Calcium handling:a strategy to fight neurodegeneration in Alzheimer's disease

作     者：Livia La Barbera Elena Spoleti Marcello D’Amelio Livia La Barbera;Elena Spoleti;Marcello D'Amelio

作者机构：Department of Sciences and Technologies for Humans and EnvironmentUniversitàCampus Bio-Medico di RomaRomeItaly Department of Experimental NeurosciencesIRCCS Santa Lucia FoundationRomeItaly Department of Medicine and SurgeryUniversitàCampus Bio-Medico di RomaRomeItaly 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2023年第18卷第12期

页      面：2685-2686页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100203[医学-老年医学] 10[医学] 

基　　金：an under-40grant from the ltalian Association for Alzheimer's Research[AIRALTZH-AGYR2021] by the Strategic University Projects-Young Researcher Independence[YRG2021]from the University Campus Bio-Medico(Rome,Italy)(to LLB) a PhD fellowship by Fondazione Melchiorri(IT)and by the Strategic University Projects-Young Researcher Independence[YRG2021]from the University Campus Bio-Medico(Rome,Italy)(to ES) the American Alzheimer's Association[AARG-18-566270 AARG-21-851219] by the Italian Ministry of Health[Research Grant:RF-2018-12365527] by Fondazione Roma(Rome,Italy)(to MDA) 

主　　题：Alzheimer clinical release 

摘      要：In the last few years,preclinical and clinical studies identified the ventral tegmental area(VTA)as one of the first brain regions to be affected in the prodromal phase of Alzheimer s disease(AD).The VTA is a deep midbrain nucleus rich in dopaminergic neurons that innervates and releases dopamine(DA)in several cortical and subcortical brain *** plays a crucial role in the modulation of both cognitive and noncognitive functions and failure of its release underlies both cognitive and neuropsychiatric symptoms in patients with AD.