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Comparison of pencil beam and Monte Carlo calculations with ion chamber array measurements for patient-specific quality assurance

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Radiation Medicine and Protection 2022年第3期3卷 115-122页

作者： Yu Deng Zhi Chen Qianxia Wang Pablo Yepes Zhuangming Shen Hongliang Chen Jie Li michael f.moyers Shanghai Proton and Heavy Ion Center Shanghai Engineering Research Center of Proton and Heavy Ion Radiation TherapyShanghai 201315China Rice University HoustonTX77005USA

Objective:To determine under what conditions and criteria comparisons between calculations made with the current clinical treatment planning system(Syngo)and an in-house built TPS(TIMPS)would allow skipping of in-beam portal-specific ***:Measurements were made with an array of 24 ion chambers in a water phantom for 227 proton and 313 carbon ion portals with and without a range shifter(RS).These measurements were compared with calculations performed with Syngo and TIMPS using metrics of average dose difference and Gamma ***:for proton portals without RS,if a Gamma comparison between TIMPS and Syngo passed using criteria of 90%of tested points being within 3%and 3 mm,then 74%of measurements would agree with both TIMPS and *** proton portals with RS,more than 80%of measurements would agree with both calculations using the same *** carbon ion portals without RS,if a Gamma evaluation between TIMPS and Syngo passed with criteria of 90%of tested points being within 2%and 2 mm,85%of measurements would agree with both *** carbon ion portals with RS,if a Gamma evaluation between TIMPS and Syngo passed with criteria of 90%of tested points being within 3%and 3 mm,60%of measurements would agree with both ***:Both the pencil beam algorithm in Syngo and the fDC algorithm in TIMPS can provide accurate dose calculations in water for most clinical *** about 75%of portals,physicists can perform comparisons of calculations instead of phantom measurements to verify Syngo calculations thereby saving a large amount of beam *** are some portals,however,such as for low-energy protons without RS and high-energy carbon ions,where agreement between the two calculations and measurements are not yet satisfactory to allow the elimination of all measurements.

关键词： Ion beam Quality assurance Monte Carlo Pencil beam

Implementation of Monte Carlo based PET verification of ion beam delivery into a TPS

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Radiation Medicine and Protection 2022年第3期3卷 131-138页

作者： Pablo Yepes Zhuangming Shen michael f.moyers Qianxia Wang Hongliang Chen Jie Li Yongqiang Li James Lin Rice University HoustonTX77005USA Shanghai Proton and Heavy Ion Center Shanghai Engineering Research Center of Proton and Heavy Ion Radiation TherapyShanghai 201315China

Objective:To develop and implement an ion beam teletherapy verification system based upon simulations of induced radioactivity and comparison with patient positron emission tomography(PET)***:A Monte Carlo algorithm was integrated into an in-house built treatment,information,management,and planning system(TIMPS■)to calculate distributions of positron emitters induced by ion *** distribu-tions are processed to simulate PET images taking into account positron diffusion,radioactive decay,biological washout,and detector *** tools were developed to register simulated PET images with planning CT images and perform comparisons of measured and simulated PET ***:Production cross-sections were generated for various isotopes and *** plans for several different body sites were used to verify the functioning and utility of the new tools for both proton and carbon ion ***:Several tools have been developed to simulate PET scans of patients irradiated with ion beams and compare the simulated images to *** commissioning and implementation into the clinic,the appropriate sizes for margins that account for uncertainties may be investigated.

关键词： ion beam PET Monte Carlo

Verification of an independent dose calculation method for portal-specific QA of proton and carbon ion beams

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Radiation Medicine and Protection 2022年第3期3卷 152-157页

作者： michael f.moyers Qianxia Wang Yu Deng Hongliang Chen Zhi Chen Xiaoli Liu Nicki Schlegel Jie Li Zhuangming Shen James Lin Pablo Yepes Shanghai Proton and Heavy Ion Center Shanghai 201315China Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy Shanghai 201315China Rice University HoustonTXUSA

Objective:To verify the accuracy of an independent dose calculation method,as incorporated into an in-house developed treatment planning system(TPS),for performing quality assurance of dose distributions delivered to a water phantom planned by a clinical ***:A Monte Carlo based track repeating algorithm was incorporated into an in-house treatment planning system for proton and carbon ion *** were performed in a flat water phantom for both a traditional pencil beam algorithm and a new Monte Carlo algorithm,and then compared to measurements made at multiple depths with a 2D ionization array for 44 patient *** comparisons utilized a Gamma ***:A total of 124 measurements were performed for proton and carbon ion patient *** a small Gamma criteria of 2%/2 mm,an average of 93%and 97%of measurement points passed for each portal for pencil beam and Monte Carlo calculations,*** passing rate was substantially higher for Monte Carlo calculations than for pencil beam calculations for portals that used a range ***:The implemented independent method has been verified against *** high passing rate with small tolerances leads to the possibility of reducing the number of required quality assurance measurements.

