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Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： krisztián Pajer Tamás Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(khyeam et al.,2021).

关键词： injured capacity modified

Formability Investigations of High-strength Dual-Phase steels

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Acta Metallurgica sinica(English Letters) 2015年第12期28卷 1471-1481页

作者： miklós Tisza Zsolt Lukács Department of Materials Processing Technology Institute of Materials Science and Technology University of Miskolc

Car manufacturing is always regarded as the key industry behind sheet metal forming, and thus, the requirements of and developments in car manufacturing play a decisive role in the development of sheet metal forming. The automotive industry is faced with contradictory demands and requirements： better performance with lower consumption and less harmful emissions, more safety and comfort; these are extremely difficult to supply simultaneously with conventional materials and conventional manufacturing processes. The fulfillment of these often contradictory requirements is one of the main driving forces in the automotive industry and thus in the material and process developments in sheet metal forming, as well. In recent years, significant developments can be observed in the application of high-strength steels. In this respect, the application of various dual-phase steels is one of the best examples. However, the application of these highstrength steels often leads to formability and manufacturing problems. One formability problem is the springback occurring after sheet metal forming. In the current research, we have dealt mainly with advanced high-strength steels, primarily with dual-phase steels. When applying them, the springback phenomenon is one of the most critical issues. To reduce the tremendous amount of experimental work needed, we also applied numerical simulation using isotropic–kinematic hardening rules. The isotropic–kinematic hardening behavior of a given material in the applied Auto Form numerical package may be characterized with three independent material parameters c, v and k（a detailed explanation of their meaning will be given in the main part of this paper）. However, we found that the material data included in simulation packages for these new high-strength steels are not fully adequate. For the determination of more reliable material parameters and to achieve better simulation results, a new testing device was developed. Numerical simulations were

关键词： springback Large-strain cyclic deformation High-strength dual-phase steels

synthesis of Telechelic Polyisobutylenes and Polyethers and Their Characterization

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复旦学报（自然科学版） 2005年第5期44卷 805-807页

作者： sándor kéki miklós Nagy Gyoergy Deók László Orosz miklós Zsuga Department of Applied Chemistry University of Debrecen H-4010 Debrecen Hungary

Telechelic polymers have attained great consideration as building blocks in the synthesis of block copolymers and networks. Telechelic polymers with various endgroups are also widely used materials for the preparation of polymeric prodrugs. several methods have been reported to obtain functionalized polymers from the corresponding polyisobutylene (PIB) and polyether derivatives. In this presentation, we will demonstrate very versatile and powerful synthetic methods to obtain telechelic polymers.

关键词：聚异丁烯聚醚遥爪聚合物合成方法

First-line eradication of Helicobacter pylori:Are the standard triple therapies obsolete? A different perspective

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World Journal of Gastroenterology 2010年第31期16卷 3865-3870页

作者： Gyrgy miklós Buzás Department of Gastroenterology Fe-rencváros Health Service Non-Profit Ltd.

studies concerning the eradication of Helicobacter pylori have resulted in a proliferation of meta-analyses. To date, there are 303 meta-analyses cited in PubMed, 113 dealing with the therapy of the infection. A chronological analysis of the results of meta-analyses performed between 1998 and 2010 shows that first-line standard triple therapies achieved eradication rates on an intention-to-treat basis of around 80%; prolonging treatment to 14, but not 10 d should improve the results. The proton pump inhibitors have a similar efficiency, and giving a double dose is more efficient than the standard doses of these drugs. Triple and quadruple therapies proved to be equivalent. Based on meta-analytical data, the decrease in efficiency over time cannot be substantiated: eradication rates s. As alternatives, ranitidine bismuth citrate-, levofloxacinor furazolidone-based therapies were shown to obtain the same eradication rates as standard triple regimens. sequential therapies and quadruple non-bismuth-based therapies were superior to standard triple therapies but their use is limited to certain countries. In the author's opinion, and from a meta-analytical viewpoint, standard triple therapies cannot yet be considered obsolete. Furthermore, noninferiority trials are proposed for the future, including assessment of local contemporary antimicrobial resistance profi les and the CagA and CYP2C19 status of the enrolled patients.

关键词： Antibiotics Eradication Helicobacter pylori Meta-analysis

Metabolic consequences of Helicobacter pylori infection and eradication

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World Journal of Gastroenterology 2014年第18期20卷 5226-5234页

作者： Gy?rgy miklós Buzás Department of Gastroenterology Ferencváros Health Centre1095 BudapestHungary

Helicobacter pylori(***)is still the most prevalent infection of the *** of the stomach by this agent will invariably induce chronic gastritis which is a low-grade inflammatory state leading to local complications(peptic ulcer,gastric cancer,lymphoma)and remote *** *** does not enter circulation,these extragastric manifestations are probably mediated by the cytokines and acute phase proteins produced by the inflammed *** epidemiologic link between the *** infection and metabolic changes is inconstant and *** delay was described mainly in low-income regions with high prevalence of the infection,where probably other nutritional and social factors contribute to *** timely eradication of the infection will lead to a more healthy development of the young population,along with preventing peptic ulcers and gastric cancer An increase of total,low density lipoprotein and high density liporotein cholesterol levels in some infected people creates an atherogenic lipid profile which could promote atherosclerosis with its complications,myocardial infarction,stroke and peripheral vascular *** designed and adequately powered long-term studies are required to see whether eradication of the infection will prevent these *** case of glucose metabolism,the most consistent association was found between *** and insulin resistance:again,proof that eradication prevents this common metabolic disturbance is *** results of eradication with standard regimens in diabetics are significantly worse than in non-diabetic patients,thus,more active regimens must be found to obtain better *** eradication itself led to an increase of body mass index and cholesterol levels in some populations,while in others no such changes were *** of the metabolic consequences of *** infection must be clarified in the future.

