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calcium handling:a strategy to fight neurodegeneration in Alzheimer's disease

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Neural Regeneration Research 2023年第12期18卷 2685-2686页

作者： Livia la Barbera Elena Spoleti Marcello D’Amelio Department of Sciences and Technologies for Humans and Environment UniversitàCampus Bio-Medico di RomaRomeItaly Department of Experimental Neurosciences IRCCS Santa Lucia FoundationRomeItaly Department of Medicine and Surgery UniversitàCampus Bio-Medico di RomaRomeItaly

In the last few years,preclinical and clinical studies identified the ventral tegmental area(VTA)as one of the first brain regions to be affected in the prodromal phase of Alzheimer's disease(AD).The VTA is a deep midbrain nucleus rich in dopaminergic neurons that innervates and releases dopamine(DA)in several cortical and subcortical brain *** plays a crucial role in the modulation of both cognitive and noncognitive functions and failure of its release underlies both cognitive and neuropsychiatric symptoms in patients with AD.

关键词： Alzheimer clinical release

Neural network control for earthquake structural vibration reduction using MRD

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Frontiers of Structural and Civil Engineering 2019年第5期13卷 1171-1182页

作者： Khaled ZIZOUNI Ley la FALI Younes SADEK Ismail Khalil BOUSSERHANE ArcihPEL laboratory University TAHRI MohammedBecharPB 417Algeria FIMAS laboratory University TAHRJ MohammedBecharPB 417Algeria laboratory of Smart-Grid and Renewable Energies University TAHRI MohammedBecharPB 417Algeria

Structural safety of building particularly that are intended for exposure to strong earthquake loads are designed and equipped with high technologies of control to ensure as possible as its protection against this brutal load. One of these technologies used in the protection of structures is the semi-active control using a Magneto Rheological Damper device. But this device need an adequate controller with a robust algorithm of current or tension adjustment to operate which is further discussed in the following of this paper. In this study, a neural network controller is proposed to control the MR damper to eliminate vibrations of 3-story scaled structure exposed to Tohoku 2011 and Boumerdes 2003 earthquakes. The proposed controller is derived from a linear quadratic controller designed to control an MR damper installed in the first floor of the structure. Equipped with a feedback law the proposed control is coupled to a clipped optimal algorithm to adapt the current tension required to the MR damper adjustment. To evaluate the performance control of the proposed design controller, two numerical simulations of the controlled structure and uncontrolled structure are illustrated and compared.

关键词： MR damper semi-active control earthquake vibration neural network linear quadratic control

POLYMERIZATION AND CHARACTERIZATION OF HIGH CONDUCTIVITY AND GOOD ADHENSION POLYPYRROLE FILMS FOR ELECTROMAGNETIC INTERFERENCE SHIELDING

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Chinese Journal of Polymer Science 2010年第6期28卷 923-930页

作者： Yong-sheng Qiao la-zhen Shen Tao Dou Ming Hu Institute of Special Chemicals Taiyuan University of Technology Taiyuan 030024 China School of Chemistry and Chemical Engineering Shanxi Datong University Datong 037009 China School of Electronic Information Engineering Tianjin University Tianjin 300072 China

Polypyrrole（PPy） shows a favorable application in the electromagnetic interference（EMI） shielding due to its good electrical conductivity and outstanding air *** PPy films with high conductivity and good adhesion were successfully polymerized on the surface of insulating epoxy resin substrates using chemical *** factors affecting the properties of PPy films,such as the surface morphology,adhesion between PPy film and substrate,electrical conductivity,EMI shielding effectiveness（SE）,were *** adhesion was improved significantly through a three-step surface pretreatment of epoxy resin substrates including removing impurities,roughening,and surface modification with silane coupling *** enhancement in the conductivity of PPy films of about one order of magnitude was achieved by adding dopant in FeCl_3 *** higher the conductivity,the better the shielding *** sodium p-toluenesulfonate doped PPy film as example,EMI SE was in the practically useful range of about 30 dB over a wide frequency range from 30 MHz to 1500 *** PPy film samples were characterized by scanning electron microscopy （SEM）,infrared spectra（IR）,X-ray photoelectron spectroscopy（XPS） and the flange coaxial transmission *** fourpoint probe method was used to measure conductivity of PPy films.

