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Tumor Volume Associated with Recurrence in Prostate Cancer Patients with Seminal Vesicle Invasion

Open Journal of Urology 2012年第3期2卷 183-187页

作者： Paul H. Johnston Timothy A. Masterson Liang Cheng michael O. Koch Department of Pathology and Laboratory Medicine Indiana University Medical Center Indianapolis USA Department of Urology Indiana University Medical Center Indianapolis USA

Objectives: To examine predictors of progression-free survival in men with seminal vesicle invasion (SVI) following radical prostatectomy (RP) for clinically localized prostate cancer. Methods and Materials: Between 1999 and 2009, 1383 men underwent RP at Indiana University. Among them, 115 men were identified with SVI. Disease progression was defined by a rise in PSA ≥ 0.2 ng/ml, receipt of salvage therapy, progression to metastatic disease, or death. After excluding 13 patients for receiving adjuvant therapy, 102 were stratified according to surgical margin (sm) and lymph node (LN) status for Kaplan-Meier analysis of disease progression. Cox proportional hazards analyses of biochemical progression-free survival were undertaken with respect to margin status, pre-operative prostate specific antigen (PSA), tumor volume, age, and post-operative Gleason sum. Stem and leaf plot was undertaken for tumor volume by biochemical PFS. Results: Mean age was 61 years, median Gleason sum was 7, mean tumor volume was 9.7 ml, and mean pre-operative PSA was 13.6 ng/ml. Mean time to disease progression was 17 months. Mean follow-up was 37 months. Kaplan-Meier analysis revealed statistically insignificant differences in progression-free survival stratified by sm and LN status (p = 0.12). Cox univariate analyses revealed tumor volume to be a statistically significant predictor of progression free survival (p = 0.02). Stem and Leaf plot revealed tumor volume to be statistically significantly larger in patients who experienced biochemical recurrence, compared to those who did not. Conclusion: Tumor volume was associated progression-free survival in this cohort of SVI patients, while pathologic Gleason sum, PSA, margin and nodal status were not.

关键词： Prostate Neoplasm Prostatectomy Seminal Vesicle Invasion Recurrence

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SALVIA MILTIORRHIZA BUNGE——~1H-NMR METABOLOMICS APPROACH IN TCM QUALITY CONTROL

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World Journal of Traditional Chinese Medicine 2016年第2期 80-81页

作者： Ka Yui Kum Anthony Booker Christine Leon José Prieto García michael Heinrich Biodiversity and Medicines Research Cluster UCL School of Pharmacy Royal Botanic Gardens

Introduction:Many Danshen(DS-Radix Salviae miltiorrhizae-sm)products are found on the global market albeit without suitable quality *** substitutes including Salvia przewalskii Maxim,*** *** Salvia sinica *** similar ... 详细信息

关键词： NMR METABOLOMICS APPROACH IN TCM QUALITY CONTROL TCM SALVIA MILTIORRHIZA BUNGE

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A novel approach for the prevention of ionizing radiation-induced bone loss using a designer multifunctional cerium oxide nanozyme

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Bioactive Materials 2023年第3期21卷 547-565页

作者： Fei Wei Craig J.Neal Tamil Selvan Sakthivel Yifei Fu Mahmoud Omer Amitava Adhikary Samuel Ward Khoa Minh Ta Samuel Moxon Marco Molinari Jackson Asiatico michael Kinzel Sergey N.Yarmolenko Vee San Cheong Nina Orlovskaya Ranajay Ghosh Sudipta Seal Melanie Coathup Biionix Cluster Department of Internal MedicineCollege of MedicineUniversity of Central FloridaOrlandoFLUSA Advanced Materials Processing and Analysis Centre Nanoscience Technology Center(NSTC)Materials Science and EngineeringCollege of MedicineUniversity of Central FloridaOrlandoFLUSA CMC Materials 870 North CommonsDrAuroraILUSA Department of Chemistry Oakland UniversityRochesterMIMIUSA School of Applied Sciences Department of Chemical SciencesUniversity of HuddersfieldUK Department of Mechanical and Aerospace Engineering University of Central FloridaOrlandoFLUSA Engineering Research Center for Revolutionizing Biomaterials North Carolina A&T UniversityGreensboroNCUSA Department of Automatic Control and Systems Engineering Insigneo Institute for In Silico MedicineUniversity of SheffieldSheffieldS13JDUK

The disability,mortality and costs due to ionizing radiation(IR)-induced osteoporotic bone fractures are sub-stantial and no effective therapy *** radiation increases cellular oxidative damage,causing an imbalance in bone turnover that is primarily driven via heightened activity of the bone-resorbing *** demonstrate that rats exposed to sublethal levels of IR develop fragile,osteoporotic *** reactive surface sites,cerium ions have the ability to easily undergo redox cycling:drastically adjusting their electronic con-figurations and versatile catalytic *** properties make cerium oxide nanomaterials *** show that an engineered artificial nanozyme composed of cerium oxide,and designed to possess a higher fraction of trivalent(Ce^(3+))surface sites,mitigates the IR-induced loss in bone area,bone architecture,and *** investigations also demonstrate that our nanozyme furnishes several mechanistic avenues of protection and selectively targets highly damaging reactive oxygen species,protecting the rats against IR-induced DNA damage,cellular senescence,and elevated osteoclastic activity in vitro and in ***,we reveal that our nanozyme is a previously unreported key regulator of osteoclast formation derived from macrophages while also directly targeting bone progenitor cells,favoring new bone formation despite its exposure to harmful levels of IR in *** findings open a new approach for the specific prevention of IR-induced bone loss using synthesis-mediated designer multifunctional nanomaterials.