关键词： Diabetes mellitus Cytokines Glucose homeostasis Growth Helicobacter pylori Interleukins Lipid metabolism Metabolic syndrome

Limsup Results and LIL for Partial sum Processes of a Gaussian Random Field

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Acta Mathematica sinica,English series 2008年第9期24卷 1497-1506页

作者： Yong-kab CHOI mikls CsRG Department of Mathematics and RINs Gyeongsang National University Jinju 660-701 Republic of Korea school of Mathematics and statistics Carleton University 1125 Colonel By DriveOttawa K1S 5B6 Canada

Let {ξ j ; j ∈ ℤ+ d be a centered stationary Gaussian random field, where ℤ+ d is the d-dimensional lattice of all points in d-dimensional Euclidean space ℝd, having nonnegative integer coordinates. For each j = (j ... 详细信息

Let {ξsUB> j sUB>; j ∈ ℤsUB>+sUB>sUP> d sUP>be a centered stationary Gaussian random field, where ℤsUB>+sUB>sUP> d sUP>is the d-dimensional lattice of all points in d-dimensional Euclidean space ℝsUP>dsUP>, having nonnegative integer coordinates. For each j = (j sUB>1 sUB>, ..., jd) in ℤsUB>+sUB>sUP> d sUP>, we denote |j| = j sUB>1 sUB>... j sUB>d sUB>and for m, n ∈ ℤsUB>+sUB>sUP> d sUP>, define s(m, n] = ΣsUB> msUB>ζsUB> j sUB>, σsUP>2sUP>(|n−m|) = Es sUP>2 sUP>(m, n], s sUB>n sUB>= s(0, n] and s sUB>0 sUB>= 0. Assume that σ(|n|) can be extended to a continuous function σ(t) of t > 0, which is nondecreasing and regularly varying with exponent α at b ≥ 0 for some 0 some additional conditions, we study limsup results for increments of partial sum processes and prove as well the law of the iterated logarithm for such partial sum processes.

关键词： stationary Gaussian random field regularly varying function large deviation probability law of the iterated logarithm

A strong approximation of self-normalized sums

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science China Mathematics 2013年第1期56卷 149-160页

作者： CsRG miklós HU Zhishui school of Mathematics and statistics Carleton University Department of statistics and Finance School of ManagementUniversity of Science and Technology of China

Let {X,Xn,n1} be a sequence of independent identically distributed random variables with EX=0 and assume that EX2I(|X|≤x) is slowly varying as x→∞,i.e.,X is in the domain of attraction of the normal *** this paper ... 详细信息

关键词： strong approximation self-normalized sums domain of attraction of the normal law

Path properties of l_p-valued Gaussian random fields

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science China Mathematics 2007年第10期50卷 1501-1520页

作者： Yong-kab CHOI miklós CsRGO Department of Mathematics Gyeongsang National UniversityJinju 660-701Korea school of Mathematics and statistics Carleton University1125 Colonel By DriveOttawaK1S 5B6Canada

General limit theorems are established for l^p-valued Gaussian random fields indexed by a multidimensional parameter,which contain both almost sure moduli of continuity and limits of large increments for the l^p-value... 详细信息

关键词： l^p-valued Gaussian random field modulus of continuity large deviation probability regularly varying function

segmented trust assessment in autonomous vehicles via eye-tracking

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Journal of Intelligent and Connected Vehicles 2024年第2期7卷 151-161页

作者： miklós Lukovics szabolcs Prónay Barbara Nagy Faculty of Economics and Business Administration University of SzegedSzeged H-6726Hungary

Previous studies have identified trust as one of the key factors in the technology acceptance of autonomousvehicles. As these studies mostly investigated the population in general, little is known about segment-specific ***, the widely used survey methods are less able to capture the deeper forms of trust—which neuroscientificmethods are much better suited to capture. The main objective of our research is to study trust as one of the key factors oftechnology acceptance related to autonomous vehicles by using neuroscientific methods for specific consumer ***-time eye-tracking tests were applied to a sample of 113 participants, combined with a posttest self-report. The testswere carried out under laboratory conditions during which our subjects watched videos recorded with the internal camerasof autonomous vehicles. Based on the fixation count, total fixation duration, and pupil dilation, we empirically verified thatthe trust level of all five identified segments is relatively low, while the trust level of the “traditional rejecting” segment is thelowest. An increase in trust level can be shown if the subjects receive extra information about the journey. Anotherimportant finding is that the self-reported trust level is not always congruent with the eye-tracking analysis results;therefore,combined approaches can lead to greater measurement validity.

关键词： autonomous vehicles(AVs) technology acceptance trust eye-tracking