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Healthy diet,depression and quality of life:A narrative review of biological mechanisms and primary prevention opportunities

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World Journal of Psychiatry 2021年第11期11卷 997-1016页

作者： Octavio Pano Elena H Martínez-Lapiscina Carmen Sayón-Orea miguel Angel Martinez-gonzalez Jose Alfredo Martinez Almudena Sanchez-Villegas Preventive Medicine and Public Health University of NavarrePamplona 31008Spain Department of Neurology Center of Neuroimmunology Hospital Clinic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi SunyerBarcelona 08036Spain Department of Preventive Medicine and Public Health University of NavarraPamplona 31008Spain IdiSNA Navarra Institute for Health ResearchPamplona 31008Spain Department of Public Health Navarra Institute of Public Health and EpidemiologyPamplona 31003Spain CIBER Pathophysiology of Obesity and Nutrition Institute of Health Carlos IIIMadrid 28049Spain Department of Nutrition Harvard T.H.Chan School of Public HealthBostonMA 02115United States Department of Food Sciences and Physiology University of NavarrePamplona 31008Spain Precision Nutrition and Cardiometabolic Health Program IMDEA Food InstituteMadrid 28049Spain Department of Clinical Sciences University of Las Palmas Gran CanariaLas Palmas Gran Canaria 35080Spain

Unipolar depressive disorder(UDD)affects more than 264 million people worldwide and was projected well before the severe acute respiratory syndrome coronavirus 2 pandemic to be the leading cause of disability-adjusted life years lost in *** is imperative for leading economies to implement preventive strategies targeted towards UDD,given consistent policies are currently *** established similarities between the aetiological hypotheses of depression and cardiometabolic diseases are shifting paradigms within this *** is believed that dietary practices could potentially reduce the incidence of depression;similar to their effects on ***,the aim of this review was to compile current evidence on healthy dietary patterns as suitable contributors towards primary prevention strategies against *** of the well-known biological mechanisms behind depression have been positively associated with healthful diets and dietary patterns to varying ***,a common factor of UDD is the production and overall effects of inflammatory cytokines,such as interleukin-6,tumor necrosis factor-α,and Creactive *** compounds have been associated with depressive symptoms,disturbances in neuroendocrine function,leaky gut,monoamine activity and brain function,while also being key factors in the development of cardiometabolic *** Mediterranean diet(MD)in particular,is well supported by first-level evidence regarding its preventive qualities against metabolic and cardiovascular diseases and thus considered a model for healthy eating by various *** one of the few clinical trials investigating these associations,the PREDIMED trial,individuals with diabetes assigned to a MD supplemented with mixed tree nuts experienced a 41%relative risk reduction for developing ***,there is a need to include health related quality of life as an indicator of physical and mental well-being,considering its putative associations

关键词： Depression Nutrition Mediterranean Quality of life Primary prevention Epidemiology

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Self-Organizing Maps in Seismic Image Segmentation

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Computer Technology and Application 2012年第9期3卷 624-629页

作者： Carlos Ramirez miguel Argaez Pablo Guiilen Gladys gonzalez Program in Computational Science The University of Texas at El Paso El Paso Texas 79968 United States Geophysics Research and Development Repsol USA the Woodlands Texas 77380 United States

Unsupervised neural networks such as the Kohonen Self-Organizing Maps （SOM） have been widely used for searching natural clusters in multidimensional and massive data. One example where the data available for analysis can be extremely large is seismic interpretation for hydrocarbon exploration. In order to assist the interpreter in identifying characteristics of interest confined in the seismic data, the authors present a set of data attributes that can be used to train a SOM in such a way that zones of interest can be automatically identified or segmented, reducing time in the interpretation process. The authors show how to associate SOM to 2D color maps to visually identify the clustering structure of the input seismic data, and apply the proposed technique to a 2D synthetic seismic dataset of salt structures.

关键词： Self-organizing maps image segmentation seismic attributes.

