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Successful multidisciplinary clinical approach and molecular characterization by whole transcriptome sequencing of a cardiac myxofibrosarcoma: A case report

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World Journal of Clinical Cases 2019年第19期7卷 3018-3026页

作者： Maristella Saponara Valentina Indio Carmine Pizzi Elena-Daniela Serban milena urbini Annalisa Astolfi Pasquale Paolisso Sofia Martin Suarez Margherita Nannini Davide Pacini Valentina Agostini Ornella Leone Valentina Ambrosini Giuseppe Tarantino Stefano Fanti Fabio Niro Francesco Buia Domenico Attinà Maria Abbondanza Pantaleo Department of Specialized Experimental and Diagnostic MedicineMedical Oncology UnitSant'Orsola-Malpighi HospitalUniversity of BolognaBologna 40138Italy “Giorgio Prodi”Cancer Research Center University of BolognaBologna 40138Italy Department of Specialized Experimental and Diagnostic MedicineCardiology and Transplantation UnitSant’Orsola-Malpighi HospitalUniversity of BolognaBologna 40138Italy Department of Pathology Cardiovascular Pathology UnitSant’Orsola-Malpighi HospitalUniversity of BolognaBologna 40138Italy Departments of Cardiovascular Surgery and Transplantation Sant'Orsola-Malpighi HospitalUniversity of BolognaBologna 40138Italy Department of Specialized Experimental and Diagnostic MedicineNuclear Medicine UnitSant'Orsola-Malpighi HospitalUniversity of BolognaBologna 40138Italy Department of Specialized Experimental and Diagnostic MedicineRadiology UnitSant'Orsola-Malpighi HospitalUniversity of BolognaBologna 40138Italy

BACKGROUND Cardiac tumors are rare and complex *** represents the cornerstone of therapy,while the role of adjuvant treatment remains unclear and,in case of relapse or metastatic disease,the prognosis is very *** of prospective,randomized clinical trials hinders the generation of high level evidence for the optimal diagnostic workup and multimodal treatment of cardiac ***,we describe the multidisciplinary clinical management and molecular characterization of a rare case of cardiac myxofibrosarcoma in an elderly *** SUMMARY A 73-year-old woman presented signs and symptoms of acute left-sided heart *** examination revealed a large,left atrial *** suspicion of a myxoma,she underwent surgery,and symptoms were promptly *** showed a cardiac myxofibrosarcoma,a rare histotype of cardiac *** months later,disease unfortunately relapsed,and after a multidisciplinary discussion,a chemotherapy with doxorubicin and then gemcitabine was started,achieving partial radiologic and complete metabolic response,which was maintained up to 2 years and is still *** report is focused on the entire clinical path of our patient from diagnosis to follow-up,through surgery and strategies adopted at ***,due to their rarity,very little is known about the molecular landscape of ***,we also performed and described preliminary genome analysis of the tumor tissue to get further insight on mechanisms involved in tumor growth,and to possibly unveil new clinically actionable *** We report a case of cardiac myxofibrosarcoma that achieved a very good prognosis due to an integrated surgical,cardiac and oncologic treatment strategy.

关键词： Cardiac sarcoma Myxofibrosarcoma Whole transcriptome sequencing Doxorubicin Gemcitabine Case report

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Treatment of spinal cord injury with biomaterials and stem cell therapy in non-human primates and humans

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Neural Regeneration Research 2025年第2期20卷 343-353页

作者： Ana milena Silva Olaya Fernanda Martins Almeida Ana Maria Blanco Martinez Suelen Adriani Marques PhD Program in Pathological Anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Biomedical Science Institute Federal University of Rio de JaneiroRio de JaneiroBrazil Graduate Program in Pathological Anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Graduate Program in Pathological Anatomy(PPGAP/UFRJ) Department of Neurobiology/Institute of BiologyCampus do GragoatáNiteróiRio de JaneiroBrazil