关键词： Ion beam Quality assurance Monte Carlo Ionization chamber array

Workshop on fast calculations for ion beam therapy

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Radiation Medicine and Protection 2022年第3期3卷 101-101页

作者： michael f.moyers Shanghai Proton and Heavy Ion Center Shanghai Engineering Research Center of Proton and Heavy Ion Radiation TherapyShanghai 201315China

During October 18 and 19,2019,a“Workshop on fast Calculations for Ion Beam Therapy”was held at the Shanghai Proton and Heavy Ion Center in Shanghai,*** program consisted of 20 presentations,10 of which were given by international invited *** subject matter for the presentations was diverse,but all involved fast calculations or optimization as part of the planning and treatment *** pre-sentations were reviews of state of the art techniques,some were scien-tific,and some were engineering.

关键词： process. China. speakers

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质子重离子放射治疗管理系统的设计应用

医学信息 2021年第20期34卷 32-36页

作者：钱海新李杰 michael f.moyers 沈庄明陈宏亮林子楠上海市质子重离子医院放射物理科/上海市放射肿瘤学重点实验室20dz2261000/上海质子重离子放射治疗工程技术研究中心

目前,治疗恶性肿瘤主要依赖于手术、化疗、放疗等手段,但放射治疗设备及其配套系统在标准化与个性化方面仍存在一定问题,导致其在国内的应用普及受到一定影响。本文针对我院引进的放疗设备,设计开发了质子重离子放射治疗流程管理系统,... 详细信息

目前,治疗恶性肿瘤主要依赖于手术、化疗、放疗等手段,但放射治疗设备及其配套系统在标准化与个性化方面仍存在一定问题,导致其在国内的应用普及受到一定影响。本文针对我院引进的放疗设备,设计开发了质子重离子放射治疗流程管理系统,阐述了系统开发的目的、硬件和软件平台以及主要功能,总结了系统应用的优势,以期为国内医院放疗设备应用系统的普及提供参考。

关键词：质子重离子放射治疗管理系统

Analysis of delivery and recalculation of dose using DICOM treatment records

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Radiation Medicine and Protection 2022年第3期3卷 123-130页

作者： Z.Chen M.f.moyers Y.Deng H.L.Chen J.Li Z.M.Shen J.Lin Q.Wang P.Yepes Shanghai Proton and Heavy Ion Center Shanghai Engineering Research Center of Proton and Heavy Ion Radiation TherapyShanghai Key Laboratory of Radiation OncologyShanghai 201315China Rice University HoustonTXUnited States

Objective:A procedure has been proposed for patient-specific QA that,instead of comparing a measurement to the planned dose,compares the dose calculated by an independent system to the dose calculated by the planning *** is still prudent,however,to check the accuracy of the beam *** this purpose,the DICOM records from the first treatment fraction can be compared to the planned treatment using an in-house developed planning ***:Totally 1,398 patient portals were subjected to the new QA *** dose distribution for each portal was first recalculated on a water phantom by two treatment planning systems and the dose distributions were *** agreement was observed,the patient was allowed to start treatment without a *** record from the first day was imported into an in-house planning system which was used to evaluate the delivery for errors and calculate the delivered dose distribution and compare it to the planned dose ***:A total of 266 portals passed a strict comparison between the clinical and QA dose calculations and directly used for treatment without *** those portals,the comparison of the delivery records to the plan showed that 99%of spot positions deviated less than 0.2 mm and 99.7%of spot metersets deviated by less than 0.3%.On the other hand,64 portals showed spot size deviations greater than the tolerance of15%with some as large as25%.for 32 portals in which the record was used to calculate the delivered dose distribution,the Gamma passing rates between the planned and delivered distributions were always above 95%using a 2%dose difference and 2 mm distance-to-agreement ***:The new QA process has been implemented slowly with strict *** amount of beam time required has been reduced while maintaining safety.

关键词： Ion beam Quality assurance Monte Carlo DICOM

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点扫描式粒子治疗患者验证分析的初步研究

中华放射医学与防护杂志 2017年第10期37卷 789-793页

作者：刘晓莉邓宇 Nicki Schlegel 黄志杰 michael f. moyers 上海市质子重离子医院放射物理科 201315

目的通过对以调强点扫描质子和碳离子技术治疗患者的验证计划测量结果分析,评估现行的计划验证方式的完善性.方法通过分析质子和碳离子验证计划的1734个射束照射记录,验证测量通过的标准是验证计划测量值与计算值之间的剂量差异≤3%... 详细信息

