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Efficacy and safety profile of LCR35 complete freeze-dried culture in irritable bowel syndrome:A randomized,double-blind study

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World Journal of Gastroenterology 2012年第17期18卷 2067-2075页

作者： michel Dapoigny Thierry Piche Philippe Ducrotte Bernard Lunaud Jean-michel Cardot Annick Bernalier-Donadille Médecine Digestive Centre Hospitalier Universitaire(CHU) Estaing CHU Clermont-FerrandClermont UniversitéInserm UMR 76663001 F-Clermont-FerrandFrance Department of Gastroenterology and Inserm 576 Hpital de l'Archet 206202 NiceCedex 3France Department of Hepatogastroenterology and Nutrition Hpital Charles NicolleInserm UMR 107376031 RouenCedexFrance Department of Gastroenterology Centre République63000 Clermont-FerrandFrance Biopharmacy Department Faculty of Pharmacy63000 Clermont-FerrandFrance UR454 Microbiology Division Institut National de la Recherche AgronomiqueResearch Centre of Clermont-Ferrand-Theix63122 Saint Genès-ChampanelleFrance

AIM:To assess the effects and safety of Lactobacillus casei rhamnosus LCR35 complete freeze-dried culture(LCR35) in patients suffering from irritable bowel syndrome(IBS).METHODS:A randomized,double-blind pilot study was performed in 50 patients complaining of IBS symptoms complying with RomeⅢ*** were allocated to receive either LCR35(n = 25) at a minimum daily dose of 6 × 108 colony forming units or placebo(n = 25) for 4 *** inclusion,after treatment and 2 wk later,patients completed the IBS severity *** from baseline in the IBS severity score at the end of treatment was the primary efficacy *** were compared between groups in the whole population and in IBS subtypes(IBS with predominance of constipation,IBS with predominance of diarrhoea,mixed IBS,unsubtyped IBS).The presence of lactobacillus casei rhamnosus in stools was investigated at inclusion and at the end of *** gastrointestinal quality of life questionnaire and the hospital anxiety and depression(HAD) scale were also ***:Both groups were balanced for baseline *** 85% of patients,stool analyses showed that lactobacillus casei rhamnosus able to survive in the digestive *** the whole population,improvements in the IBS severity score did not differ significantly between treatments with a 25% decrease after 4-wk treatment,and a 15% decrease from baseline 2 wk later in both *** IBS subgroups,statistical analysis could not be performed due to small sample size,but a clinical response in favour of LCR35 was observed in IBS patients with predominance of diarrhoea:no change in the symptom severity score was seen with the placebo after 4 wk treatment,whereas a clinically relevant decrease occurred with LCR35(-37% vs-3%).Furthermore,in spite of an increase in symptom intensity,the IBS severity score was maintained below the baseline value 2 wk later with LCR35(-19% from baseline),whilst a slight 5% increase from baseline was observ

关键词： Irritable bowel syndrome Lactobacillus casei rhamnosus Probiotics Symptom severity score

CRISPR-Cas-like system in giant viruses:why MIMIVIRE is not likely to be an adaptive immune system

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Virologica Sinica 2016年第3期31卷 193-196页

作者： Jean-michel Claverie Chantal Abergel Structural and Genomic Information Laboratory (UMR7256) CNRS Aix Marseille UniversityMediterranean Institute of Microbiology (FR 3479)

Giant viruses from the Mimiviridae family（Mimivirus,Megavirus,etc.）replicate inside their Acanthamoeba host by the mean of a large intracytoplasmic virion factory within which DNA transcription and replication take ... 详细信息

关键词： likely dsDNA Giant factory replication encoded silencing destruction discrimination clade

Efficacy and tolerability of chitin-glucan combined with simethicone(GASTRAP^(■)DIRECT)in irritable bowel syndrome:A prospective,open-label,multicenter study

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2024年第3期15卷 10-22页

作者： Nathalie Talbodec Pauline Le Roy Peggy Fournier Benoit Lesage Elodie Lepoutre François Castex Jean michel Godchaux Lionel Vandeville Benjamin Bismuth Xavier Lesage Pauline Bayart Michael Genin Christel Rousseaux Veronique Maquet Salvatore Modica Pierre Desreumaux Caroline Valibouze Department of Gastroenterology Hôpital privéLe BoisLille 59000France Department of Gastroenterology Hôpital privéde Villeneuve d’AscqVilleneuve d’Ascq 59650France Univ.Lille CHU LilleULR 2694–METRICSÉvaluation des Technologies de Santéet des Pratiques MédicalesLille 59000France Development of Intestinal Biotech 1 Avenue Oscar LambretLille 59045France KitoZyme SA Parc Industriel des hauts Sarts Zone 2Rue de MilmortHerstal 4040Belgium BiOkuris A Parc Industriel des hauts Sarts Zone 2Rue de MilmortHerstal 4040Belgium Department of Hepato-Gastroenterology Lille University HospitalLille 59000France U1286-INFINITE Institute for Translational Research in InflammationUniv.LilleInsermCHU LilleLille 59000France Department of Digestive Surgery and Transplantation Lille University HospitalLille 59037France