关键词： Ionizing radiation Osteoporosis Nanozyme Cerium oxide Bone strength Bone resorption

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VisionMap A3:创新的数字绘图系统

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中国测绘 2012年第2期 -页

作者： michael Pechatnikov Erez Shore Yuri Raizman

VisionMap.一家成立于2004年的以色列公司,其目标是创立一个全新的自动绘图系统.A3系统功能全面,其身影遍布于全球多个国家.VisionMap-A3是一个完全自动化的数字绘图系统.该系统包括一个航空数字相机帧度量一A3相机和一个地面处理系统.... 详细信息

VisionMap.一家成立于2004年的以色列公司,其目标是创立一个全新的自动绘图系统.A3系统功能全面,其身影遍布于全球多个国家.VisionMap-A3是一个完全自动化的数字绘图系统.该系统包括一个航空数字相机帧度量一A3相机和一个地面处理系统.在飞行过程中,程序化的数字相机暴露在跨轨道的航行当中,以便可在一个高速度的飞行当中提供广泛的覆盖地面角度,从而同时获得两个垂直和倾斜的图像,并能够提供四个中端产品:精确的正摄影像,倾斜和垂直的图像,D sm和大范围立体制图(SLF).A3航测摄像机由两个300毫米的摄像头,快速的压缩和存储单元,以及一个双频GPS组成.相机的旋转机制提供了一个高达1 09.的视野.后处理系统由一台PC服务器配置和一个VisionMap处理航空飞行数据软件组成,而这一切全为自动化操作.

关键词：绘图系统全自动化正射影像 VisionMap A3 数字地形模型创新

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Presolar grains in the CM2 chondrite Sutter's Mill

Presolar grains in the CM2 chondrite Sutter's Mill

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中国科学院地质与地球物理研究所2014年度（第14届）学术年会

作者： Xuchao ZHAO Yangting LIN Qing-Zhu YIN Jianchao ZHANG Jialong HAO michael ZOLENSKY Peter JENNISKENS Key Laboratory of the Earth’s Deep Interior Institute of Geology and GeophysicsChinese Academy of Sciences Department of Earth and Planetary Sciences University of California at Davis ARES NASA Johnson Space Center SETI Institute Mountain View NASA Ames Research Center Moffett Field

The Sutter’s Mill(sm)carbonaceous chondrite is a regolith breccia,composed predominantly of CM2 clasts with varying degrees of aqueous alteration and thermal *** investigation of presolar grains in four Sutter’s Mill sections,sm43,sm51,sm2-4,and sm18,was carried out using Nano SIMS ion mapping technique.A total of 37 C-anomalous grains and one O-anomalous grain have been identified,indicating an abundance of 63 ppm for presolar C-anomalous grains and 2 ppm for presolar ***-one silicon carbide(Si C),five carbonaceous grains,and one Al-oxide(Al2O3)were confirmed based on their elemental compositions determined by C-N-Si and O-Si-Mg-Al isotopic *** overall abundance of Si C grains in Sutter’s Mill(55 ppm)is consistent with those in other CM *** absence of presolar silicates in Sutter’s Mill suggests that they were destroyed by aqueous alteration on the parent ***,sm2-4 shows heterogeneous distributions of presolar Si C grains(12–54 ppm)in different matrix areas,indicating that the fine-grained matrix clasts come from different sources,with various thermal histories,in the solar nebula.

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运动负荷超声评价主动脉瓣置换术后左心室收缩功能储备

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心肺血管病杂志 2012年第4期31卷 440-443页

作者：赵映李治安孙琳何怡华杨娅刘文旭 michael Henein 首都医学大学附属北京安贞医院北京市心肺血管疾病研究所超声诊断科北京100029 瑞典于默奥大学心脏中心

目的:应用二维超声斑点追踪技术,评价主动脉瓣置换术后运动负荷试验中的左心室收缩功能储备。方法:21例因重度主动脉瓣狭窄进行瓣膜置换术的患者(左心室射血分数>50%)行运动负荷超声心动图检查,应用二维超声斑点追踪技术测量运动负荷试... 详细信息