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Immunotherapy and immunoescape in colorectal cancer

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World Journal of Gastroenterology 2007年第44期13卷 5822-5831页

作者： Guillermo Mazzolini Oihana Murillo Catalina Atorrasagasti Juan Dubrot Iigo Tirapu miguel Rizzo Ainhoa Arina Carlos Alfaro Arantza Azpilicueta Carmen Berasain José L Perez-Gracia Alvaro gonzalez Ignacio Melero Liver Unit Facultad de Ciencias Biomédicas Universidad Austral Presidente Perón 1500 (1635) Derqui-Pilar Buenos Aires Argentina Centro de Investigación Médica Aplicada and Clínica Universitaria Universidad de Navarra Pamplona Spain

Immunotherapy encompasses a variety of interventions and techniques with the common goal of eliciting tumor cell destructive immune responses. Colorectal carcinoma often presents as metastatic disease that impedes curative surgery. Novel strategies such as active immunization with dendritic cells (DCs), gene transfer of cytokines into tumor cells or administration of immunostimulatory monoclonal antibodies (such as anti-CD137 or anti-CTLA-4) have been assessed in preclinical studies and are at an early clinical development stage. Importantly, there is accumulating evidence that chemotherapy and immunotherapy can be combined in the treatment of some cases with colorectal cancer, with synergistic potentiation as a result of antigens cross-presented by dendritic cells and/or elimination of competitor or suppressive T lymphocyte populations (regulatory T-cells). However, genetic and epigenetic unstable carcinoma cells frequently evolve mechanisms of immunoevasion that are the result of either loss of antigen presentation, or an active expression of immunosuppressive substances. Some of these actively immunosuppressive mechanisms are inducible by cytokines that signify the arrival of an effector immune response. For example, induction of 2, 3 indoleamine dioxygenase (IDO) by IFNγ in colorectal carcinoma cells. Combinational and balanced strategies fostering antigen presentation, T-cell costimulation and interference with immune regulatory mechanisms will probably take the stage in translational research in the treatment of colorectal carcinoma.

关键词： Colorectal carcinoma Immunotherapy Gene therapy interleukin-12 Dendritic cells CD137 indoleamine 2, 3 dioxygenase

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Understanding Interfacial Chemistry Interactions in Energy-Dense Lithium-Ion Electrodes

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Accounts of Materials Research 2023年第2期4卷 156-167页

作者： Donghee Gueon miguel A.gonzalez Kenneth J.Takeuchi Esther S.Takeuchi Amy C.Marschilok Elsa Reichmanis Department of Chemical and Bimolecular Engineering Lehigh UniversityBethlehemPennsylvania 18015United States School of Chemical and Biomolecular Engineering Georgia Institute of TechnologyAtlantaGeorgia 30332United States Interdisciplinary Science Department Brookhaven National LaboratoryUptonNew York 11973United States Institute for Energy Sustainability and Equity Stony Brook UniversityStony BrookNew York 11794United States Department of Material Science and Chemical Engineering Stony Brook UniversityStony BrookNew York 11794United States Department of Chemistry Stony Brook UniversityStony Brook 11794United States

For the past two decades,conversion and alloying-type materials have been heralded as the natural heir to commercially available graphite anodes due to their ability to deliver high gravimetric/volumetric *** of batteries with these high-energy-density active materials could impact a variety of sectors including electric vehicles,grid storage,and consumer electronics and contribute toward an ever-increasing electrified ***,the various failure mechanisms from inherent interfacial chemical instabilities associated with these materials make them unable to be merely substituted into currently available electrode fabrication and formulation processing *** a result,realizing the high theoretical capacity and achieving commercial viability of these materials will rely on the careful manipulation of interfacial chemical interactions that dictate and control various kinetic and transport processes across multiple scales of the composite *** has led to a plethora of research that has focused on systematically understanding properties of the different electrode components and designing carefully constructed electrode formulations to achieve composite electrodes with increased chemical stability,enhanced local mixed conductivities,or improved mechanical *** Account relates recent progress in the understanding of synergetic opportunities for energy-dense,resilient composite *** understanding the interplay between components of the composite electrode,we can construct enhanced well-integrated electrodes with performance metrics that surpass empirically derived *** to the increased complexity of high-volume-expanding electrodes,performance is more than the cumulative contributions of the individual components,and therefore energy and compatibility matching are important for robust electrochemical performance across cycling,rate capability,facile lithium-ion transport,and *** this Account,sy

关键词： composite interfacial electrode

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Long-Term Postoperative Perfusion Status in Giant Retinal Tears: A Preliminary Case Report

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Open Journal of Ophthalmology 2022年第2期12卷 180-200页

作者： miguel A. Quiroz-Reyes Erick A. Quiroz-gonzalez miguel A. Quiroz-gonzalez Margarita Montano Ahmad R. Alsaber Virgilio Lima-Gomez Retina Specialists Unit Oftalmologia Integral ABC Medical and Surgical Assistance Institution (Non-Profit Organization) Postgraduate Division National Autonomous University of Mexico Mexico CityMexico Department of Mathematics and Statistics University of Strathclyde Glasgow UK Juarez Hospital Public Assistance Institution (Non-Profit Organization) Mexico City Mexico

