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Neuroprotective effects of resveratrol on retinal ganglion cells in glaucoma in rodents:A narrative review

Animal Models and Experimental Medicine 2024年第3期7卷 195-207页

作者： Maryam Golmohammadi Seyed Arash Aghaei Meibodi Sulieman Ibraheem Shelash Al-Hawary Jitendra gupta Ibrohim B.Sapaev Mazin A.A.Najm Marim Alwave Mozhgan Nazifi Mohammadreza Rahmani Mohammad Yasin Zamanian Gervason Moriasi School of Medicine Shahid Beheshti University of Medical SciencesTehranIran Department of Business Administration Business SchoolAl al-Bayt UniversityMafraqJordan Institute of Pharmaceutical Research GLA UniversityMathuraIndia Tashkent Institute of Irrigation and Agricultural Mechanization Engineers TashkentUzbekistan New Uzbekistan University TashkentUzbekistan Pharmaceutical Chemistry Department College of PharmacyAl-Ayen UniversityThi-QarIraq Medical Technical College Al-Farahidi UniversityBaghdadIraq Department of Neurology Hamadan University of Medical SciencesHamadanIran Physiology-Pharmacology Research Center Research Institute of Basic Medical SciencesRafsanjan University of Medical SciencesRafsanjanIran Department of Physiology and Pharmacology School of MedicineRafsanjan University of Medical SciencesRafsanjanIran Neurophysiology Research Center Hamadan University of Medical SciencesHamadanIran Department of Pharmacology and Toxicology School of PharmacyHamadan University of Medical SciencesHamadanIran Department of Medical Biochemistry School of MedicineCollege of Health SciencesMount Kenya UniversityThikaKenya

Glaucoma,an irreversible optic neuropathy,primarily affects retinal ganglion cells(RGC)and causes vision loss and *** damage to RGCs in glaucoma occurs by various mechanisms,including elevated intraocular pressure,oxidative stress,inflammation,and other neurodegenerative *** the disease progresses,the loss of RGCs leads to vision ***,protecting RGCs from damage and promoting their survival are important goals in managing *** this regard,resveratrol(RES),a polyphenolic phytoalexin,exerts antioxidant effects and slows down the evolution and progression of *** present review shows that RES plays a protective role in RGCs in cases of ischemic injury and hypoxia as well as in ErbB2 protein expression in the ***,RES plays protective roles in RGCs by promoting cell growth,reducing apoptosis,and decreasing oxidative stress in H_(2)O_(2)-exposed *** was also found to inhibit oxidative stress damage in RGCs and suppress the activation of mitogen-activated protein kinase signaling *** could alleviate retinal function impairment by suppressing the hypoxia-i nducible factor-1 alpha/vascular endothelial growth factor and p38/p53 axes while stimulating the PI3K/Akt ***,RES might exert potential therapeutic effects for managing glaucoma by protecting RGCs from damage and promoting their survival.

关键词： glaucoma ischemic-reperfusion injury oxidative stress resveratrol retinal ganglion cells

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成人注意缺陷多动障碍的创新疗法

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空中英语教室（高级版．彭蒙惠英语） 2024年第5期 28-29,46,47页

作者： Shalene gupta 不详

对于成年注意缺陷多动障碍的患者而言,一家公司的游戏可能作为不必服药的解决方案。七十岁的芭芭拉·瓦格纳不太能适应她的退休生活。她长年从事物业管理,又是一位成功的企业家,在2017年决定退休,但是她似乎无法进入退休的状态。她盖了... 详细信息

对于成年注意缺陷多动障碍的患者而言,一家公司的游戏可能作为不必服药的解决方案。七十岁的芭芭拉·瓦格纳不太能适应她的退休生活。她长年从事物业管理,又是一位成功的企业家,在2017年决定退休,但是她似乎无法进入退休的状态。她盖了一栋房子,接着又盖了另一栋。她搬了家,然后再度搬家。

关键词：退休生活注意缺陷多动障碍物业管理芭芭拉瓦格纳七十岁企业家创新疗法

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Chemical profiling of bioactive compounds in the methanolic extract of wild leaf and callus of Vitex negundo using gas chromatographymass spectrometry

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World Journal of Experimental Medicine 2024年第1期14卷 78-87页

