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Ombitasvir/paritaprevir/ritonavir + dasabuvir +/-ribavirin in real world hepatitis C patients

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World Journal of Gastroenterology 2019年第18期25卷 2229-2239页

作者： Nicole Loo Eric Lawitz Naim Alkhouri Jennifer Wells Carmen Landaverde Angie Coste Rossalynn Salcido michael scott Fred Poordad Academic and Clinical Affairs Texas Liver Institute

BACKGROUND The hepatitis C virus(HCV) NS5A inhibitor ABT-267(ombitasvir, OBV), the HCV NS4/4A protease inhibitor ABT-450(paritaprevir, PTV), the CYP3A inhibitor ritonavir(r) and the non-nucleoside NS5B polymerase inhibitor ABT-333(dasabuvir, DSV)(OBV/PTV/r + DSV) with or without ribavirin(RBV) is a direct-acting antiviral regimen approved in the United States and other major countries for the treatment of HCV in genotype 1(GT1) infected patients. Patients with HCV who are considered "hard-to-cure" have generally been excluded from registration trials due to rigorous study inclusion criteria, presence of comorbidities and previous treatment *** To investigate the efficacy of this regimen in HCV G1-infected patients historically excluded from clinical *** Patients were ≥ 18 years old and chronically infected with HCV GT1(GT1a, GT1b or GT1a/1b). Patients were treatment-na?ve or previously failed a regimen including pegylated interferon/RBV +/-telaprevir, boceprevir, or *** hundred patients were treated with the study drug regimen, which was administered for 12 or 24 wk +/-RBV according to GT1 subtype and presence/absence of cirrhosis. Patients were evaluated every 4 wk from treatment day 1 and at 4 and 12 wk after *** Many of the patients studied had comorbidities(44.2% hypertensive, 33.7%obese, 20.2% cirrhotic) and 16% previously failed HCV treatment. Ninety-six patients completed study follow-up and 99% achieved 12-wk sustained virologic response. The majority(88.4%) of patients had undetectable HCV RNA by week 4. The most common adverse events were fatigue(12%), headache(10%),insomnia(9%) and diarrhea(8%); none led to treatment discontinuation. Physical and mental patient reported outcomes scores significantly improved after treatment. Almost all(98%) patients were treatment *** In an all-comers HCV GT1 population, 12 or 24-wk of OBV/PTV/r + DSV +/-RBV is highly effective and tolerable and results

关键词： Hepatitis C Ombitasvir Paritaprevir Ritonavir Dasabuvir Genotype 1

Programming Language Pragmatics 2nd

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利用微流控技术应对COVID-19和其他肺部疾病的全球挑战

2006年

作者： scott, michael Lee

ISBN: (纸本)9780126339512;9780080515168

The innovative approach of the first edition of Programming Language Pragmatics provided students with an integrated view of programming language design and implementation, while offering a solid teaching text on timely language topics in a rigorous yet accessible style. The new edition carries on these distinctive features as well as the signature tradition of illustrating the most recent developments in programming language design with a variety of modern programming *** the most recent developments in programming language design, including C99, C#, and Java 5Introduces and discusses scripting languages throughout the book as well as in an entire new chapterIncludes a comprehensive chapter on concurrency, with coverage of the new Java concurrency package (JSR 166) and the comparable mechanisms in C#Updates many sections and topics, including iterators, exceptions, polymorphism, templates/generics, scope rules and declaration ordering, separate compilation, garbage collection, and threads and synchronizationHighlights the interaction and tradeoffs inherent in language design and language implementation decisions with over 100''Design and Implementation''call-out boxesAdds end-of-chapter''Exploration''exercises—open-ended, research-type activitiesProvides review questions after sections for quick self-assessmentIncludes over 800 numbered examples to help the reader quickly cross-reference and access content

关键词： Programming languages (Electronic computers)

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Engineering 2023年第5期24卷 17-20,I0001页

作者： Yuliang Xie Ryan Becker michael scott Kayla Bean Tony Jun Huang Roy J.Carver Department of Biomedical Engineering College of EngineeringUniversity of IowaIowa CityIA 52242USA Department of Biomedical Engineering Pratt School of EngineeringDuke UniversityDurhamNC 27710USA Department of Mechanical Engineering and Materials Science Pratt School of EngineeringDuke UniversityDurhamNC 27710USA

1. Introduction Pulmonary diseases present one of the most severe threats to human society. Since late 2019, the coronavirus disease 2019(COVID-19) pandemic has significantly impacted the lifestyle, culture, and politics of almost everyone in the world. COVID-19 causes severe pulmonary dysfunction, which is a major cause of mortality for those affected [1].