Spinal cord injury results in the loss of sensory,motor,and autonomic functions,which almost always produces permanent physical ***,in the search for more effective treatments than those already applied for years,which are not entirely efficient,researches have been able to demonstrate the potential of biological strategies using biomaterials to tissue manufacturing through bioengineering and stem cell therapy as a neuroregenerative approach,seeking to promote neuronal recovery after spinal cord *** of these strategies has been developed and meticulously evaluated in several animal models with the aim of analyzing the potential of interventions for neuronal repair and,consequently,boosting functional *** the majority of experimental research has been conducted in rodents,there is increasing recognition of the importance,and need,of evaluating the safety and efficacy of these interventions in non-human primates before moving to clinical trials involving therapies potentially promising in *** article is a literature review from databases(PubMed,Science Direct,Elsevier,Scielo,Redalyc,Cochrane,and NCBI)from 10 years ago to date,using keywords(spinal cord injury,cell therapy,non-human primates,humans,and bioengineering in spinal cord injury).From 110 retrieved articles,after two selection rounds based on inclusion and exclusion criteria,21 articles were ***,this review arises from the need to recognize the experimental therapeutic advances applied in non-human primates and even humans,aimed at deepening these strategies and identifying the advantages and influence of the results on extrapolation for clinical applicability in humans.

关键词： bioengineering biomaterials cell therapy humans non-human primates spinal cord injury stem cell therapy

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Beta thalassemia syndromes:New insights

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World Journal of Clinical Cases 2025年第10期13卷 1-8页

作者： Ana Dordevic Ines Mrakovcic-Sutic Sonja Pavlovic milena Ugrin Jelena Roganovic Department of Business Development Jadran Galenski LaboratorijRijeka 51000Croatia Faculty of Medicine University of RijekaRijeka 51000Croatia Institute of Molecular Genetics and Genetic Engineering University of BelgradeBelgrade 11000Serbia Department of Pediatric Hematology and Oncology Children’s Hospital ZagrebZagreb 10000Croatia Faculty of Biotechnology and Drug Development University of RijekaRijeka 51000Croatia

Beta thalassemia(β-thalassemia)syndromes are a heterogeneous group of inherited hemoglobinopathies caused by molecular defects in the beta-globin gene that lead to the impaired synthesis of beta-globin chains of the *** hallmarks of the disease include ineffective erythropoiesis,chronic hemolytic anemia,and iron *** presentation ranges from asymptomatic carriers to severe anemia requiring lifelong blood transfusions with subsequent devastating *** management of patients with severeβ-thalassemia represents a global health problem,particularly in low-income *** recently,management strategies were limited to regular transfusions and iron chelation therapy,with allogeneic hematopoietic stem cell transplantation available only for a subset of *** understanding of the underlying pathophysiological mechanisms ofβ-thalassemia syndromes and associated clinical phenotypes has paved the way for novel therapeutic options,including pharmacologic enhancers of effective erythropoiesis and gene therapy.

关键词： Beta thalassemia Hemoglobin Molecular defects Ineffective erythropoiesis Hemolysis Transfusion Iron chelation Novel therapies

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Outsmarting SARS-CoV-2 by empowering a decoy ACE2

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Signal Transduction and Targeted Therapy 2020年第1期5卷 305-307页

作者： milena Sokolowska Swiss Institute of Allergy and Asthma Research(SIAF) University of ZurichDavosSwitzerland Christine Kühne-Center for Allergy Research and Education(CK-CARE) DavosSwitzerland

Along with the current efforts to develop high-affinity neutralizing antibodies,Chan and colleagues engineered the soluble variant of human ACE2 with enhanced binding to the spike protein,outranking the soluble wild-type protein in blocking SARS-CoV-2 infection in *** addition,the newly created soluble ACE2 is enzymatically active in cleaving angiotensin-2,increasing its therapeutic potential in COVID-19.

关键词： ACE2 decoy smart

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Engineering-Geological Problems in the Moravian Karst,Czech Republic

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Acta Geologica Sinica(English Edition) 2001年第3期75卷 303-307页

作者： milena AMALIKOVA Duke Engineering & Services Sumavska 35658 56 Brno Czech Republic

The Moravian karst belongs to one of the famous karst regions in Central Europe. It is situated in Moravia in the eastern part of the Czech Republic. According to the geology it is of Devonian age and the main rocks are of different types of limestones. The process of karstification is still active. They are many caves with rich stalagmites and stalactites and the Macocha abyss, the depth of which is 138.5 m. The underground Punkva River flows through the main part of the karst, forming beautiful underground lakes. Typical karst phenomena, such as sinkholes and deep canyons, may be observed on the surface of the terrain. Because of the karstification, water erosion and frost weathering, many steep unstable slopes and walls originated. To solve the stability from a geotechnical point of view is not easy. This requests a special engineering-geological knowledge and experience.

