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Serum SCCA-IgM as a predictor of hepatocellular carcinoma in patients with liver cirrhosis

Open Journal of Gastroenterology 2012年第2期2卷 56-61页

作者： Daniela Buccione Gianluca Fatti Andrea Gallotta Elisabetta Loggi Roberto Di Donato Lilia Testa Carlo Saitta Valentina Santi Antonio Di Micoli Virginia Erroi Marta Frigerio Valentina fazio Antonino Picciotto Alessandra Biasiolo Francoise degos Patrizia Pontisso Giovanni Raimondo Franco Trevisani APHP Hopital Beaujon INSERM U 773 Clichy France Dipartimento di Medicina Clinica e Sperimentale “G. Patrassi” Università di Padova Padova Italia Dipartimento di Medicina Clinica Alma Mater Studiorum-Università di Bologna Bologna Italia Dipartimento di Medicina Interna Policlinico Universitario di Messina Messina Italia Dipartimento di Medicina Interna Università di Genova Genova Italia Xeptagen S.p.A. Venezia Italia

Aberrant Squamous Cell Carcinoma Antigen (SCCA) expression is an early hepatocarcinogenetic event and circulating SCCA-IgM complexes are elevated in most HCC patients. We evaluated whether serum SCCA-IgM levels can identify HCV +ve cirrhotic patients at low HCC risk. In this retrospective study we enrolled 29 cirrhotic patients in whom serum SCCA-IgM was measured 8 - 69 months (median 31) before HCC diagnosis, and 28 cirrhotic patients who remained HCC- free, with SCCA-IgM measured 15 - 68 months (median 48) before the study end. The best discriminating value of SCCA-IgM was calculated and tested in predicting HCC diagnosis within 12, 24 and 36 months. Sensitivity analysis, considering different HCC incidence, was conducted to identify the patient subgroup with an annual cancer risk below the threshold of a cost-effective semiannual surveillance with ultrasound. Cumulative HCC incidence at 12, 24 and 36 months was 7.0%, 15.7% and 26.3%, respectively. SCCA-IgM levels were higher in HCC than in cirrhotic patients [median: 381 (95% C.I.: 50 - 5289) vs. 100 (70 - 493) AU/mL, P = 0.005]. The SCCA-IgM value ≤ 200 AU/mL accurately identified patients at low risk of HCC development in the subsequent year (sensitivity 75%, specificity 62%, positive predictive value 13% and negative predictive value 97%). Considering an annual HCC incidence ≤ 3%, patients with SCCA-IgM ≤ 200 AU/mL (60% of the whole patients) had an HCC risk below the accepted threshold of a cost-effective surveillance (1.5%). In conclusion, provided that our provocative results are confirmed in larger studies, SCCA-IgM serum measurement could permit implementation of a two step (with different costs) surveillance: an initial serological surveillance, based on the annual monitoring of this biomarker, and the conventional surveillance by semiannual US when SCCA-IgM becomes >200 AU/mL. This could improve the cost/effectiveness of surveillance of HCV infected patients at risk of HCC.

关键词： SCCA-IgM HCC Risk Assessment Surveillance Cost/Effectiveness

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Bits, Mass and Acceleration Issues in BSC

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Journal of Physical Science and Application 2014年第8期4卷 531-535页

作者： Giuseppe fazio Mauro Giaconi Angela D'Arienzo Davide Quatrini Electronic Engineering department University of Rome Tor Vergata

The goal of the present paper is to expand already published works in the frame of "Banded speed cosmology" (BSC). In particular this paper gives validated values for physical quantities not so far investigated in previous publications, i. e., the number of individual physical entity in the universe, as well as the maximum value for acceleration. Validates values mean identical quantities from a numerical point of view obtained with different theoretical procedures, additionally compared with data based on NASA observations with Planck probe.

关键词：加速度 BSC 质量探测数据 NASA 物理量价值观出版物

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幼年性结肠息肉综合征患者的结肠手术:一组病例研究

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世界核心医学期刊文摘（胃肠病学分册） 2005年第10期1卷 14-15页

作者： Oncel M. Church J.M. Remzi F.H. fazio V.W. 郝筱倩 Cleveland Clinic Foundation 9500 Euclid Avenue A30 Cleveland OH 44195 United States Dr.

