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International consensus guidelines on robotic pancreatic surgery in 2023

Hepatobiliary Surgery and Nutrition 2024年第1期13卷 89-104页

作者： Rong Liu Mohammed Abu Hilal Marc G.Besselink Thilo Hackert Chinnusamy Palanivelu Yupei Zhao Jin He Ugo Boggi Jin-Young Jang Fabrizio Panaro Brian K.P.Goh Mikhail Efanov Yuichi Nagakawa Hong-Jin Kim Xiaoyu Yin Zhiming Zhao Yi-Ming Shyr Shridhar Iyer Eli Kakiashvili Ho-Seong Han Jae Hoon Lee Roland Croner Marco Vito marino Arun Prasad Wei Wang Songqing He Kehu Yang Qu Liu Zizheng Wang Mengyang Li Shuai Xu Kongyuan Wei Zhaoda Deng Yuze Jia Tess M.E.van Ramshorst Faculty of Hepatopancreatobiliary Surgery The First Medical Center of Chinese People’s Liberation Army(PLA)General HospitalBeijingChina Department of Surgery Poliambulanza Foundation HospitalBresciaItaly Department of Surgery University Hospital Southampton NHS Foundation TrustSouthamptonUK Amsterdam UMC location University of AmsterdamDepartment of SurgeryAmsterdamThe Netherlands Cancer Center Amsterdam AmsterdamThe Netherlands Department of General Visceral and Thoracic SurgeryUniversity Hospital Hamburg-EppendorfHamburgGermany Department of Minimal Invasive Hernia Surgery GEM Hospital and Research CentreChennaiTamil NaduIndia Department of General Surgery Peking Union Medical College Hospital BeijingBeijingChina Department of Surgery Johns Hopkins University School of MedicineBaltimoreMDUSA Division of General and Transplant Surgery University of PisaPisaItaly Department of Surgery Seoul National University HospitalSeoul National University College of MedicineSeoulKorea Department of Surgery/Division of HBP Surgery&Transplantation University of MontpellierMontpellierFrance Department of Hepatopancreatobiliary and Transplant Surgery Singapore General Hospital and National Cancer Centre SingaporeSingaporeSingapore Department of Hepato-Pancreato-Biliary Surgery Moscow Clinical Scientific CenterMoscowRussia Department of Gastrointestinal and Pediatric Surgery Tokyo Medical UniversityShinjukuTokyoJapan Department of Surgery Yeungnam University College of MedicineDaeguKorea Department of Pancreato-Biliary Surgery The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina 18 Division of Hepatobiliary Pancreatic Surgery and Liver TransplantationNational University HospitalSingaporeSingapore Department of Surgery Galilee Medical CenterNahariyaIsrael Department of Surgery Seoul National University Bundang HospitalSeoul National University College of MedicineSeongnam-siKorea Division of Hepato-Biliary and Pancreatic Surgery Department of SurgeryAsan Medical Cente

Background:With the rapid development of robotic surgery,especially for the abdominal surgery,robotic pancreatic surgery(RPS)has been applied increasingly around the ***,evidence-based guidelines regarding its application,safety,and efficacy are still *** harvest robust evidence and comprehensive clinical practice,this study aims to develop international guidelines on the use of ***:World Health Organization(WHO)Handbook for Guideline Development,GRADE Grid method,Delphi vote,and the AGREE-II instrument were used to establish the Guideline Steering Group,Guideline Development Group,and Guideline Secretary Group,formulate 19 clinical questions,develop the recommendations,and draft the *** online meetings were held on 04/12/2020,30/11/2021,and 25/01/2022 to vote on the recommendations and get advice and suggestions from all involved *** the experts focusing on minimally invasive surgery from America,Europe and Oceania made great contributions to this consensus ***:After a systematic literature review 176 studies were included,19 questions were addressed and 14 recommendations were developed through the expert assessment and comprehensive judgment of the quality and credibility of the ***:The international RPS guidelines can guide current practice for surgeons,patients,medical societies,hospital administrators,and related social *** randomized trials are required to determine the added value of RPS as compared to open and laparoscopic surgery.

