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The root-knot nematode effectorMi2G02 hijacks a host plant trihelix transcription factor to promote nematode parasitism

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Plant Communications 2024年第2期5卷 151-168页

作者： Jianlong Zhao Kaiwei Huang Rui Liu Yuqing Lai Pierre Abad Bruno Favery Heng Jian Jian Ling Yan Li Yuhong Yang Bingyan Xie michael quentin Zhenchuan Mao State Key Laboratory of Vegetable Biobreeding Institute of Vegetables and FlowersChinese Academy of Agricultural SciencesBeijing 100081China INRAE Universite´Cote d’AzurCNRSISA06903 Sophia AntipolisFrance Department of Plant Pathology and Key Laboratory of Pest Monitoring and Green Management of the Ministry of Agriculture China Agricultural UniversityBeijing 100193China

Root-knot nematodes(RKNs)cause huge agricultural losses every *** secrete a repertoire of effectors to facilitate parasitism through the induction of plant-derived giant feeding cells,which serve as their sole source of ***,the mode of action of these effectors and their targeted host pro-teins remain largely *** this study,we investigated the role of the effector Mi2G02 in Meloidogyne incognita ***-derived Mi2G02 RNA interference in Arabidopsis thaliana affected giant cell development,whereas ectopic expression of Mi2G02 promoted root growth and increased plant sus-ceptibility to *** used various combinations of approaches to study the specific interactions between Mi2G02 and *** GT-3a,a trihelix transcription ***-3a knockout in *** affected feeding-site development,resulting in production of fewer egg masses,whereas GT-3a overex-pression in *** increased susceptibility to *** and also root ***,we demon-strated that Mi2G02 plays a role in maintaining GT-3a protein stabilization by inhibiting the 26S proteasome-dependent pathway,leading to suppression of TOZ and RAD23C expression and thus promoting nematode *** work enhances our understanding of how a pathogen effector manipulates the role and regulation of a transcription factor by interfering with a proteolysis pathway to reprogram gene expression for development of nematode feeding cells.

关键词： Meloidogyne incognita effector giant cell Mi2G02 transcription factor interaction

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Percutaneous embolization by direct puncture for the treatment of high-flow priapism

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Asian Journal of Urology 2023年第2期10卷 208-209页

作者： quentin Holay michael Baboudjian Eric Lechevallier Marc Andre Pierre-Henri Savoie Department of Radiology Conception Academic HospitalMarseilleFrance Department of Urology Conception Academic HospitalMarseilleFrance Department of Urology Sainte Anne HospitalToulonFrance

Dear Editor,High-flow priapism is a persistent erection,usually caused by blunt perineal trauma,resulting in pathologically increased arterial inflow to the corpora cavernosa[1].The therapeutic strategy of high-flow priapism,although codified,leaves room for a wide choice of techniques,ranging from conservative management,selective arterial embolization to surgical management[2].The aim of this letter was to report an alternative approach of percutaneous embolization by direct puncture for the treatment of high-flow priapism.

关键词： embolization puncture arterial

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逆高斯—泊松模型的真正作用及其可操作性

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情报科学 1994年第6期15卷 59-67页

作者： quentin L.Burrell michael R.Fenton 周平

著名学者西奇尔的广义逆高斯—泊松过程分布是在情报计量模型中应用较为广泛的,具有理论研究的吸引力,由于许多情报计量数据集对于零范畴认识不足,影响了建模,文章针对其不足,推导出极大似然估计程序,克服了建模计算上的困难,使逆高斯... 详细信息

著名学者西奇尔的广义逆高斯—泊松过程分布是在情报计量模型中应用较为广泛的,具有理论研究的吸引力,由于许多情报计量数据集对于零范畴认识不足,影响了建模,文章针对其不足,推导出极大似然估计程序,克服了建模计算上的困难,使逆高斯—泊松过程分布和情报计量数据集达到较好的拟合。

关键词：情报计量模型情报学逆G-P模型

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When will it end? Long-lived intracontinental reactivation in central Australia

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Geoscience Frontiers 2019年第1期10卷 149-164页

作者： Raphael quentin de Gromard Christopher L.Kirkland Heather M.Howard michael T.D.Wingate Fred Jourdan Brent I.A.Mc Innes Martin Danisik Noreen J.Evans Bradley J.McDonald R.Hugh Smithies Geological Survey of Western Australia Department of Mines Industry Regulation and Safety School of Earth and Planetary Science/John de Laeter Centre/TIGeR Curtin University