关键词： Polypyrrole film EMI Conductivity Adhesion

Predicting Polymerase Ⅱ Core Promoters by Cooperating Transcription Factor Binding Sites in Eukaryotic Genes

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Acta Biochimica et Biophysica Sinica 2004年第4期36卷 250-258页

作者： Xiao-Tu MA, Min-Ping QIAN*, and Hai-Xu TANG1 School of Mathematical Sciences, Peking University and Center for Theoretical Biology, Peking University, Beijing 100871, China 1Department of Computer Science and Engineering, University of california, San Diego, la Jolla ca 92093-0114, USA School of Mathematical Sciences Peking University and Center for Theoretical Biology Peking UniversityBeijing 100871 China Department of Computer Science and Engineering University of CaliforniaSan Diego La Jolla CA 92093-0114 USA

Several discriminate functions for predicting core promoters that based on the potential cooperation between transcription factor binding sites (TFBSs) are discussed. It is demonstrated that the promoter predicting accuracy is improved when the cooperation among TFBSs is taken into consideration. The core promoter region of a newly discovered gene CKLFSF1 is predicted to locate more than 1.5 kb far away from the 5' end of the transcript and in the last intron of its upstream gene, which is experimentally confirmed later. The core promoters of 3402 human RefSeq sequences, obtained by extending the mRNAs in human genome sequences, are predicted by our algorithm, and there are about 60% of the predicted core promoters locating within the ± 500 bp region relative to the annotated transcription start site.

关键词： promoter transcription factor binding site transcription start site gene finding

Enzymatically prepared alginate oligosaccharides improve broiler chicken growth performance by modulating the gut microbiota and growth hormone signals

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Journal of Animal Science and Biotechnology 2023年第5期14卷 2107-2127页

作者： A la Teng Zhu la Yuqing Feng Die Hu Yimei Feng Xiaolu Jin Dan Liu Yuming Guo Gong Cheng Yongfei Hu State Key laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China State Key laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China

Background Alginate oligosaccharide(AOS)holds great potential as a novel feed supplement in farm ***,the effects of AOS on chicken health and the underlying mechanisms are not fully *** study aimed to optimize the enzymatic preparation of AOS by using bacterial alginate lyases expressed in yeast,investigate the effects of the prepared AOS on the growth performance and gut health of broiler chickens,and reveal the underlying *** Five alginate lyases from bacteria were cloned into Pichia pastoris GS115 and the alginate lyase PDE9 was expressed at relatively high yield,activity and stability in *** trials were carried out using 3201-day-old male Arbor Acres broilers(four groups;8 replicates/group×10 chicks/replicate)receiving either a basal diet or the same diet supplemented with 100,200 and 400 mg/kg PDE9-prepared AOS for 42 *** results showed that dietary supplementation of 200 mg/kg AOS displayed the highest activity in promoting the birds’ADG and ADFI(Pcated by the enhanced(Pcantly higher than the control birds(Pcated that AOS modulated the chicken gut microbiota structure,function,and microbial interactions and promoted the growth of SCFAs-producing bacteria,for example,Dorea sp.002160985;SCFAs,especially acetate,were found positively correlated with the chicken growth performance and growth-related hormone signals(Pcan be utilized by Dorea *** grow and to produce acetate in *** We demonstrated that the enzymatically

关键词： Acetate Alginate lyases Alginate oligosaccharides Dorea sp. Gut microbiota

Treatment of intractable orbital implant exposure with a large conjunctival defect by secondary insertion of the implant after preceding dermis fat graft

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International Journal of Ophthalmology(English edition) 2013年第2期6卷 193-197页

作者： Hyun Kyung Kim Tae Yoon la Department of Ophthalmology St. Vincent's Hospital College of Medicine The Catholic University of Korea

AIM: To report a procedure and results of a two-stage operation to manage intractable extensive orbital implant exposure with a large conjunctival defect which was difficult to treat with dermis fat grafts due to repeated graft necrosis. METHODS: A retrospective chart review of four patients who had extensive orbital implant exposures with large conjunctival defects and had past histories of repeated autologous or preserved dermis graft failures was done. As a first-stage operation, the problematic pre-existing orbital implants were removed and autologous dermis fat grafts alone were performed on the defect area. Four months later, new orbital implants were secondarily inserted after confirmation of graft survival. The size of the conjunctival defects and state of the extraocular muscles were checked preoperatively. Success of the operations and complications were ***: The mean size of the conjuctival defects was 17.3mm×16.0mm, and the mean time from the initial diagnosis of orbital implant exposure to implant removal and autologous dermis fat graft was 20.8 months. After implant removal and autologous dermis fat graft, no graft necrosis was observed in any patients. Also, implant exposure or fornix shortening was not observed in any patients after new orbital implant insertion. CONCLUSION: The secondary insertion of a new orbital implant after pre-existing implant removal and preceding dermis fat graft is thought to be an another selective management of intractable orbital implant exposure in which dermis fat grafts persistently fail.