关键词： Czech Republic Moravian karst engineering geology slope stability long-term monitoring

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International patterns in incidence and mortality trends of pancreatic cancer in the last three decades: A joinpoint regression analysis

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World Journal of Gastroenterology 2022年第32期28卷 4697-4714页

作者： Irena Ilic milena Ilic Faculty of Medicine University of BelgradeBelgrade 11000Serbia Department of Epidemiology Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia

BACKGROUND Pancreatic cancer,as the one of most fatal malignancies,remains a critical issue in the global burden of *** To estimate trends in pancreatic cancer incidence and mortality worldwide in the last three *** A descriptive epidemiological study was *** cancer incidence and mortality data were obtained from the database of the World Health *** of pancreatic cancer incidence and mortality during 2020 was *** age-standardized rates(ASRs,expressed per 100000)were *** estimate trends of incidence and mortality of pancreatic cancer,joinpoint regression analysis was used:the average annual percent change(AAPC)with the corresponding 95%confidence interval(95%CI)was ***,analysis was performed by sex and *** this paper,the trend analysis included only countries with high and medium data *** A total of 495773(262865 male and 232908 female)new cases and 466003(246840 male and 219163 female)deaths from pancreatic cancer were reported worldwide in *** both sexes,most of the new cases(191348;38.6%of the total)and deaths(182074;39.1%of the total)occurred in the Western Pacific *** both sexes,the highest ASRs were found in the European Region,while the lowest rates were reported in the South-East Asia *** general pattern of rising pancreatic cancer incidence and mortality was seen across countries worldwide in observed *** of all countries with an increase in pancreatic cancer incidence,females in France and India showed the most marked rise in incidence rates(AAPC=+3.9%and AAPC=+3.7%,respectively).Decreasing incidence trends for pancreatic cancer were observed in some countries,but without *** of all countries with an increase in pancreatic cancer mortality rates,Turkmenistan showed the most marked rise both in males(AAPC=+10.0%,95%CI:7.4–12.5)and females(AAPC=+6.4%,95%CI:3.5–9.5).The mortality trends of pancreatic cancer were decreasin

关键词： Pancreatic cancer Incidence Mortality Joinpoint analysis International pattern

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Epidemiology of pancreatic cancer

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World Journal of Gastroenterology 2016年第44期22卷 9694-9705页

作者： milena Ilic Irena Ilic Faculty of Medical Sciences University of Kragujevac

Cancer of the pancreas remains one of the deadliest cancer types. Based on the GLOBOCAN 2012 estimates, pancreatic cancer causes more than 331000 deaths per year, ranking as the seventh leading cause of cancer death in both sexes together. Globally, about 338000 people had pancreatic cancer in 2012, making it the 11^(th) most common cancer. The highest incidence and mortality rates of pancreatic cancer are found in developed countries. Trends for pancreatic cancer incidence and mortality varied considerably in the world. A known cause of pancreatic cancer is tobacco smoking. This risk factor is likely to explain some of the international variations and gender differences. The overall five-year survival rate is about 6%(ranges from 2% to 9%), but this vary very small between developed and developing countries. To date, the causes of pancreatic cancer are still insufficiently known, although certain risk factors have been identified, such as smoking, obesity, genetics, diabetes, diet, inactivity. There are no current screening recommendations for pancreatic cancer, so primary prevention is of utmost importance. A better understanding of the etiology and identifying the risk factors is essential for the primary prevention of this disease.

