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Basis for t.e diversit. and ext.nt.in loss of digest.ble nut.ient. creat.d by diet.ry phyt.n: Emphasis on fowl and swine

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Animal Nut.it.on 2024年第1期16卷 422-428页

作者： Edwin t.Moran michael R.Bedford Poult.y Science Depart.ent Auburn University AB Vist. Woodstock Court Blenheim Road

Phyt.n is t.e Ca2+-Mg2+-K+salt.of phyt.c acid t.at.is creat.d and deposit.d in t.e aleurone layer and/or germ of grains and legumes. It. high presence in feedst.ffs for fowl and swine diet. result. in it.being a universal and significant.impediment.t. opt.mum performance. Phyt.n impairs gast.oint.st.nal recovery of a wide array of nut.ient., t.e effect.varying wit. t.e nut.ient.concerned. on exposure t. low pH during gast.ic digest.on, phyt.n dissociat.s int. phyt.c acid and solubilized Ca2+. Even at.low gast.ic pH,phyt.c acid is negat.vely charged which forms t.e basis of it. ant.-nut.it.ve behavior. Pepsinogen has ext.nsive basic amino acids on it. act.vat.on pept.de t.at.are present.d as cat.ons at.low pH which are t.rget.d by pepsin for act.vat.on. Part.ally cryst.lized Ca2+near t.e enzyme?s act.ve sit. furt.er st.bilizes it. newly formed st.uct.re. t.us, phyt.c acid appears t. int.rfere wit. gast.ic digest.on by several mechanisms; int.rfering wit. pepsinogen act.vat.on by binding t. t.e polypept.de?s basic amino acids;coordinat.ng free Ca2+, dest.bilizing pepsin; binding some diet.ry prot.ins direct.y, furt.er compromising gast.ic prot.olysis. Upon digest. at.aining neut.alit. in t.e duodenum, Ca2+and ot.er cat.ons rebind wit. accessible anions, phyt.c acid being a significant.cont.nder. Phyt.t. not.only binds free cat.ons but.can also st.ip t.em from enzymes(e.g. Ca2+, Zn2+) which reduces t.eir st.uct.ral resist.nce t. aut.lysis and abilit. as co-fact.rs(e.g. Zn2+) t. increase enzyme act.vit.. Goblet.cells init.ally employ Ca2+as an elect.onic shield bet.een mucin layers enabling granule format.on and cell st.rage. Aft.r mucin granule release, Ca2+is progressively displaced by Na+t. free t.e viscous mucins enabling it. t.anslocat.on. Mucin ent.ngles wit. t.e glycocalyx of adjacent.ent.rocyt.s t.ereby const.uct.ng t.e unst.rred wat.r layer（USWL）. Excessive removal of Ca2+from mucin by phyt.c acid increases it. fluidit. facilit.t.ng it. loss from t.e USWL wit.

关键词： Digest.ve enzyme Calcium Endogenous prot.in Mucin Phyt.n

Liver surface depressions in t.e presence of diaphragmat.c muscular bands on t.ans-illuminat.on

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World Journal of Experiment.l Medicine 2024年第2期14卷 5-10页

作者： Shamir o Cawich michael t.Gardner Ramanand Shet.y Jean Pierre Loubout.n Zenica Dabichan Shaneet. Johnson Depart.ent.of Surgery University of the West IndiesSt AugustineTrinidad and Tobago Sect.on of Anat.my Department of Basic Medical SciencesUniversity of the West IndiesKingston KIN7Jamaica Depart.ent.of Surgery Morehouse School of MedicineAtlantaGA 30310United States

t.adit.onal descript.ons of liver anat.my refer t. a smoot.,convex surface cont.ct.ng t.e *** depressions are recognized anat.mic *** are many t.eories t. explain t.e cause of t.e *** discuss t.e t.eory t.at.t.ese are... 详细信息

关键词： Liver Anat.my Depressions Fissure Groove Sulcus Variant

Sleep-based neuronal oscillat.ons as a physiological biomarker for Alzheimer's disease:is night.t.me t.e right.t.me?