The post-Mesoproterozoic tectonometamorphic history of the Musgrave Province, central Australia, has previously been solely attributed to intracontinental compressional deformation during the 580 -520 Ma Petermann Orogeny. However, our new structurally controlled multi-mineral geochronology results,from two north-trending transects, indicate protracted reactivation of the Australian continental interior over ca. 715 million years. The earliest events are identified in the hinterland of the orogen along the western transect. The first tectonothermal event, at ca. 715 Ma, is indicated by40 Ar/39 Ar muscovite and U e Pb titanite ages. Another previously unrecognised tectonometamorphic event is dated at ca. 630 Ma by Ue Pb analyses of metamorphic zircon rims. This event was followed by continuous cooling and exhumation of the hinterland and core of the orogen along numerous faults, including the Woodroffe Thrust,from ca. 625 Ma to 565 Ma as indicated by muscovite, biotite, and hornblende40 Ar/39 Ar cooling ages. We therefore propose that the Petermann Orogeny commenced as early as ca. 630 Ma. Along the eastern transect,40 Ar/39 Ar muscovite and zircon(Ue Th)/He data indicate exhumation of the foreland fold and thrust system to shallow crustal levels between ca. 550 Ma and 520 Ma, while the core of the orogen was undergoing exhumation to mid-crustal levels and cooling below 600-660℃. Subsequent cooling to 150 -220℃ of the core of the orogen occurred between ca. 480 Ma and 400 Ma(zircon [Ue Th]/He data)during reactivation of the Woodroffe Thrust, coincident with the 450 -300 Ma Alice Springs *** of the footwall of the Woodroffe Thrust to shallow depths occurred at ca. 200 Ma. More recent tectonic activity is also evident as on the 21 May, 2016(Sydney date), a magnitude 6.1 earthquake occurred, and the resolved focal mechanism indicates that compressive stress and exhumation along the Woodroffe Thrust is continuing to the present day. Overall, these results

关键词： Intracontinental deformation Thermochronology Petermann orogen Musgrave Province Plate tectonics Cratonization

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Characterization of α-conotoxin TxIB and TxID for smoking cessation and drug rehabilitation

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中国药理学与毒理学杂志 2018年第9期32卷 711-713页

作者： ZHANGSUN Dong-ting ZHU Xiao-peng ZHANGSUN Man-qi WU Yong LI Xiao-dan Sean CHRISTENSEN quentin KAAS Peta J HARVEY David J CRAIK J michael MCINTOSH LUO Su-lan Key Laboratory of Tropical Biological Resources of Ministry of Education Key Lab for Marine Drug of Haikou Hainan University Haikou570228 China Departments of Biology and Psychiatry University of Utah Salt Lake City Utah 84112 USA Instit

Nicotinic acetylcholine receptors(nAChRs) are widely distributed ligand gated ion channels throughout the peripheral and central nervous systems of *** are 16 different n AChR subunits,α1-α7,α9,α10 and β1-β4,as well as γ,δ,and ε,which assemble into pentamers to form different nAChR subtypes with distinct pharmacological properties in *** them α6β2*(*designates other possible subunit),α3β4 and α4β2 nAChR subtypes are potential therapeutic targets for the treatment of ***,various n AChR subtypes are very difficult to pharmacologically distinguish from each *** α6* n AChRs are expressed by dopaminergic neurons in the central nervous system,which modulate the release of dopamine and are believed to be important in mediating tobacco,morphine,cocaine and ethanol *** α3β4 nAChRs present in the medial habenula with important role in influencing nicotine *** of α3β4 nAChRs in the medial habenula decreased the dose of nicotine that rodents would ***,new antagonists of α6β2* or α3β4 nA ChR subtypes are of considerable interest,which would give strategies to selectively modulate α6β2* or α3β4 nA ChR *** characterized an α-conotoxin(α-CTx)TxIB with 16 amino acids and an α-CTx TxID with 15 amino acids from Conus *** sequence of TxIB is *** sequence of TxID is GCCSHPVCSAMSPIC with C-terminal amidation *** peptides with a Ⅰ-Ⅲ and Ⅱ-Ⅳ disulfide con-nectivity were chemically *** residues between Cys-Ⅱ and Cys-Ⅲ and Cys-Ⅲand Cys-Ⅳ of α-CTx are commonly referred to as loops 1 and 2,*** number of residues in each of these loops is used to further classify the α-*** TxIB is classified as a 4/7α-CTx,whereas the α-CTx TxIB has a 4/6 *** peptides were tested on rat nAChRs heterologously expressed in Xenopus laevis *** α-CTx TxIB blocked α6/α3β2β3 nAChR with an IC50 of 28 nmol·L^(-1),which showed little or no block of all th

关键词： acetylcholine receptors smokingcessation drug rehabilitation α-conotoxins

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A novel Hainan ConotoxinPotently Blocks a9alO Nicotinic Acetylcholine Receptors

A novel Hainan ConotoxinPotently Blocks a9alO Nicotinic Acet...