作者： Gunjan Garg Alok Bharadwaj Shweta Chaudhary Veena gupta School of Biotechnology Gautam Buddha UniversityGreater Noida 201312Uttar PradeshIndia Biotechnology GLA UniversityMathura 281406Uttar PradeshIndia Division of Germplasm Conservation Indian Council of Agricultural Research-National Bureau of Plant Genetic ResourcesNew Delhi 110012New DelhiIndia

BACKGROUND The investigation of plant-based therapeutic agents in medicinal plants has revealed their presence in the extracts and provides the vision to formulate novel techniques for drug *** negundo(***),a perennial herb belonging to the Varbanaceae family,is extensively used in conventional *** To determine the existence of therapeutic components in leaf and callus extracts from wild *** plants using gas chromatography-mass spectrometry(GCMS).METHODS In this study,we conducted GC-MS on wild plant leaf extracts and correlated the presence of constituents with those in callus *** growth regulators such as 6-benzylaminopurine(BAP),2,4-dichlorophenoxyacetic acid(2,4-D),α-naphthylacetic acid(NAA),and di-phenylurea(DPU)were added to plant leaves and in-vitro callus and grown on MS *** The results clearly indicated that the addition of BAP(2.0 mg/L),2,4-D(0.2 mg/mL),DPU(2.0 mg/L)and 2,4-D(0.2 mg/mL)in MS medium resulted in rapid callus *** plant profile of Vitex extracts by GC-MS analysis showed that 24,10,and 14 bioactive constituents were detected in the methanolic extract of leaf,green callus and the methanolic extract of white loose callus,*** Octadecadienoic acid,hexadecanoic acid and methyl ester were the major constituents in the leaf and callus methanolic *** acid was the most common constituent in all *** maximum concentration of octadecadienoic acid in leaves,green callus and white loose callus was 21.93%,47.79%and 40.38%,*** findings demonstrate that the concentration of octadecadienoic acid doubles in-vitro compared to *** addition to octadecadienoic acid;butyric acid,benzene,1-methoxy-4-(1-propenyl),dospan,tridecanedialdehyde,methylcyclohexenylbutanol,chlorpyrifos,n-secondary terpene diester,anflunine and other important active compounds were also *** these components were only available in callus formed in-vit

关键词： Leaf extracts Callus extracts Methanolic extract Octadecadienoic acid Hexadecanoic acid Methyl ester Gas chromatography-mass spectrometry analysis

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Efficacy of a Diabetes Specific Nutritional Supplement (DSNS) on Glycemic Response in Prediabetic Adults: A Two-Armed, Open-Labelled Randomized Controlled Study

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Food and Nutrition Sciences 2024年第7期15卷 612-643页

作者： Deepti Khanna Kejal Joshi Reddy Hema S. Gopalan Jaladhi Bhatt Jayanti gupta Simran Sethi Parth Joshi Manoj Pareek Department of R&D Hindustan Unilever Limited Gurugram India Mumbai India Cliantha Research Ahmedabad India

It is well known that Diabetes Specific Nutritional Supplements (DSNSs) are linked to improved glycemic control in individuals with diabetes. However, data on efficacy of DSNSs in prediabetics is limited. This was a two-armed, open-labelled, randomized controlled six-week study on 199 prediabetics [30 - 65 years;Glycosylated Hemoglobin (HbA1c) 5.7% - 6.4% and/or Fasting Blood Glucose (FBG) 100-125 mg/dl]. Two parallel phases were conducted: Acute Blood Glucose Response (ABGR) and Intervention phase. Prediabetic participants were randomized into test (n = 100) and control (n = 99). The primary objective was to assess the ABGR of DSNS versus an isocaloric snack, measured by incremental Area under the Curve (iAUC). Test and control received 60 g of DSNS and 56 g of isocaloric snack (cornflakes) respectively, both in 250 ml double-toned milk on visit days 1, 15, 29 and 43. Postprandial Blood Glucose (PPG) was estimated at 30, 60, 90, 120, 150 and 180 minutes. During the 4 weeks intervention phase, the test group received DSNS with lifestyle counselling (DSNS + LC) and was compared with the control receiving lifestyle counselling alone (LC alone). Impact was studied on FBG, HbA1C, anthropometry, body composition, blood pressure, nutrient intake, and physical activity. The impact of DSNS was also studied using CGM between two 14-day phases: CGM1 baseline (days 1 - 14) and CGM2 endline (days 28 - 42). DSNS showed significantly lower PPG versus isocaloric snack at 30 (p 12, and chromium were reported by DSNS + LC versus LC alone. No other significant changes were reported between groups. It may be concluded that DSNS may be considered as a snack for prediabetic or hyperglycemic individuals requiring nutritional support for improved glycemic control.