BACKGROUND Irritable bowel syndrome(IBS),defined according to the Rome IV diagnostic criteria,is a chronic functional gastrointestinal disorder characterized by recurrent abdominal pain related to altered bowel ***-line recommended treatments are limited to combining drugs targeting predominant symptoms,particularly pain(antispasmodics),constipation(laxatives),and diarrhea(loperamide),yielding only a limited therapeutic ***^(■)DIRECT is a class IIa medical formulation composed of a combination of chitin-glucan and simethicone indicated for the symptomatic treatment of gas-related gastrointestinal disorders by combining different mechanisms of *** To evaluate the efficacy,tolerability,and safety of 4-week GASTRAP^(■)DIRECT treatment in patients with *** In this prospective,multicenter,open-label trial,120 patients with IBS received three sticks of GASTRAP^(■)DIRECT(1.5 g/d of chitin-glucan and 0.75 mg/d of simethicone)per day for 4 *** primary endpoint was the responder rate,defined as the number of patients whose abdominal pain score decreased by≥30%from baseline to week(W)*** analysis was performed using the per-protocol *** symptoms,impact of global symptoms on daily life,change in stool consistency,and improvement in defecatory disorders were *** Overall,100 patients were *** W4,67%(95%CI:57-75)showed improvement in abdominal pain(score:5.8±2.4 vs 2.9±2.0,P<0.0001).Similar improvements were observed for bloating[8.0±1.7 vs 4.7±2.9,P<0.0001;60%(95%CI:50-70)responders],abdominal distension[7.2±2.1 vs 4.4±3.1,P<0.0001;53%(95%CI:43-63)responders],and impact of global symptoms on daily life[7.1±2.0 vs 4.6±2.9,P<0.0001;54%(95%CI:44-64)responders].Stool consistency improved in most patients(90%and 57%for patients with liquid and hard stools,respectively).Overall,42%of patients with defecatory disorders reported very much/considerable improvements by *** severe adverse event occurred,and tolerabil

关键词： Chitin-glucan Irritable bowel syndrome Abdominal pain Flatulence Defecatory disorders Stool consistency Natural non-pharmacological treatment

Effect of presence of lifting pocket on the THD performance of a large tilting-pad thrust bearing

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Friction 2015年第4期3卷 266-274页

作者： michel FILLON MichałWODTKE MichałWASILCZUK Institut Pprime CNRS-Universitéde Poitiers-ISAE-ENSMADépartement Génie Mécanique et Systèmes ComplexesBP 30169SP2MI86962 Futuroscope Chasseneuil CedexFrance Faculty of Mechanical Engineering Gdansk University of TechnologyGdanskPoland

Hydrostatic assistance is a commonly used method to improve limited load carrying ability of tilting-pad thrust bearings during transient states of operation of vertical shaft *** of special hydraulic equipment(as pumps,valves,etc.),it also requires manufacturing of special recesses/pockets at pad sliding surfaces,into which oil is injected under high *** allows to lift the rotor before start-up of the machine and form a hydrostatic film between pads and *** is a quite wide variety of geometry of recesses(shape,depth,and size)met in practical large bearing *** presence of a hydrostatic pocket(usually located in the sliding surface above the pivot area,where thin film,high oil pressure and temperature are observed)affects bearing performance under hydrodynamic *** theoretical researches,there is an almost common practice not to include hydrostatic recess in thermohydrodynamic(THD)or thermoelastohydrodynamic(TEHD)*** is probably due to the problems with obtaining solution for oil film geometry with pocket,the order of magnitude of the pocket depths being larger than gap *** this paper,an attempt was taken to study the effect of lifting pocket on THD performance of a large tilting-pad thrust bearing of Itaipu power *** performance was evaluated including recess shape for several cases of its *** results show that hydrostatic recess changes calculated bearing properties quite significantly,especially in vicinity of the pocket.

关键词： lifting pocket tilting-pad thrust bearing THD regime numerical simulations

Capsule endoscopy in non-steroidal anti-inflammatory drugs-enteropathy and miscellaneous,rare intestinal diseases

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World Journal of Gastroenterology 2008年第34期14卷 5237-5244页

作者： Gerard Gay michel Delvaux Muriel Frederic Department of Internal Medicine and Digestive Pathology Hopitaux de BraboisCHU of NancyVandoeuvre les Nancy F-54511France

Despite significant advances over the last decade, mucosal lesions of the small bowel are poorly detected by imaging studies such as CT scan, MRI-enteroclysis and contrast-enhanced abdominal ultrasound. Capsule endoscopy (CE) has dramatically changed the diagnostic approach to intestinal diseases. Moreover, the use of CE can be extended to include other conditions. However, it is diffi cult to assess the positive influence of CE on patient outcomes in conditions involving a small number of patients, or in critically ill and diff icult to examine patients. CE has the advantage of diagnosing intestinal lesions and of directing the use of double balloon enteroscopy (DBE) in order to obtain biopsy specimens. Moreover, CE allows repeated assessment in chronic conditions, especially to detect relapse of an infectious disease.

