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3xidative phosphorylation versus glycolysis： what Fuel do spermatozoa use？

Asian Journal of Andrology 2015年第2期17卷 230-235,I0007,I0008页

作者： Stefan S du Plessis Ashok Agarwal Gayatri Mohanty michelle van der linde Division of Medical Physiology Department of Biomedical Sciences Faculty of Medicine and Health Sciences Stellenbosch University Tygerberg South Africa Center for Reproductive Medicine Cleveland Clinic Cleveland Ohio USA Department of Zoology Ravenshaw University Cuttack Odisha India

Spermatozoa are highly specialized cells. Adenosine triphosphate （ATP）, which provides the energy for supporting the key functions of the spermatozoa, is formed by 2 metabolic pathways, namely glycolysis and oxidative phosphorylation （OXPHOS）. It is produced in the mitochondria through OXPHOS as well as in the head and principal piece of the flagellum through glycolysis. However, there is a great discrepancy as to which method of ATP production is primarily utilized by the spermatozoa for successful fertilization. Mitochondrial respiration is considered to be a more efficient metabolic process for ATP synthesis in comparison to glycolysis. However, studies have shown that the diffusion potential of ATP from the mitochondria to the distal end of the flagellum is not sufficient to support sperm motility, suggesting that glycolysis in the tail region is the preferred pathway for energy production. It is suggested by many investigators that although glycolysis forms the major source of ATP along the flagellum, energy required for sperm motility is mainly produced during mitochondrial respiration. Nevertheless, some studies have shown that when glycolysis is inhibited, proper functioning and motility of spermatozoa remains intact although it is unclear whether such motility can be sustained for prolonged periods of time, or is sufficiently vigorous to achieve optimal fertilization. The purpose of this article is to provide an overview of mammalian sperm energy metabolism and identify the preferred metabolic pathway for ATP generation which forms the basis of energy Droduction in human spermatozoa during fertilization.

关键词： adenosine triphosphate energy glycolysis oxidative phosphorylation spermatozoa

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Taxonomy of Ochroconis, genus including opportunistic pathogens on humans and animals

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Fungal Diversity 2014年第2期65卷 89-126页

作者： K.Samerpitak E.van der linde H.-J.Choi A.H.G.Gerrits van den Ende M.Machouart C.Gueidan G.S.de Hoog CBS-KNAW Fungal Biodiversity Centre UtrechtThe Netherlands Department of Microbiology Faculty of MedicineKhon Kaen UniversityKhon KaenThailand Institute for Biodiversity and Ecosystem Dynamics University of AmsterdamAmsterdamThe Netherlands Mycology Unit Biosystematics ProgrammePlant Protection Research InstituteAgricultural Research CouncilPretoriaSouth Africa Evangelisches und Johanniter Klinikum Niederrhein DuisburgGermany Service de Parasitologie-Mycologie CHU de BraboisVandœuvre-lès-NancyFrance Department Life Sciences Division of Microbial&Genomic DiversityNatural History MuseumLondonUK Peking University Health Science Center Research Center for Medical MycologyBeijingChina Sun-Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhouChina Second Medical Military University ShanghaiChina

The genus Ochroconis(Sympoventuriaceae,Venturiales)is revised and currently contains 13 species for which the phylogenetic position has been determined using multilocus *** older generic name Scolecobasidium is considered to be of doubtful identity because the type specimen is *** the Ochroconis lineage,phylogenetic distances of all markers analyzed are exceptionally large,both between and within species.A new genus Verruconis is proposed for the neurotropic opportunist Ochroconis *** accepted within the lineages are keyed out on the basis of phenotypic *** ecological traits within each species are *** species are thermophilic and one of them is an important agent of infection in the brain,while Ochroconis is mesophilic,several species causing infections in cold-blooded animals.

关键词： Taxonomy Ecology Thermophilic fungi Human infection Avian pathogen Fish pathogen Neurotropism

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The influence of prolapse surgery on sexual activity of women

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Open Journal of Obstetrics and Gynecology 2014年第3期4卷 158-164页

作者： linde T. van Genugten Paul J. Q. van der linden Department of Gynaecology and Obstetrics Deventer Hospital Deventer The Netherlands

Aims: A prospective study to assess sexual activity in patients with pelvic organ prolapse (POP) and evaluate changes in sexual functioning after surgery. Secondary outcomes were quality of life and anatomical results. Methods: Patients completed the validated Leiden Questionnaire (LQ) and the short form 36 (SF-36) pre- and two months postoperatively. SPSS 19.0 was used for statistical analysis. Results: 74 patients (average age 61.5 years) were approached, of whom 33.8% were sexually inactive due to other reasons than POP. 23 patients (average age 56.7 years) were included for further analysis. Postoperatively we found a significant improvement for orgasm during intercourse. The remaining domains didn’t change significantly. A trend is noted, indicating that sexual activity stayed unchanged in 82.6% of patients. Dyspareunia improved in 47.8% of patients, lubrication in 34.8% and sexual satisfaction in 40%. Quality of life improved in 73.9%. We found a significant improvement in POP grading. Conclusion: More than a third of the patients presenting with POP are not sexually active due to other reasons than POP. POP surgery appears to improve lubrication, dyspareunia, sexual satisfaction and orgasm during intercourse in a considerable part of patients. Furthermore, there’s no negative influence on sexual activity. POP surgery improves quality of life in the majority of patients.

