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Effect of intra-abdominal pressure on respiratory function in patients undergoing ventral hernia repair

World Journal of Critical Care Medicine 2013年第2期2卷 9-16页

作者： Konstantin M Gaidukov Elena N Raibuzhis Ayyaz Hussain Alexey y Teterin Alexey A Smetkin Vsevolod V Kuzkov Manu LNG Malbrain mikhail y kirov Department of Anesthesiology and Intensive Care Medicine Northern State Medical University Department of Anesthesiology and Intensive Care Medicine City Hospital #1 of Arkhangelsk Department of General Surgery City Hospital #1 of Arkhangelsk Intensive Care Unit and High Care Burn Unit Ziekenhuis Netwerk Antwerpen ZNA Campus Stuivenberg

AIM: To determine the influence of intra-abdominal pressure(IAP) on respiratory function after surgical repair of ventral hernia and to compare two different methods of IAP measurement during the perioperative period. METHODS: Thirty adult patients after elective repair of ventral hernia were enrolled into this prospective *** monitoring was performed via both a balloontipped nasogastric probe [intragastric pressure(IGP), Ci MON, Pulsion Medical Systems, Munich, Germany] and a urinary catheter [intrabladder pressure(IBP), Uno Meter Abdo-Pressure Kit, Uno Medical, Denmark] on five consecutive stages:(1) after tracheal intubation(AI);(2) after ventral hernia repair;(3) at the end of surgery;(4) during spontaneous breathing trial through the endotracheal tube; and(5) at 1 h after tracheal extubation. The patients were in the complete supine position during all study ***: The IAP(measured via both techniques) increased on average by 12% during surgery compared to AI(P y 43% during spontaneous breathing through the endotracheal tube(P y, reaching a maximum during the spontaneous breathing trial. The PаO2/Fi O2 decreased by 30% one hour after tracheal extubation(P = 0.02). The dynamic compliance of respiratory system reduced intraoperatively by 15%-20%(P ying from-0.19 mm Hg(2SD 7.25 mm Hg) to-1.06 mm Hg(2SD 8.04 mm Hg) depending on the study stage. Taking all paired measurements together(n = 133), the median IGP was 8.0(5.5-11.0) mm Hg and the median IBP was 8.8(5.8-13.1) mm Hg. The overall r2 value( n = 30) was 0.76(P ysis showed an overall bias for the mean values per patient of 0.6 mm Hg(2SD 4.2 mm Hg) with percentage error of 45.6%. Looking at changes in IAP between the different study stages

关键词： Intra-abdominal pressure Gastric pressure Bladder pressure Intra-abdominal hypertension Hernia Oxygenation Respiratory function

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Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage

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Neural Regeneration Research 2025年第9期20卷 2454-2463页

作者： Victoria Jiménez Carretero IrisÁlvarez-Merz Jorge Hernández-Campano Sergei A.kirov Jesús M.Hernández-Guijo Department of Pharmacology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ramón y Cajal Institute for Health Research(IRyCIS) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neuroscience and Regenerative Medicine&Department of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excitatory amino acids glutamate and aspartate in ce rebral ischemia and excitotoxicity is ***,the role of non-excitatory amino acids in brain damage following a stroke or brain trauma remains largely *** release of amino acids by necrotic cells in the ischemic core may contribute to the expansion of the *** findings indicated that the reversible loss of field excitato ry postsynaptic potentials caused by transient hypoxia became irreversible when exposed to a mixture of just four non-excitatory amino acids(L-alanine,glycine,L-glutamine,and L-serine)at their plasma *** amino acids induce swelling in the somas of neurons and astrocytes during hypoxia,along with permanent dendritic damage mediated by N-methyl-D-aspartate *** N-methyl-D-aspartate receptors prevented neuronal damage in the presence of these amino acids during *** is likely that astroglial swelling caused by the accumulation of these amino acids via the alanine-serine-cysteine transporter 2 exchanger and system N transporters activates volume-regulated anion channels,leading to the release of excitotoxins and subsequent neuronal damage through N-methyl-D-aspartate receptor ***,previously unrecognized mechanisms involving non-excitatory amino acids may contribute to the progression and expansion of brain injury in neurological emergencies such as stroke and traumatic brain *** these pathways co uld highlight new therapeutic targets to mitigate brain injury.