Background: Information on the long-term perfusion status of patients after successful surgery for giant retinal tear (GRT) macula-off rhegmatogenous retinal detachment (RRD) is limited. Purpose: To examine long-term structural, functional, and perfusion outcomes in normal control eyes and eyes treated for different degrees of GRT-associated extensions of RRD. Methods: One emmetropic normal eye (control), one healthy highly myopic eye (control myopic), and three eyes surgically treated for GRT (surgical), were included in the study for a long-term comparison of study outcomes. The surgical eyes were classified based on the degree of GRT-associated RRD extension as follows: one eye with GRT-associated RRD extension ˚one eye with GRT-associated RRD extension between 180˚- 270˚and one eye with GRT-associated RRD extension > 270˚. Structural, functional, and perfusion outcomes were compared with those of the control eyes. Results: All three eyes were phakic and the condition was monocular. The mean age of the patients was 48.67 ± 8.50 years (range, 39 - 55 years). All three eyes had GRT macula-off RRD. The mean preoperative time for GRT surgery was 1.2 weeks. The mean pre- and postoperative best corrected visual acuities (BCVA) were 1.87 logMAR and 0.46 logMAR, respectively. The mean postoperative follow-up period was 19.67 ± 5.69 months. Proliferative vitreoretinopathy resulted in multiple surgeries in one eye (31.5%). Long-term postoperative optical coherence tomography (OCT) showed abnormal retinal thickness, ellipsoid zone disruption, and external limiting membrane line discontinuities in one eye. OCT angiography yielded abnormal perfusion indices in the surgically treated eyes. Conclusions: Our data showed multiple structural alterations in spectral-domain OCT biomarkers. One eye that developed secondary epiretinal membrane (ERM) proliferation showed a significantly improved BCVA after proliferation and internal limiting membrane were removed. P

关键词： Choriocapillaris Subfoveal Plexus Deep Vascular Plexus Giant Retinal Tears Macular Perfusion Indices Rhegmatogenous Retinal Detachment

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Land-use change and windstorms legacies drove the recolonization dynamics of laurel forests in Tenerife, Canary islands

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Forest Ecosystems 2023年第1期10卷 113-124页

作者： Vicente Rozas Maria A.Garcia-Lopez Jose M.Olano Gabriel Sanguesa-Barreda miguel Garcia-Hidalgo Susana Gomez-gonzalez Roberto Lopez-Rubio Jose M.Fernandez-Palacios Ignacio Garcia-gonzalez Laura Lozano-Lopez Paula Garcia-gonzalez Ana I.Garcia-Cervigon EiFAB-iuFOR Universidad de ValladolidCampus Duques de Soria42004SoriaSpain Departamento de Biologia-IVAGRO Universidad de CadizCampus Rio San Pedro11510Puerto RealSpain Center for Climate and Resilience Research(CR)2 Blanco Encalada 20028370449SantiagoChile Area de Biodiversidad y Conservacion Universidad Rey Juan Carlosc/Tulipan s/n28933MostolesSpain Grupo de Ecologia y Biogeografia Insular Universidad de La Laguna38206La LagunaTenerifeSpain BIOAPLIC Departamento de BotanicaEscola Politecnica Superior de EnxenariaCampus TerraUniversidade de Santiago de CompostelaLugo27002Spain

Laurel forests are quite relevant for biodiversity conservation and are among the island ecosystems most severely damaged by human *** the past,Canary laurel forests have been greatly altered by logging,livestock and *** remains of laurel forests are currently protected in the Canary Islands(Spain).However,we miss basic information needed for their restoration and adaptive management,such as tree longevity,growth potential and responsiveness to natural and anthropogenic *** dendrochronological methods,we studied how forest dynamic is related to land-use change and windstorms in two well-preserved laurel forests on Tenerife *** cores were collected from over 80 trees per stand at three stands per *** used ring-width series to estimate tree ages and calculate annual basal area increments(BAI),cumulative diameter increases,and changes indicative of released and suppressed *** tree species were found in all stands,with Laurus novocanariensis,Ilex canariensis and Morella faya being the most common *** some individuals were over 100 years old,61.8%-88.9% of the trees per stand established between 1940 and 1970,coinciding with a post-war period of land abandonment,rural exodus and the onset of a tourism *** trees have shown growth rates larger than 1 cm diameter per year and most species have had increasing BAI trends over the past *** growth releases occurred after windstorms at both sites,but the effects of windstorms were site-dependent,with the 1958 storm affecting mainly the eastern tip of the island(Anaga massif)and the 1991 storm the western tip(Teno massif).Given the great ability of laurel forest trees to establish after land use cessation and to increase growth after local disturbances such as windstorms,passive restoration may be sufficient to regenerate this habitat in currently degraded areas.

