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Neural Regeneration Research 2025年第9期20卷 2589-2590页

作者： mikio shimizu Tatsusada Okuno Department of Neurology Osaka University Graduate School of MedicineSuitaJapan Department of Neurology Osaka General Medical CenterOsakaJapan

Amyotrophic lateral sclerosis(ALS)is a devastating neurological disease characterized by the accumulation of aberrant proteins in motor neurons of the brain and spinal *** with ALS develop skeletal muscle weakness,resulting in death from respiratory paralysis,which usually occurs 2-4 years after clinical onset(Goutman et al.,2022).

关键词： paralysis sclerosis

Visualization study on the coarse graining DEM for large-scale N gas-solid flow systems

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Particuology 2021年第6期19卷 24-33页

作者： Yuki Mori mikio Sakai Department of Nuclear Engineering and Management School of EngineeringThe University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8656Japan Resilience Engineering Research Center School of EngineeringThe University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8656Japan

Gas-solid flows are ubiquitous in industrial *** coupled model of the discrete element method(DEM)and computational fluid dynamics(CFD)is one of the techniques for the simulation of the gas-solid *** enhance the applicability of the DEM-CFD method,the coarse graining DEM has been developed to simulate large-scale powder *** coarse graining DEM is a scaling law model and hence can simulate large-scale systems using a smaller number of particles than the actual *** the coarse graining DEM enables to effectively simulate large-scale powder systems on a single PC,visualized image is lack of reality due to reduced spatial *** a novel visualization method is developed to produce realistic *** the proposed technique,the virtual particles are located by considering the motion and location of the coarse grain *** show the adequacy of the proposed method,two types of visualization based on the computational results are made:a blow-up of powder due to injected gas flow and a spouted *** these systems,the visualized images are shown to be improved by the proposed visualization *** effectiveness of the proposed method is proved by the agreement of the images based on the calculation results between the standard DEM-CFD method and coarse graining DEM.

关键词： DEM-CFD method Coarse graining DEM Computer graphics

Parallel computing of discrete element method on multi-core processors

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Particuology 2011年第4期9卷 398-405页

作者： Yusuke Shigeto mikio Sakai Department of Systems Innovation School of Engineering The University of Tokyo

This paper describes parallel simulation techniques for the discrete element method （DEM） on multi-core processors. Recently, multi-core CPU and GPU processors have attracted much attention in accelerating computer simulations in various fields. We propose a new algorithm for multi-thread parallel computation of DEM, which makes effective use of the available memory and accelerates the computation. This study shows that memory usage is drastically reduced by using this algorithm. To show the practical use of DEM in industry, a large-scale powder system is simulated with a complicated drive unit. We compared the performance of the simulation between the latest GPU and CPU processors with optimized programs for each processor. The results show that the difference in performance is not substantial when using either GPUs or CPUs with a multi-thread parallel algorithm. In addition, DEM algorithm is shown to have high scalabilitv in a multi-thread parallel computation on a CPU.

关键词： Discrete element method Parallel computing Multi-core processor GPGPU

Electro-Oxidation of Concentrated Ce(Ⅲ) at Carbon Felt Anode in Nitric Acid Media

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Journal of Rare Earths 2006年第3期24卷 257-263页

作者： Jelinek Ludek mikio Kumagai Nuclear Chemistry and Chemical Engineering Center Institute of Research and Innovation 1201 Takada Kashiwa 277-0861 Chiba-ken Japan

Electro-oxidation of Ce （ Ⅲ ） to Ce （ Ⅳ ） in parallel plate flow type electrolyzer divided with cation exchange membrane was carried out in nitric acid media at carbon felt anode under galvanostatic conditions. Carbon felt was used as an anode for its high specific surface area and high oxygen evolution overpotential. Pt coated Ti plates were used as cathode and anode current feeder. The oxidation of 1 mol· L^-1 Ce（ Ⅲ ） solution in 2 mol· L^- 1 HNO3 was proceeding with a high current efficiency （92%） until about 80% of Ce（ Ⅲ ） was oxidized. Then, oxygen evolution, accompanied by terminal voltage jump, took place, lowering current efficiency. Ce（ Ⅲ ） was oxidized up to 90% with current efficiency of 62%. In this mode, strong carbon felt anode oxidation was observed. The wear out of carbon felt was 46% in six consequent runs （6 h of operation）. After each run, carbon felt surface had to be renewed with slightly alkaline solution to remove carbon oxidation products and ensure regular operational conditions. When anode surface was blocked, oxygen evolution took place from the beginning of electrolysis due to higher actual current density. The wear out of carbon felt anode could be minimized by means of oxygen evolution prevention. In the case when electrolysis had been stopped before oxygen evolution started （at Ce（ Ⅳ ） conversion of about 80% ）, the wear out of anode was less than 2% during 6 consequent runs （4 h of operation）.

关键词： electrolyzer Ce oxidation carbon felt anode rare earths

Adsorption of Ce(Ⅳ) Anionic Nitrato Complexes onto Anion Exchangers and Its Application for Ce(Ⅳ) Separation from Rare Earths(Ⅲ)

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Journal of Rare Earths 2006年第4期24卷 385-391页

作者： Ludek Jelinek mikio Kumagai Nuclear Chemistry and Chemical Engineering Center Institute of Research and Innovation1201 Takada Kashiwa 277-0861 Chiba-prefecture Japan