关键词： Diabetes Specific Nutritional Supplement Prediabetes Acute Blood Glucose Response Incremental Area under Curve Lifestyle Counselling

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Primary carbohydrate metabolism genes participate in heat-stress memory at the shoot apical meristem of Arabidopsis thaliana

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Molecular Plant 2024年第4期17卷 676-676页

作者： Justyna Jadwiga Olas Federico Apelt Maria Grazia Annunziata Sheeba John Sarah Isabel Richard Saurabh gupta Friedrich Kragler Salma Balazadeh Bernd Mueller-Roeber 不详

(Molecular Plant 14,1508-1524,September 62021)After the original publication of the above article,attentive readers identified errors in Figure 4H that needed correction as *** 4H contained the erroneous labels“10 DAP(7 DAT),”which should have each read,“7 DAP(4 DAT).”To avoid any confusion and ensure consistency across our figures,we modified some of the Col-0 images in a corrected version of Figure 4H below to resemble the exact same Col-0 images as in Figure *** details of the changes are as follows:rotation(Col-0 Primed,all timepoints;Col-0 Triggered,3 DAP and 5 DAP;Col-0 Primed/triggered,3 DAP and 5 DAP),replacement(Col-0 Triggered,7 DAP),and different cropping(Col-0 Primed/triggered,7 DAP).

关键词： Figure metabolism Prime

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Hybrid Image Compression-Encryption Scheme Based on Multilayer Stacked Autoencoder and Logistic Map

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China Communications 2022年第1期19卷 238-252页

作者： Neetu gupta Ritu Vijay Computer Science&Engineering Department Banasthali VidyapithBanasthaliIndia Department of Electronics Engineering Banasthali VidyapithBanasthaliIndia.

Secure transmission of images over a communication channel, with limited data transfer capacity, possesses compression and encryption schemes. A deep learning based hybrid image compression-encryption scheme is proposed by combining stacked auto-encoder with the logistic map. The proposed structure of stacked autoencoder has seven multiple layers, and back propagation algorithm is intended to extend vector portrayal of information into lower vector space. The randomly generated key is used to set initial conditions and control parameters of logistic map. Subsequently, compressed image is encrypted by substituting and scrambling of pixel sequences using key stream sequences generated from logistic *** proposed algorithms are experimentally tested over five standard grayscale images. Compression and encryption efficiency of proposed algorithms are evaluated and analyzed based on peak signal to noise ratio(PSNR), mean square error(MSE), structural similarity index metrics(SSIM) and statistical,differential, entropy analysis respectively. Simulation results show that proposed algorithms provide high quality reconstructed images with excellent levels of security during transmission..

关键词： compression-encryption stacked autoencoder chaotic system back propagation algorithm logistic map

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An Adaptive Genetic Algorithm-Based Load Balancing-Aware Task Scheduling Technique for Cloud Computing

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Computers, Materials & Continua 2022年第12期73卷 6103-6119页

作者： Mohit Agarwal Shikha gupta Deptartment of Computer Science&Engineering School of Engineering&TechnologySharda UniversityGreater NoidaUttar Pradesh201319India Department of Information Technology Maharaja Agrasen Institute of TechnologyDelhi110086India

Task scheduling in highly elastic and dynamic processing environments such as cloud computing have become the most discussed problem among *** scheduling algorithms are responsible for the allocation of the tasks among the computing resources for their execution,and an inefficient task scheduling algorithm results in under-or over-utilization of the resources,which in turn leads to degradation of the ***,in the proposed work,load balancing is considered as an important criterion for task scheduling in a cloud computing environment as it can help in reducing the overhead in the critical decision-oriented *** this paper,we propose an adaptive genetic algorithm-based load balancing(GALB)-aware task scheduling technique that not only results in better utilization of resources but also helps in optimizing the values of key performance indicators such as makespan,performance improvement ratio,and degree of *** concept of adaptive crossover and mutation is used in this work which results in better adaptation for the fittest individual of the current generation and prevents them from the *** simulator has been used to carry out the simulations and obtained results establish that the proposed GALB algorithm performs better for all the key indicators and outperforms its peers which are taken into the consideration.