关键词： Sexual Activity Sexual Functioning Pelvic Organ Prolapse Surgery Leiden Questionnaire

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Effects of Fruit Thinning Severity on Yield and Quality in ‘Sensation’ Mango(Mangifera indica)

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果树学报 2003年第3期20卷 190-194页

作者： T.Yeshitela P.J.Robbertse P.J.C.Stassen J.Grimbeek M.van der linde Alemaya University Department of Plant SciencesP.O.Box 165 Dire Dawa Department of Plant Production&Soil SciencesUniversity of PretoriaDepartement of HorticltureUniversity of Stellen boschDepartement of HorticltureUniversity of Stellen boschDepartement of HorticltureUniversity of Stellen bosch EthiopiaPretoria0002South AfricaStellenbosch7600South AfricaStellenbosch7600South AfricaStellenbosch7600South Africa

Four different fruit thinning severities were *** thinning treatments were carried out in October before the occurrence of physiological fruit *** parameters were measured(both qualitative and quantitative)and the results compared among treatments as well as to that of the *** results showed that where fruit on‘Sensation’mango pani-cles were thinned to two fruit per panicle,a significant difference was obtained for most of the quantitative *** fruits of the treatment where one fruit per panicle was retained and50%panicles removed,produced the best results for most of the qualitative parameters.

关键词：芒果果实产量果实品质疏花疏果定量分析定性分析

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Colonoscopic yield of colorectal neoplasia in daily clinical practice

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World Journal of Gastroenterology 2009年第9期15卷 1085-1092页

作者： Jochim S Terhaar sive Droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder Department of Gastroenterology and Hepatology VU University Medical CentrePO Box 70571007 MBAmsterdamThe Netherlands Gastroenterology and Hepatology Kennemer Gasthuis2000 AKHaarlemThe Netherlands Gastroenterology and Hepatology Academic Medical Centre1100 DDAmsterdamThe Netherlands Epidemiology and Biostatistics VU University Medical Centre1007 MBAmsterdamThe Netherlands Pathology VU University Medical Centre1007 MBAmsterdamThe Netherlands Gastroenterology and Hepatology Slotervaart Hospital1006 BKAmsterdamThe Netherlands Gastroenterology and Hepatology Medical Centre Alkmaar1800 AMAlkmaarThe Netherlands Gastroenterology and Hepatology Sint Lucas Andreas Hospital1061 AEAmsterdamThe Netherlands

AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per ***:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or ***:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients.

关键词： Colorectal cancer Screening Advanced neoplasia Colonoscopy Adenoma

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雏鸡成功运输的关键问题

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国外畜牧学（猪与禽） 2016年第9期36卷 29-32页

作者：王晶晶(译) 邹建忠(校) 靳文广(制图表) Gerrit van der linde 不详荷兰Heering公司

家禽的健康和生产力在不同生产环境中会表现出较大的变化。了解可导致这种差异的条件及其影响,有助于协调为获得更佳生产性能的支出。良好的开端必不可少,易受攻击的1日龄雏鸡对这些复杂条件的反应会有所不同。繁殖包括遗传和育种;种蛋... 详细信息

家禽的健康和生产力在不同生产环境中会表现出较大的变化。了解可导致这种差异的条件及其影响,有助于协调为获得更佳生产性能的支出。良好的开端必不可少,易受攻击的1日龄雏鸡对这些复杂条件的反应会有所不同。繁殖包括遗传和育种;种蛋包括重量、贮存时间和胚胎所处发育状态,因此每一个标明的因子是一个组合体。

关键词：发育状态生产性能环境控制种鸡群父母代种鸡冷应激育雏期时间范围贮存时间环境气候条件

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α_1-肾上腺素受体拮抗剂可加强L-NAME诱发的全身和肾脏血管收缩作用

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世界核心医学期刊文摘（心脏病学分册） 2005年第11期1卷 55-56页

作者： van der linde N. A. J. Boomsma F. van Den Meiracker A. H. 郝广华 Erasmus MC Dr. Molewaterplein 40 3015 GD Rotterdam Netherlands Dr.

