Platelet-rich plasma： combinational treatment modalities for musculoskeletal conditions

作     者：Isabel Andia Michele Abate 

作者机构：Regenerative Medicine Laboratory RioCruces Health Research Institute Cruces University Hospital 48903 Barakaldo Spain Department of Medicine and Science of Aging University G. d'Annunzio Chieti-Pescara 66013 Chieti Scalo Italy 

出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)

年 卷 期：2018年第12卷第2期

页      面：139-152页

核心收录：

学科分类：0710[理学-生物学] 0832[工学-食品科学与工程（可授工学、农学学位）] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 083203[工学-农产品加工及贮藏工程] 

主　　题：regenerative medicine joint conditions muscle injuries platelet rich plasma tendinopathy healing mechanisms 

摘      要：Current research on common musculoskeletal problems, including osteoart]cular cona]t]ons, tendinopathies, and muscle injuries, focuses on regenerative translational medicine. Platelet-rich plasma therapies have emerged as a potential approach to enhance tissue repair and regeneration. Platelet-rich plasma application aims to provide supraphysiological concentrations of platelets and optionally leukocytes at injured/pathological tissues mimicking the initial stages of healing. However, the efficacy of platelet-rich plasma is controversial in chronic diseases because patients＇ outcomes show partial improvements. Platelet-rich plasma can be customized to specific conditions by selecting the most appropriate formulation and timing for application or by combining platelet-rich plasma with synergistic or complementary treatments. To achieve this goal, researchers should identify and enhance the main mechanisms of healing. In this review, the interactions between platelet-rich plasma and healing mechanisms were addressed and research opportunities for customized treatment modalities were outlined. The development of combinational platelet-rieh plasma treatments that can be used safely and effectively to manipulate healing mechanisms would be valuable and would provide insights into the processes involved in physiological healing and pathological failure.