PURPOSE: Juvenile polyposis syndrome is characterized by multiple hamartomatous polyps in the large intestine. When indicated, the surgical choices in symptomatic juvenile polyposis syndrome patients are colectomy with ileorectal anastomosis or proctocolectomy with pouch. The aim of this study was to evaluate the long-term outcomes of the surgical options in juvenile polyposis syndrome patients who present with symptomatic colonic polyps. METHODS: The charts of all juvenile polyposis syndrome patients who had had at least one colonic operation since 1953 in our institution were reviewed. The following data were abstracted: demographics, the number and site of the polyps, symptoms, the intervals and types of the colonic operation, follow-up, and the patients’current status. RESULTS: There were 13 patients (6 males) with a median age of 10 years (range, 1-50 years) at the time of diagnosis. Patients had colonic (n = 13), rectal (n = 12), and gastric (n = 6) polyps. Rectal bleeding (n = 11) was the most common presenting symptom. Three patients underwent proctectomy as the initial operation. Although a rectum-preserving operation was initially performed in ten patients, a subsequent proctectomy was required in five of them within a median of 9 years (range, 6-34 years). Therefore, eight patients had their rectum removed during the study period; five had an ileal pouch-anal anastomosis, one had a Koch pouch as a restorative surgery, and two had an end ileostomy. No relation was observed between the number of colonic and rectal polyps and the type of surgery or the need for proctectomy. Patients were followed up a median of 3 years (range, 2-24 years) after their ultimate operations. During this period, one patient (20 percent) who underwent restorative proctectomy and 4 patients (80 percent)-whose rectums were preserved required multiple endoscopic polypectomies for recurrent polyps in the pouch (first patient)-or their rectums (the other four patients). The patient who

关键词：肠息肉综合征幼年性结肠手术病例研究回肠直肠吻合术直肠切除术回肠袋末端回肠造口术结肠袋肛门直肠

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Precision pulmonary trans-arterial chemoembolization（PPTACE） plus RFA for lung neoplasms:safety and feasibility

Precision pulmonary trans-arterial chemoembolization（PPTACE...

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2009年世界肿瘤介入学术大会

作者： Cosmo Gadaleta Annamaria Catino Giuseppe Rubini Vito fazio Girolamo Ranieri Gennaro Gadaleta-Caldarola Antonio Cramarossa Eugenio Canniello Francesco Armenise Angela Gaudiano Gaetano Martinelli Elena Ludovico Gianluca Vinciarelli Giuseppe Laricchia Veronica Goffredo Vittorio Mattioli Oncology Institute Bari-Italy Nuclear Medicine University of Bari-Italy Miulli Hospital Acquaviva d.f.-Italy

＜正＞Objectives:The study aimed to evaluate the feasibility and safety of precision pulmonary arterial chemoembolization （PPTACE）followed by percutaneous RFA in patients with unresectable lung neoplasms. Patients and methods:From November 2007 to April 2009,twelve patients（5 male,7 female,median age 57）and 20 nodules were treated in 14 sessions.

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混凝土破损结构的补偿收缩修补砂浆

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膨胀剂与膨胀混凝土 2007年第4期 21-25页

作者： S.Collepardi G.Corazza G.fazio S.Monosi R.Troli 刘立

补偿收缩砂浆通常为预拌水泥基材料。在众多粉状组成成分中便含有膨胀剂,以死烧氧化钙(CaO)或硫铝酸钙(CSA)为代表的膨胀剂,在钢筋或粗糙混凝土基层摩擦力的限制作用下,在修补砂浆中产生压应力。由于CaO或CSA膨胀剂只有在有水的情况下... 详细信息

补偿收缩砂浆通常为预拌水泥基材料。在众多粉状组成成分中便含有膨胀剂,以死烧氧化钙(CaO)或硫铝酸钙(CSA)为代表的膨胀剂,在钢筋或粗糙混凝土基层摩擦力的限制作用下,在修补砂浆中产生压应力。由于CaO或CSA膨胀剂只有在有水的情况下才能水化,因此为保证使用效果,砂浆必须仔细养护,如不进行仔细的潮湿养护,修补工作很可能由于没有产生有效的压应力而失败,预压应力由限制膨胀产生。本工作致力于研究含CaO或CSA膨胀剂、减缩剂(SRA)砂浆在有无潮湿养护下的性能。由于有减缩剂SRA与膨胀剂的配合,即使在没有任何潮湿养护措施下,也会产生限制膨胀。但是,当CaO与减缩剂SRA复合使用时,这种效应比CSA膨胀剂更明显。

关键词：膨胀剂修补砂浆减缩剂

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Apple whole genome sequences:recent advances and new prospects

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Horticulture Research 2019年第1期6卷 1247-1270页

