检索结果-南通市图书馆

Short Sleep Duration is Associated with Central Arterial Stiffness in Children Independent of Other lifestyle Behaviors

引用

Journal of Science in Sport and Exercise 2020年第3期2卷 236-245页

作者： lee Stoner Simon Higgins Katherine Black Kim Boggess michelle l.meyer Andrea Chou Barbara Galland Jillian J.Haszard Kim Meredith-Jones Pouya Saeedi Sheila Skeaff Paula M.l.Skidmore Department of Exercise and Sport Science University of North Carolina at Chapel HillChapel HillNCUSA Department of Exercise Science Elon UniversityElonNCUSA Department of Human Nutrition University of OtagoDunedinNew Zealand Division of Maternal-Fetal Medicine School of MedicineUniversity of North Carolina at Chapel HillChapel HillNCUSA Department of Emergency Medicine School of MedicineUniversity of North Carolina at Chapel HillChapel HillNCUSA Department of Women and Childrens Health University of OtagoDunedinNew Zealand Department of Medicine University of OtagoDunedinNew Zealand Department of Medicine University of OtagoChristchurchNew Zealand

Purpose Children require 9-11 h sleep to ensure adequate growth and development by optimizing the efficiency of a number of biological systems,including the cardiovascular *** study aim was to determine whether short sleep duration(levated aortic arterial stiffness in children aged 9-11 years,independent of other lifestyle behav-iors,including physical activity,sedentary behaviour and dietary *** This cross-sectional study included 421 children(51%female)aged 9-11 *** arterial stiffness was measured using carotid-femoral pulse wave velocity(cfPWV),sleep duration,time spent sedentary,and moderate-vigorous physical activity were measured using wrist actigraphy,and dietary patterns using a food frequency ***-tions between short sleep duration and cfPWV were examined using mixed effects *** There was a positive[unadjusted]association between short sleep duration and cfPWV(β=0.245,95%CI 0.093-0.396).This association persisted following adjustment for demographic factors and was strengthened following adjustment for lifestyle behaviors(β=0.331,95%CI 0.109-0.553).Conclusions Short sleepers(linically meaningful elevated aortic arterial stiffness in comparison to those sleeping the recommended daily 9-11 *** duration may be important for cardiovascular health independent of other lifestyle behaviors.

关键词： Pulse wave velocity Cardiovascular disease Sedentary behaviour Physical activity Diet

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Polyethylene glycol has immunoprotective effects on sciatic allografts, but behavioral recovery and graft tolerance require neurorrhaphy and axonal fusion

引用

Neural Regeneration Research 2025年第4期20卷 1192-1206页

作者： Tyler A.Smith liwen Zhou Cameron l.Ghergherehchi michelle Mikesh Cathy Z.Yang Haley O.Tucker JuliAnne Allgood Jared S.Bushman George D.Bittner Department of Molecular Biosciences University of Texas at AustinAustinTXUSA Department of Neuroscience University of Texas at AustinAustinTXUSA Division of Pharmaceutical Sciences University of WyomingLaramieWYUSA

Behavioral recovery using(viable)peripheral nerve allografts to repair ablation-type(segmental-loss)peripheral nerve injuries is delayed or poor due to slow and inaccurate axonal ***,such peripheral nerve allografts undergo immunological rejection by the host immune *** contrast,peripheral nerve injuries repaired by polyethylene glycol fusion of peripheral nerve allografts exhibit excellent behavioral recovery within weeks,reduced immune responses,and many axons do not undergo Wallerian *** relative contribution of neurorrhaphy and polyethylene glycol-fusion of axons versus the effects of polyethylene glycol per se was unknown prior to this *** hypothesized that polyethylene glycol might have some immune-protective effects,but polyethylene glycol-fusion was necessary to prevent Wallerian degeneration and functional/behavioral *** examined how polyethylene glycol solutions per se affect functional and behavioral recovery and peripheral nerve allograft morphological and immunological responses in the absence of polyethylene glycol-induced axonal ***-type sciatic nerve injuries in outbred Sprague–Dawley rats were repaired according to a modified protocol using the same solutions as polyethylene glycol-fused peripheral nerve allografts,but peripheral nerve allografts were loose-sutured(loose-sutured polyethylene glycol)with an intentional gap of 1–2 mm to prevent fusion by polyethylene glycol of peripheral nerve allograft axons with host *** to negative control peripheral nerve allografts not treated by polyethylene glycol and in contrast to polyethylene glycol-fused peripheral nerve allografts,animals with loose-sutured polyethylene glycol peripheral nerve allografts exhibited Wallerian degeneration for all axons and myelin degeneration by 7 days postoperatively and did not recover sciatic-mediated behavioral functions by 42 days *** morphological signs of rejection,such as col

关键词： allograft rejection axotomy macrophage myelin nerve repair polyethylene glycol(PEG) sciatic nerve T cell transplantation Wallerian degeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The epigenome in pediatric acute lymphoblastic leukemia: drug resistance and therapeutic opportunities

