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Virologica Sinica 2024年第2期39卷 351-354页

作者： Xiangju Wu Lei chen chao Sui Yue Hu Dandan Jiang Fan Yang Laura c.miller Juntong Li Xiaoyan cong Nataliia Hrabchenko changhee Lee Yijun Du Jing Qi Shandong Key Laboratory of Animal Disease control and Breeding Key Laboratory of Livestock and Poultry Multi-omics of MARAInstitute of Animal Science and Veterinary MedicineInstitute of Crop Germplasm ResourcesShandong Academy of Agricultural SciencesJinan250100China college of Life Science Shandong Normal UniversityJinan250358China State Key Laboratory of Veterinary Etiological Biology National Foot and Mouth Disease Reference LaboratoryKey Laboratory of Animal Virology of Ministry of AgricultureLanzhou Veterinary Research InstituteChinese Academy of Agricultural SciencesLanzhou730050China Department of Diagnostic Medicine and Pathobiology College of Veterinary MedicineKansas State UniversityManhattanKS66506USA college of Veterinary Medicine and Virus Vaccine Research center Gyeongsang National UniversityJinju52828Republic of Korea

Due to our negligence,the original version of this article,published online on Mar 14,2023,contained some mistakes in several *** Fig.2D,the positions of the bands for protein 3A and 3B were incorrectly *** has been m... 详细信息

关键词： STAT1 FMDV bands

伊伐布雷定引起的心动过缓可减轻与压力相关的焦虑

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中华高血压杂志(中英文) 2024年第4期32卷 400-400页

作者： Woodman R Student J miller c Lockette W 刘青练桂丽

背景：心率较高且焦虑的高血压患者心血管疾病发病率和死亡率较高。尽管高血压、心率和焦虑之间存在相关性，但人们很少关注高血压药物治疗对心血管疾病行为结果的影响。伊伐布雷定是一种超极化激活的环核苷酸门控通道(hyperpolarizatio...

背景：心率较高且焦虑的高血压患者心血管疾病发病率和死亡率较高。尽管高血压、心率和焦虑之间存在相关性，但人们很少关注高血压药物治疗对心血管疾病行为结果的影响。伊伐布雷定是一种超极化激活的环核苷酸门控通道(hyperpolarization-activated, cyclic nucleotide-gated funny channels, HcN)抑制剂，已在临床上用于降低心率，并已被证明可以改善心绞痛和心力衰竭患者的生活质量。

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Incidence of brain metastasis in patients with esophageal carcinoma

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World Journal of Gastroenterology 2011年第19期17卷 2407-2410页

作者： Ron S Smith Robert c miller Department of Radiation Oncology Andreas Cancer Center-Mayo Health SystemMankatoMN 56002United States Department of Radiation Oncology Mayo ClinicRochesterMN 56002United States

AIM:To determine the incidence of brain metastasis in a contemporary group of patients with carcinoma of the ***:Retrospective analysis of 53 patients with esophageal carcinoma who received radiotherapy as a component of treatment between 1998 and 2007,including patient and tumor characteristics,and subsequent diagnosis of brain *** association between the histological type of esophageal cancer and the incidence of brain metastasis was assessed using Fisher's exact ***:Forty-four of the fifty-three patients in this study had adenocarcinoma and nine had squamous cell carcinoma,ranging from stage ⅡA-Ⅳ*** treatment was surgery with neoadjuvant chemoradiotherapy (trimodality therapy) in 19% of patients;chemoradiotherapy in 42%;and surgery and adjuvant radiotherapy in 7%.Twenty-five percent of patients inthis study received palliative *** overall incidence of brain metastasis in this cohort was 13%.Adenocarcinoma was the primary tumor histology in all of the patients who developed brain metastasis,representing an incidence of 16% in this *** patients with squamous cell carcinoma received trimodality *** association between histology and brain metastasis was not statistically ***:The incidence of brain metastasis in this contemporary cohort of patients with esophageal carcinoma is higher than previously reported and was confined to those with adenocarcinoma.

