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Light(Science & Applications) 2019年第1期8卷 732-738页

作者： michela f.picardi Martin Neugebauer Jorg S.Eismann Gerd Leuchs Peter Banzer francisco J.Rodriguez-fortuno Anatoly V.Zayats Department of Physics and London Centre for Nanotechnology King’s College LondonStrandLondon WC2R LS UK.2Max Planck Institute for the Science of LightStaudtstr.2D-91058 ErlangenGermany Institute of Optics Information and PhotonicsUniversity Erlangen-NurembergStaudtstr.7/B2D-91058 ErlangenGermany

The electromagnetic field scattered by nano-objects contains a broad range of wavevectors and can be efficiently coupled to waveguided *** dominant contribution to scattering from subwavelength dielectric and plasmonic nanoparticles is determined by electric and magnetic dipolar ***,we experimentally demonstrate spectral and phase selective excitation of Janus dipoles,sources with electric and magnetic dipoles oscillating out of phase,in order to control near-field interference and directional coupling to *** show that by controlling the polarisation state of the dipolar excitations and the excitation wavelength to adjust their relative contributions,directionality and coupling strength can be fully ***,we introduce a novel spinning Janus dipole featuring cylindrical symmetry in the near and far field,which results in either omnidirectional coupling or *** the propagation of guided light waves via fast and robust near-field interference between polarisation components of a source is required in many applications in nanophotonics and quantum optics.

关键词： coupling spinning excitation

Enhancing sensitivity of triple-negative breast cancer to DNA-damaging therapy through chemical inhibition of the m6A methyltransferase METTL3

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Cancer Communications 2024年第2期44卷 282-286页

作者： Bianca Cesaro Alessia Iaiza fabio Piscopo Marco Tarullo Eleonora Cesari Dante Rotili Antonello Mai Alberto Diana michela Londero Luca Del Giacco Riccardo Masetti Alba Di Leone Chiara Naro Silvia Masciarelli Giulia fontemaggi Claudio Sette francesco fazi Alessandro fatica Department of Anatomical HistologicalForensic&Orthopedic SciencesSection of Histology&Medical EmbryologySapienza University of RomeRomeItaly Department of Biology and Biotechnologies“Charles Darwin” Sapienza University of RomeRomeItaly GSTeP Organoids Research Core facility Fondazione Policlinico A.Gemelli Istituto di Ricovero e Cura a Carattere Scientifico(IRCCS)RomeItaly Department of Drug Chemistry and Technologies Sapienza University of RomeRomeItaly Pasteur Institute Cenci-Bolognetti FoundationSapienza University of RomeRomeItaly Department of BioSciences University of MilanMilanItaly Multidisciplinary Breast Center Dipartimento Scienze della Salute della Donna e del Bambino e di SanitàPubblicaCatholic University of the Sacred HeartRomeItaly Department of Neuroscience Section of Human AnatomyCatholic University of the Sacred HeartRomeItaly Oncogenomic and Epigenetic Unit IRCCS Regina Elena National Cancer InstituteRomeItaly

Dear Editor,N 6-methyladenosine(m^(6)A)is a critical mRNA modi-fication catalyzed by the enzyme methyltransferase-like 3(METTL3),with implications in RNA ***3 upregulation is associated with cancer progres-sion,metast... 详细信息

关键词： cancer methyltransferase metastasis

Estrogens still represent an attractive therapeutic approach for Alzheimer’s disease

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Neural Regeneration Research 2022年第1期17卷 93-94页

作者： Elena Tamagno michela Guglielmotto Department of Neuroscience University of TorinoTorinoItaly(Tamagno EGuglielmotto M)Neuroscience Institute of Cavalieri Ottolenghi Foundation(NICO)University of TorinoTorinoItaly

Alzheimer’s disease(AD)is a progressive neurodegenerative condition that goes f rom mild cogni t ive impai rment in prodromal disease to severely disabling deficits in advanced *** risk for AD development,as well as progression and severity,clearly differ between men and women(Pike,2017).Epidemiological studies have shown that there is a significantly increased prevalence in the development of AD in women compared to men,which is usually explained by the longer lifespan of *** increased frequency may be due to the interplay between age and sex,in which genetic factors together with hormonal and metabolic patterns play a crucial ***,cognitive impairment has been confirmed to be greater in women than in men at the same stage of AD,likely due to reduced estrogen levels in postmenopausal women(Laws et al.,2016).