引用

Cancer Drug Resistance 2019年第2期2卷 313-325页

作者： lauren K.meyer michelle l.Hermiston Department of Pediatrics University of CaliforniaSan FranciscoCA 94143USA

Acute lymphoblastic leukemia(All)is the most common malignancy of *** genomic landscape of pediatric All has been extensively characterized,allowing for the identification of distinct molecular subtypes of this *** in turn has facilitated improvements in risk stratification and tailoring of therapy,resulting in dramatic improvements in survival rates over the past several ***,despite these improvements,outcomes remain dismal for the ten percent of patients who continue to fail therapy and *** the genetic landscape of pediatric All is well-understood,increasing evidence suggests that genetic alterations alone are insufficient to promote leukemogenesis and the acquisition of chemoresistance that leads to disease ***,cooperating epigenetic alterations are now recognized as important contributors to the aberrant gene expression profiles that are characteristic of the molecular subtypes of All,and changes in the epigenetic landscape are now thought to underlie the development of chemoresistance and ultimately disease *** review article focuses on the expanding knowledge of the role of the epigenome in All pathogenesis,progression,and response to therapy,and highlights preclinical and clinical efforts to target the epigenome as a means of overcoming chemoresistance and improving outcomes for children with All.

关键词： Acute lymphoblastic leukemia methylation histone modification epigenetic modulator

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The bone marrow microenvironment as a mediator of chemoresistance in acute lymphoblastic leukemia

引用

Cancer Drug Resistance 2019年第4期2卷 1164-1177页

作者： lauren K.meyer michelle l.Hermiston Department of Pediatrics University of CaliforniaSan FranciscoSF 94158USA

Acute lymphoblastic leukemia(All)is a malignancy of immature lymphoid cells that arises due to clonal expansion of cells that undergo developmental arrest and acquisition of pathogenic *** the introduction of intensive multi-agent chemotherapeutic regimens,survival rates for All have improved dramatically over the past several decades,though survival rates for adult All continue to lag behind those of pediatric *** to chemotherapy remains a significant obstacle in the treatment of All,and chemoresistance due to molecular alterations within All cells have been *** addition to these cell-intrinsic factors,the bone marrow microenvironment has more recently been appreciated as a cell-extrinsic mediator of chemoresistance,and it is now known that stromal cells within the bone marrow microenvironment,through direct cell-cell interactions and through the release of lymphoid-acting soluble factors,contribute to All pathogenesis and *** review discusses mechanisms of chemoresistance mediated by factors within the bone marrow microenvironment and highlights novel therapeutic strategies that have been investigated to overcome chemoresistance in this context.

关键词： Acute lymphoblastic leukemia chemotherapy chemoresistance bone marrow microenvironment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of Shading due to Photovoltaic Module Frame

Effect of Shading due to Photovoltaic Module Frame

引用

第十五届国际光伏科学与工程大会

作者： Edson l.meyer Michael Simon Institute of Technology University of Fort Hare South Africa 5700 Institute of Technology University of Fort Hare South Africa 5700

＜正＞ The optimum performance of a module is obtained for equal current-voltage characteristics （I-V） of each cell, in the absence of shade and defect. Total or partial cell shading results in mismatching conditions, which lowers the output of photovoltaic （PV） modules. This mismatch condition may partially or compromise PV module performance. Extensive research has been conducted in finding factors that cause mismatch effect in solar cells. These amongst others include mismatched conditions due to cracked cells, low quality cells in the series string, and transient or permanent shading. Shading due to module features such as frame height is often neglected when the sun is lower in the sky （sunrise/sunset）. In this study the east-west frames of one module were removed and performance was compared to an identical module with all frames intact. Results obtained from this study indicate that a considerable amount of power is lost due to module especially when the sun is lower in the sky. This paper presents the detailed analysis of the results obtained outdoor at 16h30 together with a description of the system used to continuously monitor module performance.

关键词： Module Frame Shading Outdoor Performance Current-Voltage Characteristics

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

The Effect of Temperature on the Performance of Photovoltaic Modules at Regulated Voltage

The Effect of Temperature on the Performance of Photovoltaic...

引用

第十五届国际光伏科学与工程大会

作者： Edson l.meyer Beginner Mapuranga Institute of Technology University of Fort Hare Alice South Africa

Photovoltaic home systems (PHS) are a viable alternative as a source of electricity particularly in rural areas where grid electrification is more expensive. However, the cost of photovoltaic (PV) modules is still relatively high and prohibitive. In addition, PV modules are rated and priced per STC (25℃cell temperature, 1000 W/m irradiance) watts. If however, these modules operate outdoors, conditions are different from STC and performance is normally lower. The effects of temperature and irradiance variations on PV module performance are well documented. When deployed outdoors in a regulated system, however, temperature and irradiance significantly affect PV system output. This paper investigates the effect of temperature and irradiance on the operating power of PV modules deployed in a regulated system.