关键词：微流控技术肺部疾病全球挑战

Calibration of CO<sub>2</sub>Trapping in Alkaline Solutions during Soil Incubation at Varying Temperatures Using a Respicond VI

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Open Journal of Soil Science 2014年第5期4卷 161-167页

作者： Natalya Smirnova michael scott Demyan Frank Rasche Georg Cadisch Torsten Müller Institute of Crop Science (340i) University of Hohenheim Stuttgart Germany Institute of Plant Production and Agroecology in the Tropics and Subtropics (380a) University of Hohenheim Stuttgart Germany

Measurements of carbon dioxide (CO2)-evolution from soils are important in evaluating biomass and activity of soil microorganisms, as well as decomposition of soil organic matter. The Respicond VI is a fully computerized system allowing continuous measurement of CO2 evolution in short- and long-term soil incubation experiments in up to 96 incubation vessels. The measurement of CO2 evolution is based on the absorption of CO2 by an electrolyte (KOH solution) producing a change in the cell conductance measured using two electrodes. In this study, the Respicond VI was recalibrated yielding 174.5 mg CO2 as constant A expressing the theoretical maximum amount of CO2 absorbed in 10 ml 0.5 M KOH. This value of A corresponds to 34.9 mg CO2 ml-1 1 M KOH. The constant A does neither depend on the investigated incubation temperatures (5°C - 25°C) nor on the concentrations of the KOH solutions (0.5, 0.1, 0.05 M KOH). To eliminate any influence of changing incubation temperatures, either induced by uncertainties in temperature control or as a part of the experimental setup, on the conductance of KOH solution, a correction procedure was developed using a factor calculated from changing conductance of KOH solutions in incubation vessels without soil.

关键词： Respirometer Soil Respiration Carbon Dioxide Incubation

LOCA FREQUENCY EVALUATION USING EXPERT ELICITATION

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LOCA FREQUENCY EVALUATION USING EXPERT ELICITATION

第十八届国际反应堆结构力学大会

作者： Robert Lee Tregoning Lee Richard Abramson Paul michael scott Nilesh Chokshi United States Nuclear Regulatory Commission United States Nuclear Regulatory Commission Battelle Memorial Institute United States Nuclear Regulatory Commission

＜正＞ The double-ended-guillotine break （DEGB） criterion of the largest primary piping system in the plant, which generally provides the limiting condition for the emergency core cooling system requirements, is widely recognized as an extremely unlikely event. As a result, US Nuclear Regulatory Commission （NRC） staff are currently considering a risk-informed revision of the design-basis break size requirements for commercial nuclear power plants. In support of this effort, loss-of-coolant accident （LOCA） frequency estimates have been developed using an expert elicitation process by consolidating service history data and

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这个女人能否驾驭澳大利亚双速经济？

商业周刊（中文版） 2013年第9期 16-17页

作者： michael Heath Jason scott Elisabeth Behrmann Dan Pete 永年(译)

澳元走强冲击了制造业，澳大利亚总理吉拉德正在失去工党支持 “今年以来，我们创造了5万个就业岗位。在过去的12个月，我们已经创造了10万个就业岗位”4月8日，通用汽车公司宣布，将在澳大利亚霍顿的子公司裁减大约500个岗位。公司董... 详细信息

澳元走强冲击了制造业，澳大利亚总理吉拉德正在失去工党支持 “今年以来，我们创造了5万个就业岗位。在过去的12个月，我们已经创造了10万个就业岗位”4月8日，通用汽车公司宣布，将在澳大利亚霍顿的子公司裁减大约500个岗位。公司董事总经理迈克·德弗罗（MikeDevereux）表示，这是澳元过于强劲、日元大幅贬值、其他货币太过疲软所造成的。南于澳大利亚的货币持续走高，

