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Plasmonic mid-infrared third harmonic generation in germanium nanoantennas

Light(Science & Applications) 2018年第1期7卷 19-25页

作者： Marco P.Fischer Aaron Riede Kevin Gallacher Jacopo Frigerio Giovanni Pellegrini michele ortolani Douglas J.Paul Giovanni Isella Alfred Leitenstorfer Paolo Biagioni Daniele Brida Department of Physics and Center for Applied Photonics University of Konstanz78457 KonstanzGermany School of Engineering University of GlasgowRankine BuildingOakfield AvenueGlasgow G128LTUK L-NESS Dipartimento di Fisica del Politecnico di MilanoVia Anzani 4222100 ComoItaly Dipartimento di Fisica Politecnico di MilanoPiazza Leonardo da Vinci 3220133 MilanoItaly Department of Physics Sapienza University of Rome00185 RomeItaly Physics and Materials Science Research Unit University of Luxembourg162a avenue de la FaïencerieL-1511 LuxembourgLuxembourg

We demonstrate third harmonic generation in plasmonic antennas consisting of highly doped germanium grown on silicon substrates and designed to be resonant in the mid-infrared frequency range that is inaccessible with conventional nonlinear plasmonic *** to the near-field enhancement,the result is an ultrafast,subdiffraction,coherent light source with a wavelength tunable between 3 and 5μm,and ideally overlapping with the fingerprint region of molecular *** observe the nonlinearity in this challenging spectral window,a highpower femtosecond laser system equipped with parametric frequency conversion in combination with an all-reflective confocal microscope setup is *** demonstrate spatially resolved maps of the linear scattering cross section and the nonlinear emission of single isolated antenna structures.A clear third-order power dependence as well as mid-infrared emission spectra prove the nonlinear nature of the light *** support the observed resonance length of the double-rod antenna and demonstrate that the field enhancement inside the antenna material is responsible for the nonlinear frequency mixing.

关键词： antenna antennas scattering

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Getting physical with medical education:Exercise based virtual anatomy review classes for medical students

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World Journal of Methodology 2025年第1期15卷 20-25页

作者： Nadeesha R Samarasinghe Taniya S Nagpal michele L Barbeau Charys M Martin Division of General Surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Faculty of Kinesiology Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anatomy and Cell Biology University of Western OntarioLondon N6A 3K7ONCanada Department of Anatomy and Cell Biology Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of regular physical activity are well ***,few studies have examined the effectiveness of integrating physical activity(PA)into curricula within a post-secondary *** investigate the incorporation of PA into medical curriculum,we developed a series of optional exercise-based review sessions designed to reinforce musculoskeletal(MSK)anatomy course *** synchronous sessions were co-taught by a group fitness instructor and an anatomy *** fitness instructor would lead students through both strength and yoga style exercises,while the anatomy instructor asked questions about relevant anatomical structures related to course material previously *** the sessions,participants were asked to evaluate the classes on their self-reported exam preparedness in improving MSK anatomy knowledge,PA levels,and mental *** participants completed surveys;a majority agreed that the classes increased understanding of MSK concepts(90.0%)and activity levels(97.7%).Many(70.0%)felt that the classes helped reduce *** majority of respondents(90.0%)agreed that the classes contributed to increased feelings of social ***,medical students saw benefit in PA based interventions to supplement MSK course *** with increasing activity levels and promoting health behaviours,integrating PA into medical curriculum may improve comprehension of learning material,alleviate stress and foster social connectivity among medical students.

