咨询与建议

看过本文的还看了

相关文献

该作者的其他文献

文献详情 >The bone marrow microenvironme... 收藏

The bone marrow microenvironment as a mediator of chemoresistance in acute lymphoblastic leukemia

作     者:Lauren K.Meyer Michelle L.Hermiston 

作者机构:Department of PediatricsUniversity of CaliforniaSan FranciscoSF 94158USA 

出 版 物:《Cancer Drug Resistance》 (癌症耐药(英文))

年 卷 期:2019年第2卷第4期

页      面:1164-1177页

学科分类:1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基  金:Meyer LK is supported by a Genentech Foundation Fellowship Award.Hermiston ML is supported by the National Cancer Institute Grant R01 CA193776 the Buster Posey Family Foundation,the Campini Foundation,and the Pepp Family Foundation 

主  题:Acute lymphoblastic leukemia chemotherapy chemoresistance bone marrow microenvironment 

摘      要:Acute lymphoblastic leukemia(ALL)is a malignancy of immature lymphoid cells that arises due to clonal expansion of cells that undergo developmental arrest and acquisition of pathogenic *** the introduction of intensive multi-agent chemotherapeutic regimens,survival rates for ALL have improved dramatically over the past several decades,though survival rates for adult ALL continue to lag behind those of pediatric *** to chemotherapy remains a significant obstacle in the treatment of ALL,and chemoresistance due to molecular alterations within ALL cells have been *** addition to these cell-intrinsic factors,the bone marrow microenvironment has more recently been appreciated as a cell-extrinsic mediator of chemoresistance,and it is now known that stromal cells within the bone marrow microenvironment,through direct cell-cell interactions and through the release of lymphoid-acting soluble factors,contribute to ALL pathogenesis and *** review discusses mechanisms of chemoresistance mediated by factors within the bone marrow microenvironment and highlights novel therapeutic strategies that have been investigated to overcome chemoresistance in this context.

读者评论 与其他读者分享你的观点

用户名:未登录
我的评分