关键词： Robotic surgery guidelines pancreatectomy pancreaticoduodenectomy distal pancreatectomy(DP)

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Eye reflux:an ocular extraesophageal manifestation of gastric reflux

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International Journal of Ophthalmology(English edition) 2018年第9期11卷 1503-1507页

作者： Danilo Mazzacane Valerio Damiani Michela Silvestri Giorgio Ciprandi Pierfranco marino Asst Pavia and Asst Melegnano and Martesana Pavia 27100Italy DMG Medical Department Pomezia 00071Italy Istituto Giannina Gaslini Genoa 16147Italy Ospedale Policlinico San Martino Genoa 16132Italy Dipartimento di Scienze della Salute Universita del MoliseCampobasso 86100Italy

AIM： To suspect laryngopharyngeal reflux（LPR） in patients with ocular surface disease（OSD）. METHODS： The present study evaluated a group of subjects with OSD assessing the Ocular Surface Disease Index（OSDI） and the Reflux Symptom Index（RSI） to detect patients with suspected LPR and define a possible relationship between ***： Two hundred and ninety subjects（175 females, mean age： 60.41±15.68y） were consecutively visited at ophthalmologist offices. One hundred and one（34%） patients had pathological RSI（〉13） and consequently a suspected ***： The current study shows that suspected LPR may be common（34%） in patients with OSD and a suspected LPR may be considered in OSD patients when RSI score is 〉13 and OSDI score is 〉42.

关键词： gastric reflux eye reflux ocular surface disease index reflux symptom score

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Potential protective role of ACE-inhibitors and AT1 receptor blockers against levodopa-induced dyskinesias:a retrospective case-control study

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Neural Regeneration Research 2021年第12期16卷 2475-2478页

作者： Elena Contaldi Luca Magistrelli Anna VMilner Marco Cosentino Franca marino Cristoforo Comi Movement Disorders Centre Neurology UnitDepartment of Translational MedicineUniversity of Piemonte OrientaleNovaraItaly PhD Program in Medical Sciences and Biotechnology University of Piemonte OrientaleNovaraItaly PhD Program in Clinical and Experimental Medicine and Medical Humanities University of InsubriaVareseItaly Center of Research in Medical Pharmacology University of InsubriaVareseItaly Center for Research in Neuroscience University of InsubriaVareseItaly

Growing evidence has highlighted that angiotensin-converting enzyme(ACE)-inhibitors(ACEi)/AT1 receptor blockers(ARBs)may influence the complex interplay between dopamine and the renin-angiotensin system in the nigrostriatal pathway,thus affecting the development of levodopa-induced dyskinesia in Parkinson’s disease(PD).In the present study,we analyzed whether the use of this class of medication was associated with a reduced occurrence of levodopa-induced dyskinesia,using electronically-stored information of idiopathic PD patients enrolled at Novara University Hospital“Maggiore della Carità”.We conducted a retrospective case-control study identifying PD patients with dyskinesias(PwD;n=47)as *** each PwD we selected a non-dyskinetic control(NoD),nearly perfectly matched according to sex,Unified Parkinson’s Disease Rating Scale(UPDRS)part III score,and duration of antiparkinsonian *** logistic regression was used to evaluate whether dyskinesias were associated with ACEi/ARBs ***-four PD patients were included,aged 72.18±9 years,with an average disease duration of 10.20±4.8 years and 9.04±4.9 years of antiparkinsonian *** mean UPDRS part III score was 18.87±7.6 and the median HY stage was *** the NoD group,25(53.2%)were users and 22(46.8%)non-users of ACEi/***,in the PwD group,11(23.4%)were users and 36 non-users(76.6%)of this drug class(Pearson chi-square=8.824,P=0.003).Concerning general medication,there were no other statistically significant differences between *** controlling for tremor dominant phenotype,levodopa equivalent daily dose,HY 3-4,and disease duration,ACEi/ARBs use was a significant predictor of a lower occurrence of dyskinesia(OR=0.226,95%CI:0.080-0.636,P=0.005).Therefore,our study suggests that ACEi/ARBs may reduce levodopa-induced dyskinesia occurrence and,thanks to good tolerability and easy management,represent a feasible choice when dealing with the treatment of hypertension in PD patients.