关键词： Medical education Musculoskeletal Anatomy Exercise Online learning

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Doped high-entropy glassy materials to create optical coherence from maximally disordered systems

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Light(Science & Applications) 2022年第9期11卷 1945-1947页

作者： michele Marrocco Department of Energy Technologies and Renewable Resources ENEA(Italian National Agency for New TechnologiesEnergy and Sustainable Economic Development)RomeItaly

Control over excitation wavelengths,sample size,and doping concentrations in glassy materials with high levels of configuration entropy shows promises of efficient correlation between absorption and build-up of cohere... 详细信息

关键词： entropy optical high

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Innovative Services for Electric Mobility Based on Virtual Sensors and Petri Nets

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IEEE/CAA Journal of Automatica Sinica 2023年第9期10卷 1845-1859页

作者： Agostino Marcello Mangini michele Roccotelli Department of Electrical and Information Engineering Polytechnic University of BariBari 70126Italy

About 60%of emissions into the earth’s atmosphere are produced by the transport sector,caused by exhaust gases from conventional internal combustion *** effective solution to this problem is electric mobility,which significantly reduces the rate of urban *** use of electric vehicles(EVs)has to be encouraged and facilitated by new information and communication technology(ICT)*** help achieve this goal,this paper proposes innovative services for electric vehicle users aimed at improving travel and charging *** goal is to provide a smart service to allow drivers to find the most appropriate charging solutions during a trip based on information such as the vehicle’s current position,battery type,state of charge,nearby charge point availability,and *** particular,the drivers are supported so that they can find and book the preferred charge option according to time availability and the final cost of the charge points(CPs).To this purpose,two virtual sensors(VSs)are designed,modeled and simulated in order to provide the users with an innovative service for smart CP searching and *** particular,the first VS is devoted to locate and find available CPs in a preferred area,whereas the second VS calculates the charging cost for the EV and supports the driver in the booking phase.A UML activity diagram describes VSs operations and cooperation,while a UML sequence diagram highlights data exchange between the VSs and other electromobility ecosystem actors(CP operator,EV manufacturer,etc.).Furthermore,two timed Petri Nets(TPNs)are designed to model the proposed VSs,functioning and interactions as discrete event *** Petri Nets are synchronized by a single larger TPN that is simulated in different use cases and scenarios to demonstrate the effectiveness of the proposed VSs.

关键词： Charge point booking electric mobility EV charging Petri Net virtual sensor

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Thermodynamics and dielectric response of BaTiO_(3)by data-driven modeling

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npj Computational Materials 2022年第1期8卷 1998-2014页

作者： Lorenzo Gigli Max Veit michele Kotiuga Giovanni Pizzi Nicola Marzari michele Ceriotti Laboratory of Computational Science and Modeling(COSMO) Institute of MaterialsÉcole Polytechnique Fédérale de LausanneCH-1015LausanneSwitzerland Theory and Simulation of Materials(THEOS)and National Centre for Computational Design and Discovery of Novel Materials(MARVEL) École Polytechnique Fédérale de LausanneCH-1015LausanneSwitzerland

Modeling ferroelectric materials from first principles is one of the successes of density-functional theory and the driver of much development effort,requiring an accurate description of the electronic processes and the thermodynamic equilibrium that drive the spontaneous symmetry breaking and the emergence of macroscopic *** demonstrate the development and application of an integrated machine learning model that describes on the same footing structural,energetic,and functional properties of barium titanate(BaTiO_(3)),a prototypical *** model uses ab initio calculations as a reference and achieves accurate yet inexpensive predictions of energy and polarization on time and length scales that are not accessible to direct ab initio *** predictions allow us to assess the microscopic mechanism of the ferroelectric *** presence of an order-disorder transition for the Ti off-centered states is the main driver of the ferroelectric transition,even though the coupling between symmetry breaking and cell distortions determines the presence of intermediate,partly-ordered ***,we thoroughly probe the static and dynamical behavior of BaTiO_(3)across its phase diagram without the need to introduce a coarse-grained description of the ferroelectric ***,we apply the polarization model to calculate the dielectric response properties of the material in a full ab initio manner,again reproducing the correct qualitative experimental behavior.

关键词： transition ferroelectric dielectric

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Angiotensin-converting enzyme 2 and AMPK/mTOR pathway in the treatment of liver fibrosis:Should we consider further implications?

