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Tribology of enzymatically degraded cartilage mimicking early osteoarthritis

Friction 2023年第9期11卷 1724-1740页

作者： Ke REN miguel alejandro reina mahecha Maike HÜBNER Zhiwei CUI Hans J.KAPER Hugo C.VAN DER VEEN Prashant K.SHARMA Department of Biomedical Engineering University Medical Centre GroningenUniversity of GroningenGroningen 9713AVthe Netherlands Department of Mechanical Engineering Eindhoven University of TechnologyEindhoven 5600MBthe Netherlands Department of Orthopedic Surgery University Medical Centre GroningenUniversity of GroningenGroningen 9700RBthe Netherlands

Healthy cartilage is a water-filled super lubricious *** type II provides it structural stability,and proteoglycans absorb water to keep the cartilage in a swollen condition,providing it the ability to creep and provide weeping ***(OA)is a degenerative and debilitating disorder of diarthrodial joints,where articular cartilage damage originates from enzymatic degradation and mechanical damage(wear).The objective of this research is to observe the level of cartilage damage present in knee arthroplasty patients and to understand the friction and creep behavior of enzymatically degraded bovine cartilage in ***(Lat)and medial(Med)condylar cartilages from OA patients undergoing total knee arthroplasty showed signs of enzymatic degradation and mechanical *** cartilages were exposed to collagenase III and chondroitinase ABC to degrade collagen and proteoglycans,*** loss of proteoglycans or collagen network and morphological changes were observed through histology and the atomic force microscope(AFM),respectively.A significant effect on creep due to enzymatic treatment was not *** the enzymatic treatment was found to significantly decrease the coefficient of friction(COF)at 4 N,while higher COF was shown from chondroitinase ABC degraded cartilage at 40 *** III treatment leads to the release of intact proteoglycans at the sliding interface,while chondroitinase ABC treatment leads to the loss of chondroitin sulfate(CS)from the *** ABC-digested bovine cartilage mimicked patient samples the best because of the similar distributions of proteoglycans,collagen network,and friction behavior.

关键词： lubrication cartilage boundary lubrication osteoarthritis(OA)

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A prototype for on-site generation of chlorinated disinfectant for use in rural aqueducts

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Water Science and Engineering 2024年第1期17卷 33-40页

作者： Diana Marcela Cuesta Parra Felipe Correa mahecha Andrés Felipe Rubio Pinzon Davidcamilo Ramirez Bustos Leonel Alveyro Teran Llorente miguel Fernando Jimenez Jimenez Chemical and Environmental Engineering Department Fundacion Universidad de AmericaBogota 117111Colombia Chemical Engineering Department Fundacion Universidad de AmericaBogota 117111Colombia Mecanical Engineering Department Fundacion Universidad de AmericaBogota 117111Colombia

Sodium hypochlorite has significant potential as a sanitation solution in hard-to-reach *** studies have investigated the optimal electrolysis parameters for its production with volumes greater than 1o *** study evaluated sodium hypochlorite production through electrolysis in a 22-L prototype and identified the optimal operating *** were performed using graphite electrodes with areas of 68.4 cm^(2) at the laboratory scale and 1865.0 cm^(2) at the prototype scale.A design for experiments with different operating times,chloride concentrations,and electric current intensities was *** optimal operating time,sodium chloride concentration,and current intensity at the laboratory scale were 120 min,150 g of chloride per liter,and 3 A,respectively,leading to the production of 5.02 g/L of the disinfectant with an energy efficiency of 12.21 mg of Cl_(2) per *** the prototype scale,the maximum sodium hypochlorite concentration of 3.99 g of chloride per liter was achieved with an operating time of 120 min,a sodium chloride concentration of 100 g of chloride per liter,and a current intensity of 70 A,reaching an energy efficiency of 42.56 mg of Cl_(2) per *** addition,this study evaluated the influences of the chloride concentration,current intensity,and operating time on the production of sodium hypochlorite at the two scales,and formulated the equations showing the trends of sodium hypochlorite production and energy efficiency in the electrochemical *** 22-L prototype model for production of this oxidizing substance is promising for disinfection of large volumes of water in areas that are difficult to access.