关键词： angiotensin-converting enzyme inhibitors AT1 receptor blockers dyskinesias hypertension levodopa motor complications neuroinflammation Parkinson’s disease renin-angiotensin system

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Effects of vertical position on trematode parasitism in larval anurans

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Current Zoology 2019年第6期65卷 657-664页

作者： Jacob R.JONES Camille L.STEENROD John A.marino Jr. Biology Department Bradley UniversityPeoriaILUSA Department of Geography University of MarylandCollege ParkMDUSA

Spatial distributions of animals can affect interactions with their natural enemies,such as parasites,and thus have important implications for host-parasite *** spatial variation in infection risk has been explored in many systems at the landscape scale,less attention has been paid to spatial structure at smaller ***,we explore a hypothesized relationship between a common spatial variable,vertical position,and risk of parasite infection in a model aquatic system,larval frogs(Rana)and trematode(Digenea)*** position is relevant to this system given evidence that the densities of snail first intermediate hosts,tadpole second intermediate hosts,and trematode infective stages can vary with *** test the effects of depth on infection risk of larval frogs by trematodes,we performed two enclosure experiments,one in the laboratory and one in the field,in which larval frogs in cages just below the water surface or near the bottom of the water column were exposed to *** with near-surface cages,mean infection load(number of cysts)in tadpoles in near-bottom cages was 83%higher after 48-h exposures in the laboratory and 730%higher after 10-day exposures in the *** findings thus indicate that infection risk depends on depth,which may have adaptive significance,as tadpoles have previously been shown to change vertical position in response to parasite *** results motivate future work examining vertical variation in infection risk and may have broader implications for host-parasite dynamics and evolution of host and parasite behavior.

关键词： avoidance behavior cercariae Echinostomatidae host-parasite interactions Rana spatial structure

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Scatterhoarding rodents favor higher predation risks for cache sites:The potential for predators to influence the seed dispersal process

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Integrative Zoology 2015年第3期10卷 257-266页

作者： Michael A.STEELE Ghislain ROMPRÉ Jeffrey A.STRATFORD Hongmao ZHANG Matthew SUCHOCKI Shealyn marino Department of Biology Wilkes UniversityWilkes-BarrePAUSA The Scotts Company MarysvilleOHUSA School of Life Science Central China Normal UniversityWuhanChina

Scatterhoarding rodents often place caches in the open where pilferage rates are reduced,suggesting that they tradeoff higher risks of predation for more secure cache *** tested this hypothesis in two study systems by measuring predation risks inferred from measures of giving-up densities(GUDs)at known cache sites and other sites for *** GUDs were measured with small trays containing 3 L of fine sand mixed with sunflower *** the first experiment,we relied on a 2-year seed dispersal study in a natural forest to identify caches of eastern gray squirrels(Sciurus carolinensis)and then measured GUDs at:(i)these caches;(ii)comparable points along logs and rocks where rodent activity was assumed highest;and(iii)a set of random *** found that GUDs and,presumably,predation risks,were higher at both cache and random points than those with *** the second site,we measured GUDs of eastern gray squirrels in an open park system and found that GUDs were consistently lowest at the base of the tree compared to more open sites,where previous studies show caching by squirrels to be highest and pilferage rates by naïve competitors to be *** results confirm that predation risks can influence scatterhoarding decisions but that they are also highly context dependent,and that the landscape of fear,now so well documented in the literature,could potentially shape the temporal and spatial patterns of seedling establishment and forest regeneration in systems where scatterhoarding is common.