关键词： cell swelling N-methyl-D-aspartate receptor non-excitatory amino acids stroke synaptic transmission

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Cortical hem signaling center: functions, development, and potential implications for evolution and brain disorders

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Neural Regeneration Research 2025年第4期20卷 1079-1080页

作者： Victor V.Chizhikov Igor y.Iskusnykh Department of Anatomy and Neurobiology University of Tennessee Health Science CenterMemphisTNUSA

Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical *** such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in *** cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)*** cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;Dal-Valle-Anton and Borrell,2022).

关键词： epithelium Figure center

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Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S y yau Kwok-Fai So Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

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Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

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Predictive modelling of ferroelectric tunnel junctions

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npj Computational Materials 2016年第1期2卷 150-162页

作者： Julian P Velev John D Burton mikhail ye Zhuravlev Evgeny y Tsymbal Department of Physics and Astronomy University of NebraskaLincolnNEUSA Department of Physics and Astronomy University of Puerto RicoSan JuanPuerto RicoUSA Nebraska Center for Materials and Nanoscience University of NebraskaLincolnNEUSA Kurnakov Institute for General and Inorganic Chemistry Russian Academy of SciencesMoscowRussia Faculty of Liberal Arts and Sciences St Petersburg State UniversitySt PetersburgRussia

Ferroelectric tunnel junctions combine the phenomena of quantum-mechanical tunnelling and switchable spontaneous polarisation of a nanometre-thick ferroelectric film into novel device *** the ferroelectric barrier polarisation direction produces a sizable change in resistance of the junction—a phenomenon known as the tunnelling electroresistance *** a fundamental perspective,ferroelectric tunnel junctions and their version with ferromagnetic electrodes,i.e.,multiferroic tunnel junctions,are testbeds for studying the underlying mechanisms of tunnelling electroresistance as well as the interplay between electric and magnetic degrees of freedom and their effect on *** a practical perspective,ferroelectric tunnel junctions hold promise for disruptive device *** a very short time,they have traversed the path from basic model predictions to prototypes for novel non-volatile ferroelectric random access memories with non-destructive *** remarkable progress is to a large extent driven by a productive cycle of predictive modelling and innovative experimental *** this review article,we outline the development of the ferroelectric tunnel junction concept and the role of theoretical modelling in guiding experimental *** discuss a wide range of physical phenomena that control the functional properties of ferroelectric tunnel junctions and summarise the state-of-the-art achievements in the field.

关键词： ferroelectric tunnel resistance

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用y/Ho比值指示俄罗斯乌拉尔南部晶质菱镁矿矿床的成因(英文)

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岩石学报 2004年第4期20卷 803-816页

作者： mikhail T KRUPENIN Institute of Geology and Geochemistry Urals Branch of Russian Academy of Sciences Per. Pochtovy 7 620151 Ekaterinburg Russia

乌拉尔省南部赋存有两种类型的晶质菱镁矿:1)白云岩地层中的层状矿体;2)白云质灰岩中的透镜状矿体。晶质菱镁矿矿体位于Riphean系列中下层的白云岩中,而在上层的白云岩单元中缺失。这两种类型的菱镁矿可通过矿体形态、晶体大小、石英和... 详细信息

乌拉尔省南部赋存有两种类型的晶质菱镁矿:1)白云岩地层中的层状矿体;2)白云质灰岩中的透镜状矿体。晶质菱镁矿矿体位于Riphean系列中下层的白云岩中,而在上层的白云岩单元中缺失。这两种类型的菱镁矿可通过矿体形态、晶体大小、石英和白云石含量不同来进行区分。第一种类型的菱镁矿储量巨大,菱镁矿呈粗粒结构,晶体粒径>10mm(最大达150mm);一般来说,矿体与白云岩围岩界限清楚,这种类型矿床以产在Riphean序列下部为特征。第二种类型的菱镁矿由于菱镁矿矿体穿插进入到白云岩围岩中,矿体很不规则,菱镁矿晶体也相对较小(1-5mm),这种类型的矿体主要产在Riphean中部层位中。这两种矿体都显示了交代成因的特征。但这两种菱镁矿矿石在一些主量元素和稀土元素的分布上具有不同的特征:与第二种类型相比,第一种菱镁矿具有较低的FeO,CaO和SiO2含量,与白云岩围岩(La／Lu>1)相比,具La／Luy／Ho值的重要性,因为该比值在菱镁矿和围岩中的类似性使得划分菱镁矿形成中的热液和成岩交代过程成为可能。因此我们认为,第一种类型菱镁矿,如具有高y／Ho比值的Satka和Bakal矿床的形成属于沉积盆地发育过程中的早期成岩阶段;