关键词： Disinfection Electrolysis Energy efficiency Optimization Sodium hypochlorite

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Global variations in critical drought thresholds that impact vegetation

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National Science Review 2023年第5期10卷 180-193页

作者： Xiangyi Li Shilong Piao Chris Huntingford Josep Pe?uelas Hui Yang Hao Xu Anping Chen Pierre Friedlingstein Trevor F.Keenan Stephen Sitch Xuhui Wang Jakob Zscheischler miguel D.mahecha Laboratoire de Météorologie Dynamique Institut Pierre-Simon LaplaceCNRS-ENS-UPMC-XDépartement de GeósciencesEcole Normale Superieure Earth and Environmental Sciences Area Lawrence Berkeley National Laboratory Department of Environmental Science Policy&ManagementUniversity of California Berkeley Department of Geography College of Life and Environmental SciencesUniversity of Exeter Department of Computational Hydrosystems Helmholtz Centre for Environmental Research—Ufz Remote Sensing Centre for Earth System Research Leipzig University Sino-French Institute for Earth System Science College of Urban and Environmental SciencesPeking University Key Laboratory of Alpine Ecology and Biodiversity Institute of Tibetan Plateau ResearchCenter for Excellence in Tibetan Earth ScienceChinese Academy of Sciences UK Centre for Ecology and Hydrology CSIC Global Ecology Unit CREAF-CSIC-UAB CREAF Cerdanyola de Vallès Department of Biogeochemical Integration Max Planck Institute for Biogeochemistry Department of Biology Colorado State University Graduate Degree Program in Ecology Colorado State University Department of Mathematics College of Engineering Mathematics and Physical SciencesUniversity of Exeter

Identifying the thresholds of drought that,if crossed,suppress vegetation functioning is vital for accurate quantification of how land ecosystems respond to climate variability and *** present a globally applicable framework to identify drought thresholds for vegetation responses to different levels of known soil-moisture deficits using four remotely sensed vegetation proxies spanning *** thresholds identified represent critical inflection points for changing vegetation responses from highly resistant to highly vulnerable in response to drought stress,and as a warning signal for substantial vegetation *** thresholds varied geographically,with much lower percentiles of soil-moisture anomalies in vegetated areas covered by more forests,corresponding to a comparably stronger capacity to mitigate soil water deficit stress in forested ***,those lower thresholds are detected in more humid ***-of-the-art land models,however,overestimated thresholds of soil moisture(*** drought impacts),especially in more humid areas with higher forest covers and arid areas with few forest *** on climate model projections,we predict that the risk of vegetation damage will increase by the end of the twenty-first century in some hotspots like East Asia,Europe,Amazon,southern Australia and eastern and southern *** data-based results will inform projections on future drought impacts on terrestrial ecosystems and provide an effective tool for drought management.

关键词： drought threshold inflection points vegetation response soil moisture drought impacts

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Identification of characteristic plant co-occurrences in neotropical secondary montane forests

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Journal of Plant Ecology 2009年第1期2卷 31-41页

作者： miguel D.mahecha Alfredo Martı´nez Holger Lange Markus Reichstein Erwin Beck Max Planck Institute for Biogeochemistry PO Box 10016407701 JenaGermany Department of Environmental Sciences Swiss Federal Institute of Technology—ETH Zurich8092 ZurichSwitzerland Bayreuth Centre for Ecology and Environmental Research University of Bayreuth95440 BayreuthGermany Fundacion Cordillera Tropical Jaime Roldos 4-80 y Huayna CapacEd.El Consorcio of.412CuencaEcuador Norwegian Forest and Landscape Institute PO Box 1151431 AsNorway