关键词： giving-up densities predation risk scatterhoarding Sciurus seed dispersal

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A comparison between chemical and gas hypoxia as models of global ischemia in zebrafish (Danio rerio)

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Animal Models and Experimental Medicine 2020年第3期3卷 256-263页

作者： Kaitlyn M.marino Emani R.Silva James A.Windelborn Department of Biology Washington CollegeChestertownMDUSA Department of Psychology Washington CollegeChestertownMDUSA

Background:Zebrafish models for neurovascular diseases offer new methods for elucidation of molecular pathways to tissue *** fertilization and high fecundity provide opportunities for transgenics and other forms of genetic manipulation that are more accessible than offered by mammalian models of ***,behavioral analyses of zebrafish allow for connection of molecular pathways to organismal outputs such as locomotion,learning,and ***,a zebrafish model of hypoxia-ischemia has been slow to catch on,possibly due to hypoxia exposure protocols that are challenging to reproduce and result in high ***:In this study,we have introduced a predictable and simple method of hypoxia induction,the addition of sodium sulfite to aquarium *** effects of this treatment on zebrafish locomotion were compared to those of zebrafish exposed to hypoxia induced by nitrogen gas bubbling,a method used in previous ***:We found that hypoxia induced by sodium sulfite significantly impaired locomotion in the hours following treatment,and its effects did not differ from those caused by nitrogen gas ***:These results indicate that hypoxia by sodium sulfite represents an effective and easily reproducible method for the study of hypoxia-ischemia in zebrafish.

关键词： hypoxia hypoxic-ischemia ischemia

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Recent advances concerning polyurethane in leather applications:an overview of conventional and greener solutions

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Collagen and Leather 2023年第1期5卷 1-15页

作者： Jize Liu Federica Recupido Giuseppe Cesare Lama Maria Oliviero Letizia Verdolotti marino Lavorgna Institute for Polymers Composites and Biomaterials(IPCB-CNR)Piazzale Enrico Fermi 180055 Portici(Naples)Italy

Leather is one of the most popular products across globe and holds a significant place in the economy,while the pollution,associated to traditional leather industry,is far away on the"green chemistry"*** this sense,polyurethanes,which exhibit tunable chemical structures by selecting suitable precursors,can fit specific requirements,and the developments of green strategies make them important candidates for leather *** mini review briefly outlines the recent development of conventional(petrol-based)and sustainable polyurethanes in the leather industry,including their design and properties,in applications such as synthetic leather and surface-finishing(coatings/binders).Finally,outlooks of the future tendency,including more environmental-friendly strategies,bio-sourced/recycled materials and development of high-value multifunctional leather materials,are also here proposed.

关键词： Conventional leather Artificial leather polyurethane-synthetic leather polyurethane-based binders polyurethane-based-materials Polyurethane-based-coatings

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Natural Products Diversity of Marine Ascidians(Tunicates;Ascidiacea)and Successful Drugs in Clinical Development

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Natural Products and Bioprospecting 2017年第1期7卷 1-111页

作者： Satheesh Kumar Palanisamy N.M.Rajendran Angela marino Department of Chemical BiologicalPharmaceutical and Environmental ScienceUniversity of Messina98166 MessinaItaly Key Laboratory of Engineering Plastics and Beijing National Laboratory for Molecular Sciences Institute of ChemistryChinese Academy of SciencesBeijing 100190China

This present study reviewed the chemical diversity of marine ascidians and their pharmacological applications,challenges and recent developments in marine drug discovery reported during 1994–2014,highlighting the structural activity of compounds produced by these *** date only 5%of living ascidian species were studied from\3000 species,this study represented from family didemnidae(32%),polyclinidae(22%),styelidae and polycitoridae(11–12%)exhibiting the highest number of promising *** to 580 compound structures are here discussed in terms of their occurrence,structural type and reported biological ***-cancer drugs are the main area of interest in the screening of MNPs from ascidians(64%),followed by anti-malarial(6%)and remaining *** approved ascidian compounds mechanism of action along with other compounds status of clinical trials(phase 1 to phase 3)are discussed here *** review highlights recent developments in the area of natural products chemistry and biotechnological approaches are emphasized.