关键词： Riphean地层前寒武纪晶质菱镁矿交代流体 REE 乌拉尔南部

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A Laboratory Investigation into the Fuel Atomization Process in a Diesel Engine for Different Configurations of the Injector Nozzles and Flow Conditions

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Fluid Dynamics & Materials Processing 2020年第4期16卷 747-760页

作者： mikhail G.Shatrov Valery I.Malchuk Andrey y.Dunin Ishlinsky Institute for Problems in Mechanics RAS Moscow119526Russia Moscow Automobile and Road Construction State Technical University(MADI) Moscow125319Russia

This paper reports a laboratory investigation of the fuel injection process in a diesel *** atomization process of the considered fuel(a hydrocarbon liquid)and the ensuing mixing with air is studied experimentally under high-pressure *** types of injector nozzles are examined,including(two)new configurations,which are compared in terms of performances to a standard injector manufactured by the Bosch *** the two alternate configurations,the intake edges of one atomizing hole(hole No.1)are located in the sack volume while for the other(hole No.2)they are located on the locking cone of the needle *** injection process,the fuel atomization fineness and fuel supply speed characteristics are studied as functions of high-pressure fuel pump camshaft speed and rotation *** results obtained show that a decrease in the high-pressure fuel pump camshaft speed can produce fuel redistribution depending on the injector *** general,however,the hole No.1 can ensure fuel flow with higher speed with respect to the hole No.2 for all the operation modes of the *** on such an analysis,we conclude that the use of certain injectors can enable a fine tuning of the propagation process of fuel sprays into various areas of the diesel engine combustion chamber.

关键词： Injection atomization injector nozzle channel injection characteristic flow coefficient

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Plastic deformation behavior of Mg97Zn1y2 extruded alloys

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Transactions of Nonferrous Metals Society of China 2010年第7期20卷 1259-1268页

作者： K.HAGIHARA A.KINOSHITA y.SUGINO M.yAMASAKI y.KAWAMURA H.y.yASUDA y.UMAKOSHI Division of Materials and Manufacturing Science Graduate School of EngineeringOsaka University2-1Yamada-okaSuitaOsaka 565-0871Japan Department of Materials Science Kumamoto University2-39-1KurokamiKumamoto 860-8555Japan National Institute for Materials Science 1-2-1SengenTsukubaIbaraki 305-0047Japan

The mechanical properties of the Mg97Znly2 extruded alloy containing the long-period stacking ordered phase, the so-called LPSO-phase, with a volume fraction of 24%-25%, were examined by compression tests and cyclic tension-compression deformation tests. The plastic behavior of the extruded alloys with compositions of Mg99.2Zn0.2y0.6 and Mg89Zn4y7 （molar fraction, %）, which were almost the same compositions of Mg matrix phase and LPSO phase in Mg97Zn1y2 Mg/LPSO two-phase alloy, respectively, were also prepared. By comparing their mechanical properties, the strengthening mechanisms operating in the Mg97Zn1 y2 extruded alloy were discussed. Existence of the LPSO-phase strongly enhanced the refinement of Mg matrix grain size during extrusion, which led to a large increment of the strength of alloy. In addition, the LPSO-phases, which were aligned along the extrusion direction in Mg97Zn1y2 extruded alloy, acted as hardening phases, just like reinforced fibers.

关键词： plastic deformation yield stress LPSO-phase dislocation twinning

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GNSS-based BiSAR imaging using modified range migration algorithm

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Science China(Information Sciences) 2015年第8期58卷 144-156页

作者： ZENG Tao LIU FeiFeng ANTONIOU Michail CHERNIAKOV mikhail Beijing Key Laboratory of Embedded Real-time Information Processing Technology Beijing Institute of Technology School of Electronic Electrical and Systems Engineering University of Birmingham

This paper proposed a new focusing approach for the bistatic SAR systems with a GNSS(Global Navigation Satellite System) satellite as the transmitter. Because of the long integration time the inherited curvature of the transmitter’s trajectory was adopted and the spatial variance of the equivalent velocity was derived under the principal of equivalent slant range model in the system signal model. The proposed focusing approach consists of two-step processing. Firstly, the general Doppler phase from constant velocity of the echo data is focused by modified Stolt mapping. Secondly, the residual nonlinear Doppler phase due to velocity variation is compensated by means of block-processing-based adaptive phase compensation to achieve large scene focusing. The simulation and experimental results validate the proposed algorithm in GNSS-based Bi SAR systems.

关键词： GNSS-based Bi SAR equivalent slant range model curvature of trajectory two-step processing modified Stolt mapping

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