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Dorsolateral prefrontal cortex, working memory and episodic memory processes: insight through transcranial magnetic stimulation techniques

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Neuroscience Bulletin 2013年第3期29卷 381-389页

作者： michela Balconi Laboratory of Cognitive Psychology Department of Psychology Catholic University of Sacred Heart

The ability to recall and recognize facts we experienced in the past is based on a complex mechanism in which several cerebral regions are implicated. Neuroimaging and lesion studies agree in identifying the frontal lobe as a crucial structure for memory processes, and in particular for working memory and episodic memory and their relationships. Furthermore, with the introduction of transcranial magnetic stimulation （TMS） a new way was proposed to investigate the relationships between brain correlates, memory functions and behavior. The aim of this review is to present the main findings that have emerged from experiments which used the TMS technique for memory analysis. They mainly focused on the role of the dorsolateral prefrontal cortex in memory process. Furthermore, we present state-of-the-art evidence supporting a possible use of TMS in the clinic. Specifically we focus on the treatment of memory deficits in depression and anxiety disorders.

关键词： transcranial magnetic stimulation dorsolateral prefrontal cortex memory working memory anxiety depression

Traces and echoes of De Architectura by Marcus Vitruvius Pollio in the work of Xu Guangqi in 17th century China

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Frontiers of Mechanical Engineering 2016年第1期11卷 3-11页

作者： michela CIGOLA Yibing FANG DART Laboratory of Documentation Analysis and Survey of Architecture and Territory University of Cassino and South LatiumCassino 03043 Italy Institute for the History of Natural Science Chinese Academy of Sciences

This study aims to investigate the role played by Xu Guangqi （1562-1633）, minister of the Ming Dynasty, in the development of European scientific and technical knowledge in China between the 16th and 17th centuries by analyzing a book of Western technology that he wrote, namely, Taixi Shuifa （On Western Hydraulics）. Several Western books related to machine knowledge are searched to trace the source of the illustrations in Taixi Shuifa. We found that Archimedes＇ screw and Ctesibius＇ machine, which are included in Vitruvius＇ De Architectura volumes, also appear in the work of Xu Guangqi.

关键词： Vitruvius' De Architectura Xu Guangqi'sTaixi Shuifa Jesuit missionaries Italian Renaissance,drawing representation

Estrogens still represent an attractive therapeutic approach for Alzheimer’s disease

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Neural Regeneration Research 2022年第1期17卷 93-94页

作者： Elena Tamagno michela Guglielmotto Department of Neuroscience University of TorinoTorinoItaly(Tamagno EGuglielmotto M)Neuroscience Institute of Cavalieri Ottolenghi Foundation(NICO)University of TorinoTorinoItaly

Alzheimer’s disease(AD)is a progressive neurodegenerative condition that goes f rom mild cogni t ive impai rment in prodromal disease to severely disabling deficits in advanced *** risk for AD development,as well as progression and severity,clearly differ between men and women(Pike,2017).Epidemiological studies have shown that there is a significantly increased prevalence in the development of AD in women compared to men,which is usually explained by the longer lifespan of *** increased frequency may be due to the interplay between age and sex,in which genetic factors together with hormonal and metabolic patterns play a crucial ***,cognitive impairment has been confirmed to be greater in women than in men at the same stage of AD,likely due to reduced estrogen levels in postmenopausal women(Laws et al.,2016).

关键词： Alzheimer attractive therapeutic

Mitochondria replacement from transplanted amniotic fluid stem cells:a promising therapy for non-neuronal defects in spinal muscular atrophy

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Neural Regeneration Research 2024年第5期19卷 971-972页

作者： michela Pozzobon Camilla Bean Women’s and Children’s Health Department University of Padova Foundation Institute of Pediatric Research Cittàdella Speranza PadovaItaly Department of Medicine University of UdineUdineItaly

Spinal muscular atrophy(SMA)is a genetic disorder that primarily affects infants and leads to muscle weakness,atrophy,and *** main cause is the homozygous mutation or deletion of the SMN1 gene,resulting in inadequate levels of the survival motor neuron(SMN)*** treatments focus on restoring SMN levels through various approaches,but there is a need for“SMN-independent”therapies that target other pathological *** muscle is closely involved in SMA pathology,with impaired muscle function observed before motor neuron *** have revealed that SMN loss leads to skeletal muscle mitochondrial structural abnormalities,impaired respiration,and accumulation of reactive oxygen species.