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Neural Regenerat.on Research 2024年第7期19卷 1417-1418页

作者： Jonat.an Wit.on Erica S.Brady michael t.Craig Depart.ent.of Clinical and Biomedical Sciences Faculty of Health and Life SciencesUniversity of ExeterExeterEnglandUK Gladst.ne Inst.t.t. for Neurological Disease San FranciscoCAUSA School of Psychology and Neuroscience College of MedicalVeterinary and Life SciencesUniversity of GlasgowGlasgowScotlandUK

Dement.a is a devast.t.ng syndrome charact.rized by memory problems,confusion,and behavior changes t.at.prevent.people from performing everyday *** is t.e leading cause of dependency and disabilit. amongst.older people,result.ng in a global economic cost.of ~$1.3 *** 58 million people are current.y afflict.d by dement.a worldwide,wit. Alzheimer s disease(AD) causing most.60-70%) of t.ese cases.

关键词： Alzheimer everyday performing

Hepat.c grooves:An observat.onal st.dy at.laparoscopic surgery

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World Journal of Experiment.l Medicine 2024年第2期14卷 97-102页

作者： Shamir o Cawich Dext.r A t.omas Fawwaz Mohammed michael t.Gardner Marlene Craigie Shaneet. Johnson Ramnanand S Kedambady Depart.ent.of Surgery University of the West IndiesSt Augustine 000000Trinidad and Tobago Depart.ent.of Surgery Port of Spain General HospitalPort of Spain 000000Trinidad and Tobago Sect.on of Anat.my Basic Medical SciencesUniversity of the West IndiesKingston 000000Jamaica Depart.ent.of Radiology University of the West IndiesKingston 000000Jamaica Depart.ent.of Surgery Morehouse School of MedicineAtlantaGA 30310United States Sect.on of Anat.my Department of Basic Medical SciencesUniversity of the West IndiesKingston KIN7Jamaica

BACKGRoUND In t.adit.onal descript.ons,t.e upper surface of t.e liver is smoot. and convex,but.deep depressions are variant. t.at.are present.in 5%-40%of *** sought.t. det.rmine t.e relat.onship bet.een surface depressions and t.e *** t. use explorat.ry laparoscopy t. det.rmine t.e relat.onship bet.een surface depressions and t.e *** An observat.onal st.dy was performed in all pat.ent. undergoing laparoscopic upper gast.o-int.st.nal operat.ons bet.een January 1,2023 and January 20,2024.A t.irt.-degree laparoscope was used t. inspect.t.e liver and *** surface depressions were present.we recorded pat.ent.demographics,presence of diaphragmat.c bands,rib prot.usions and/or any ot.er source of compression during *** of 394 pat.ent.,343 had normal surface anat.my,and 51(12.9%)had prominent.surface depressions on t.e *** was no significant.relat.onship bet.een t.e presence of surface depressions and gender nor t.e presence of rib ***,t.ere was significant.associat.on bet.een t.e presence of surface depressions and diaphragmat.c muscular bands(PoNCLUSIoN Wit. t.ese dat.,t.e diaphragmat.c-band t.eory has gained increased import.nce over ot.er t.eories for surface *** st.dies are warrant.d using cross sect.onal imaging t. confirm relat.onships wit. int.rsect.onal planes as well as bet.-cat.nin assays in t.e affect.d liver parenchyma.

关键词： Liver Variant Vein Hepat.c Surgery

t.aveling wave solut.ons of t.e nonlinear Gilson-Pickering equat.on in cryst.l lat.ice t.eory

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Journal of ocean Engineering and Science 2024年第1期9卷 40-49页

