The bone marrow microenvironment as a mediator of chemoresistance in acute lymphoblastic leukemia
作者机构：Department of PediatricsUniversity of CaliforniaSan FranciscoSF 94158USA
出 版 物：《Cancer Drug Resistance》 (癌症耐药（英文）)
年 卷 期：2019年第2卷第4期
页 面：1164-1177页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Meyer LK is supported by a Genentech Foundation Fellowship Award.Hermiston ML is supported by the National Cancer Institute Grant R01 CA193776 the Buster Posey Family Foundation,the Campini Foundation,and the Pepp Family Foundation
主 题：Acute lymphoblastic leukemia chemotherapy chemoresistance bone marrow microenvironment
摘 要：Acute lymphoblastic leukemia(ALL)is a malignancy of immature lymphoid cells that arises due to clonal expansion of cells that undergo developmental arrest and acquisition of pathogenic *** the introduction of intensive multi-agent chemotherapeutic regimens,survival rates for ALL have improved dramatically over the past several decades,though survival rates for adult ALL continue to lag behind those of pediatric *** to chemotherapy remains a significant obstacle in the treatment of ALL,and chemoresistance due to molecular alterations within ALL cells have been *** addition to these cell-intrinsic factors,the bone marrow microenvironment has more recently been appreciated as a cell-extrinsic mediator of chemoresistance,and it is now known that stromal cells within the bone marrow microenvironment,through direct cell-cell interactions and through the release of lymphoid-acting soluble factors,contribute to ALL pathogenesis and *** review discusses mechanisms of chemoresistance mediated by factors within the bone marrow microenvironment and highlights novel therapeutic strategies that have been investigated to overcome chemoresistance in this context.
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