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Canadian children’s and youth’s adherence to the 24-h movement guidelines during the COVId-19 pandemic: A decision tree analysis

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Journal of Sport and Health Science 2020年第4期9卷 313-321页

作者： michelle d.guerrero Leigh M.Vanderloo Ryan E.Rhodes Guy Faulkner Sarah A.Moore Mark S.Tremblay Children’s Hospital of Eastern Ontario Research Institute OttawaON K1H 8L1Canada ParticipACTION TorontoON M5S 1M2Canada Child Health and Evaluative Sciences Hospital for Sick ChildrenTorontoON M5G 0A4Canada Behavioral Medicine Laboratory School of Exercise SciencePhysical and Health EducationUniversity of VictoriaVictoriaBC V8W 2Y2Canada School of Kinesiology University of British ColumbiaVancouverBC V6T 1Z1Canada department of Therapeutic Recreation Faculty of ChildFamilyand Community StudiesDouglas CollegeCoquitlamBC V3B 7X3Canada School of Health and Human Performance Dalhousie UniversityHalifaxNS B3H 4R2Canada department of Pediatrics University of OttawaOttawaON K1H 8L1Canada

Purpose:The purpose of this study was to use decision tree modeling to generate profiles of children and youth who were more and less likely to meet the Canadian 24-h movement guidelines during the coronavirus disease-2019(COVId-19)***:data for this study were from a nationally representative sample of 1472 Canadian parents(Meanage=45.12,Sd=7.55)of children(511 years old)or youth(1217 years old).data were collected in April 2020 via an online *** items assessed demographic,behavioral,social,micro-environmental,and macro-environmental *** decision trees of adherence and non-adherence to all movement recommendations combined and each individual movement recommendation(physical activity(PA),screen time,and sleep)were ***:Results revealed specific combinations of adherence and non-adherence *** associated with adherence to the recommendation(s)included high parental perceived capability to restrict screen time,annual household income ofCAd 100,000,increases in children’s and youth’s outdoor PA/sport since the COVId-19 outbreak began,being a boy,having parents younger than 43 years old,and small increases in children’s and youth’s sleep duration since the COVId-19 outbreak *** associated with non-adherence to the recommendation(s)included low parental perceived capability to restrict screen time,youth aged 1217 years,decreases in children’s and youth’s outdoor PA/sport since the COVId-19 outbreak began,primary residences located in all provinces except Quebec,low parental perceived capability to support children’s and youth’s sleep and PA,and annual household income ofCAd 99,***:Our results show that specific characteristics interact to contribute to(non)adherence to the movement behavior *** highlight the importance of targeting parents’perceived capability for the promotion of children’s and youth’s movement behaviors during challengin

关键词： decision tree analysis Parental perceived capability Physical activity Screen time Sleep

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Neuroprotective effects of G9a inhibition through modulation of peroxisome-proliferator activator receptor gamma-dependent pathways by miR-128

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Neural Regeneration Research 2024年第11期19卷 2532-2542页

作者： Aina Bellver-Sanchis Pedro AAvila-López Iva Tic david Valle-García Marta Ribalta-Vilella Luis Labrador deb Ranjan Banerjee Ana guerrero Gemma Casadesus Coralie Poulard Mercè Pallàs Christian Grinán-Ferré department of Pharmacology and Therapeutic Chemistry Institut de Neurociències-Universitat de BarcelonaBarcelonaSpain department of Biochemistry and Molecular Genetics Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Institute of Biotechnology National Autonomous University of MexicoCuernavacaMexico department of Pharmacology and Therapeutics Health Science Center-University of FloridaGainesvilleFLUSA department of Chemistry National Institute of Technology DurgapurM G AvenueDurgapurWest BengalIndia Cancer Research Cancer Lyon Universitéde LyonLyonFrance Inserm U1052 Centre de Recherche en Cancérologie de LyonLyonFrance CNRS UMR5286 Centre de Recherche en Cancérlogie de LyonLyonFrance Centro de Investigación en Red Enfermedades Neurodegenerativas(CIBERNED)Instituto de Salud Carlos IIIMadridSpain Neuroimmunology department National Institute of Neurology and Neurosurgery“Manuel Velasco Suárez”Mexico CityMexico