关键词： impaired atrophy muscular

Interpreting map usage patterns using geovisual analytics and spatiotemporal clustering

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International Journal of Digital Earth 2015年第8期8卷 599-622页

作者： Gavin McArdle Ali Tahir michela Bertolotto National Center for Geocomputation National University of IrelandMaynoothIreland Institute of Geographical Information Systems School of Civil and Environmental EngineeringNational University of Sciences and TechnologyIslamabadPakistan School of Computer Science and Informatics University College DublinDublinIreland

Extracting meaningful information from the growing quantity of spatial data is a *** issues are particularly evident with spatio-temporal data describing *** data typically corresponds to movement of humans,animals and machines in the physical *** article considers a special form of movement data generated through human–computer interactions with online web *** a user interacts with a web map using a mouse as a pointing tool,invisible trajectories are *** examining the spatial features on the map where the mouse cursor visits,a user’s interests and experience can be *** analyse this valuable information,we have developed a geovisual analysis tool which provides a rich insight into such user *** focus of this paper is on a clustering technique which we apply to mouse trajectories to group trajectories with similar behavioural *** experiments reveal that it is possible to identify experienced and novice users of web mapping environments using an incremental clustering *** results can be used to provide personalised map interfaces to users and provide appropriate interventions for completing spatial tasks.

关键词： geovisual analytics spatio-temporal clustering behavioural clustering map personalisation digital globe

MORTALITY AND FAME IN AKKADIAN TEXTS

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Journal of Ancient Civilizations 2018年第1期33卷 1-25页

作者： michela Piccin IHAC NENU

1. Introduction1Death, mankind’s unavoidable destiny, has been considered by humans from all eras and in all places, and our discomfort in dealing with death and dying connects us across historical and geographical divides.2 Following the example set by anthropologists, scholars in other fields have begun to realize the importance of studying the reactions of diferent civilizations to the eternal problem of death, both verbally and nonverbally. Among the classic studies on the subject, the work of Robert Hertz and Ernesto De Martino merits special mention.

关键词：死亡人文 mais

ASSYRIAN TREATIES: “PATCHWORK” TEXTS

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Journal of Ancient Civilizations 2020年第1期35卷 33-70,133,134页

作者： michela Piccin North-West University(NWU) SA

The article offers a linguistic and stylistic analysis of the Neo-Assyrian treaties culled from the SAA Ⅱ(1988).The analysis focuses on defining scribal procedures in building up the text,which may then be conclusively labelled as a“patchwork.”Proceeding through the preamble,list of witnesses,and content,I explore a range of sampling which demonstrates the substantially fixed-albeit expandable-structure of the treaties'texts.I argue that this evidence shows that the structure of the treaties’texts had a great communicative efficacy thanks to its standardized character,as well as facilitated the scribes’editorial *** fixed nature of these texts was also related to the principles of the legal tradition,which itself was adapted to the historical and political circumstances of the Neo-Assyrian period.

关键词： legal patch adapted

The Ins and Outs of the Rice AGAMOUS Subfamily

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Molecular Plant 2013年第3期6卷 650-664页

作者： Ludovico Dreni michela Osnato Martin M. Kater Department of Biosciences Università degli Studi di Milano via Celoria 26 20133 Milan Italy

Genes of the AGAMOUS subfamily have been shown to play crucial roles in reproductive organ identity determination, fruit, and seed development. They have been deeply studied in eudicot species and especially in Arabidopsis. Recently, the AGAMOUS subfamily of rice has been studied for their role in flower development and an enormous amount of data has been generated. In this review, we provide an overview of these data and discuss the conservation of gene functions between rice and Arabidopsis.

关键词： transcriptional control and transcription factors floral development reproductive biology Arabidopsis rice.

Is the Bismuth-Corlette IIIb stage really an unfavorable situation for resectability of Klatskin tumors?A critical appraisal

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Hepatobiliary & Pancreatic Diseases International 2020年第5期19卷 505-506页

作者： Marcello Donati michela Zanatta Francesco Basile Department of Surgery and Medical Surgical Specialties Surgical Clinic UnitUniversity Hospital of Catania95123 CataniaItaly

We read with considerable interest the paper from Passeri et al.[1]questioning how the IIIb preoperative determination of a Klatskin tumor could be considered a risk factor for unresectability,and we could not refrain from making some critical recommendations about *** the paper was nicely written,in our opinion,no meaningful conclusion should however be drawn from it,due to the small sample size of the reported series.

关键词： al. critical really