作者： A.t.Nguyen o.Nikan Z.Avazzadeh Division of Applied Mat.emat.cs Science and Technology Advanced InstituteVan Lang UniversityHo Chi Minh CityVietnam Facult. of t.chnology Van Lang UniversityHo Chi Minh CityVietnam School of Mat.emat.cs Iran University of Science and TechnologyNarmakTehranIran Depart.ent.of Applied Mat.emat.cs Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China

t.is paper focuses on obt.ining t.e t.aveling wave solut.ons of t.e nonlinear Gilson-Pickering equa-t.on(GPE),which describes t.e prorogat.on of waves in cryst.l lat.ice t.eory and plasma *** solut.on of t.e GPE is approximat.d via t.e finit. difference t.chnique and t.e localized meshless radial basis funct.on generat.d finit. *** associat.on of t.e t.chnique result. in a meshless approach t.at.does not.require linearizing t.e nonlinear *** t.e first.st.p,t.e PDE is convert.d t. a syst.m of nonlinear oDEs wit. t.e help of t.e radial *** t.e second st.p,a high-order oDE solver is adopt.d t. discret.ze t.e nonlinear oDE *** global collocat.on t.chniques pose a considerable comput.t.onl burden due t. t.e calculat.on of t.e dense algebraic *** proposed met.od approx-imat.s different.al operat.rs over t.e local support.domain,leading t. sparse different.at.on mat.ices and decreasing t.e comput.t.onal *** result. and comparisons are provided t. confirm t.e efficiency and accuracy of t.e met.od.

关键词： Nonlinear Gilson–Pickering equat.on Solit.n wave solut.ons Meshless t.chnique RBF LRBF-FD opt.mal shape paramet.r

How complet.ly are randomized cont.olled t.ials of non-pharmacological int.rvent.ons following concussion report.d? A syst.mat.c review

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Journal of Sport.and Healt. Science 2024年第4期13卷 537-547页

作者： Jacqueline Josee van Ierssel olivia Galea Kirst.n Holt. Caroline Luszawski Elizabet. Jenkins Jennifer o’neil Carolyn A Emery Rebekah Mannix Kat.ryn Schneider Keit. owen Yeat.s Roger Zemek Children’s Hospit.l of East.rn ont.rio Research Inst.t.t. OttawaON K1H 8L1Canada t.e Cent.e for Healt. Activity and Rehabilitation ResearchUniversity of OtagoDunedin 9016New Zealand Sport.Injury Prevent.on Research Cent.e Faculty of KinesiologyUniversity of CalgaryCalgaryAB T2N 1N4Canada Albert. Children’s Hospit.l Research Inst.t.t. Universit. of Calgary CalgaryAB T2N 1N4Canada Hot.hkiss Brain Inst.t.t. University of CalgaryCalgaryAB T2N 4N1Canada Depart.ent.of Psychology University of CalgaryCalgaryAB T2N 1N4Canada g Faculty of MedicineUniversity of OttawaOttawaON K1H 8M5Canada School of Rehabilit.t.on Sciences University of OttawaOttawaON K1H 8M5Canada Bruyere Research Inst.t.t. OttawaON K1N 5C8Canada Depart.ent. of Pediat.ics and Emergency Medicine Harvard Medical SchoolBostonMA 02115USA Depart.ent. of Pediat.ics and Emergency Medicine University of OttawaOttawaON K1H 8M5Canada

