drug *** findings in each of these factors will help us explore deeper into mechanisms of drug resistance and suggest new resistance-associated markers and therapeutic targets.

关键词： Tumor microenvironment macropinocytosis ATP internalization ABC transporters biological markers apoptosis