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第12届生物毒素研究及医药应用学术大会

作者： Sulan Luo Dongting Zhangsun Peta J.Harvey quentin Kaas Yong Wu Xiaopeng Zhu Yuanyan Hu Xiaodan Li Victor Tsetlin Melissa McIntyre Cheryl Dowell James C.Baxter Keith S Elmslie David J.Craik J.michael McIntosh Key Laboratory of Tropical Biological Resources Ministry of EducationKey Lab for Marine Drug of HaikouHainan University Institute for Molecular Bioscience The University of Queensland Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences George E.Wahlen Veterans Affairs Medical Center and Departments of Biology and Psychiatry University of Utah

The a9al0 nicotinic acetylcholine receptor(nAChR) subtype is a recently identified target for the development of breast cancer chemotherapeutics and analgesics,particularly to treat neuropathic ***/function analyses of antagonists of this subtype are therefore essential for the development of specific therapeutic *** we report that αO-conotoxinGeXIVA(GeXVLA) from *** native to Hainan,China is a potent and selective antagonist of theα9α10 nAChR *** signal sequence of GeXVLA has high similarity with the O1-gene conotoxin *** predicted mature peptide(GeXVLA) has four Cys residues and its three disulfide isomers were *** pharmacologically characterized Ol-superfamily peptides contain six Cys residues are calcium,sodium or potassium channel ***,GeXTVA did not inhibit calcium channels but antagonized nAChRs,most potently on the α9α10nAChR subtype with an IC of 3.8 *** block was voltage dependent and kinetic analysis of toxin dissociation indicated that the binding site of GeXTVA does not overlap with that of the competitive antagonist ***,the most active disulfide isomer of GeXTVA is the bead isomer,comprising,according to NMR analysis,two well-resolved but uncoupled disulfide restrained *** ribbon isomer is almost as potent but has a more rigid structure built around a short *** contrast to most a-conotoxins,the globular isomer is the least potent and has a flexible,multi-conformational *** reduced mechanical hyperalgesia in the rat chronic constriction injury model of neuropathic pain,but had no effect on motor performance,warranting its further investigation as a possible therapeutic *** displays unique structural properties among other Conus peptides and represents a novel template for molecules active against neuropathic pain.

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实验室水系统中总有机碳含量的测定和意义

实验室水系统中总有机碳含量的测定和意义

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BCEIA2005分析仪器应用技术报告会

作者： Jacques Moulin Paul Melanson michael Retzik 法国Cedex Millipore Saint-Quentin-Yvelines公司美国哥伦比亚博尔德Anasel公司

＜正＞多年来,人们认为总有机碳（TOC）是半导体、发电应用中高纯度水系统的一种污染物。最近,人们又发现它还是制药应用中高纯度水的污染物。由于用于有效检测总有机碳的设备价格昂贵,因此尽管实验室水系统中的有机污染与上述领域中一...

＜正＞多年来,人们认为总有机碳（TOC）是半导体、发电应用中高纯度水系统的一种污染物。最近,人们又发现它还是制药应用中高纯度水的污染物。由于用于有效检测总有机碳的设备价格昂贵,因此尽管实验室水系统中的有机污染与上述领域中一样普遍,人们仍未认识到它的潜在负面影响。因此,开发一种经济的用于高纯度实验室用水生产的总有机碳分析器被提上日程。下文中将介绍这种系统。在半导体工业中,总有机碳检测在

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拍卖行化身多元艺术空间——嘉德艺术中心

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设计家 2018年第1期 102-106页

作者： Marcel Holmberg Sun Ke Emily Liang Cecilia Lei Yingda Ahrens Mark Biemans Kim Bjarke Catarina Canas Alicia Casals michael Cavander Jeffrey Cheng Patrick Conway Dyno Du Nicolaz Frez Brian Fung Daniel Hawkins Xinran Ji Philipp Kramer Emeline Laurencon Yuyang Lin Mavis Liu Wymen Lo Max Ma Rafael Merino John Murphey Marcin Olszowski Kevin Ou Kevin Park Yanyadech Phornphong Aaron Powers Klementina Savickaite Jim Shi Chiara Storino Joseph Tang Yang Tao Elena Yang quentin Yiu Francis Young Lei Yu Danny Zhang Bruno Zhao Weiwei Zhang Yi Zhu Catarina Canas Brian Fung Paloma Hernaiz Marcel Holmberg Tait Kaplan Jaime Oliver Joseph Tang Beijing Institute of Architectural Design (BIAD) Beijing Buro Ole Scheeren MQ-Studio Shanghai(Hotel)

嘉德艺术中心紧邻紫禁城,作为一座全新的综合文化机构,将北京的古城韵味与现代大都会的蓬勃生机以及多元艺术融为一体.嘉德艺术中心是世界上第一个量身定制的拍卖行总部,在北京的中心创建了一个全新的多元艺术机构类型.建筑提供博物馆... 详细信息

嘉德艺术中心紧邻紫禁城,作为一座全新的综合文化机构,将北京的古城韵味与现代大都会的蓬勃生机以及多元艺术融为一体.嘉德艺术中心是世界上第一个量身定制的拍卖行总部,在北京的中心创建了一个全新的多元艺术机构类型.建筑提供博物馆硬件质量的展示空间和最先进的艺术品保护设施,同时也是一个灵活丰富的文化空间,与餐馆、酒店、公共交通基础设施结合在一起.

关键词：艺术中心拍卖行艺术空间化身交通基础设施机构类型文化空间量身定制

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