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World Journal of Gastroenterology 2024年第18期30卷 2391-2396页

作者： michele Barone Section of Gastroenterology Department of Precision and Regenerative Medicine-Jonian Area-University of BariBari 70124Italy

This editorial contains comments on the article by Zhao et al in print in the World Journal of *** mechanisms responsible for hepatic fibrosis are also involved in ***,we recapitulated the complexity of the renin-angiotensin system,discussed the role of hepatic stellate cell(HSC)autophagy in liver fibrogenesis,and analyzed the possible implications in the development of hepatocarcinoma(HCC).Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers definitively contribute to reducing hepatic fibrogenesis,whereas their involvement in HCC is more evident in experimental conditions than in human ***-converting enzyme 2(ACE2),and its product Angiotensin(Ang)1-7,not only regulate HSC autophagy and liver fibrosis,but they also represent potential targets for unexplored applications in the field of ***,ACE2 overexpression inhibits HSC autophagy through the AMP-activated protein kinase(AMPK)/mammalian target of rapamycin(mTOR)*** this case,Ang 1-7 acts binding to the MasR,and its agonists could modulate this ***,since AMPK utilizes different targets to suppress the mTOR downstream complex mTOR complex 1 effectively,we still need to unravel the entire pathway to identify other potential targets for the therapy of fibrosis and liver cancer.

关键词： Renin-angiotensin system Liver fibrosis Hepatic stellate cells Autophagy Hepatocellular carcinoma

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Ordering and disordering of in situ grown MgAl-layered double hydroxide and its effect on the structural and corrosion resistance properties

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International Journal of Minerals,Metallurgy and Materials 2019年第12期26卷 1570-1577页

作者： Muhammad Ahsan Iqbal michele Fedel Department of Industrial Engineering University of Trento

A MgAl-layered double hydroxide(MgAl-LDH)protective film was developed on AA6082 substrates via the in situ hydrothermal growth method to obtain a distinct cauliflower-like LDH structure,and coated substrates were further heat-treated in air at temperatures from 100 to 250℃ to further improve the corrosion resistance of MgAl-LDH by taking advantage of the LDH memory effect;also,the effect of calcination on MgAl-LDH structural stability and the corresponding corrosion resistance properties were *** structural characterization of uncalcined and calcined LDH films were examined using scanning electron microscopy,energy-dispersive spectroscopy,X-ray diffraction,thermogravimetric analysis,differential scanning calorimetry,and Fourier transform infrared *** corresponding corrosion protection efficiency of the developed coating was studied through potentiodynamic polarization experiments and by electrochemical impedance *** with uncalcined MgAl-LDH,the calcined film showed a relatively lower corrosion current density and a higher impedance value,especially after heat treatment at 250℃.The findings demonstrate that calcination strongly affects the oriented growth of the LDH and causes an increase in the surface area and contraction of the basal spacing,which in turn caused a compact structure that substantially influenced the LDH corrosion resistance properties.

关键词： layered double hydroxide calcination in situ growth thin films corrosion protection

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Platelet-rich plasma： combinational treatment modalities for musculoskeletal conditions

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Frontiers of Medicine 2018年第2期12卷 139-152页

作者： Isabel Andia michele Abate Regenerative Medicine Laboratory RioCruces Health Research Institute Cruces University Hospital 48903 Barakaldo Spain Department of Medicine and Science of Aging University G. d'Annunzio Chieti-Pescara 66013 Chieti Scalo Italy