关键词： Pancreatic cancer Epidemiology Incidence Mortality Trend Risk factors

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Epidemiology of stomach cancer

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World Journal of Gastroenterology 2022年第12期28卷 1187-1203页

作者： milena Ilic Irena Ilic Department of Epidemiology Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Faculty of Medicine University of BelgradeBelgrade 11000Serbia

Despite a decline in incidence and mortality during the last decades,stomach cancer is one of the main health challenges *** to the GLOBOCAN 2020 estimates,stomach cancer caused approximately 800000 deaths(accounting for 7.7%of all cancer deaths),and ranks as the fourth leading cause of cancer deaths in both genders *** 1.1 million new cases of stomach cancer were diagnosed in 2020(accounting for 5.6%of all cancer cases).About 75%of all new cases and all deaths from stomach cancer are reported in *** cancer is one of the most lethal malignant tumors,with a five-year survival rate of around 20%.There are some well-established risk factors for stomach cancer:Helicobacter pylori infection,dietary factors,tobacco,obesity,and *** date,the most important way of preventing stomach cancer is reduced exposure to risk factors,as well as screening and early *** research on risk factors can help identify various opportunities for more effective *** programs for stomach cancer have been implemented in a few countries,either as a national or opportunistic screening of high-risk individuals ***,due to its high aggressiveness and heterogeneity,stomach cancer still remains a severe global health problem.

关键词： Stomach cancer Epidemiology Incidence Mortality Survival Predictive factors Prevention

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Cancer mortality in Serbia, 1991-2015: an age-period-cohort and joinpoint regression analysis

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Cancer Communications 2018年第1期38卷 120-135页

作者： milena Ilic Irena Ilic Department of Epidemiology Faculty of Medical SciencesUniversity of KragujevacS.Markovica 69Kragujevac 34000Serbia Faculty of Medicine University of BelgradeBelgrade 11000Serbia

Background:As the result of dramatic political changes,civil wars,and a long-term refugee crisis from the end of the last to beginning of this century,the population of Serbia has experienced significant health *** aim of this study was to assess cancer mortality trends in ***:This nationwide study was carried out to analyze cancer mortality in Serbia during 1991-2015 using offi-cial *** age-standardized mortality rates(per 100,000)were calculated by direct standardization,using the world standard population by *** average annual percent change(AAPC)and corresponding 95%confidence interval(CI)were computed using joinpoint regression ***-period-cohort analysis was performed to address the possible underlying reasons for the observed temporal ***:Over the 25-year study period,there were 466,075 cancer deaths(266,043 males and 200,032 females)in *** cancer mortality increased between 1991 and 2009 in both males(by+0.9%per year)and females(by+0.8%per year)and has been decreasing since then,by−0.9%annually in both *** almost all major cancers except stomach cancer,cancer mortality in Serbia demonstrated upward trends during the study *** largest increases were noted in lung cancer among females(AAPC=+3.7,95%CI 3.5-3.9)and prostate cancer in males(AAPC=+1.9,95%CI 1.4-2.3).Conclusions:After two decades of increase,cancer mortality rates are finally declining in *** this,these rates place Serbia among the countries with the highest cancer mortality in the world.

关键词： Cancer Mortality Trend Joinpoint regression analysis Age-period-cohort analysis

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DESCENT DIRECTION STOCHASTIC APPROXIMATION ALGORITHM WITH ADAPTIVE STEP SIZES

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Journal of Computational Mathematics 2019年第1期37卷 76-94页

作者： Zorana Luzanin Irena Stojkovska milena Kresoja Department of Mathematics and Informatics Faculty of SciencesUniversity of Novi Sad Novi SadSerbia Department of Mathematics.Faculty of Natural Sciences and Mathematics Ss.Cyril and Methodius UniversitySkopjeMacedonia

A stochastic approximation (SA)algorithm with new adaptive step sizes for solving unconstrained minimization problems in noisy environment is *** adaptive step size scheme uses ordered statistics of fixed number of previous noisy function values as a criterion for accepting good and rejecting bad *** scheine allows the algorithm to move in bigger steps and avoid steps proportional to 1/k when it is expected that larger steps will improve the *** algorithin with the new adaptive scheme is defined for a general descent *** ahnost sure convergence is *** performance of new algorithm is tested on a set of standard test problems and compared with relevant *** results support theoretical expectations and verify efficiency of the algorithm regardless of chosen search direction and noise *** results on probleins arising in machine learning are also *** regression problem is considered using real data *** results suggest that the proposed algorithln shows proinise.

关键词： Unconstrained optimization Stochastic optimization Stochastic approximation Noisy function Adaptive step size Descent direction Linear regression model

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