dysregulation of G9a,a histone-lysine N-methyltransferase,has been observed in Alzheimer’s disease and has been correlated with increased levels of chronic inflammation and oxidative ***,microRNAs are involved in many biological processes and diseases playing a key role in pathogenesis,especially in multifactorial diseases such as Alzheimer’s ***,our aim has been to provide partial insights into the interconnection between G9a,microRNAs,oxidative stress,and *** better understand the biology of G9a,we compared the global microRNA expression between senescence-accelerated mouse-prone 8(SAMP8)control mice and SAMP8 treated with G9a inhibitor *** found a downregulation of miR-128 after a G9a inhibition treatment,which interestingly binds to the 3′untranslated region(3′-UTR)of peroxisome-proliferator activator receptor γ(PPARG)***,Pparg gene expression levels were higher in the SAMP8 group treated with G9a inhibitor than in the SAMP8 control *** also observed modulation of oxidative stress responses might be mainly driven Pparg after G9a *** confirm these antioxidant effects,we treated primary neuron cell cultures with hydrogen peroxide as an oxidative *** this setting,treatment with G9a inhibitor increases both cell survival and antioxidant ***,up-regulation of PPARγby G9a inhibitor could also increase the expression of genes involved in dNA damage responses and *** addition,we also described that the PPARγ/AMPK axis partially explains the regulation of autophagy markers ***,PPARγ/GAdd45αpotentially contributes to enhancing synaptic plasticity and neurogenesis after G9a ***,we propose that pharmacological inhibition of G9a leads to a neuroprotective effect that could be due,at least in part,by the modulation of PPARγ-dependent pathways by miR-128.

关键词： aging cognitive decline epigenetics G9a inhibition microRNAs miR-128 peroxisome-proliferator activator receptorγ(PPARγ) PPARG SAMP8

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Influence of Angiotensin II on α₁-Adrenergic Receptors Function in Rat Aorta and Expression in Vascular Smooth Muscle Cells

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Journal of Biosciences and Medicines 2024年第4期12卷 123-134页

作者： Itzell Alejandrina Gallardo-Ortíz Juan Pablo de Jesús Benítez-Garrido Santiago C. Sigrist-Flores Juan Javier López-guerrero Enrique Hong Rafael Villalobos-Molina Unidad de Biomedicina Facultad de Estudios Superiores Iztacala Universidad Nacional Aut&#243noma de M&#233xico Tlalnepantla M&#233xico Carrera de Enfermerí a Facultad de Estudios Superiores Iztacala Universidad Nacional Aut&#243noma de M&#233xico Tlalnepantla M&#233xico departamento de Farmacobiologí a Centro de Investigaci&#243n and de Estudios Avanzados-IPN Ciudad de M&#233xico M&#233xico Carrera de Mé dico Cirujano Facultad de Estudios Superiores Iztacala Universidad Nacional Aut&#243noma de M&#233xico Tlalnepantla M&#233xico

Angiotensin II (Ang II) is the main mediator of the Renin-Angiotensin-System acting on AT1 and other AT receptors. It is regarded as a pleiotropic agent that induces many actions, including functioning as a growth factor, and as a contractile hormone, among others. The aim of this work was to examine the impact of Ang II on the expression and function of α1-adrenergic receptors (α1-ARs) in cultured rat aorta, and aorta-derived smooth muscle cells. Isolated Wistar rat aorta was incubated for 24 h in dMEM at 37˚C, then subjected to isometric tension and to the action of added norepinephrine, in concentration-response curves. Ang II was added (1 × 10−5 M), and in some experiments, 5-Methylurapidil (α1A-AR antagonist), AH11110A (α1B-AR antagonist), or BMY-7378 (α1d-AR antagonist), were used to identify the α1-AR involved in the response. desensitization of the contractile response to norepinephrine was observed due to incubation time, and by the Ang II action. α1d-AR was protected from desensitization by BMY-7378;while RS-100329 and prazosin partially mitigated desensitization. In another set of experiments, isolated aorta-derived smooth muscle cells were exposed to Ang II and α1-ARs proteins were evaluated. α1d-AR increased at 30 and 60 min post Ang II exposure, the α1A-AR diminished from 1 to 4 h, while α1B-AR remained unchanged over 24 h of Ang II exposure. Ang II induced an increase of α1d-AR at short times, and BMY-7378 protected α1d-AR from desensitization.

