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Immunological aspects of liver cell transplantation

World Journal of Transplantation 2016年第1期6卷 42-53页

作者： Felix Oldhafer michael bock Christine S Falk Florian WR Vondran Regenerative Medicine and Experimental Surgery (Re Medi ES) Department of General Visceral and Transplant Surgery Hannover Medical School Department of Gastroenterology Hepatology and Endocrinology Hannover Medical School German Center for Infection Research (DZIF) Partner Site Hannover-Braunschweig Institute of Transplant Immunology Integrated Research and Treatment Centre Transplantation (IFB-Tx) Hannover Medical School

Within the field of regenerative medicine, the liver is of major interest for adoption of regenerative strategies due to its well-known and unique regenerative capacity. Whereas therapeutic strategies such as liver resection and orthotopic liver transplantation(OLT) can be considered standards of care for the treatment of a variety of liver diseases, the concept of liver cell transplantation(LCTx) still awaits clinical breakthrough. Success of LCTx is hampered by insufficient engraftment/long-term acceptance of cellular allografts mainly due to rejection of transplanted cells. This is in contrast to the results achieved for OLT where longterm graft survival is observed on a regular basis and, hence, the liver has been deemed an immuneprivileged organ. Immune responses induced by isolated hepatocytes apparently differ considerably from those observed following transplantation of solid organs and, thus, LCTx requires refined immunological strategies to improve its clinical outcome. In addition, clinical usage of LCTx but also related basic research efforts are hindered by the limited availability of high quality liver cells, strongly emphasizing the need for alternative cell sources. This review focuses on the various immunological aspects of LCTx summarizing data available not only for hepatocyte transplantation but also for transplantation of non-parenchymal liver cells and liver stem cells.

关键词： Liver cell transplantation Cell-based therapy Hepatocyte transplantation Transplant immunology Regenerative medicine

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RFID使C部件供应稳定性最佳

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现代制造 2015年第29期 38-40页

作者： michael bock michael bock

多达100万种零部件的分类系统组成了一个最佳化的C部件拣选运作的基础。受到人们关注是因为该方案采用了面向客户且能够确保准时的Kanban零部件供应系统和容器物流的零部件供应方案。

关键词：供应系统零部件 RFID 稳定性 Kanban 分类系统面向客户最佳化

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The tri-band high spectral resolution spectrometer with gratings in tandem for the charge-exchange recombination spectroscopy diagnostic system on HL-2A tokamak

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Plasma Science and Technology 2024年第6期26卷 103-110页

作者：刘亮余德良马倩何小斐 Maarten DE bock Manfred von HELLERMANN michael WALSH 陈文锦何小雪魏彦玲张能李栋魏会领 the HL-2A Team Southwestern Institute of Physics Chengdu 610041People’s Republic of China College of Physics and Optoelectronic Technology Baoji University of Arts and SciencesBaoji 721000People’s Republic of China ITER Organization Route de Vinon-sur-VerdonCS 90046St.Paul Lez Durance Cedex 13067France Fusion Spectroscopy Markgraf-Albrecht Str.14Berlin 10711Germany

Charge-exchange(CX) recombination spectroscopy is a powerful tool monitoring ion temperature and plasma rotation with good temporal and spatial resolutions. A compact, new design for a high-throughput, tri-band high spectral resolution spectrometer has been developed for the charge-exchange recombination spectroscopy measurement on the HL-2A tokamak. The simultaneous measurements of He II(468.57 nm), C VI(529.1 nm), and Dα(656.1 nm accompanied by beam emission spectra) with an acquisition frequency up to 400 Hz are achieved by vertically binning the spectrum from each fiber in experiments. Initial results indicate that the system can provide radial profiles of not only ion temperature and rotation velocity,but also concentration of carbon. For the case of helium, the measurements for the ion temperature and rotation velocity are straightforward but the apparent concentration associated with the observed CX intensity is obviously too high. Modeling of the active He II CX feature including plume contributions needs to be carried out to extract the true helium *** spectrometer could become a prototype for the ITER charge-exchange recombination spectroscopy diagnostic and the pilot experiments, as presented here, demonstrate the possibility of impurity concentrations measurements based on the combined measurement of local beam emission and charge-exchange recombination spectroscopy spectra.

关键词： CXRS ion temperature plasma rotation impurity concentration

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In memoriamWalter Joseph bock—a life dedicated to teaching and research in the biological sciences(20 November 1933-27 January 2022)

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Integrative Zoology 2022年第6期17卷 1215-1218页

作者： michael SCHMITT John BUCKERIDGE Universität Greifswald Allgemeine&Systematische ZoologieGreifswaldGermany Professor Emeritus RMIT UniversityMelbourneVictoriaAustralia

Walter Joseph bock(Fig.1)was born in Woodhaven,Queens County,New York,NY(USA),the second of 4 children of Paul and Anne bock,née *** grew up in a German speaking family who discontinued speaking German only at the outset of *** 1947 to 1951 he attended Brooklyn Technical High School,where there was considerable emphasis on technological *** 1951,he entered Cornell University in Ithaca,NY,graduating with a Bachelor of Science in *** Cornell,he attended a short lecture series presented by the famed ethologist Konrad Lorenz,and began an association with the ornithologist Charles *** links provided Walter with a growing appreciation of the wonders of the world of biology.

关键词： teaching Walter continued

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Agro-pedological Assessment of the Traditional Yuanyang Rice Terraces of Yunnan Province, China

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Journal of Resources and Ecology 2011年第4期2卷 353-361页

作者： Gilles COLINET Keiko KOULOS 吴伯志李永梅 Daniel LACROIX1 苏友波 Jean CHAPELLE michael A. FULLEN Trevor HOCKING Laurent bock 列日大学让布鲁农业与生物技术学院云南农业大学昆明650201 伍尔弗汉普顿大学

As a contribution to a long-term evaluation of the sustainability of agro-ecosystems in the Yuanyang rice terraces, this paper reviews the bio-physical environment of the terraced landscape in a small catchment around Qingkou village and assesses soil fertility in the village crop growing area. A soil- landscape organization pattern was developed using a geomorphopedological approach. Anthropogenic, climatic and topographic factors were identified as the main soil forming factors. Soil capability and associated edaphic constraints were assessed and the main soil types were identified and classified using FAO protocols. Spatial patterns of soil fertility appear quite homogeneous. Soils are acid and cation exchange capacity and nutrient reserves are generally low. The agro-ecosystem has largely been developed by the Hani population. This agro-ecosystem has succeeded in maintaining a relatively dynamic nutrient circulation system. Current research is focusing on：（i） the evaluation of the representativeness of the studied area compared to the whole terraced system in the Yuanyang terraced landscape; （ii） measurements of nutrients flows at the field scale; （iii） the effects of soil properties on crop yields; and （iv） up-scaling field levels results to larger spatial units.

关键词： terraced paddy fields geomorphopedological approach soil fertility diagnosis Yuanyang rice terraces sustainable agriculture

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