作者： Cameron P.Peace Luca Bianco Michela Troggio Eric van de Weg Nicholas P.Howard Amandine Cornille Charles-Eric Durel Sean Myles ZoëMigicovsky Robert J.Schaffer Evelyne Costes Gennaro fazio Hisayo Yamane Steve van Nocker Chris Gottschalk Fabrizio Costa David Chagné Xinzhong Zhang Andrea Patocchi Susan E.Gardiner Craig Hardner Satish Kumar Francois Laurens Etienne Bucher Dorrie Main Sook Jung Stijn Vanderzande department of Horticulture Washington State UniversityPullmanWA 99164USA Computational Biology Fondazione Edmund MachSan Michele all’AdigeTN 38010Italy department of Genomics and Biology of Fruit Crops Fondazione Edmund MachSan Michele all’AdigeTN 38010Italy Plant Breeding Wageningen University and ResearchWageningen 6708PBThe Netherlands department of Horticultural Science University of MinnesotaSt.PaulMN 55108USA Institut für Biologie und Umweltwissenschaften Carl von Ossietzky Universität26129 OldenburgGermany GQE-Le Moulon Institut National de la Recherche AgronomiqueUniversity of Paris-SudCNRSAgroParisTechUniversitéParis-Saclay91190 Gif-sur-YvetteFrance Institut National de la Recherche Agronomique Institut de Recherche en Horticulture et SemencesUMR 134549071 BeaucouzéFrance department of Plant Food and Environmental SciencesFaculty of AgricultureDalhousie UniversityTruroNS B2N 5E3Canada The New Zealand Institute for Plant and Food Research Ltd Motueka 7198New Zealand School of Biological Sciences University of AucklandAuckland 1142New Zealand AGAP INRACIRADMontpellier SupAgroUniversity of MontpellierMontpellierFrance Plant Genetic Resources Unit USDA ARSGenevaNY 14456USA Laboratory of Pomology Graduate School of AgricultureKyoto UniversityKyoto 606-8502Japan department of Horticulture Michigan State UniversityEast LansingMI 48824USA The New Zealand Institute for Plant and Food Research Ltd(Plant&Food Research) Palmerston North Research CentrePalmerston North 4474New Zealand College of Horticulture China Agricultural University100193 BeijingChina Agroscope 8820 WädenswilSwitzerland Queensland Alliance of Agriculture and Food Innovation University of QueenslandSt Lucia 4072Australia New Cultivar Innovation Plant and Food ResearchHavelock North 4130New Zealand Agroscope 1260 ChanginsSwitzerland

In 2010,a major scientific milestone was achieved for tree fruit crops:publication of the first draft whole genome sequence(WGS)for apple(Malus domestica).This WGS,v1.0,was valuable as the initial reference for sequence information,fine mapping,gene discovery,variant discovery,and tool development.A new,high quality apple WGS,GDDH13 v1.1,was released in 2017 and now serves as the reference genome for *** the past decade,these apple WGSs have had an enormous impact on our understanding of apple biological functioning,trait physiology and inheritance,leading to practical applications for improving this highly valued *** gene identities for phenotypes of fundamental and practical interest can today be discovered much more ***-wide polymorphisms at high genetic resolution are screened efficiently over hundreds to thousands of individuals with new insights into genetic relationships and ***-density genetic maps are constructed efficiently and quantitative trait loci for valuable traits are readily associated with positional candidate genes and/or converted into diagnostic tests for *** understand the species,geographical,and genomic origins of domesticated apple more precisely,as well as its relationship to wild *** WGS has turbo-charged application of these classical research steps to crop improvement and drives innovative methods to achieve more durable,environmentally sound,productive,and consumer-desirable apple *** review includes examples of basic and practical breakthroughs and challenges in using the apple *** for“what’s next”focus on necessary upgrades to the genome sequence data pool,as well as for use of the data,to reach new frontiers in genomics-based scientific understanding of apple.

关键词： breakthrough hundreds frontier

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Hartmann手术与术后不良事件的相关性研究

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世界核心医学期刊文摘（胃肠病学分册） 2006年第6期2卷 17-18页

作者： Aydin H. N. Remzi F.H. Tekkis P. P. fazio V.W. 张欣(译) 史敏(校) 不详 department of Colorectal Surgery/A30 Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland OH 44195 United States