关键词： conjunctival defect dermis fat graft orbital implant exposure

Improved Angina Symptoms Following Coronary Sinus Flow Reducer Implantation in a Patient with Refractory Angina and Chronic Total Occlusion: A case Report

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International Journal of Clinical Medicine 2019年第11期10卷 604-612页

作者： Crt langel Mrak miha Nejc Pavsic Matjaz Bunc Clinical Institute of Radiology University Medical Center Ljubljana Zaloska Ljubljana Slovenia Clinical Department of cardiology University Medical Center Ljubljana Zaloska Ljubljana Slovenia

Background: Due to the aging population and increased survival of the patients with coronary artery disease, there is an increasing number of patients with debilitating angina refractory to optimal medical treatment who are not candidates for revascularization. In case of low ischemic load, the treatment of stable refractory angina is aimed at symptom reduction. There are several new treatment methods targeting myocardial ischemia available, including coronary sinus flow reducer (CFR) implantation. case Report: We report a case of a patient suffering from CCS class IV angina despite optimal medical therapy, with further revascualrization options exhausted, who was successfully treated with coronary sinus flow reducer (CFR). Besides technical skill to reach ostium of coronary sinus, the most important technical tip is precise positioning of the CFR. The reduction of angina symptoms started after epithelisation of CFR frame, usually 6 - 7 weeks after implantation. At 6-month follow-up, the patient reported a marked reduction of angina symptoms, with CCS grade improving by three classes (from IV to I). At 10-month follow-up, the sustainment of CCS grade I angina symptoms was reported by the patient. Conclusions: We conclude that CFR can be safely and successfully implanted in patients suffering from refractory angina. Considerable improvements in CCS grade may be experienced in certain cases.

关键词： Chest Pain Refractory Angina Pectoris Myocardial Ischemia Coronary Sinus Flow Reducer Chronic Total Occlusion

Towards unfolding the prion misfolding mystery: Protein free radical chemistry in transmissible spongiform encephalopathies

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Nuclear Science and Techniques 2003年第3期14卷 199-205页

作者： YANG Chi-Ming( Neurochemlstry Group, College of Chemistry, Nankai University, Tianjin 300071 Institute for Life Sciences & Health, la Jolla (San Diego), ca 92039-2035, USA) Neurochemistry Group College of Chemistry Nankai University 天津 300071

Owing to the high oxygen-respiration in the brain of mammals, oxidative damage to prion protein hasbeen suggested to be an additional factor. A large body of intriguing features of scrapie and prion diseases haveprovided multiple lines of indirect chemistry evidence, suggesting that the infectious agents may be putative forms ofsequence-specific prion radicals (SSPR) and/or their immediate precursors in the transmissible spongiform encepha-lopathies (TSE). Here a molecular mechanism corresponding to the self-replication of scrapie protein mediated byprion free-radical processes, consonant with "protein-only" hypotheses is proposed. This new theory may not onlyaid our understanding of the occurrence of prions, but also provides new insight into the possible chemistry principlesunderlying the neurodegenerative disorders. It is anticipated that future studies based on this suggestion and chem-istry principles of genetic diseases may allow us to determine an effective approach to stop mad cow disease and itshuman version, new variant of Creutzfeldt-Jakob disease (v CJD).

关键词：蛋白感染素蛋白质海绵状脑病遗传性疾病克劳伊氏病

First Total Synthesis of Optically Active Oplopandiol Acetate, a Potent Antimycobacterial Polyyne Isolated from Oplopanax horridus

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Chinese Chemical Letters 2000年第3期11卷 213-216页

作者： Xu, la Wu, XH Zheng, GR cai, JC Chinese Acad Sci Shanghai Inst Mat Med Shanghai 200031 Peoples R China

The first stereoselective total synthesis of oplopandiol acetate 1, a potent antimycobacterial polyyne isolated from Oplopanax horridus, is presented. And its absolute configuration is confirmed to be (11S,16S).

关键词： total synthesis oplopandiol acetate