关键词： Capsule endoscopy Non-steroidal anti-inflammatory drugs-enteropathy Intestinal diseases

A Stein deficit for the logarithmic Sobolev inequality

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Science China Mathematics 2017年第7期60卷 1163-1180页

作者： LEDOUX michel NOURDIN Ivan PECCATI Giovanni Institut de Mathematiques de Toulouse Universite de Toulouse-Paul-Sabatier Toulouse F-31062 France Institut Universitaire de France UR en Mathematiques-FSTC Luxembourg University Luxembourg City L-1359 Luxembourg

We provide some lower bounds on the deficit in the Gaussian logarithmic Sobolev inequality in terms of the so-called Stein characterization of the Gaussian *** techniques are based on the representation of the relative Fisher information along the Ornstein-Uhlenbeck semigroup by the Minimum Mean-Square Error from information theory.

关键词： deficit logarithmic Sobolev inequality Ornstein-Uhlenbeck semigroup minimum mean-square error Stein kernel

Practice functional morphology in unambiguous contexts -- A comment on Slabakova (2014)

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外语教学与研究 2015年第4期47卷 617-619页

作者： michel Paradis McGill University 1085 Doctor Penfield Avenue Montreal H3A 1A5 Canada.

Slabakova(2014)discusses the pedagogical implications of the bottleneck of second language acquisition,namely that functional morphemes and their features are the most difficult aspects of the grammar to acquire because they posit a higher cognitive load in *** concludes that"in a sense,drilling of the functional morphology is inevitable if the form has to move from the declarative to the procedural memory of

关键词：英语教学教学方法阅读教学课外阅读

Feedback Stabilization for a Scalar Conservation Law with PID Boundary Control

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Chinese Annals of Mathematics,Series B 2015年第5期36卷 763-776页

作者： Jean michel CORON Simona Oana TAMASOIU Sorbonne Universités UPMC University Paris 06 NUMR 7598 Laboratoire Jacques-Louis Lions F-75005Paris France Université Paris Sud F-91405 Orsay France

This paper deals with a scalar conservation law in 1-D space dimension, and in particular, the focus is on the stability analysis for such an equation. The problem of feedback stabilization under proportional-integral-derivative(PID for short) boundary control is addressed. In the proportional-integral(PI for short) controller case, by spectral analysis, the authors provide a complete characterization of the set of stabilizing feedback parameters, and determine the corresponding time delay stability interval. Moreover, the stability of the equilibrium is discussed by Lyapunov function techniques, and by this approach the exponential stability when a damping term is added to the classical PI controller scheme is proved. Also, based on Pontryagin results on stability for quasipolynomials, it is shown that the closed-loop system sub ject to PID control is always unstable.

关键词： Boundary feedback FID controllers Linear scalar conservation law

Late-entry commercial thinning effects on Pinus banksiana:growth, yield, and stand dynamics in Québec, Canada

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Journal of Forestry Research 2019年第1期30卷 95-106页

作者： Martin-michel Gauthier Stéphane Tremblay Ministère des Forêts de la Faune et des Parcs du Québec Natural Resources Canada Canadian Forest Service

We studied late-entry commercial thinning effects on growth, yield, and regeneration in a 48-year-old jack pine(Pinus banksiana Lamb.) stand. Applied thinning intensities were 27, 32, and 47% of merchantable basal area(BA) excluding skidding trails. After 15 years, mean diameter at breast height of surviving trees in the 47% BA removal increased by 4.9 cm(25%) compared to the unthinned control. The 47% BA removal also increased gross merchantable volume(GMV) tree-1by 46% compared to the control. The 27% BA removal had twice as much GMV ha-1compared to the 47% BA removal after15 years. Moreover, cumulative GMV ha-1was much higher in the 27% BA removal than in the unthinned control. The highest thinning intensity produced larger trees on average, while the lowest thinning intensity maximized volume production per hectare. Maintenance of acceptable growing stock throughout the 15-year period in the 27% BA removal could provide other ecosystem functions such as biodiversity enhancement or wildlife habitat by delaying senescence. Regeneration data showed that a shift in species composition occurred in the understory. After 15 years, the understory was dominated by black spruce(Picea mariana(Mill.) B.S.P.), white birch(Betula papyrifera Marsh.), and trembling aspen(Populus tremuloides Michx.). If regenerating jack pine is an objective after final overstory removal, additional efforts will be needed to re-establish this species.

关键词： Jack pine Commercial thinning Stand yield Succession Delayed senescence Tree regeneration