检索结果-南通市图书馆

the influence of non-bound amino acid inclusions and starch-protein digestive dynamics on growth performance of broiler chickens offered wheat-based diets with two crude protein concentrations

引用

Animal Nutrition 2023年第4期15卷 399-408页

作者： Shemil P.Macelline michael t.kidd Peter V.Chrystal Mehdi toghyani Peter H.Selle Sonia Y.Liu Poultry Research Foundation The University of SydneyCamden NSW 2570Australia School of Life and Environmental Sciences Faculty of ScienceThe University of SydneySydney NSW 2006Australia Center of Excellence for Poultry Science University of ArkansasFayettevilleAR 72701USA Complete Feed Solutions Howick2145New Zealand Sydney School of Veterinary Science The University of SydneySydney NSW 2006Australia

the primary objective of this study was to investigate the influence of high and low inclusions of nonbound amino acid(NBAA)in standard and reduced-crude protein(CP),wheat-based diets on growth performance in broiler *** treatments were formulated to either 210 or 180 g/kg ***210 g/kg CP diets contained either 12.1 or 21.1 g/kg NBAA and 180 g/kg CP diets contained either 44.0 or55.5 g/kg *** formulations also generated different dietary starch:protein ratios which impacted on starch-protein digestive *** of the four dietary treatments were offered to 7 replicates of15 birds housed in floor pens from 14 to 35 days post-hatch or a total of 420 male Ross 308 *** performance,relative abdominal fat-pad weights,breast muscle and leg shank yields were *** starch and protein(N)digestibility coefficients,disappearance rates and starch:protein disappearance rate ratios were *** ileal digestibility coefficients and disappearance rates of 16 amino acids were determined at 35 days post-hatch and free concentrations of 20 amino acids in systemic plasma were determined at 34 days *** transition from 210 to 180 g/kg CP diets depressed weight gain by 11.3%(1742 versus 1964 g/bird)and FCR by 10.4%(1.606 versus 1.455),although both parameters were subject to treatment *** treatment interaction(Ptly improved FCR by 4.17%(1.424 versus1.486)in birds offered 210 g/kg CP diets,but significantly depressed FCR by 3.36%(1.632 versus 1.579)in180 g/kg CP diets.A quadratic relationship(r=0.860;Ptween dietary NBAA inclusions and FCR was detected,which indicated that when NBAA inclusions exceed 18.5 g/kg efficiency of feed conversion ***,a multiple linear regression(r=0.913;Ptected for FCR where both NBAA inclusions and analysed dietary starch:protein ratios were significantly(Pted to ***

关键词： Amino acid Broiler Non-bound amino acid Reduced-crude protein

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Assessment of limiting dietary amino acids in broiler chickens offered reduced crude protein diets

引用

Animal Nutrition 2022年第3期10卷 1-11页

作者： Craig W.Maynard michael t.kidd Peter V.Chrystal Leon R.McQuade Bernie V.McInerney Peter H.Selle Sonia Y.Liu Center of Excellence for Poultry Science University of ArkansasFayettevilleAR72701United States Poultry Research Foundation Faculty of ScienceThe University of Sydney425 Werombi RoadCamdenNSW2570Australia School of Life and Environmental Sciences Faculty of ScienceThe University of SydneySydneyNSW2006Australia Australian Proteome Analysis Facility Macquarie UniversitySydneyNSW2109Australia Sydney School of Veterinary Science Faculty of ScienceThe University of SydneySydneyNSW2006Australia

As lowering crude protein(CP)in poultry diets continues to minimize amino acid excess,it is important to understand the limiting order of amino acids and the impact of their ***,a pair of experiments were conducted to observe the effects of individual amino acid deletions on growth performance,carcass traits,and nutrient *** experiments involved 3 control diets based on wheat and soybean meal,including a 210.0 g/kg CP industry control(IC),186.7 g/kg CP positive control(PC)supplemented with feed-grade amino acids to match the IC amino acid profile,186.7 g/kg CP negative control(NC)with reducing N corrected apparent metabolizable energy(AMEN)by 0.5 MJ/kg and removing feed-grade amino acids beyond L-Lys-HCl,DL-Met,and L-thr from *** deletion diets where the following supplemented amino acids were individually removed from the PC:Val,Ile,Leu,trp,Arg,His,Phe t tyr,glycine equivalence(Glyequi),Pro,and Energy(0.5 MJ/kg reduction in AMEN of the PC).All diets were formulated to contain similar concentrations of digestible Lys,total sulfur amino acid(tSAA)and *** diets were offered to broiler chickens from 15 to 22 d postehatch in a cage study(Exp.1)to gain digestibility and nutrient utilization data;whereas they were offered from 15 to 35 d post ehatch in a floor-pen study(Exp.2)to gain performance and carcass yield *** removal of supplemented Val,Arg,and Ile resulted in reduction on broiler performance(Pthe removal of Val,Arg,Ile,and Glyequi negatively influenced carcass traits(Pts from both experiments indicate that Val and Arg are co-limiting in wheat-soybean meal diets,but that Ile and Glyequi may potentially limit breast and thigh development.

