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Microengineering double layer hydrogel structures towards the recapitulation of the hematopoietic stem cell niche

Science Bulletin 2018年第20期63卷 1319-1323页

作者： Pilar Carreras Rodrigo Cortrim Chaves miguel gallardo Alejandra Ortiz Joaquin Martinez Lopez Samuel K.Sia Department of Biomedical Engineering Columbia UniversityNew YorkNY 10032USA Hematology Department Research Institute i+12Hospital 12 OctubreMadrid 2804Spain Hematological Malignancies Clinical Research Unit H120 CNIOMadrid 28029Spain

Adult stem cells,especially from bone marrow,have a tremendous therapeutic potential,and its application in regenerative medicine has been increasingly studied [1,2].It is well known that three-dimensional (3D)cell culture matrix promotes many biological relevant functions not observed in two-dimensional (2D) monolayer cell culture [3]and therefore,engineering 3D cell culture platforms to mimic the native in vivo biological systems represents a realistic approach for studies of bone marrow stem cells. High-throughput microfluidics constitutes a promising technology to generate hydrogel three dimensional constructs [4,5],however, its application to host adult stem cells remains still a challenge.

关键词： hydrogel hematopoietic stem cell

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Self-assembling protein nanocarrier for selective delivery of cytotoxic polypeptides to CXCR4^(+) head and neck squamous cell carcinoma tumors

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2578-2591页

作者： Elisa Rioja-Blanco Irene Arroyo-Solera Patriciaálamo Isolda Casanova Alberto gallardo Ugutz Unzueta Naroa Serna Laura Sánchez-García Miquel Quer Antonio Villaverde Esther Vázquez Ramon Mangues Lorena Alba-Castellón Xavier León Institut d'InvestigacióBiomèdica Sant Pau(IIB-Sant Pau) Barcelona 08041Spain Institut de Recerca contra la Leucèmia Josep Carreras Barcelona 08025Spain CIBER de Bioingeniería Biomateriales y Nanomedicina(CIBER-BBN)Madrid 28029Spain Department of Pathology Hospital de la Santa Creu i Sant PauBarcelona 08041Spain Institut de Biotecnologia i de Biomedicina Universitat Autònoma de BarcelonaBellaterra 08193Spain Departament de Genètica i de Microbiologia Universitat Autònoma de BarcelonaBellaterra 08193Spain Department of Otorhinolaryngology Hospital de la Santa Creu i Sant PauBarcelona 08041Spain

Loco-regional recurrences and distant metastases represent the main cause of head and neck squamous cell carcinoma(HNSCC) mortality. The overexpression of chemokine receptor 4(CXCR4) in HNSCC primary tumors associates with higher risk of developing loco-regional recurrences and distant metastases, thus making CXCR4 an ideal entry pathway for targeted drug delivery. In this context, our group has generated the self-assembling protein nanocarrier T22-GFP-H6, displaying multiple T22 peptidic ligands that specifically target CXCR4. This study aimed to validate T22-GFP-H6 as a suitable nanocarrier to selectively deliver cytotoxic agents to CXCR4^(+)tumors in a HNSCC model. Here we demonstrate that T22-GFP-H6 selectively internalizes in CXCR4^(+)HNSCC cells, achieving a high accumulation in CXCR4^(+)tumors in vivo, while showing negligible nanocarrier distribution in non-tumor bearing organs. Moreover, this T22-empowered nanocarrier can incorporate bacterial toxin domains to generate therapeutic nanotoxins that induce cell death in CXCR4-overexpressing tumors in the absence of histological alterations in normal organs. Altogether, these results show the potential use of this T22-empowered nanocarrier platform to incorporate polypeptidic domains of choice to selectively eliminate CXCR4^(+)cells in HNSCC. Remarkably, to our knowledge, this is the first study testing targeted proteinonly nanoparticles in this cancer type, which may represent a novel treatment approach for HNSCC patients.

