Immunological aspects of liver cell transplantation
Immunological aspects of liver cell transplantation作者机构：Regenerative Medicine and Experimental Surgery (Re Medi ES) Department of General Visceral and Transplant Surgery Hannover Medical School Department of Gastroenterology Hepatology and Endocrinology Hannover Medical School German Center for Infection Research (DZIF) Partner Site Hannover-Braunschweig Institute of Transplant Immunology Integrated Research and Treatment Centre Transplantation (IFB-Tx) Hannover Medical School
出 版 物：《World Journal of Transplantation》 (世界移植杂志)
年 卷 期：2016年第6卷第1期
页 面：42-53页
学科分类：10[医学]
基 金：Supported by Grants of the German Research Foundation(DFG,SFB 738,projects B3,C11) BMBF 01EO1302
主 题：Liver cell transplantation Cell-based therapy Hepatocyte transplantation Transplant immunology Regenerative medicine
摘 要：Within the field of regenerative medicine, the liver is of major interest for adoption of regenerative strategies due to its well-known and unique regenerative capacity. Whereas therapeutic strategies such as liver resection and orthotopic liver transplantation(OLT) can be considered standards of care for the treatment of a variety of liver diseases, the concept of liver cell transplantation(LCTx) still awaits clinical breakthrough. Success of LCTx is hampered by insufficient engraftment/long-term acceptance of cellular allografts mainly due to rejection of transplanted cells. This is in contrast to the results achieved for OLT where longterm graft survival is observed on a regular basis and, hence, the liver has been deemed an immuneprivileged organ. Immune responses induced by isolated hepatocytes apparently differ considerably from those observed following transplantation of solid organs and, thus, LCTx requires refined immunological strategies to improve its clinical outcome. In addition, clinical usage of LCTx but also related basic research efforts are hindered by the limited availability of high quality liver cells, strongly emphasizing the need for alternative cell sources. This review focuses on the various immunological aspects of LCTx summarizing data available not only for hepatocyte transplantation but also for transplantation of non-parenchymal liver cells and liver stem cells.
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