Current research on common musculoskeletal problems, including osteoart]cular cona]t]ons, tendinopathies, and muscle injuries, focuses on regenerative translational medicine. Platelet-rich plasma therapies have emerged as a potential approach to enhance tissue repair and regeneration. Platelet-rich plasma application aims to provide supraphysiological concentrations of platelets and optionally leukocytes at injured/pathological tissues mimicking the initial stages of healing. However, the efficacy of platelet-rich plasma is controversial in chronic diseases because patients＇ outcomes show partial improvements. Platelet-rich plasma can be customized to specific conditions by selecting the most appropriate formulation and timing for application or by combining platelet-rich plasma with synergistic or complementary treatments. To achieve this goal, researchers should identify and enhance the main mechanisms of healing. In this review, the interactions between platelet-rich plasma and healing mechanisms were addressed and research opportunities for customized treatment modalities were outlined. The development of combinational platelet-rieh plasma treatments that can be used safely and effectively to manipulate healing mechanisms would be valuable and would provide insights into the processes involved in physiological healing and pathological failure.

关键词： regenerative medicine joint conditions muscle injuries platelet rich plasma tendinopathy healing mechanisms

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Scour process caused by multiple subvertical non-crossing jets

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Water Science and Engineering 2017年第1期10卷 17-24页

作者： Stefano Pagliara michele Palermo DESTEC-Department of Energy SystemsTerritory and Construction EngineeringUniversity of Pisa56122 PisaItaly

The scour process induced by plunging jets is an important topic for hydraulic engineers. In recent decades, several researchers have developed new strategies and methodologies to control the scour morphology, including different jet arrangements and structures located in the stilling basin. It has been found that multiple jets can cause less scouring than single plunging jets. Based on this evidence, this study aimed to investigate the equilibrium morphology caused by multiple non-crossing jets. A dedicated laboratory model was built and experimental tests were carried out under different combinations of jet inclination angles, by varying the tailwater level and the virtual crossing point location, which was set below the original channel bed level. It was experimentally shown that the equilibrium scour morphology depends on the jet discharge, the differences in non-crossing jet inclination angles, the downstream water level, and the distance of the virtual crossing point from the original channel bed level. In particular, the last parameter was found to be one of the most influential parameters, because of the resulting flow patterns inside the water body. Furthermore, the analysis of experimental evidence allowed for a complete and detailed classification of the scour hole typologies. Three different scour typologies were distinguished and classified. Finally, based on previous studies, two novel re-lationships have been proposed to predict both the maximum scour depth and length within a large range of hydraulic and geometric parameters.

关键词： Multiple subvertical jets Plunge pool Scour Spillway Tailwater

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Neoadjuvant treatment for resectable pancreatic cancer: Time for phase Ⅲ testing?

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World Journal of Gastroenterology 2010年第39期16卷 4883-4887页

作者： michele Reni Medical Oncology Unit Department of OncologySan Raffaele Scientific Institute

This paper discusses the rationale for phaseⅢtesting of neoadjuvant therapy in patients affected by resectable pancreatic *** therapeutic management of patients affected by resectable pancreatic cancer is particularly troublesome due to the aggressiveness of the disease and to the limited efficacy and sometimes unfavourable risk-benefit ratio of the available therapeutic *** data on the role of adjuvant chemoradiation have been reported,while adjuvant single-agent chemotherapy significantly improved overall survival(OS)when compared to surgery alone. However,the OS figures for adjuvant chemotherapy remain *** effect,pancreatic cancer exhibits a prominent tendency to recur after a brief median time interval from surgery and extra-pancreatic dissemination represents the predominant pattern of disease *** treatment has a strong rationale in this disease but limited information on the efficacy of this approach is available from single arm trials with low levels of ***,in spite of two decades of investigation there is currently no evidence to support the routine use of pre-surgical therapy in clinical practice. To foster knowledge on the optimal management of this disease,and to produce evidence-based treatment guidelines,there is no alternative to well designed randomized *** chemotherapy is a candidate for testing because it is supported by a more robust rationale than *** chemotherapy regimens with elevated activity in advanced disease warrant *** would suggest the running of an exploratory phaseⅡrandomized trial before embarking on a large phase Ⅲ study.

关键词： Pancreatic cancer Neoadjuvant therapy Phase Ⅲ trial Chemotherapy

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