目的:应用二维超声斑点追踪技术,评价主动脉瓣置换术后运动负荷试验中的左心室收缩功能储备。方法:21例因重度主动脉瓣狭窄进行瓣膜置换术的患者(左心室射血分数>50%)行运动负荷超声心动图检查,应用二维超声斑点追踪技术测量运动负荷试验中静息状态下及峰值负荷时的左心室收缩期长轴整体应变率(GLSRs),同时记录峰值负荷时的心肌摄氧量(pVO2)。结果与21例正常健康对照者进行比较。结果:静息状态下,病例组与对照组超声指标无明显差异。峰值负荷时,病例组pVO2低于正常组(Psm)均明显低于正常组(Psm:r=0.65,P=0.002)。多重线性回归分析,病例组峰值负荷时的左心室收缩期应变率为pVO2的唯一影响因素。结论:主动脉瓣狭窄患者瓣膜置换术后,尽管静息状态下左心室功能正常,但运动负荷试验后,左心室收缩功能储备仍然低于正常。

关键词：运动负荷超声主动脉瓣置换左心室应变率收缩功能储备

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The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine

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Genes & Diseases 2019年第3期6卷 201-223页

作者： Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid The University of Chicago Pritzker School of Medicine ChicagoIL 60637USA Laboratory of Craniofacial Biology and Development Section of Plastic and Reconstructive SurgeryDepartment of SurgeryThe University of Chicago MedicineChicagoIL 60637USA Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Rosalind Franklin University Chicago Medical SchoolNorth ChicagoIL 60064USA SIR Program Illinois Math and Science Academy(IMSA)AuroraIL 60506USA Department of Biomedical Engineering Northwestern UniversityEvanstonIL60208USA The Department of Surgery Feinberg School of MedicineNorthwestern UniversityChicagoIL60616USA

Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological *** roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ *** of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP *** it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other *** effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of ***,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and *** review aims to summarize our current understanding of BMP9 across biology and the body.

关键词： Adipogenesis Bone morphogenetic proteins(BMPs) BMP9/GDF2 Mesenchymal stem cells(MSCs) Metabolism Osteogenesis Regenerative medicine Tumorigenesis

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广州地区尘螨患者的血清中屋尘螨与仓储螨间的IgE交叉反应

广州地区尘螨患者的血清中屋尘螨与仓储螨间的IgE交叉反应

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中华医学会2009年全国变态反应学术会议

作者：张纯青 Gjesing Birgitte 赖旭新 Spangfort michael Dho 钟南山广州市呼吸疾病研究所丹麦ALK公司亚太研究部

目的研究广州地区家居尘螨(HDM,包括屋尘螨Der p和粉尘螨Der f)和仓储螨(sm,包括热带螨Blo t,粗足粉螨Aca s,腐食酪螨Tyr p,害食磷螨Lep d和家食甜螨Gly d)在过敏性病人中的阳性率,以及其血清学IgE的交叉反应。方法412例门诊的过敏性哮...

目的研究广州地区家居尘螨(HDM,包括屋尘螨Der p和粉尘螨Der f)和仓储螨(sm,包括热带螨Blo t,粗足粉螨Aca s,腐食酪螨Tyr p,害食磷螨Lep d和家食甜螨Gly d)在过敏性病人中的阳性率,以及其血清学IgE的交叉反应。方法412例门诊的过敏性哮喘和/或鼻炎患者参与本研究。所有患者均接受了7种螨的皮肤点刺试验,244例患者接受了7种螨的血清sIgE检验,而29例患者的血清进行了屋尘螨和5种仓储螨间IgE交叉反应的测试。结果Der p和Der f是最主要的致敏螨种,其SPT

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错误怀孕诉讼:孩子的抚养费应否赔偿?——马萨诸塞州最高法院伯克诉里武案述评

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中国卫生法制 2018年第2期26卷 26-33,46页

作者：迈克尔.帕利森唐超汕头大学法学院广东汕头市515063

在错误怀孕诉讼中,计划外孩子的抚养费用是否应予赔偿,取决于原告寻求医疗服务的动机。为治疗目的而接受相关医疗服务的,应排除抚养费请求。为优生目的而接受相关医疗服务的,得请求赔偿因孩子残疾所致的额外抚养费用。出于纯粹经济动机... 详细信息

在错误怀孕诉讼中,计划外孩子的抚养费用是否应予赔偿,取决于原告寻求医疗服务的动机。为治疗目的而接受相关医疗服务的,应排除抚养费请求。为优生目的而接受相关医疗服务的,得请求赔偿因孩子残疾所致的额外抚养费用。出于纯粹经济动机接受相关医疗服务的,应赔偿计划外孩子的全部抚养费用。出于社会经济动因接受相关医疗服务的,则应考察经济动因在其中的份量。

关键词：错误怀孕计划外孩子抚养费动机分析

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一种在线自动吸烟机/GC/MS系统分析研究新鲜主流烟气气相成分

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中国烟草学报 2006年第1期12卷 46-46页

作者： Henry Chung michael F.Borgerding 雷诺烟草公司 R.J.Reynolds tobacco company雷诺烟草公司

摘要: 设计构建了一套在线自动与吸烟机连接的气相色谱/质谱仪(sm/GC/MS)系统。

关键词： GC/MS分析主流烟气自动系统气相成分系统分析吸烟机在线新鲜气相色谱气体样品

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