关键词： Brain metastasis Esophageal carcinoma

A primer on the use of probability generating functions in infectious disease modeling

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Infectious Disease Modelling 2018年第1期3卷 192-248页

作者： Joel c.miller Institute for Disease Modeling BellevueWAUSA

We explore the application of probability generating functions(PGFs)to invasive processes,focusing on infectious disease introduced into large *** goal is to acquaint the reader with applications of PGFs,moreso than to derive new *** help predict a number of properties about early outbreak behavior while the population is still effectively infinite,including the probability of an epidemic,the size distribution after some number of generations,and the cumulative size distribution of non-epidemic *** show how PGFs can be used in both discrete-time and continuous-time settings,and discuss how to use these results to infer disease parameters from observed *** the large population limit for susceptible-infected-recovered(SIR)epidemics PGFs lead to survival-function based models that are equivalent to the usual mass-action SIR models but with fewer *** use these to explore properties such as the final size of epidemics or even the dynamics once stochastic effects are *** target this primer at biologists and public health researchers with mathematical modeling experience who want to learn how to apply PGFs to invasive diseases,but it could also be used in an applications-based mathematics course on *** include many exercises to help demonstrate concepts and to give practice applying the *** summarize our main results in a few *** we provide a small python package which performs many of the relevant calculations.

关键词： generating functions negligible

Mathematical models of SIR disease spread with combined non-sexual and sexual transmission routes

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Infectious Disease Modelling 2017年第1期2卷 35-55页

作者： Joel c.miller Monash University School of Mathematical SciencesMelbourne 3800Australia Institute for Disease Modeling BellevueWAUSA

The emergence of Zika and Ebola demonstrates the importance of understanding the role of sexual transmission in the spread of diseases with a primarily non-sexual transmission *** this paper,we develop low-dimensional models for how an SIR disease will spread if it transmits through a sexual contact network and some other transmission mechanism,such as direct contact or *** show that the models derived accurately predict the dynamics of simulations in the large population limit,and investigateℛ0 and final size relations.

关键词： network Mathematical spread

X-ray Multiple Diffraction Topographic Imaging Technique For Growth History Study of Habit Modifying Impurity Doped crystals

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chemical Research in chinese Universities 2004年第4期20卷 411-416页

作者： LAI X. MA c. K. J. Robert M. c. miller Institute of Particle Science and Engineering Department of Chemical Engineering University of LeedsInstitute of Particle Science and Engineering Department of Chemical Engineering University of LeedsInstitute of Particle Science and Engineering Department of Chemical Engineering University of LeedsCCLRC Daresbury Laboratory Daresbury Leeds LS2 9JT UKLeeds LS2 9JT UKLeeds LS2 9JT UKWarrington Cheshire WA4 4AD UK

A novel crystal characterization instrument has been built up in which a combination of X-ray multiple diffraction and X-ray topography is applied to enabling the cross-correlation between micro-crystallographic symmetry and its spatial dependence in relation to lattice defects. This facility is used to examine, in a self-consistent manner, growth sector-dependant changes to both the crystallographic structure and the lattice defects associated with the action of habit-modifying additives in a number of representative crystal growth systems. In addition, the new instrument can be used to probe micro-crystallographic aspects(such as distortion to crystal symmetry) and relate these in a spatially resolved manner to the crystal defect structure in crystals doped with known habit modifiers.

关键词： X-ray diffraction X-ray multiple diffraction X-ray topography Habit modification crystal growth Growth defects

3c^(pro)of FMDV inhibits type II interferon-stimulated JAK-STAT signaling pathway by blocking STAT1 nuclear translocation

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Virologica Sinica 2023年第3期38卷 387-397页