关键词： Canary islands Dendroecology Disturbance Forest structure Macaronesia Management cessation Tree rings

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Are Ni/and Ni5Fe1/biochar catalysts suitable for synthetic natural gas production?A comparison with g-Al2O3 supported catalysts

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Green Energy & Environment 2023年第3期8卷 744-756页

作者： M.gonzalez-Castano C.Morales J.C.Navarro de miguel J.H.Boelte O.Klepel J.I.Flege H.Arellano-García Department of Process and Plant Technology Brandenburg University of Technology(BTU)Cottbus-SenftenbergPlatz der Deutschen 1Cottbus03046Germany Applied Physics and Semiconductor Spectroscopy Brandenburg University of Technology Cottbus-SenftenbergKonrad-Zuse-Strasse 1Cottbus03046Germany Department of Inorganic Chemistry Institute of Materials Science of SevilleConsejo Superior de Investigaciones Cientificas(CSIC)Universidad de Sevilla(US)Avenida Americo Vespucio 49Seville41092Spain Institute of Materials Chemistry Brandenburg University of Technology Cottbus–SenftenbergUniversitatsplatz 1SenftenbergD-01968Germany

Among challenges implicit in the transition to the post-fossil fuel energetic model,the finite amount of resources available for the technological implementation of CO_(2) revalorizing processes arises as a central *** development of fully renewable catalytic systems with easier metal recovery strategies would promote the viability and sustainability of synthetic natural gas production circular *** Ni and NiFe catalysts supported over g-Al_(2)O_(3) oxide as reference materials,this work evaluates the potentiality of Ni and NiFe supported biochar catalysts for CO_(2) *** development of competitive biochar catalysts was found dependent on the creation of basic sites on the catalyst *** lower Turn Over Frequencies than Ni/Al catalyst,the absence of basic sites achieved over Ni/C catalyst was related to the depleted catalyst *** NiFe catalysts,analogous Ni_(5)Fe_(1) alloys were constituted over both alumina and biochar *** highest specific activity of the catalyst series,exhibited by the NiFe/C catalyst,was related to the development of surface basic sites along with weaker NiFe-C interactions,which resulted in increased Ni0:NiO surface populations under reaction *** summary,the present work establishes biochar supports as a competitive material to consider within the future low-carbon energetic panorama.

关键词： Biochar catalysts Carbon catalysts Ni catalysts NiFe alloy Bimetallic catalysts Synthetic natural gas CO_(2)methanation

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3D printed tacrolimus suppositories for the treatment of ulcerative colitis

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Asian Journal of Pharmaceutical Sciences 2021年第1期16卷 110-119页

作者： Iria Seoane-Viano Jun Jie Ong Asteria Luzardo-Alvarez miguel gonzalez-Barcia Abdul W.Basit Francisco J.Otero-Espinar Alvaro Goyanes Department of Pharmacology Pharmacy and Pharmaceutical TechnologyFaculty of PharmacyUniversity of Santiago de CompostelaSantiago de Compostela 15782Spain Department of Pharmaceutics UCL School of PharmacyUniversity College LondonLondon WC1N 1AXUK Pharmacy Department University Clinical Hospital Santiago de Compostela(SERGAS)(CHUS)Santiago de Compostela 15706Spain FabRx Ltd. AshfordKent TN240RWUK Departamento de Farmacologia Farmacia y Tecnologia FarmaceuticaI+D Farma Group(GI-1645)Universidade de Santiago de CompostelaSantiago de Compostela 15782Spain

Ulcerative colitis is a global health problem,affecting millions of individuals *** an inflammatory condition localised in the large intestine,rectal delivery of immunosuppressive therapies such as tacrolimus is a promising strategy to maximise drug concentration at the site of action whilst minimising systemic side ***,for the first time,self-supporting 3D-printed tacrolimus suppositories were prepared without the aid of moulds using a pharmaceutical semi-solid extrusion(SSE)3D *** suppositories were printed vertically in three different sizes using combinations of two lipid pharmaceutical excipients(Gelucire 44/14 or Gelucire 48/16)and coconut *** both suppository formulations had the appropriate viscosity characteristics for printing,the Gel 44 formulation required less energy and force for extrusion compared to the Gel 48 *** Gel 44 disintegrated more rapidly but released tacrolimus more slowly than the Gel 48 *** the tacrolimus release profiles were significantly different,both suppository systems released more than 80% drug within 120 *** and XRD analysis was inconclusive in determining the solid-state properties of the drug in the *** summary,this article reports on the fabrication of 3D printed selfsupporting suppositories to deliver personalised doses of a narrow therapeutic index drug,with potential benefits for patients with ulcerative colitis.