PURPOSE: The aim of this study was to ascertain the prevalence and pattern of surgical and medical adverse events in patients undergoing Hartmann’s reversal for diverticular disease. A comparison of postoperative outcomes is made between Hartmann’s reversal and primary resection and anastomosis. METHODS: Data were collected from patients who underwent successful Hartmann’s reversal (Group 1, n = 121) and primary resection and anastomosis (Group 2, n = 731) for diverticular disease in a single center from January 1981 to May 2003. Multivariate logistic regression was used to compare early postoperative mortality, medical and surgical complications and readmission rates between the two groups. RESULTS: Hartmann’s reversal was associated with a higher prevalence of surgical or medical complications compared with primary resection and anastomosis (43.8 percent and 9.1 percent for Hartmann’s reversal vs. 26.0 percent and 4.8 percent for primary resection and anastomosis). There was no difference in the readmission rates (7.2 percent vs. 7.6 percent, respectively, P = 0.88) or early postoperative mortality (1.7 percent vs. 0.7 percent, P = 0.25) between Hartmann’s reversal and primary resection and anastomosis. The need for reoperation, prolonged ileus, respiratory tract infections, and renal failure were more common adverse events in the Hartmann’s reversal group (P dex), and operative urgency, patients who underwent Hartmann’s reversal were 2.1 times more likely to have adverse surgical events during their postoperative period (95 percent confidence interval for odds ratio = 1.3-3.3). CONCLUSIONS: Hartmann’s reversal is a complex surgical procedure that is associated with a high prevalence of postoperative adverse events in comparison with primary resection and anastomosis. To minimize the prevalence of such adver

关键词： Hartmann手术术后不良 logistic回归分析临床并发症肠吻合术早期死亡率一期切除外科术式手术患者外科并发症

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高密度脂蛋白可追踪脑卒中恢复情况

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中华高血压杂志 2020年第11期28卷 1099-1099页

作者： Plubell DL Fenton AM Rosario S Bergstrom P Wilmarth PA Clark WM Zakai NA Quinn JF Minnier J Alkayed NJ fazio S Pamir N 刘青(译) 刘莉(摘/审校) 不详

前瞻性队列研究质疑高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)在脑卒中风险预测中的价值。该文旨在探讨长期功能恢复与高密度脂蛋白(high density lipoprotein,HDL)蛋白质组和功能的关系。方法与结果:测定急性... 详细信息

前瞻性队列研究质疑高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)在脑卒中风险预测中的价值。该文旨在探讨长期功能恢复与高密度脂蛋白(high density lipoprotein,HDL)蛋白质组和功能的关系。方法与结果:测定急性缺血性脑卒中后2个时间点(24小时,35例;96小时,20例)和35例对照组HDL蛋白组成和功能(胆固醇流出能力)的变化。

关键词：急性缺血性脑卒中前瞻性队列研究胆固醇流出高密度脂蛋白功能恢复蛋白质组

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妊娠早期钆对比剂暴露：美国460万例妊娠妇女的应用研究

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国际医学放射学杂志 2019年第6期 740-740页

作者： S.T.Bird K.Gelperin L.Sahin K.B.Bleich E.fazio-Eynullayeva C.Woods 蒋梦迪 Food and Drug Administration Center for Drug Evaluation and Research Office of Pharmacovigilance and Epidemiology Division of Epidemiology

摘要因为妊娠期使用钆对比剂(GBCA)的安全性尚未确定,除非对孕妇或胎儿的健康是必须的,否则不推荐在妊娠期间使用钆对比剂。目的评估GBCA在大样本胎儿安全

关键词：钆对比剂妊娠早期增强检查

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利用组织多普勒检查对心肌致密化不全患儿舒张功能的评估

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世界核心医学期刊文摘（心脏病学分册） 2007年第8期3卷 45-45页

作者： fazio G. Pipitone S. Iacona M.A. 郭俊 department of Cardiology University of Palermo Italy

组织多普勒分析是评价舒张功能的一种新型超声心动图检查方式。本文报道对1组15例心肌致密化不全患儿进行组织多普勒分析的结果。二维超声心动图检查显示只有8例患者的收缩功能降低。分析发现有7例患者的舒张功能发生改变:2例患者的全... 详细信息

组织多普勒分析是评价舒张功能的一种新型超声心动图检查方式。本文报道对1组15例心肌致密化不全患儿进行组织多普勒分析的结果。二维超声心动图检查显示只有8例患者的收缩功能降低。分析发现有7例患者的舒张功能发生改变:2例患者的全部节段均可见E波降低,3例患者的舒张功能障碍限于尖段和外侧段,其余2例患者的E波降低仅见于尖段。收缩功能障碍和舒张功能障碍之间存在强相关性:事实上,存在舒张功能障碍的所有患者亦表现出收缩功能的显著降低。

关键词：心肌致密化不全收缩功能舒张功能障碍组织多普勒超声心动图多普勒检查外侧段检查方式

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