作者： Xiangju Wu Lei chen chao Sui Yue Hu Dandan Jiang Fan Yang Laura c.miller Juntong Li Xiaoyan cong Nataliia Hrabchenko changhee Lee Yijun Du Jing Qi Shandong Key Laboratory of Animal Disease control and Breeding/Key Laboratory of Livestock and Poultry Multi-omics of MARA Institute of Animal Science and Veterinary MedicineInstitute of Crop Germplasm ResourcesShandong Academy of Agricultural SciencesJinan250100China college of Life Science Shandong Normal UniversityJinan250358China State Key Laboratory of Veterinary Etiological Biology/National Foot and Mouth Disease Reference Laboratory/Key Laboratory of Animal Virology of Ministry of Agriculture Lanzhou Veterinary Research InstituteChinese Academy of Agricultural SciencesLanzhou730050China Department of Diagnostic Medicine and Pathobiology College of Veterinary MedicineKansas State UniversityManhattanKS66506USA college of Veterinary Medicine and Virus Vaccine Research center Gyeongsang National UniversityJinju52828Republic of Korea

Foot-and-mouth disease virus(FMDV)has developed various strategies to antagonize the host innate *** Lpro and 3cpro interfere with type I IFNs through different *** structural protein VP3 of FMDV degrades Janus kinase 1 to suppress IFN-γsignaling *** non-structural proteins of FMDV are involved in restraining type II IFN signaling pathways is *** this study,it was shown that FMDV replication was resistant to IFN-γtreatment after the infection was established and FMDV inhibited type II IFN induced expression of IFN-γ-stimulated genes(ISGs).We also showed for the first time that FMDV non-structural protein 3c antagonized IFN-γ-stimulated JAK-STAT signaling pathway by blocking STAT1 nuclear translocation.3c^(pro)expression significantly reduced the ISGs transcript levels and palindromic gamma-activated sequences(GAS)promoter activity,without affecting the protein level,tyrosine phosphorylation,and homodimerization of ***,we provided evidence that 3c protease activity played an essential role in degrading KPNA1 and thus inhibited ISGs mRNA and GAS promoter *** results reveal a novel mechanism by which an FMDV non-structural protein antagonizes host type II IFN signaling.

关键词： Foot-and-mouth disease virus(FMDV) 3c IFN-γ JAK-STAT signaling pathway STAT1 KPNA1

A Meditation on Education in Honour of Dewey’s One Hundred and Fiftieth Birthday,celebrated in the Land of Kongzi

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A Meditation on Education in Honour of Dewey’s One Hundred ...

Delmar''s practice questions for NcLEX-PN

The Mid-term conference of Research committee on the Sociology of Leisure (ISA Rc 13) and 2009 china Annual Symposium on Leisure and Social Progress

作者： Marjorie c.miller Professor Department of Philosophy Purchase CollegeSUNYU.S.A Currently a Fulbright Senior Lecturer in PhilosophyPusan National UniversityPusanKorea

＜正＞Dewey shares with confucius a strange characteristic:both of the great teachers induced the development of educational systems "honoured" by association with their names:confucian education describes the educational system utilized by East Asians for thousands of years;whereas the educational system of the United States （and others countries who followed） is known,for roughly the period from the late 1930s to the present,as Dewey’s progressive

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Transcriptome sequencing and annotation of the halophytic microalga Dunaliella salina

2004年

作者： Judith c. miller

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ISBN: (纸本)1401804039

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关键词： Nursing careExamination Questions.

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2017年第10期18卷 833-844页

作者： Ling HONG Jun-li LIU Samira Z.MIDOUN Philip c.miller Department of Genetics and Developmental Biology College of Life Science and TechnologyHuazhong University of Science and Technology Systems Biology Research Group Bioengineering Department University of California

The unicellular green alga Dunaliella salina is well adapted to salt stress and contains compounds（including β-carotene and vitamins） with potential commercial value.A large transcriptome database of *** during the adjustment, exponential and stationary growth phases was generated using a high throughput sequencing *** characterized the metabolic processes in *** with a focus on valuable metabolites, with the aim of manipulating *** to achieve greater economic value in large-scale production through a bioengineering *** expression profiles under salt stress verified using quantitative polymerase chain reaction（qPcR） implied that salt can regulate the expression of key *** study generated a substantial fraction of *** transcriptional sequences for the entire growth cycle, providing a basis for the discovery of novel *** first full-scale transcriptome study of *** establishes a foundation for further comparative genomic studies.

关键词： Dunaliella salina Transcriptome profile Metabolic processes and adjustment Regulatory metabolism Salt stress