关键词： Alzheimer attractive therapeutic

Laboratory study of fracture initiation and propagation in Barre granite under fluid pressure at stress state close to failure

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第3期15卷 538-550页

作者： Bing Q.Li michela Casanova Herbert H.Einstein Department of Civil and Environmental Engineering Massachusetts Institute of TechnologyCambridgeUSA Department of Civil and Environmental Engineering Western UniversityLondonCanada School of Architecture Civil and Environmental EngineeringÉcole Polytechnique Fédérale de LausanneLausanneSwitzerland

Hydraulic fracturing is frequently used to increase the permeability of rock formations in energy extraction scenarios such as unconventional oil and gas extraction and enhanced geothermal systems(EGSs).The present study addresses uncertainties in the hydraulic fracturing process pertaining to EGSs in crystalline rock such as ***,there is debate in the literature on the mechanisms(*** and/or shear)by which these fractures initiate,propagate,and *** present experiments on Barre granite with pre-cut flaws where the material is loaded to high far-field stresses close to shear failure,and then the fluid pressure in the flaws is increased to move the Mohr’s circle to the left and observe the initiation and propagation of fractures using high-speed imaging and acoustic emissions(AEs).We find that the hydraulic fractures initiate as tensile microcracks at the flaw tips,and then propagate as a combination of tensile and shear *** focal mechanisms also show elevated levels of tensional microfracturing near the flaw tips during pressurization and final *** then consider a numerical model of the experimental setup,where we find that fractures are indeed likely to initiate at flaw tips in tension even at relatively high far-field stresses of 40 MPa where shear failure is generally expected.

关键词： Acoustic emission(AE) Hydraulic fracturing Enhanced geothermal system(EGS) Microseismicity

Allergy in total knee replacement surgery:Is it a real problem?

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World Journal of Orthopedics 2019年第2期10卷 63-70页

作者： Maristella f Saccomanno Giuseppe Sircana Giulia Masci Gianpiero Cazzato michela florio Luigi Capasso Marco Passiatore Giovanni Autore Giulio Maccauro Enrico Pola Department of Orthopaedics and Traumatology Fondazione Policlinico Universitario A.Gemelli IRCCS

Total knee arthroplasty is a common procedure, with extremely good clinical results. Despite this success, it produces 20% unsatisfactory results. Among the causes of these failures is metal hypersensitivity. Metal sensitization is higher in patients with a knee arthroplasty than in the general population and is even higher in patients undergoing revision surgery. However, a clear correlation between metal sensitization and symptomatic knee after surgery has not been ascertained. Surely, patients with a clear history of metal allergy must be carefully examined through dermatological and laboratory testing before surgery. There is no globally accepted diagnostic algorithm or laboratory test to diagnose metal hypersensitivity or metal reactions. The patch test is the most common test to determine metal hypersensitivity, though presenting some limitations. Several laboratory assays have been developed, with a higher sensitivity compared to patch testing, yet their clinical availability is not widespread, due to high costs and technical complexity. Symptoms of a reaction to metal implants present across a wide spectrum, ranging from pain and cutaneous dermatitis to aseptic loosening of the arthroplasty. However, although cutaneous and systemic hypersensitivity reactions to metals have arisen, thereby increasing concern after joint arthroplasties, allergies against implant materials remain quite rare and not a well-known problem. The aim of the following paper is to provide an overview on diagnosis and management of metal hypersensitivity in patients who undergo a total knee arthroplasty in order clarify its real importance.

关键词： Knee arthroplasty Total knee arthroplasty Metal hypersensitivity Metal allergy Non-allergenic implants

Accuracy and responses of genomic selection on key traits in apple breeding

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Horticulture Research 2015年第1期2卷 1-12页

作者： Hélène Muranty michela Troggio Inès Ben Sadok Mehdi Al Rifaï Annemarie Auwerkerken Elisa Banchi Riccardo Velasco Piergiorgio Stevanato W.Eric van de Weg Mario Di Guardo Satish Kumar françois Laurens Marco C.A.M.Bink Institut de Recherche en Horticulture et Semences UMR1345 INRASFR 4207 QUASAVF-49071 BeaucouzeFrance Research and Innovation Center Fondazione Edmund MachSan Michele all’AdigeTrentoItaly Better 3 fruit RillaarBelgium DAfNAE Dipartimentodi Agronomia Animali Alimenti Risorse Naturalie Ambienteviale Università1635020 Legnaro(PD)Universitàdegli Studi di PadovaItaly Wageningen UR Plant Breeding Wageningen University and Research CenterWageningenThe Netherlands The New Zealand Institute for Plant&food Research Limited Private Bag 1401Havelock North 4157New Zealand Biometris Wageningen University and Research CenterWageningenThe Netherlands