关键词： Angiotensin II α1d-AR α1-AR Expression Rat aorta Smooth Muscle Cells

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Bed-roughness investigation for a 2-d model calibration:the San Martin case study at Lower Parana

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International Journal of Sediment Research 2013年第4期28卷 458-469页

作者： Massimo guerrero Alberto LAMBERTI Laboratory of Hydraulic Engineering University of Bologna Environmental and Materials Engineering department University of Bologna

This paper illustrates how the acoustic doppler current profiler(AdCP) and single-beam echo-sounder(SBI:S)recordings can be used for the calibration of existing software to assist in generalizing the morphodynamie processes in large rivers at key sites such as bifurcations and *** of the MIKH21C numerical model by the danish Hydraulic Institute at the 25-km-long reach of Lower Parana near Rosario(Argentina) is *** reach includes two downstream confluences and two *** model simulates a 2-1) depth-averaged How velocity and the related sediment fluxes to predict the bifurcation morphodynamics that affects the Parana *** investigate the river channel bathymetry,roughness,flow discharge allocation at bifurcations,suspended sediment concentration and grain size distributions,several instruments were *** instruments included two AdCPs by Teledyne RdI working at frequencies of 600 and 1,200 kHz,a Sontek AdCP working at a frequency of 1,000 kHz and a *** method to assess suspended sediment concentration and grain size distributions has been previously *** paper focuses primarily on investigating dune morphology(by means of SBES depth measurements) and friction velocity(by means of AdCP profiling) to determine the river channel ***2-d model results agree with observed values of bed-roughness,flow velocity and suspended sediment concentration distributions at the investigated sections,known data of water slope and total load of bed sediment are in good agreement with model results.

关键词： 2-d model calibration AdCP Bed-roughness Parana River

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Use of electroporation as an option to transform the horn fly, Haematobia irritans： a species recalcitrant to microinjection

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Insect Science 2016年第4期23卷 621-629页

作者： Qiang Xu Felix d. guerrero Azhahianambi Palavesam Adalberto A. Perez de Leon department of Biology Abilene Christian University Abilene TX 79699 USA USdA-ARS Knipling-Bushland U.S. Livestock Insects Research Laboratory 2700 Fredericksburg Rd. Kerrville TX 78028 USA USdA-ARS Veterinary Pest Genomics Center Kerrville TX 78028 USA

The horn fly, Haematobia irritans, is a serious pest of cattle in North America. The control of horn flies has primarily relied on insecticides. However, the heavy use of insecticides has led to the development of insecticide resistance in horn flies. Novel methods to control horn flies are greatly needed. Transgenic technology is an effective tool to genetically modify insects and may lead to novel methods of pest control based on genomic approaches. Here we report apiggyBac-mediated transformation of the horn fly via electroporation. Transformation with a dsRed fluorescent marker protein coding region was verified by PCR analysis of individual fly bodies and pupal cases and sequencing of PCR products. However, Southern blot analysis failed to indicate the dsRed gene was integrated into the horn fly genome. Thus, the electroporation protocol may have caused the dsRed gene to be integrated into bacterial symbionts of the horn fly.

关键词： dsRed EGFP electroporation Haematobia irritans horn fly transformation transgenic insect

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Nanotrains and Self-Assembled Two-dimensional Arrays Built from Carboranes Linked by Hydrogen Bonding of dipyridones

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Nano Research 2008年第5期1卷 412-419页

作者： Takashi Sasaki Jason M.guerrero Ashley d.Leonard James M.Tour department of Chemistry Department of Mechanical Engineering and Materials ScienceRice UniversityMS 2226100 Main St.HoustonTexas 77005USA

The strong hydrogen bonding ability of 2-pyridones were exploited to build nanotrains on *** wheels on axles difunctionalized with 2-pyridone hydrogen bonding units were synthesized and displayed spontaneous formation of linear nanotrains by self-assembly on SiO_(2)or mica *** using atomic force microscopy confi rmed linear formations with lengths up to 5μm and heights within the range of the molecular height of the carborance-tipped axles.

关键词： Nanovehicles nanotrains 2-pyridone hydrogen bonding self-assembly

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通过人工性转换产生的雄性莫桑比克罗非鱼的养殖

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淡水渔业 1977年第11期7卷 37-39页

作者： Rafael d.guerrero 夏德全祝培福不详菲律宾

罗非鱼作为食用鱼极其广泛地养殖在世界温水地区。该属鱼养殖中的一个主要问题是繁殖过多．导致群体过密而阻碍生长。已经证明有三种方法在产生生长较快的雄性罗非鱼以及阻止共繁殖方面是有效的。这方些法是：单性养殖、杂交和性转换。

关键词：鱼养殖雄性罗非鱼繁殖生长食用鱼杂交温水莫桑比克世界产生

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The human application of gene therapy to re-program T-cell specificity using chimeric antigen receptors