Aims Inferring environmental conditions from characteristic patterns of plant co-occurrences can be crucial for the development of conservation strategies concerning secondary neotropical ***,nomethodological agreement has been achieved so far regarding the identification and classification of characteristic groups of vascular plant species in the *** study examines botanical and,in particular,statistical aspects to beconsidered in such *** on these,we propose a novel data-driven approach for the identification of characteristic plantco-oc currences in neotropical secondary mountain *** Floristic inventory data were gathered in secondary tropical mountain forests in *** classification was performed by coupling locally adaptive isometric feature mapping,a non-linear ordination method and fuzzy-c-means *** approach was designed for dealing with underlying non-linearities and uncertainties in the inventory *** Findings The results indicate that the applied non-linear mapping in combination with fuzzy classification of species occurrence allows an effective identification of characteristic groups of co-occurring species as fuzzy-defined *** selected species indicated groups representing characteristic life-form distributions,as they correspond to various stages of forest *** the identified‘characteristic species groups’with meta-information derived from accompanying studies indicated that the clusters can also be related to habitat *** conclusion,we identified species groups either characteristic of different stages of forest succession after clear-cutting or of impact by fire or a *** expect that the proposed data-mining method will be useful for vegetation classification where no a priori knowledge is available.

关键词： secondary tropical mountain forests characteristic species groups non-linear ordination fuzzy-c-means clustering Ecuador

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Postural control quantification in minimally and moderately impaired persons with multiple sclerosis:The reliability of a posturographic test and its relationships with functional ability

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Journal of Sport and Health Science 2020年第6期9卷 677-684页

作者： David Barbado Ramon Gomez-Illan Pedro Moreno-Navarro Gregori Valero-Conesa Raul reina Francisco J.Vera-Garcia Department of Sport Sciences Sports Research CentreMiguel Hern_andez University of ElcheElche(Alicante)03202Spain

Background:Postural control has been associated with the functional impairment in persons with multiple sclerosis(pwMS).However,there is a need for reliable methods to assess postural control in early stages of the disease,when subtle changes can be difficult to *** aims of this study were to assess the absolute and relative reliability of a standing and a sitting posturographic protocol in minimally(Expanded Disability Status Scale≤2)and moderately(2.5≤Expanded Disability Status Scale≤4)impaired pwMS,and to analyze relationships among postural control and functional mobility and gait ***:To assess postural control in an upright stance,14 minimally and 16 moderately impaired pwMS performed six 70 s trials in tandem stance,3 with their weaker leg behind(TSWL)and 3 with their stronger leg behind(TSSL).Additionally,participants completed five 70 s trials using an unstable sitting protocol(US)to assess trunk *** mean radial errors of TSWL,TSSL,and US trials were calculated as postural control ***,participants performed the Timed Up and Go test(TUG)and the Timed 25-foot Walk test(T25FW)to measure their functional mobility and gait speed,*** was evaluated using the intraclass correlation coefficient(ICC3,1)and the standard error of measurement(SEM).Analyses of variances were carried out to assess between-group ***’g index(dg)was used to estimate the effect size of *** correlation analyses(r)were performed to examine the relationships among the postural control and the functional ***:Posturographic tests showed a high reliability in both minimally(0.87≤ICC≤0.92;9.32%≤SEM≤11.76%)and moderately(0.80≤ICC≤0.92;10.33%≤SEM≤15.33%)impaired ***,T25FW and TUG displayed a high consistency in minimally(0.89≤ICC≤0.94;3.43%≤SEM≤5.17%)and moderately(0.85≤ICC≤0.93;5.57%≤SEM≤6.56%)impaired *** impaired pwMS showed a better performance on the TUG,T25FW

关键词： Balance Consistency of the assessment Core stability Functional mobility

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Healthcare use among people with diabetes mellitus in Europe:a population-based cross-sectional study

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Family Medicine and Community Health 2022年第4期10卷 16-23页

作者： Álvaro Fuentes-Merlos JoséAntonio Quesada-Rico Raul reina Domingo Orozco-Beltrán Faculty of Medicine Miguel Hernandez University of ElcheSant Joan D'AlacantSpain Department of Sports Sciences Sport Research CentreMiguel Hernandez University of ElcheElcheSpain