The application of genomic selection in fruit tree crops is expected to enhance breeding eficiency by increasing prediction accuracy,increasing selection intensity and decreasing generation *** objectives of this study were to assess the accuracy of prediction and selection response in commercial apple breeding programmes for key *** training population comprised 977 individuals derived from 20 pedigreed fllsib *** phenotypic data were available on 10 traits related to productivity and fruit external appearance and genotypic data for 7829 SNPs obtained with an llumina 20K SNP *** these data,a genome-wide prediction model was built and subsequently used to calculate genomic breeding values of five application fllsib *** application families had genotypes at 364 SNPs from a dedicated 512 SNP array,and these genotypic data were extended to the high-density level by *** five families were phenotyped for 1 year and their phenotypes were compared to the predicted breeding *** of genomic prediction across the 10 traits reached a maximum value of 0.5 and had a median value of *** accuracies were strongly affected by the phenotypic distribution and heritability of *** the largest family,significant selection response was observed for traits with high heritability and symmetric phenotypic *** that showed non-significant response often had reduced and skewed phenotypic variation or low *** the five application families the accuracies were uncorrelated to the degree of relatedness to the training *** results underline the potential of genomic prediction to accelerate breeding progress in outbred fruit tree crops that still need to overcome long generation intervals and extensive phenotyping costs.

关键词： breeding crops traits

Apple whole genome sequences:recent advances and new prospects

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Horticulture Research 2019年第1期6卷 1247-1270页

作者： Cameron P.Peace Luca Bianco michela Troggio Eric van de Weg Nicholas P.Howard Amandine Cornille Charles-Eric Durel Sean Myles ZoëMigicovsky Robert J.Schaffer Evelyne Costes Gennaro fazio Hisayo Yamane Steve van Nocker Chris Gottschalk fabrizio Costa David Chagné Xinzhong Zhang Andrea Patocchi Susan E.Gardiner Craig Hardner Satish Kumar francois Laurens Etienne Bucher Dorrie Main Sook Jung Stijn Vanderzande Department of Horticulture Washington State UniversityPullmanWA 99164USA Computational Biology Fondazione Edmund MachSan Michele all’AdigeTN 38010Italy Department of Genomics and Biology of fruit Crops Fondazione Edmund MachSan Michele all’AdigeTN 38010Italy Plant Breeding Wageningen University and ResearchWageningen 6708PBThe Netherlands Department of Horticultural Science University of MinnesotaSt.PaulMN 55108USA Institut für Biologie und Umweltwissenschaften Carl von Ossietzky Universität26129 OldenburgGermany GQE-Le Moulon Institut National de la Recherche AgronomiqueUniversity of Paris-SudCNRSAgroParisTechUniversitéParis-Saclay91190 Gif-sur-YvetteFrance Institut National de la Recherche Agronomique Institut de Recherche en Horticulture et SemencesUMR 134549071 BeaucouzéFrance Department of Plant Food and Environmental SciencesFaculty of AgricultureDalhousie UniversityTruroNS B2N 5E3Canada The New Zealand Institute for Plant and food Research Ltd Motueka 7198New Zealand School of Biological Sciences University of AucklandAuckland 1142New Zealand AGAP INRACIRADMontpellier SupAgroUniversity of MontpellierMontpellierFrance Plant Genetic Resources Unit USDA ARSGenevaNY 14456USA Laboratory of Pomology Graduate School of AgricultureKyoto UniversityKyoto 606-8502Japan Department of Horticulture Michigan State UniversityEast LansingMI 48824USA The New Zealand Institute for Plant and food Research Ltd(Plant&food Research) Palmerston North Research CentrePalmerston North 4474New Zealand College of Horticulture China Agricultural University100193 BeijingChina Agroscope 8820 WädenswilSwitzerland Queensland Alliance of Agriculture and food Innovation University of QueenslandSt Lucia 4072Australia New Cultivar Innovation Plant and Food ResearchHavelock North 4130New Zealand Agroscope 1260 ChanginsSwitzerland

In 2010,a major scientific milestone was achieved for tree fruit crops:publication of the first draft whole genome sequence(WGS)for apple(Malus domestica).This WGS,v1.0,was valuable as the initial reference for sequence information,fine mapping,gene discovery,variant discovery,and tool development.A new,high quality apple WGS,GDDH13 v1.1,was released in 2017 and now serves as the reference genome for *** the past decade,these apple WGSs have had an enormous impact on our understanding of apple biological functioning,trait physiology and inheritance,leading to practical applications for improving this highly valued *** gene identities for phenotypes of fundamental and practical interest can today be discovered much more ***-wide polymorphisms at high genetic resolution are screened efficiently over hundreds to thousands of individuals with new insights into genetic relationships and ***-density genetic maps are constructed efficiently and quantitative trait loci for valuable traits are readily associated with positional candidate genes and/or converted into diagnostic tests for *** understand the species,geographical,and genomic origins of domesticated apple more precisely,as well as its relationship to wild *** WGS has turbo-charged application of these classical research steps to crop improvement and drives innovative methods to achieve more durable,environmentally sound,productive,and consumer-desirable apple *** review includes examples of basic and practical breakthroughs and challenges in using the apple *** for“what’s next”focus on necessary upgrades to the genome sequence data pool,as well as for use of the data,to reach new frontiers in genomics-based scientific understanding of apple.

关键词： breakthrough hundreds frontier