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Chinese Journal of Cancer 2014年第9期33卷 421-433页

作者： Alan d.guerrero Judy S Moyes Laurence JN Cooper division of Pediatrics The University of Texas MD Anderson Cancer Center The University of Texas Graduate School of Biomedical Sciences

The adoptive transfer of T cells is a promising approach to treat cancers. Primary human T cells can be modified using viral and non-viral vectors to promote the specific targeting of cancer cells via the introduction of exogenous T-cell receptors(TCRs) or chimeric antigen receptors(CARs). This gene transfer displays the potential to increase the specificity and potency of the anticancer response while decreasing the systemic adverse effects that arise from conventional treatments that target both cancerous and healthy cells. This review highlights the generation of clinical-grade T cells expressing CARs for immunotherapy, the use of these cells to target B-cell malignancies and, particularly, the first clinical trials deploying the Sleeping Beauty gene transfer system, which engineers T cells to target Cd19+ leukemia and non-Hodgkin's lymphoma.

关键词： T细胞受体基因治疗异性重新编程抗原嵌合基因转移系统非病毒载体

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Synchronization of Robot Manipulators Actuated By Induction Motors with Velocity Estimator

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Computer Modeling in Engineering & Sciences 2019年第11期121卷 609-630页

作者： Felipe J.Torres Gerardo V.guerrero Carlos d.García Ricardo Zavala-Yoe Mario A.García Adolfo R.López University of Guanajuato Division of Engineering Campus Irapuato-SalamancaCarretera Salamanca-Valle de Santiago km 3.5+1.8GuanajuatoSalamanca36885México National Technological of Mexico/National Center of Research and Technological development Av.Palmira S/N colonia PalmiraMorelosCuernavaca62490México School of Engineering and Sciences Monterrey TechnologicalPuente 222 Ejidos de HuipulcoCiudad de México14380México Superior Technological Institute of Irapuato Carretera Irapuato-Silao km 12.5GuanajuatoIrapuato36821México

A complete modeling(including the actuator dynamics)of a robot manipulator that uses three-phase induction motors is presented in this paper.A control scheme is designed to synchronize robot manipulators actuated by induction motors under a masterslave scheme in the case where the joint velocity of the slave robots is *** of the research on the synchronization of robot manipulators assumes the use of ideal actuators to drive the joints;for that reason,in this work,a three-phase induction motor is considered to be a direct-drive actuator for each *** entire model of the mated system is obtained by a combination of the dynamics of the induction motor and robot ***,the synchronization control algorithm for a master-slave scheme in both the joint space and workspace of robot manipulators driven by induction motors is *** observer based on the entire model is proposed to estimate the joint velocity of the slave robot *** the Lyapunov criterion,a stability analysis of the synchronization control with a velocity estimator is *** analytical results show the synchronization and estimation errors are globally,uniformly,and ultimately *** with multiple robots demonstrate the performance of the proposed control algorithm.

关键词： Synchronization robot manipulator induction motor Lyapunov stability observer based on the model

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Epigenomics and gene regulation in mammalian social systems

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Current Zoology 2020年第3期66卷 307-319页

作者： Tania P.guerrero Jorns FICKEL Sarah BENHAIEM Alexandra WEYRICH department Evolutionary Genetics Leibniz-Institute for Zoo and Wildlife Research(IZW)Alfred-Kowalke-Str.17BerlinD-10315Germany Faculty of Environment and Natural Resources Albert Ludwig University of FreiburgTennenbacher Str.4FreiburgD-79085Germany Instute for Biochemistry and Biology University of PotsdamKarl-Liebknecht-Str.2425Potsdam14476Germany department Ecological dynamics Leibniz-Institute for Zoo and Wildife Research(IZW)Alfred-Kowalke Str.17BerlinD-10315Germany

Social epigenomics is a new field of research that studies how the social environment shapes the epigenome and how in turn the epigenome modulates *** focus on describing known gene-environment interactions(GEIs)and epigenetic mechanisms in different mammalian social *** illustrate how epigenetic mechanisms integrate GEIs,we highlight examples where epigenetic mechanisms are associated with social behaviors and with their maintenance through neuroendocrine,locomotor,and metabolic *** discuss future research trajectories and open questions for the emerging field of social epigenomics in nonmodel and naturally occurring social ***,we outline the technological advances that aid the study of epigenetic mechanisms in the establishment of GEIs and vice versa.

关键词： epigenetics dNA methylation histone modification rank social status social systems

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