关键词： 3D printed drug products Semi-solid extrusion 3D printing Inflammatory bowel disease Suppository drug delivery Pressure assisted syringe M3dimaker

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A Comparative Study of Non-Volatile Compounds Present in 3R4F Cigarettes and iQOS Heatsticks Utilizing GC-MS

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American Journal of Analytical Chemistry 2019年第3期10卷 76-85页

作者： miguel Penin Ibanez Daniel Martin Alicia gonzalez Gonzalvez Helmut H.Telle Angel gonzalez Urena Departamento de Quimica Fisica Aplicada Facultad de CienciasUniversidad Autonoma de MadridMadridSpain

It is now widely suggested that people who are dependent on nicotine should switch from ordinary tobacco smoking to alternative products, which at least reduce the overall harm from smoking. A number of alternatives are now popular, including electronic cigarettes and heatsticks. In this work comparative analysis of the smoke/aerosol emission from 3R4F standard cigarettes and iQOS heatsticks was undertaken. For this, gas chromatography-mass spectrometry (GC-MS) analysis was applied, to measure the non-volatile compounds of smoke/aerosol emission from individual samples, with the specific aim to determine their content of nicotine and selected other main components. All measurement data were collected under the Health Canada Intense (HCI) puffing regime. The most relevant findings of the present investigation can be summarized as follows. First, the number of measured aerosol components in the iQOS samples, with respect to those of 3R4F samples, was significantly lower (notably 37 versus 12 components). Second, the analysis of the iQOS and 3R4F GC-MS chromatographic fingerprints indicated a non-nicotine global component reduction (number and areas excluding nicotine) of larger than 80% for the iQOS samples in comparison to 3R4F samples. Third, the nicotine content of the iQOS aerosol was less than half that contained in the 3R4F smoke. The results from the present investigation indicate that—except for nicotine—smokers are exposed to a largely reduced number and amount of non-volatile, non-nicotine components in the iQOS heatstick aerosol, in comparison to those in the 3R4F cigarette smoke.

关键词： Cigarette Heatstick Chromatographic Analysis Nicotine Tobacco Harm Reduction(THR)

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Development and characterization of whey protein films incorporated with tarbush polyphenols and candelilla wax

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Food Bioscience 2022年第1期45卷 1-7页

作者： Olga B.Alvarez-Perez Janeth M.Ventura-Sobrevilla Cristian Torres-Leon Romeo Rojas-Molina Raúl Rodríguez-Herrera miguel A.Aguilar-gonzalez Cristobal N.Aguilar Bioprocesses and Bioproducts Research Group Food Research DepartmentSchool of ChemistryUniversidad Autonoma de Coahuila25280SaltilloCoahuilaMexico School of Health Sciences Universidad Autonoma de Coahuila26090Piedras NegrasCoahuilaMexico School of Agronomy Research Center and Development for Food IndustryUniversidad Autonoma de Nuevo Leon6050General EscobedoNuevo LeonMexico Center for Research and Advanced Studies of the National Polytechnique Institute Parque Industrial Saltillo-Ramos ArizpeCoahuilaMexico

Edible films were prepared with whey protein incorporating candelilla wax,and glycerol in aqueous *** polyphenols were added as bioactive *** optimization based on the water vapor permeability(WVP)of the formulation was performed using a Box-Behnken *** films were characterized by the determination of WVP,moisture,solubility,color,antioxidant and antifungal *** electron microscopy(SEM)was also performed to observe the surface and cross-section *** lowest permeability values were found with concentrations of 1.27,0.3 and 0.5% of protein,wax and glycerol *** was proved that the addition of polyphenols into films causes a significant effect only on solubility and transparency *** films have suitable properties as a barrier for the goods they could be applied *** is proposed for use in foods such as fresh or minimally processed fruits and vegetables.

关键词： Edible films Whey protein Shelf life Candelilla wax Euphorbia antisyphilitica Fluorensia cernua polyphenols

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