Objective This study aimed to determine the association of health determinants,lifestyle and socioeconomic variables on healthcare use in people with diabetes in *** A cross-sectional study was conducted using data from the European Health Interview Survey wave 2(ie,secondary analysis).Setting The sample included data from 25 European *** The sample included 16270 patients with diabetes aged 15 years or older(49.1%men and 50.9%women).Results The survey data showed that 58.2%of respondents had seen their primary care physician in the past month and 22.6%had been admitted to the hospital in the past *** of primary care was associated with being retired(prevalence ratio(PR)1.13,95%CI 1.07 to 1.19)and having very poor self-perceived health(PR 1.80,95%CI 1.51 to 2.15),long-standing health problems(PR 1.14,95%CI 1.04 to 1.24),high blood pressure(PR 1.06,95%CI 1.03 to 1.10)and chronic back pain(PR 1.07,95%CI 1.04 to 1.11).Hospital admission was associated with very poor self-perceived health(PR 3.03,95%CI 2.14 to 4.31),accidents at home(PR 1.54,95%CI 1.40 to 1.69),chronic obstructive pulmonary disease(COPD)(PR 1.34,95%CI 1.22 to 1.47),high blood pressure(PR 1.08,95%CI 1.01 to 1.17),chronic back pain(PR 0.91,95%CI 0.84 to 0.98),moderate difficulty walking(PR 1.33,95%CI 1.21 to 1.45)and severe difficulty walking(PR 1.67,95%CI 1.51 to 1.85).Conclusions In the European diabetic population,the high cumulative incidences of primary care visits and hospital admissions are associated with labour status,alcohol consumption,self-perceived health,long-standing health problems,high blood pressure,chronic back pain,accidents at home,COPD and difficulty walking.

关键词： admitted sectional difficulty

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Macrocystic serous cystadenoma of the pancreas

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Hepatobiliary & Pancreatic Diseases International 2019年第6期18卷 587-589页

作者： Patricia Pastor Pérez Francisco miguel González Valverde Francisco Pastor Quirante Department of General Surgery Reina Sofia General University Hospital University of Murcia

Cystic pancreatic lesions are common,and about 90%of these lesions are pseudocysts or retention *** cysts of the pancreas are *** majority of pancreatic serous cystadenomas are *** serous cystadenoma is an unusual and essentially benign pancreatic *** radiologic features of this subtype may resemble a pseudocyst or a mucinous ***,it is often difficult to make a correct diagnosis[1,2].Herein,we report on a macrocystic serous cystadenoma of the pancreas in a 46-year-old female patient,with a preoperative diagnosis of pancreatic pseudocyst by radiologic imaging.

关键词： pancreas adenoma diagnosis

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Prevalence and Genotype Distribution of Oncogenic-Risk Human Papilloma Virus in the Cervix of Climacteric Women with Normal Pap Smears

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Open Journal of Epidemiology 2014年第3期4卷 164-168页

作者： miguel ángel Olalla Herrera Isabel María Jurado Navarrete Rosario Moyano López Susana Pérez Rodríguez María Pilar Espejo reina María del Mar Olalla Jiménez LGT Unit Gynaecology Department V. de la Victoria University Hospital Malaga University of Malaga (UMA) Málaga Spain The Unit of Lower Genital Tract (LGT) Pathology of the Department of Gynaecology V. de la Victoria University Hospital the University of Malaga (UMA) Málaga Spain

Objective: To find out the incidence of high-risk HPV infections on climacteric women within our area of influence;and to typify HPV genotypes on women with normal cytology that come to our hospitalary unit of menopausia. Material and Method: Cross-sectional study;with a random sample of 140 cases of climacteric women of ≥50 years of age, with normal Pap smears for the last 12 months. HPV determination was carried out by PCR for screening, and by hybrid capture for genotype typification. Results: The percentage of climacteric women who are carriers of oncogenic HPV and a normal Pap smear was of 11.43% (16/140 cases). The genotype found most frequently was HPV-16, followed by HPV-58, 51 and 18. Conclusions: We found a high prevalence of women who were carriers of oncogenic HPV in climacteric women with normal Pap smears (latent infections) in our health region. We consider that cervical cancer screening, either by PCR or conventional Pap smear, should not be minimized or ignored from 50 years of age onwards.