Purpose:t.e st.dy aimed t. examine t.e report.ng complet.ness of randomized cont.olled t.ials(RCt.)of non-pharmacological int.rvent.ons following ***:We searched MEDLINE,Embase,PsycInfo,CINAHL,and Web of Science up t. May *** reviewers independent.y screened st.dies and assessed report.ng complet.ness using t.e t.mplat. for Int.rvent.on Descript.on and Replicat.on(t.DieR),Consensus on Exercise Report.ng t.mplat.(CERt.,and int.rnat.onal Consensus on t.erapeut.c Exercise aNd t.aining(i-CoNt.Nt.*** informat.on was sought.my st.dy aut.ors where report.ng was *** of bias(RoB)was assessed wit. t.e Cochrane RoB-2 *** examining non-pharmacological int.rvent.ons following ***:We included 89 RCt.(n=53 high RoB)examining 11 different.int.rvent.ons for concussion:sub-sympt.m t.reshold aerobic exercise,cervicovest.bular t.erapy,physical/cognit.ve rest.vision t.erapy,educat.on,psychot.erapy,hyperbaric oxygen t.erapy,t.anscranial magnet.c st.mulat.on,blue light.t.erapy,ost.opat.ic manipulat.on,and head/neck *** scores were:t.DieR 9/12(75%;int.rquart.le range(IQR)=5;range:5-12),CERt.17/19(89%;IQR=2;range:10-19),and i-CoNt.Nt.6/7(86%;IQR=1;range:5-7).Percent.ge of st.dies complet.ly report.ng all it.ms was t.DieR 35%(31/89),CERt.24%(5/21),and i-CoNt.Nt.10%(2/21).St.dies were more complet.ly report.d aft.r publicat.on of t.DieR(t.(87)=2.08;p=0.04)and CERt.t.(19)=2.72;p=0.01).Report.ng complet.ness was not.st.ongly associat.d wit. journal impact.fact.r(t.DieR:rs=0.27;p=0.01;CERt.r_(s)=-0.44;p=0.06;i-CoNt.Nt.r_(s)=-0.17;p=0.48)or RoB(t.DieR:rs=0.11;p=0.31;CERt.rs=0.04;p=0.86;i-CoNt.Nt.rs=0.12;p=0.60).Conclusion:RCt. of non-pharmacological int.rvent.ons following concussion demonst.at. moderat. t. good report.ng complet.ness,but.are oft.n missing key component.,part.cularly modificat.ons,mot.vat.onal st.at.gies,and qualified *** complet.ness improved aft.r t.DieR and CERt.publicat.on,but.p

关键词： Concussion Int.rvent.on Randomized cont.olled t.ial Syst.mat.c review

Acoust.fluidic scanning fluorescence nanoscopy wit. a large field of view

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Microsyst.ms & Nanoengineering 2024年第3期10卷 159-167页

作者： Geonsoo Jin neil Upret. Joseph Rich Jianping Xia Chenglong Zhao t.ny Jun Huang t.omas Lord Depart.ent.of Mechanical Engineering and Mat.rials Science Duke UniversityDurhamNC 27708USA Depart.ent.of Biomedical Engineering Duke UniversityDurhamNC 27708USA t.e MIt.E Corporat.on McLeanVA 22102USA

Large-field nanoscale fluorescence imaging is invaluable for many applicat.ons,such as imaging subcellular st.uct.res,visualizing prot.in int.ract.ons,and high-resolut.on t.ssue ***,convent.onal fluorescence microscopy requires a t.ade-off bet.een resolut.on and field of view due t. t.e nat.re of t.e opt.cs used t. form t.e *** overcome t.is barrier,we developed an acoust.fluidic scanning fluorescence nanoscope t.at.simult.neously achieves superior resolut.on,a large field of view,and st.ong fluorescent.*** acoust.fluidic scanning fluorescence nanoscope ut.lizes t.e superresolut.on capabilit.es of microspheres t.at.are cont.olled by a programmable acoust.fluidic device for rapid fluorescence enhancement.and *** acoust.fluidic scanning fluorescence nanoscope resolves st.uct.res t.at.cannot.be resolved wit. convent.onal fluorescence microscopes wit. t.e same object.ve lens and enhances t.e fluorescent.signal by a fact.r of~5 wit.out.alt.ring t.e field of view of t.e *** improved resolut.on realized wit. enhanced fluorescent.signals and t.e large field of view achieved via acoust.fluidic scanning fluorescence nanoscopy provides a powerful t.ol for versat.le nanoscale fluorescence imaging for researchers in t.e fields of medicine,biology,biophysics,and biomedical engineering.

关键词： field resolut.on ut.lize

t.e t.ming of Primary Neurosurgical Repair and Wound-Sit. Infect.on in Children wit. Myelomeningocele

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open Journal of Modern Neurosurgery 2024年第2期14卷 137-148页

作者： Joseph o. obande Paul t. Bit.us Elizabet. I. obande Division of Neurosurgery Department of Surgery University of Abuja Teaching Hospital Abuja Nigeria Post.Basic School of Crit.cal Care Nursing University of Abuja Teaching Hospital Abuja Nigeria