关键词： Amino acid Broiler chicken Crude protein Low protein diet

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Like a G6-nal:transcriptional control of G-protein coupled receptors during oligodendroglial development

引用

Neural Regeneration Research 2025年第7期20卷 2001-2002页

作者： tim Aberle michael Wegner Institut für Biochemie Friedrich-Alexander-Universität Erlangen-NürnbergErlangenGermany

Multilayered control of myelination:Quick,saltatory conduction of action potentials along nerve fibers requires the electrical insulation of axons by myelinating *** the central nervous system,this role is taken up by *** are marked by the expression of the lineage determinants Sox10 and Olig2 and arise from oligodendrocyte precursor cells(OPCs)during embryonal *** the majority of OPCs differentiate into mature oligodendrocytes when nearby axonal segments require myelination,a small subpopulation of OPCs persist as a progenitor ***,the timing of myelination and maintenance of the OPC pool both need to be precisely *** transcription factors either positively or negatively affect oligodendrocyte differentiation and maintenance of the OPC pool as components of a complex gene regulatory network(reviewed in Sock and Wegner,2021).Network activity is additionally influenced by extracellular signaling molecules that bind to receptors on the oligodendroglial cell surface and activate intracellular signaling *** the receptors are linked to the network is poorly understood so far,but pivotal to understanding the overall regulation of central nervous system(CNS)myelination in response to environmental *** insights were recently gained for Gpr37(Schmidt et al.,2024),a G-protein coupled receptor(GPCR)with known relevance in differentiating oligodendrocytes(Yang et al,2016).

关键词： gained insulation conduction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

引用

Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao michael S.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-Secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-Secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-Stay-trim,”“Sliding-Unwinding,”and“tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

NECAB family of neuronal calcium-binding proteins in health and disease

引用

Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno michael K.E.Schafer Sudena Wang michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

the N-terminal EF-hand calcium-binding proteins 1–3(NECAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one EF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NECAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NECAB2 interacts with predominantly striatal G-protein-coupled receptors, while NECAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. this demonstrates the capacity of the family for interactions with various classes of proteins. NECAB proteins exhibit distinct subcellular localizations: NECAB1 is found in the nucleus and cytosol, NECAB2 resides in endosomes and the plasma membrane, and NECAB3 is present in the endoplasmic reticulum and Golgi apparatus. the antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NECAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NECAB proteins by controlling the availability of protein–protein interaction domains situated between the EF hands and the antibiotic biosynthesis monooxygenase domain. this review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium EF hand mitochondria nervous system signal transduction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Small extracellular vesicles derived from cerebral endothelial cells with elevated microRNA 27a promote ischemic stroke recovery

引用

Neural Regeneration Research 2025年第1期20卷 224-233页

作者： Yi Zhang Zhongwu Liu michael Chopp michael Millman Yanfeng Li Pasquale Cepparulo Amy Kemper Chao Li Li Zhang Zheng Gang Zhang Department of Neurology Henry Ford HospitalDetroitMIUSA Department of Physics Oakland UniversityRochesterMIUSA Department of Pathology Henry Ford HospitalDetroitMIUSA Division of Pharmacology Department of NeuroscienceReproductive and Dentistry SciencesSchool of MedicineUniversity of Naples“Federico Ⅱ”NaplesItaly

Axonal remodeling is a critical aspect of ischemic brain repair processes and contributes to spontaneous functional *** previous in vitro study demonstrated that exosomes/small extracellular vesicles(sEVs)isolated from cerebral endothelial cells(CEC-sEVs)of ischemic brain promote axonal growth of embryonic cortical neurons and that microRNA 27a(miR-27a)is an elevated miRNA in ischemic *** the present study,we investigated whether normal CEC-sEVs engineered to enrich their levels of miR-27a(27a-sEVs)further enhance axonal growth and improve neurological outcomes after ischemic stroke when compared with treatment with non-engineered CEC-sEVs.27a-sEVs were isolated from the conditioned medium of healthy mouse CECs transfected with a lentiviral miR-27a expression *** EVs isolated from CECs transfected with a scramble vector(Scra-sEVs)were used as a *** male mice were subjected to permanent middle cerebral artery occlusion and then were randomly treated with 27a-sEVs or *** array of behavior assays was used to measure neurological *** with treatment of ischemic stroke with Scra-sEVs,treatment with 27a-sEVs significantly augmented axons and spines in the peri-infarct zone and in the corticospinal tract of the spinal grey matter of the denervated side,and significantly improved neurological *** vitro studies demonstrated that CEC-sEVs carrying reduced miR-27a abolished 27a-sEV-augmented axonal *** analysis revealed that 27a-sEVs systemically administered preferentially localized to the pre-synaptic active zone,while quantitative reverse transcription-polymerase chain reaction and Western Blot analysis showed elevated miR-27a,and reduced axonal inhibitory proteins Semaphorin 6A and Ras Homolog Family Member A in the peri-infarct *** of the Clathrin-dependent endocytosis pathway substantially reduced neuronal internalization of *** data provide evidence that 27a-sEVs have