关键词：澳大利亚经济驾驭女人就业岗位通用汽车公司公司董事制造业

Targeting KRAS in pancreatic adenocarcinoma:Progress in demystifying the holy grail

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World Journal of Clinical Oncology 2023年第8期14卷 285-296页

作者： Ahmed Elhariri Ahmed Alhaj Daniel Ahn Mohamad Bassam Sonbol Tanios Bekaii-Saab Christina Wu michael scott Rutenberg John Stauffer Jason Starr Umair Majeed Jeremy Jones Mitesh Borad Hani Babiker Division of Hematology-Oncology Department of MedicineMayo Clinic FloridaMayo Clinic Cancer CenterJacksonvilleFL 32224United States Division of Hematology-Oncology Department of MedicineMayo Clinic ArizonaMayo Clinic Cancer CenterPhoenixAZ 85054United States Department of Radiation-Oncology Mayo Clinic FloridaMayo Clinic Cancer CenterJacksonvilleFL 32224United States Department of Surgical Oncology Hepatopancreatobiliary SurgeryMayo Clinic FloridaJacksonvilleFL 32224United States

Pancreatic cancer(PC)remains one of the most challenging diseases,with a very poor 5-year overall survival of around 11.5%.Kirsten rat sarcoma virus(KRAS)mutation is seen in 90%-95%of PC patients and plays an important role in cancer cell proliferation,differentiation,metabolism,and survival,making it an essential mutation for targeted *** extensive efforts in studying this oncogene,there has been little success in finding a drug to target this pathway,labelling it for decades as“undruggable”.In this article we summarize some of the efforts made to target the KRAS pathway in PC,discuss the challenges,and shed light on promising clinical trials.

关键词： Kirsten rat sarcoma virus Targeted therapy Pancreatic cancer Drug resistance Next generation sequencing Clustered regularly interspaced short palindromic repeats

Hypothalamic Glucagon Like Peptide regulates food intake

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Hypothalamic Glucagon Like Peptide regulates food intake

第三届中国生物物理学会代谢生物学分会学术研讨会

作者：刘际 Kristie Conde Zihui Xu Jay phansalkar Byung Kook Lim RANDy J.Seeley Julius J.Zhu michael M.scott Zhiping P.Pang 中国科学技术大学 Child Health Institute of New Jersey Department of Neuroscience and Cell Biology Rutgers University Robert Wood Johnson Medical School Department of Neurobiology University of California San Diego Department of Surgery University of Michigan Department of Pharmacology University of Virginia

＜正＞Glucagon Like Peptide 1 （GLP-1）-expressing neurons in the hindbrain send robust projections to the hypothalamus,including paraventricular nucleus of the hypothalamus （PVN） and dorsal medial hypothalamus （DMH）,which are involved in the regulation of food ***,we describe that stimulation of GLP-1 afferent fibers in both PVN and DMH are sufficient to suppress food intake independent of glutamate *** the PVN,GLP-1 receptor （GLP-1R） activation augments

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专家系统:对管理者的下一个挑战

计算机科学 1988年第2期 16-21页

作者： Fred L.Luconi Thomas W.Malone michael S.scott Morton 曲晓飞滕学应用专家系统公司麻省理工学院麻省理工学院

在“微芯片革命”时代,实际管理者正在寻找学习和使用新型微处理机的各种途径.本文讨论专家系统在事务应用方面的实际可能性.作者认为,目前包含在专家系统中的知识还不足以作为进行满意决策的基础,因此主张应重点放在设计专家支持系统上... 详细信息

在“微芯片革命”时代,实际管理者正在寻找学习和使用新型微处理机的各种途径.本文讨论专家系统在事务应用方面的实际可能性.作者认为,目前包含在专家系统中的知识还不足以作为进行满意决策的基础,因此主张应重点放在设计专家支持系统上,这种系统将帮助决策者,而不是代替决策者.

关键词：管理者管理人员专家决策者决策个体结构化决策问题求解策略 ESS