关键词： Cloud computing genetic algorithm(GA) load balancing makespan resource utilization task scheduling

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Nonalcoholic steatohepatitis and hepatocellular carcinoma: Beyond the boundaries of the liver

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World Journal of Gastroenterology 2022年第36期28卷 5380-5382页

作者： Tarana gupta Department of Medicine Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical SciencesRohtak 124001HaryanaIndia

The burden of non-alcoholic steatohepatitis (NASH) related hepatocellularcarcinoma (HCC) is drawing attention due to the emerging epidemic of obesityand metabolic syndrome and is expected to increase in the near *** medications, air pollutants, and newer genetic mutations are latestconcerns as risk factors for HCC development in patients with NASH. Althoughmolecular signatures are very accurate, they are not cost-effective and cannot beapplied in larger population due to logistic issues. We need multicentric longitudinalstudies including diverse geographical areas to evaluate the complexinterplay of different risk factors and genetics in these patients.

关键词： Non-alcoholic steatohepatitis Hepatocellular carcinoma Cirrhosis Genetic factors Lifestyle factors Surveillance

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Hepatitis B core-related antigen:Are we near a treatment endpoint?

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World Journal of Gastroenterology 2022年第27期28卷 3532-3534页

作者： Tarana gupta Medicine Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical SciencesRohtak 124001HaryanaIndia

Different serological and virological markers in chronic hepatitis B patients guide staging of viral infection,and initiation and response to *** to the persistence of intrahepatic covalently closed circular DNA(cccDNA)in the hepatocyte nucleus,hepatitis B is not *** after undetectable hepatitis B virus DNA levels,the persistence of hepatitis B surface antigen and novel markers such as hepatitis B core-related antigen(HBcrAg)indicate the persistence of intrahepatic *** this study,HBcrAg levels at baseline and after 24 and 48 wk of antiviral therapy predicted hepatitis B e antigen *** to the poor sensitivity of assays and detectable levels in HBsAg-negative patients,the long-term utility of HBcrAg needs future research.

关键词： Hepatitis B core-related antigen Chronic hepatitis B Covalently closed circular DNA Hepatitis B e antigen seroconversion Hepatitis B virus DNA Pregenomic RNA

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Gallbladder perforation:A single-center experience in north India and a step-up approach for management

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 168-174页

作者： Vivek gupta Abhijit Chandra Vishal gupta Ravi Patel Amit Dangi Ajay Pai Department of Surgical Gastroenterology King George’s Medical UniversityLucknowUttar Pradesh 226003India

Background: Spontaneous gallbladder perforation(GBP) is an uncommon diagnosis. This study presented the experience of managing spontaneous GBP over nine years at a large, tertiary care university hospital in north India and investigated the outcomes and treatment strategies. Methods: A retrospective review of prospectively maintained digital database of consecutive patients was performed. All patients received medical and/or surgical treatment for spontaneous GBP in our department between January 2010 and June 2018. Results: We identifed 151 patients(81 females and 70 males) with mean age of 53 years. Most common presenting features were pain(96.7%), fever(54.3%) and jaundice(31.1%). Most common cause was gallbladder stones(84.8%) followed by common bile duct stones(30.5%), xanthogranulomatous cholecystitis(17.9%) and malignancy(11.9%). As per Niemeier classifcation, 8.6% had type 1 GBP(free perforation in peritoneal cavity), 76.2% had type 2 GBP(localized perforation) and 13.2% had type 3 GBP(cholecystoenteric fstula). About 60% of the perforations were diagnosed preoperatively. Type 1 was more common in patients with diabetes and also had the worst prognosis. Surgery was performed in 109 patients(72.2%). Seven patients(4.6%) had a postoperative morbidity of Clavien-Dindo Ⅲ or higher. There were three mortalities in patients who underwent surgery. Conclusions: High index of suspicion is required for preoperative diagnosis of GBP, especially in types 2 and 3. Laparoscopic cholecystectomy can be difficult in these patients and patients may require open or partial cholecystectomy. Early diagnosis and step-up approach for the treatment of GBP is critical.

关键词： Acute calculus cholecystitis Cholecystectomy Cholecysto-enteric fstula Niemeier classifcation

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