关键词： Temperature Dependence Regulated Voltage Operating Power

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

金鱼再生的视神经在顶盖投射精确化的DiI顺行标记研究

引用

实验生物学报 1994年第2期27卷 143-151页

作者：王子仁 Ronald l.meyer 兰州大学生物系兰州730000 美国加利福尼亚大学Irvine分校发育生物学中心

本文用微量显微注射法,在金鱼视网膜的背侧用亲脂类荧光染料DiI标记少量神经节细胞,通过顺行标记研究了视神经再生过程中视网膜顶盖投射的精确化过程。在损伤视神经后的不同时期观察了再生视神经纤维在顶盖整装片上的分布。在再生早期... 详细信息

本文用微量显微注射法,在金鱼视网膜的背侧用亲脂类荧光染料DiI标记少量神经节细胞,通过顺行标记研究了视神经再生过程中视网膜顶盖投射的精确化过程。在损伤视神经后的不同时期观察了再生视神经纤维在顶盖整装片上的分布。在再生早期它们以超出正常的途径由背腹两侧进入顶盖,广泛分布。但其中大部分仍分布于顶盖腹侧的靶区。在再生晚期通过精确化,重建如正常鱼一样精确的视网膜顶盖投射。这个精确化过程表现在以下三方面:(1)再生于顶盖错误区域的再生视神经纤维的消失;(2)再生早期视神经纤维主干上生长的侧部分支的消失;(3)到达靶区的再生视神经纤维形成重迭的终末分支。由以上结果推测,顶盖中可能存在两类不同的因子:一类是普通诱向因子,存在于整个顶盖中,它在再生早期引导再生的视神经纤维长入顶盖。另一类是神经营养因子,它具区域特异性,在再生晚期引导视神经纤维到达顶盖靶区,形成精确的视网膜顶盖投射。

关键词：金鱼视神经再生投射精确化

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Viscoelastic analysis of single-component and composite PEG and alginate hydrogels

引用

Acta Mechanica Sinica 2014年第1期30卷 7-14页

作者： Jenna M.Shapiro michelle l.Oyen Cambridge University Engineering Department CambridgeUK Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health

Hydrogels, three-dimensional hydrophilic polymer networks, are appealing candidate materials for study- ing the cellular microenvironment as their substantial water content helps to better mimic soft tissue. However, hydrogels can lack mechanical stiffness, strength, and tough- ness. Composite hydrogel systems have been shown to improve upon mechanical properties compared to their single- component counterparts. Poly （ethylene glycol） dimethacrylate （PEGDMA） and alginate are polymers that have been used to form hydrogels for biological applications. Single- component and composite PEGDMA and alginate systems were fabricated with a range of total polymer concentrations. Bulk gels were mechanically characterized using spherical indentation testing and a viscoelastic analysis framework. An increase in shear modulus with increasing polymer con- centration was demonstrated for all systems. Alginate hydro- gels were shown to have a smaller viscoelastic ratio than the PEGDMA gels, indicating more extensive relaxation over time. Composite alginate and PEGDMA hydrogels exhib- ited a combination of the mechanical properties of the con- stituents, as well as a qualitative increase in toughness. Additionally, multiple hydrogel systems were produced that had similar shear moduli, but different viscoelastic behaviors. Accurate measurement of the mechanical properties of hydrogels is necessary in order to determine what parameters are key in modeling the cellular microenvironment.

关键词： Hydrogel Viscoelastic Indentation Nanoin-dentation Composite

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

引用

Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton UK Dementia Research Institute at King’s College london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

静电流化床用粉末树脂化学性能与物理性能的平衡

引用

绝缘材料通讯 1975年第Z1期 51-53页

作者： CURT l.meyer

粉末树脂的多用性已为广泛的工业应用所肯定,这些应用可分为几种不同的类别,最明显的有如下三类:1.电绝缘、2.装筛涂敷、3.防腐保护。金属基印刷电路板、定子、电枢、变压器密封盖、母线、精致家俱、金属玩具、电动机机壳和大小直径管... 详细信息

粉末树脂的多用性已为广泛的工业应用所肯定,这些应用可分为几种不同的类别,最明显的有如下三类:1.电绝缘、2.装筛涂敷、3.防腐保护。金属基印刷电路板、定子、电枢、变压器密封盖、母线、精致家俱、金属玩具、电动机机壳和大小直径管子等是目前粉末树脂的一些应用方面。所用粉末树脂类型(环氧、乙烯基酯、聚酯、丙烯酸酯)取决于应用环境要求。一种类型与另一类型之间,以及某一特定类型内不同的粉末树脂的电气、耐气候、机械及

关键词：粉末树脂涂敷工业应用电枢流化床法电机构件静电流化床波纹电压

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：