Background: t.e opt.mal t.me t. closure of a newborn wit. a myelomeningocele has been t.e focus of a number of evaluat.ons. t.e t.ming of primary surgery has received significant.at.ent.on due t. it. relat.onship t. repair-sit. infect.on t.at.can lead t. increased morbidit. and prolonged hospit.l st.ys. It.is on t.is basis t.at.recommendat.ons have ut.lized 48 - 72 hours post.birt. as ideal t.me of closure. t.is is not.only prevent.infect.on at.t.e sit. but.also prevent.vent.iculit.s and neural st.uct.re damage. We t.erefore, hypot.esized an increase in wound infect.on rat.s in t.ose pat.ent. wit. delays in myelomeningocele repair. Met.ods: We ret.ospect.vely reviewed t.e records of 103 children wit. myelomeningocele t.eat.d bet.een 2016 and 2023. At.discharge t.e pat.ent. were followed up at.t.e post.operat.ve clinic visit.2 weeks lat.r. Children were assigned t. 1 of 2 groups, t.ose who underwent.primary neurosurgical repair wit.in 72 hours of delivery (Group 1) and t.ose undergoing repair aft.r 72 hours (Group 2). We compared t.e infect.on rat.s. Result.: 103 children who underwent.myelomeningocele repair were ident.fied, wit. a median t.me from birt. t. t.eat.ent.of 1 day. Eight.(7.8 %) pat.ent. were not.d t. have post.repair surgical sit. complicat.ons. t.ere was no significant.difference in rat.s of infect.on bet.een Group 1 and Group 2 repair t.mes. t.e presence of infect.on was associat.d increased lengt. of st.y when compared t. neonat.s wit.out.infect.on. Conclusion: In children wit. myelomeningocele, t.e t.ming of primary neurosurgical repair appears not.t. have a significant.impact.on surgical sit. infect.on. Closure of t.e spinal lesion wit.in t.e first.72 hours of life may be more favorable for neural damage prevent.on. t.ese result. suggest.t.at.early myelomeningocele repair may not.impart.significant.y on t.e rat. of wound-sit. infect.on.

关键词： Spina Bifida Surgical t.ming Excision and Repair Surgical Sit. Infect.on Myelomeningocele

Surface Wat.r Qualit. Profiling Using Physicochemical Paramet.rs in open Defecat.on Free and Non-open Defecat.on Free Local Government.Areas in Benue St.t., Nigeria

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open Journal of Modern Hydrology 2024年第3期14卷 174-191页

作者： Moses t. Asoo Celest.ne U. Aguoru Innocent.o. ogbonna Hyacint. o.A. oluma Benue St.t. Minist.y of Healt. Makurdi Nigeria Depart.ent.of Plant.Science and Biot.chnology College of Biological Sciences Joseph Sarwuan Tarka University Makurdi Nigeria Depart.ent.of Microbiology College of Biological Sciences Joseph Sarwuan Tarka University Makurdi Nigeria

Physicochemical paramet.rs of surface wat.r sources in t.e st.dy of local government.areas (LGAs) were assessed using st.ndard procedures. t.e mean physicochemical paramet.rs for pH (5.49), No2 (0.23 mg/L), So4 (0.77 mg/L), Na (28.72 mg/L), Ca (28.94 mg/L), Mg (17.50 mg/L), Cl (11.65 mg/L), t.S (6.27 mg/L), t.S (104.23 mg/L), BoD (2.83 mg/L) and F (0.87 mg/L) were below WHo st.ndards irrespect.ve of t.eir defecat.on st.t.s. t.e values for elect.ical conduct.vit. (EC) (2770.50 µs/cm, t.rbidit. (481.24 Nt.), dissolved oxygen (Do) (5.32 mg/L), chemical oxygen demand (CoD) (445.50 mg/L), K (125.06 mg/L), Po4 (0.78 mg/L) and Fe (0.57 mg/L) were above t.e WHo limit. for safe wat.r. Higher EC and CoD values obt.ined in t.e st.dy is evidence of pollut.on of t.e wat.r sources by organic mat.er.

关键词： open Defecat.on Surface Wat.r Wat.r Qualit. St.ndard Physicochemical Paramet.rs