Background: Acute inhibition of nitric oxide synthase results in systemic and renal vasoconstriction, which might be attributable to unopposed activity of the sympathetic nervous(SNS) and the renin-angiotensin system(RAS). We studied the effects of NG-nitro-L-arginine methyl ester(L-NAME)during α1-adrenoceptor blockade and concomitant angiotensin II type 1(AT1)receptor blockade in hypertensive individuals pretreated with hydrochlorothiazide(Hct; 25 mg once daily). Methods: Thirteen individuals(47±9 years) were studied during administration of placebo, and after pretreatment with Hct +doxazosin(Dox; 8 mg twice daily for 9 days), with Hct+Dox+losartan(Los; 50 mg twice daily for 9 days), or(n=5) with doxazosin or Dox+Los without hydrochlorothiazide. Mean arterial pressure(MAP) and cardiac output were derived from the finger blood pressure signal recorded by Finapres. Systemic vascular resistance(SVR) was calculated as MAP/cardiac output. Five renal clearance studies of 40 min were performed. Renal vascular resistance(RVR) was calculated as MAP divided by renal blood flow(RBF). L-NAME(12.5 μg/kg per min intravenously) was given during the third clearance period. Results: MAP was 113±11 mmHg at baseline and decreased to 99±10 mmHg during the administration of Hct+Dox and to 92±10 mmHg during Hct+Dox+Los. This decrease in MAP was caused by a decrease in SVR(P=0.0009). Pretreatment with Hct+Dox or Hct+Dox+Los had no effect on glomerular filtration rate or RBF. Infusion of L-NAME during the administration of Hct+Dox resulted in an augmented(P< 0.0001) increase in MAP(18%), SVR(61%)and RVR(70%) compared with those observed with placebo(8, 30 and 49%, respectively). This augmentation was abolished by losartan. Conclusion: L-NAME-in-duced systemic and renal vasoconstrictor responses are potentiated during α1-adrenoceptor blockade. This potentiation was abolished by AT1-receptor antagonism. In man, unopposed activity of the SNS or SNS and RAS is not involved in the systemic and

关键词：收缩作用 L-NAME 肾脏血管肾上腺素受体血管紧张素一氧化氮合酶受体拮抗剂收缩反应比值计血管阻力

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磁共振显示胸腺癌1例报告

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放射学实践 1994年第4期9卷 190-192页

作者： linde.,I 周勤北京卫生部外事司

目前，用磁共振检查病人还比较少，常常是用各种方法进行分级诊断，直到最后才采用磁共振来进行检查。如果用磁共振对肿瘤的诊断已确定，那么用ＣＴ进行诊断性穿刺术常常是必要的。

关键词： NMR 成像胸腺肿瘤癌

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二叶主动脉瓣狭窄病人的升主动脉扩张:前瞻性的心脏MR研究

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国际医学放射学杂志 2013年第3期 285-285页

作者： A.Rossi D.van der linde S.C.Yap T.Lapinskas S.Kirschbaum T.Springeling 刘义涛 Department of Cardiology Erasmus University Medical Center's

背景本研究的目的是评估主动脉扩张的自然发展过程及其与二叶主动脉瓣(BAV)病人的主动脉狭窄(AoS)的关联性。方法采用心脏磁共振对BAV和AoS病人的主动脉扩张进行前瞻性研究。在基线及3年随访中对主动脉根部、升主动脉、主动脉峰值血流... 详细信息

背景本研究的目的是评估主动脉扩张的自然发展过程及其与二叶主动脉瓣(BAV)病人的主动脉狭窄(AoS)的关联性。方法采用心脏磁共振对BAV和AoS病人的主动脉扩张进行前瞻性研究。在基线及3年随访中对主动脉根部、升主动脉、主动脉峰值血流速度、左室舒缩功能与质量进行评估。结果纳入的33例病人中5例需要手术治疗,28例[男性17例,平均年龄(31±8)岁]完成了研究。在主动脉环、冠状窦及管状升主动脉水平主动脉直径显著增加(P<0.050)。管状升主动脉扩张的病人数量从32%增加到43%。主动脉窦和升主动脉连接处的直径没有显著增加。在随访组主动脉峰值血流速度、射血分数及心肌质量显著增加,然而早/晚填充率则显著下降(P<0.050)。在基线升主动脉直径的进展速度与主动脉峰值血流速度呈弱相关(R2=0.16,P=0.040)。结论伴有AoS的BAV病人显示主动脉直径的逐步增加,其最大值显示在管状升主动脉水平。主动脉扩张的进展与AoS的严重程度呈弱相关性。要点①BAV是最常见的先天性心脏缺陷。②BAV病人发展成AoS的风险增加。③BAV病人发展成胸主动脉扩张的风险增加。④主动脉瓣狭窄的严重程度与主动脉扩张的进展相关。⑤心脏MRI可以快速评估BAV的病人。

关键词：二叶主动脉瓣主动脉瓣狭窄胸主动脉扩张血流动力学理论心脏磁共振

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