关键词： Prevalence Oncogenic Human Papilloma Virus Climacteric

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How to express tumours using membrane systems

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Progress in Natural Science:Materials International 2007年第4期17卷 449-457页

作者： miguel A. Gutiérrez-Naranjo Mario J. Pérez-Jiménez Agustín Riscos-Núez Francisco J. Romero-Campero Department of Computer Science and Artificial Intelligence University of Seville Avda. Reina Mercedes s/n41012SevillaSpain

In this paper we discuss the potential usefulness of membrane systems as tools for modelling tumours. The approach is followed both from a macroscopic and a microscopic point of view. In the first case, one considers the tumour as a growing mass of cells, focusing on its external shape. In the second case, one descends to the microscopic level, studying molecular signalling pathways that are crucial to determine if a cell is cancerous or not. In each of these approaches we work with appropriate variants of membrane systems.

关键词： tumour membrane system modeling.

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Tuning gelatin-based hydrogel towards bioadhesive ocular tissue engineering applications

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Bioactive Materials 2021年第11期6卷 3947-3961页

作者： Sina Sharifi Mohammad Mirazul Islam Hannah Sharifi Rakibul Islam Darrell Koza Felisa Reyes-Ortega David Alba-Molina Per H.Nilsson Claes H.Dohlman Tom Eirik Mollnes James Chodosh miguel Gonzalez-Andrades Massachusetts Eye and Ear and Schepens Eye Research Institute Department of OphthalmologyHarvard Medical SchoolBostonMAUSA Department of Immunology Oslo University HospitalRikshospitaletUniversity of OsloOsloNorway Department of Physical Sciences Eastern Connecticut State UniversityWillimanticCTUSA Linnaeus Center for Biomaterials Chemistry Linnaeus UniversityKalmarSweden Research Laboratory Nordland HospitalBodøNorway Centre of Molecular Inflammation Research Norwegian University of Science and TechnologyTrondheimNorway Maimonides Biomedical Research Institute of Cordoba(IMIBIC) Department of OphthalmologyReina Sofia University Hospital and University of CordobaCordobaSpain Faculty of Health Sciences K.G.Jebsen TRECUniversity of TromsøNorway

Gelatin based adhesives have been used in the last decades in different biomedical applications due to the excellent biocompatibility,easy processability,transparency,non-toxicity,and reasonable mechanical properties to mimic the extracellular matrix(ECM).Gelatin adhesives can be easily tuned to gain different viscoelastic and mechanical properties that facilitate its ocular *** herein grafted glycidyl methacrylate on the gelatin backbone with a simple chemical modification of the precursor,utilizing epoxide ring-opening reactions and visible *** chemical modification allows the obtaining of an elastic protein-based hydrogel(GELGYM)with excellent biomimetic properties,approaching those of the native *** can be modulated to be stretched up to 4 times its initial length and withstand high tensile stresses up to 1.95 MPa with compressive strains as high as 80%compared to Gelatin-methacryloyl(GeIMA),the most studied derivative of gelatin used as a *** is also highly biocompatible and supports cellular adhesion,proliferation,and migration in both 2 and 3-dimensional *** characteristics along with its super adhesion to biological tissues such as cornea,aorta,heart,muscle,kidney,liver,and spleen suggest widespread applications of this hydrogel in many biomedical areas such as transplantation,tissue adhesive,wound dressing,bioprinting,and drug and cell delivery.

关键词： Natural-based hydrogel Gelatin Biocompatible Biomimetic Bioadhesive Cornea

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