关键词： Targeted drug delivery Protein nanoparticles CXCR4 receptor HNSCC Cell targeting Recombinant proteins Nanotoxins Cancer therapy

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Lignin in storage and renewable energy applications： A review

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Journal of Energy Chemistry 2018年第5期27卷 1422-1438页

作者： Jose Luis Espinoza-Acosta Patricia I. Torres-Chavez Jorge L. Olmedo-Martinez Alejandro Vega-Rios Sergio Flores-gallardo E. Armando Zaragoza-Contreras Department of Engineering and Materials Chemistry Centro de Investigacion en Materiales Avanzados Miguel de Cervantes # 120. Complejo Industrial Chihuahua Chihuahua Mexico Departamento de Investigacion y Posgrado en Alimentos (DIPA) Universidad de Sonora Hermosillo Sonora Mexico

Lignin is a cheap, abundant and non-toxic group of complex phenolic polymers obtained in large amounts from the papermaking and cellulosic biofuel industries. Although the application of lignin has been ex- plored in these and several more industries, there are limited applications of lignin in the energy industry. However, numerous research revealed a great interest in the exploration of this renewable biopolymer in storage energy devices. Some of these applications include the use of lignin as an expander for lead-acid batteries, electrodes for primary and rechargeable batteries, electrodes for electronic double layer capac- itors and electrochemical pseudocapacitors, and to feed different types of fuel cells. The use of lignin in energy storage devices improves not only the performance of these devices but also decreases the price and toxicity, contributing to obtaining greener energy devices. Based on the above, this review provides an overview of the main research work related to the use of lignin as a renewable component, suitable to replace some synthetic and toxic compounds used in the fabrication of energy storage devices with particular emphasis on batteries, advanced supercapacitors, and solar and fuel cells.

关键词： Lignin Batteries Lithium-ion batteries Supercapacitors Solar cells Fuel cells

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Selective agonists reveal that alphalA-and alphalB-adrenoceptors contract tail artery of the young rat

Selective agonists reveal that alphalA-and alphalB-adrenocep...

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第十五届国际药理学大会

作者： gallardo-Ortiz Itzell A. Pares-Hipolito Jaime Gomez-Zamudio Jaime H. Lopez-Guerrero J.Javier Santamaria-Ortiz Jessica Ibarra Maximiliano Villalobos-Molina Rafael Depto.Farmacobiologia Cmvestav. Escuela Militar de Graduados de Sanidad. Depto.Farmacobiologia Cmvestav Depto.Farmacobiologia Cmvestav Unidad de Biomedicina EESIUNAM. Unidad de Biomedicina EESIUNAM. Unidad de Biomedicina EESIUNAM.

＜正＞ Multiple alphal-adrenoceptors seem to contract rat tail artery. AlphalA- predominates and either alpha1B-,alpha1D-,or alpha1L-is the second population. We characterized alphal-adrenoceptors with selective agonists/antagonists in tail artery of young Wistar rat. Tail artery was exposed to A61603 （N-[5-（4.5- dihy-dro- 1H- imidazol - 2 - yl） - 2 - hydroxy - 5. 6. 7. 8 - tetrahydronaphthalen- 1 - yl] methanesulfonamide） or to phenylephrine （alphalA- and alphal- agonists ）, and to prazosin （alphal- antagonist）, the alphal A-antagonists 5 - methy-lurapidil,RS 100329 （5-methyl - 3 - [3 - [4 - [2 - （2,2,2,-trifluoroethoxy） phenyl] - 1-piperazinyl] propyl] - 2,4-（1H）-pyrimidinedione）,RS 17053 （N- [2（2-cyclopropylmethoxy） ethyl] - 5-chloro-a, a-dimethyl - 1H-indole - 3-ethylamine）, and the alpha1D-antagonist BMY 7378 （8-[2-[4-（2-methoxyphenyl） - 1-piperazinyl] ethyl] - 8 - azaspiro[4.5] decane - 7,9 -dione） . A61603 showed 100 fold higher affinity over PHE. Prazosin,RS100329,5-MU,and RS17053 displaced agonists with high affinity indicating alphal A-adrenoceptors while PHE activated alphal B-adrenoceptors since BMY 7378 had low affinity.

关键词： alphalA/B-adrenoceptors rat tail artery

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