关键词： axonal remodeling cerebral endothelial cells exosomes miR-27a mitochondria Semaphorin 6A small extracellular vesicles stroke

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

引用

Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： Shan Ping Yu Emily Choi michael QJiang Ling Wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Progress of amino acid nutrition for diet protein reduction in poultry

引用

Journal of Animal Science and Biotechnology 2021年第3期12卷 819-827页

作者： M.t.kidd C.W.Maynard G.J.Mullenix Center of Excellence for Poultry Science Division of AgricultureUniversity of Arkansas SystemFayettevilleAR 72701USA

there is growing interest among nutritionists in feeding reduced protein diets to broiler *** nearly a century of research has been conducted providing biochemical insights on the impact of reduced protein diets for broilers,practical limitation still *** present review was written to provide insights on further reducing dietary protein in *** construct this review,eighty-nine peer reviewed manuscripts in the area of amino acid nutrition in poultry were ***,nutritional research areas of low protein diets,threonine,glycine,valine,isoleucine,leucine,phenylalanine,histidine,and glutamine have been assessed and combined in this text,thus providing concepts into reduced protein diets for *** addition,linkages between the cited work and least cost formation ingredient and nutrient matrix considerations are *** conclusion,practical applications in feeding reduced protein diets to broilers are advancing,but more work is warranted.

关键词： Amino acid Broiler chicken Glutamine Histidine Low protein threonine Valine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

家庭医学的全球发展及对中国的启示

引用

中国全科医学 2016年第13期19卷 1485-1486页

作者： michael kidd 世界家庭医生组织

世界家庭医生组织（WONCA）是全球家庭医生的组织,有来自150多个国家的50多万名家庭医生。WONCA把全世界的家庭医生汇聚到一起,以尽可能高的标准支持家庭医学领域的教育、培训及研究。正如WONCA第一任主席Monty Kent Hughes讲到的：＂... 详细信息

世界家庭医生组织（WONCA）是全球家庭医生的组织,有来自150多个国家的50多万名家庭医生。WONCA把全世界的家庭医生汇聚到一起,以尽可能高的标准支持家庭医学领域的教育、培训及研究。正如WONCA第一任主席Monty Kent Hughes讲到的：＂我们家庭医学专业的未来将由我们为人类医疗服务的整体合作能力所决定＂,为此我们一直在努力、在合作。

关键词：家庭医学全球中国

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dietary branched-chain amino acid assessment in broilers from 22 to 35 days of age

引用

Journal of Animal Science and Biotechnology 2021年第2期12卷 755-762页

作者： M.t.kidd F.Poernama t.Wibowo C.W.Maynard S.Y.Liu Center of Excellence for Poultry Science Division of AgricultureUniversity of Arkansas SystemFayettevilleAR 72701USA Pt JAPFA Comfeed Indonesia tbk Jakarta 12810Indonesia School of Life and Environmental Sciences Faculty of ScienceThe University of SydneyBrownlow HillSydneyNSW 2570Australia

Background:Valine and isoleucine are similar in chemical structure and their limitation in broiler chicken *** evaluate their limitation and interactive effects,multivariate assessment nutrition studies for the branched-chain amino acids(BCAA)are needed.A three level(−1,0,+1),three-factor Box-Behnken design study was conducted to assess dietary BCAA ratios to lysine of 65,75,and 85 for valine,58,66,and 74 for isoleucine,and 110,130,and 150 for leucine in male and female Lohman Indian River broilers from 22 to 35 d of ***:Live performance of male broilers was not affected by BCAA ***,male broilers fed increasing isoleucine had improved(P=0.07)carcass yield as leucine and valine were *** broilers had improved body weight gain(P=0.05)and feed conversion(P=0.003)when leucine and isoleucine were at their lowest levels,independent of valine,but increasing leucine impaired live performance and warranted concomitant increases in isoleucine to restore *** dietary isoleucine and valine in female broilers increased breast meat yield(P=0.05),but increasing leucine tended to diminish the ***:the female Lohman Indian River broiler is more sensitive to BCAA diet manipulation than ***,as dietary leucine is increased in female broilers,dietary isoleucine increases were needed to offset the negative *** increases in dietary valine and isoleucine improved breast meat yield in female broilers,but only when birds were fed the lowest dietary leucine.

关键词： Broiler Crude protein Isoleucine Leucine Response surface Valine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：