Ce （Ⅳ） nitrato complexes were adsorbed on two anion exchangers based on polyvinyl pyridine （PVP） and quatemized PVP incorporated into porous silica matrix. The effect of nitric acid concentration （0.5～6 mol·L^-1） and temperature （278 ～318 K） on Ce（ Ⅳ ） sorption efficiency was investigated. Sorption increased with increasing nitric acid concentration, indicating that [Ce（NO3）6]^2- complex is the main adsorbed Ce（Ⅳ） species. Oxidation of sorbents by adsorbed Ce （ Ⅳ ） species resulting in Ce （ Ⅲ ） release to the solution was observed. Pyridine based anion exchangers exhibited higher oxidation stability compared to the commercial strong base anion exchanger. Ce（ Ⅳ ） reduction was temperature dependent and obeyed pseudo-first-order reaction kinetics. Column separation of Ce （ Ⅳ ） from La （ Ⅲ ） and Y （ Ⅲ ） was carried out from 6 mol·L^-1 nitric acid with PVP based anion exchanger. Reasonable Ce （Ⅳ） breakthrough capacity （0.7 mol·kg^-1 PVP） was achieved. No remarkable decrease of capacity was observed within 3 consequent runs. In contrast, Ce （Ⅲ） leakage due to reduction decreased and breakthrough capacity slightly increased. This effect was more pronounced with increasing temperature. Regeneration with 0.1 mol·L^- 1 nitric acid was successful （recovery 100% ± 4% ） and Ce solution of high purity （〉 99.97% ） with respect to La and Y content was gained.

关键词： ion exchange tetravalent cerium separation rare earths

Prostate-specific antigen-based population screening for prostatecancer： current status in Japan and future perspective in Asia

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Asian Journal of Andrology 2015年第3期17卷 475-480页

作者： Yasuhide Kitagawa mikio Namiki Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science Kanazawa 920-8640 Japan

In Western countries, clinical trials on prostate cancer screening demonstrated a limited benefit for patient survival. In the Asia-Pacific region, including Japan, the rate of prostate-specific antigen （PSA） testing remains very low compared with Western countries, and the benefits of population-based screening remain unclear. This review describes the current status of population screening and diagnosis for prostate cancer in Japan and discusses the efficacy of population screening for the Asian population. Since the 1990s, screening systems have been administered by each municipal government in Japan, and decreases in the prostate cancer mortality rate are expected in some regions where the exposure rate to PSA screening has increased markedly. A population-based screening cohort revealed that the proportion of metastatic disease in cancer detected by screening gradually decreased according to the increased exposure rate, and a decreasing trend in the proportion of cancer with high serum PSA levels after population screening was started. The prognosis of the prostate cancer detected by population screening was demonstrated to be more favorable than those diagnosed outside of the population screening. Recent results in screening cohorts demonstrated the efficacy of PSA. These recent evidences regarding population-based screening in Japan may contribute to establishing the optimal prostate cancer screeninK system in Asian individuals.

关键词： free prostate-specific antigen pro-prostate-specific antigen prostate cancer prostate cancer gene 3 prostate-specificantigen-based population screening serum prostate-specific antigen distribution

On a New Geometric Constant Related to the Modulus of Smoothness of a Banach Space

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Acta Mathematica Sinica,English Series 2014年第9期30卷 1526-1538页

作者： Yasuji TAKAHASHI mikio KATO Department of System Engineering Okayama Prefectural University Department of Mathematics Faculty of EngineeringShinshu University

We shall introduce a new geometric constant A（X） of a Banach space X, which is closely related to the modulus of smoothness px （T）, and investigate it in relation with the constant As （X） by Baronti et al., the von Neumann-Jordan constant CNj（X） and the James constant J（X）. A sequence of recent results on these constants as well as some other geometric constants will be strengthened and improved.

关键词： Constant A(X) von Neumann-Jordan constant James constant modulus of smoothness modulus of convexity uniform non-squareness

Electron Temperature Measurement by Floating Probe Method Using AC Voltage

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Plasma Science and Technology 2016年第11期18卷 1089-1094页

作者： Satoshi NODOMI Shuichi SATO mikio OHUCHI Department of Electrical and Electronic Engineering Tokyo Denki University

This study presents a novel floating probe method to measure electron temperatures using a hollow cathode-type discharge tube. The proposed method detects a shift in the floating potential when an AC voltage is applied to a probe through an intermediary blocking capacitor. The shift in the floating potential is described as a function of the electron temperature and the applied AC voltage. The floating probe method is simpler than the Langmuir probe method because it does not require the measurement of volt-ampere characteristics. As the input AC voltage increases, the electron temperature converges. The electron temperature measured using the floating probe method with an applied sinusoidal voltage shows a value close to the first （tail） electron temperature in the range of the floating potential.

关键词： electrostatic probe Langmuir probe floating potential electron temperature sheath

What is appropriate neoadjuvant/adjuvant androgen deprivation for high-risk/locally advanced prostate cancer？

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Asian Journal of Andrology 2011年第4期13卷 624-625页

作者： mikio Namiki Hiroyuki Konaka Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medica Science Ishikawa 920-8640 Japan

The majority of low-risk patients with clinically localized prostate cancer have a high likeliihood of disease-free survival, regardless of the treatment option chosen.

关键词： Physical sciences Theoretical physics

Updated results from the European Randomized Study of Prostate-Specific Antigen （PSA） Screening for Prostate Cancer： are Asian countries encouraged to promote PSA screening？

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Asian Journal of Andrology 2012年第4期14卷 522-524页

作者： mikio Sugimoto Yoshiyuki Kakehi Department of Urology Kagawa University Faculty of Medicine Kita-gun Kagawa 761-0793 Japan

An updated result of European Randomized Screening Trial for Prostate Cancer encourages Asian countries to proceed prostate-specific antigen （PSA） screening for early detection. On the other hand, the issue of overtreatment is emerging as a serious problem. Active surveillance （AS） should be more prevalent than now to avoid overtreatment for patients with favourablerisk prostate cancer （PCa） detected by PSA test.

关键词： Disease genetics Dyslipidaemias Endocrine system and metabolic diseases Therapeutics