Cancer stem cells,epithelial-mesenchymal transition,ATP and their roles in drug resistance in cancer

作     者：Haiyun Zhang Alexander Steed Milo Co Xiaozhuo Chen 

作者机构：Department of Biological ScienceOhio UniversityAthensOH 45701USA Edison Biotechnology InstituteOhio UniversityAthensOH 45701USA Interdisciplinary Graduate Program in Molecular and Cellular BiologyOhio UniversityAthensOH 45701USA Heritage College of Osteopathic MedicineOhio UniversityAthensOH 45701USA Department of Biomedical SciencesOhio UniversityAthensOH 45701USA. 

出 版 物：《Cancer Drug Resistance》 (癌症耐药（英文）)

年 卷 期：2021年第4卷第3期

页      面：684-709页

学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported in part by a NIH grant R15 CA242177-01 to Chen X 

主　　题：Tumor microenvironment macropinocytosis ATP internalization ABC transporters biological markers apoptosis 

摘      要：The cancer stem cell(CSC)state and epithelial-mesenchymal transition(EMT)activation are tightly *** cells that acquire the EMT/CSC phenotype are equipped with adaptive metabolic changes to maintain low reactive oxygen species levels and stemness,enhanced drug transporters,anti-apoptotic machinery and DNA repair *** present in the tumor microenvironment such as hypoxia and the communication with non-cancer stromal cells also promote cancer cells to enter the EMT/CSC state and display related ***,particularly the high levels of intratumoral extracellular ATP functioning through both signaling pathways and ATP internalization,induces and regulates EMT and *** three of them work together to enhance drug *** findings in each of these factors will help us explore deeper into mechanisms of drug resistance and suggest new resistance-associated markers and therapeutic targets.