目的通过对以调强点扫描质子和碳离子技术治疗患者的验证计划测量结果分析,评估现行的计划验证方式的完善性.方法通过分析质子和碳离子验证计划的1734个射束照射记录,验证测量通过的标准是验证计划测量值与计算值之间的剂量差异≤3%或距离一致性（distance-to-agreement,DTA）差异≤3 mm,同时满足所有电离室的剂量偏差平均值≤3%,电离室矩阵中24个电离室中有至少22个通过此标准为验证计划通过,测量结果按照不同的测量水箱、测量房间和电离室矩阵测量深度等测量信息分类.结果测量结果分类分析显示,验证测量通过率和测量参数存在部分相关性,质子和碳离子总的计划通过率分别为97.7%和91.9%.对于质子射束,验证测量通过率在任意深度都较高,但对于碳离子的验证测量,验证测量通过率会随着测量深度的增加而降低.多数电离室性能稳定,不同水箱,不同治疗机房间验证通过率无明显差异.结论用三维水箱测量到的点剂量和治疗计划系统（TPS）计算的剂量值之间有较好的一致性.当电离室矩阵在水中的测量深度〉150 mm时,碳离子通过率会略差,可能由于在高剂量跌落的区域,水箱内电离室矩阵摆位的不确定性（左右和深度方向）造成,也可能是TPS散射模型对碳离子在深度〉150 mm处剂量贡献评估存在不足造成,此现象仍需要做进一步研究.

关键词：剂量验证调强点扫描粒子射束

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Ⅱ类错(牙合)的鉴别诊断第一部分:与Ⅱ类错有关的面型

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国外医学.口腔医学分册 1981年第4期 224-226页

作者： moyers R E 赵美英

近年来,推论式多变方法有所发展,并应用于分类学,这些方法较容易的使分类图式化,并可推论亚类,便于作进一步的研究。本文的目的是为了研究:在Ⅱ类错(牙合)中是否可以鉴定出不同的骨骼面型,有多少型,其骨骼特征如何? 资料作者多年来积累... 详细信息

近年来,推论式多变方法有所发展,并应用于分类学,这些方法较容易的使分类图式化,并可推论亚类,便于作进一步的研究。本文的目的是为了研究:在Ⅱ类错(牙合)中是否可以鉴定出不同的骨骼面型,有多少型,其骨骼特征如何? 资料作者多年来积累并数字化,以及贮存了大量治疗过的和未治疗的Ⅱ类错(牙合)于计算机中。本研究所用资料为697例儿童的侧位头影像。所有头影像均描绘并数字化和贮存于计算机中。具体方法作者1974年已报导。

关键词：面型骨骼功能性运动器官切牙前颅底水平型垂直型正畸医师前突

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质子重离子肿瘤放疗的临床注册试验初步报告

中华肿瘤杂志 2018年第1期40卷 52-56页

作者：陆嘉德叶明郭小毛傅深 moyers f. michael 章青茅静芳孔琳 HSI Wen Chien Shahnazi Kambiz 赵静芳章真马秀梅来松涛张晓萌麻宁一高云生蔡昕管西寅张军华吴斌程竞仪盛尹祥子任炜赵俊孙力宁蒋国梁上海市质子重离子医院放疗科 201315 上海市质子重离子医院物理科 201315 上海市质子重离子医院放射诊断科 201315 上海市质子重离子医院核医学科 201315 上海交通大学医学院仁济医院放疗科 200127 复旦大学附属肿瘤医院放疗科上海200032 复旦大学附属肿瘤医院放射诊断科上海200032 复旦大学附属肿瘤医院核医学科上海200032 上海交通大学医学院瑞金医院放疗科 200025

目的探讨IONTRIS粒子放疗设备临床应用的安全性和有效性。方法2014年6月至2014年8月间共有35例肿瘤患者入组，其中男性31例，女性4例：年龄36～80岁，中位年龄69岁。头颈肿瘤10例（均为手术后复发），胸部肿瘤4例，原发性肝癌1例，腹膜... 详细信息

目的探讨IONTRIS粒子放疗设备临床应用的安全性和有效性。方法2014年6月至2014年8月间共有35例肿瘤患者入组，其中男性31例，女性4例：年龄36～80岁，中位年龄69岁。头颈肿瘤10例（均为手术后复发），胸部肿瘤4例，原发性肝癌1例，腹膜后肉瘤术后复发1例．前列腺癌19例。碳离子照射剂量为2．74—10GyE／次，质子照射剂量为2—5．5GyE／次，5次／周。放疗前对每个放射野进行水箱剂量验证。结果碳离子照射22例，质子照射13例。放疗后1年，35例患者全部生存。在16例头颈部、胸部和腹盆腔肿瘤患者中，完全缓解2例，部分缓解1例，疾病稳定12例，疾病进展1例，1年无进展生存率为93．8％（15／16）。19例前列腺癌患者的1年无生化复发生存率为100％。35例患者对粒子放疗的耐受性良好，放疗期间的美国东部肿瘤协作组评分和体重无明显改变。25例（71．4％）患者发生了与粒子放疗相关的急性不良事件（AE）33例次，均为1级．在放疗1年时急性AE全部消失。有6例（17．1％）患者在放疗后1年发生后期AE6例次，全部为1级。结论采用IONTRIS设备治疗肿瘤患者安全、有效。

关键词：肿瘤质子重离子放射治疗临床试验

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