关键词： Cancer Cytotoxicity Diversity Metabolites Pharmacology

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Indian time:time,seasonality,and culture in Traditional Ecological Knowledge of climate change

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Ecological Processes 2018年第1期7卷 274-284页

作者： Samantha Chisholm Hatfield Elizabeth marino Kyle Powys Whyte Kathie D.Dello Philip W.Mote Oregon Climate Change Research Institute Oregon State University104 CEOAS Admin BuildingCorvallisOR 97331USA Department of Social Sciences Oregon State University Cascades Campus2600 NW College WayBendOR 97701USA Department of Philosophy Michigan State University503 S.Kedzie HallEast LansingMI 48824-1032USA Department of Community Sustainability Michigan State University503 S.Kedzie HallEast LansingMI 48824-1032USA

Introduction:Western climate science and Traditional Ecological Knowledge(TEK)represent complementary and overlapping views of the causes and consequences of *** particular,observations of changes in abundance,distribution,phenology,or behavior of the natural environment(including plants and animals)can have a rich cultural and spiritual interpretation in Indigenous communities that may not be present in western science ***:Using interviews with Indigenous elders and other Traditional Knowledge holders,we demonstrate that assumptions about the nature,perception,and utilization of time and timing can differ across knowledge systems in regard to climate ***:Our interviewees’focus on relationality predisposes them to notice interactional changes among humans and other species,to be sensitive to smaller scale examples of change,to be more likely to see climate change as part of a broader time scale,and to link changes to a greater suite of socio-political phenomena,including the long arc of *** implication of this research and the interactions among humans and other species is that policies restricting Native and non-Native access to resources(i.e.,hunting and fishing)to certain calendar seasons may need to be revisited in a changing climate.

关键词： Traditional Ecological Knowledge(TEK) Traditional Knowledge(TK) Indigenous Knowledge(IK) Climate change Phenology Seasonality Time

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Split-root systems applied to the study of the legume-rhizobial symbiosis: What have we learned?

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Journal of Integrative Plant Biology 2014年第12期56卷 1118-1124页

作者： Estíbaliz Larrainzar Erena Gil-Quintana Cesar Arrese-Igor Esther M.González Daniel marino Department of Environmental Sciences Public University of Navarra Pamplona E-31006 Spain Department of Plant Biology and Ecology University of the Basque Country UPV/EHU Bilbao E-48080 Spain Ikerbasque Basque Foundation for Science Bilbao E-48011 Spain

Split-root system（SRS） approaches allow the differential treatment of separate and independent root systems, while sharing a common aerial part. As such, SRS is a useful tool for the discrimination of systemic（shoot origin）versus local（root/nodule origin） regulation mechanisms. This type of approach is particularly useful when studying the complex regulatory mechanisms governing the symbiosis established between legumes and Rhizobium bacteria. The current work provides an overview of the main insights gained from the application of SRS approaches to understand how nodule number（nodulation autoregulation） and nitrogen fixation are controlled both under non-stressful conditions and in response to a variety of stresses. Nodule number appears to be mainly controlled at the systemic level through a signal which is produced by nodule/root tissue, translocated to the shoot, and transmitted back to the root system, involving shoot Leu-rich repeat receptor-like kinases. In contrast, both local and systemic mechanisms have been shown to operate for the regulation of nitrogenase activity in nodules. Under drought and heavy metal stress, the regulation is mostly local,whereas the application of exogenous nitrogen seems to exert a regulation of nitrogen fixation both at the local and systemic levels.

关键词： legume-rhizobia nitrogen fixation nodulation split-root system symbiosis

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