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Peridynamic Modeling of Brittle Fracture in Mindlin-Reissner Shell Theory

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Computer Modeling in Engineering & Sciences 2022年第5期131卷 715-746页

作者： sai Li Xin lai Lisheng Liu Department of Engineering Structure and Mechanics Wuhan University of TechnologyWuhan430070China Hubei Key Laboratory of Theory and Application of Advanced Materials Mechanics Wuhan University of TechnologyWuhan430070China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan430070China

In this work,wemodeled the brittle fracture of shell structure in the framework of Peridynamics Mindlin-Reissener shell theory,in which the shell is described by material points in themean-plane with its drilling rotation neglected in kinematic *** improve the numerical accuracy,the stress-point method is utilized to eliminate the numerical instability induced by the zero-energy mode and *** crack surface is represented explicitly by stress points,and a novel general crack criterion is proposed based on *** of the critical stretch used in common peridynamic solid,it is convenient to describe thematerial failure by using the classic constitutive model in continuum *** this work,a concise crack simulation algorithm is also provided to describe the crack path and its development,in order to simulate the brittle fracture of the shell *** examples are presented to validate and demonstrate our proposed *** reveal that our model has good accuracy and capability to represent crack propagation and branch spontaneously.

关键词： Peridynamic brittle fracture Reissner-Mindlin shell theory

Membrane lipid binding molecules for the isolation of bona fide extracellular vesicle types and associated biomarkers in liquid biopsy

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Journal of Cancer Metastasis and Treatment 2019年第9期4卷 1-9页

作者： Ruenn Chai lai Kok Hian Tan sai Kiang Lim A*STAR Institute of Medical Biology 8A Biomedical Grove#05-05 ImmunosSingapore 138648Singapore Department of Maternal Fetal Medicine KK Women’s&Children’s HospitalSingapore 229899Singapore Department of Surgery YLL School of MedicineNUSSingapore 119074Singapore

Cancer exacts a heavy socioeconomic cost. Earlier detection and treatment are likely to mitigate this cost. Unfortunately, conventional tissue biopsy, the gold standard in cancer diagnosis cannot fulfill the goal of earlier detection. While liquid biopsy is a promising alternative to tissue biopsy, it has its challenges and limitations. A major challenge is the isolation of bona fide lipid membrane vesicles from biological fluids. In this review, we presented a new perspective of isolating different types of extracellular vesicles (EVs) by their affinity for membrane lipid binding ligands for liquid biopsy. EVs are lipid membrane particles naturally released by almost all cells and are found in almost all biological fluids suitable for liquid biopsy. They carry materials from the secreting cells that could affect the biology of the recipient cells and could thus inform on the state and progress of the disease. However, isolating bona fide EVs is a technical challenge as biological fluids have a complex composition and contain particles or aggregates that are physically similar to EVs. Here we review the use of membrane lipid-binding ligands to isolate different bona fide EV subtypes, and to circumvent the problem of co-isolating physically similar non-EV complexes in current EV isolation protocols. We will discuss the advantages of this technique and its potential for accelerated biomarker discovery and validation through examples of pre-clinical studies. We propose that isolating EV subtypes is a technically viable and robust strategy to overcome the current bottleneck of isolating EVs for liquid biopsy.

关键词： Membrane lipid binding molecules extracellular vesicle cholera toxin B shiga toxin B annexin V biomarker

Optimization of equitable irrigation water delivery for a large-scale rice irrigation scheme

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International Journal of Agricultural and Biological Engineering 2018年第5期11卷 160-166页

作者： Md Rowshon Kamal Muhammad Iqbal Md Abdul Mojid Mohd Amin Mohd Soom lai sai Hin Department of Biological and Agricultural Engineering Faculty of EngineeringUniversiti Putra Malaysia(UPM)UPM Serdang 43400Selangor DEMalaysia Department of Agricultural Engineering and Technology Faculty of Agricultural SciencesGhazi UniversityDera Ghazi KhanPakistan Department of Irrigation and Water Management Faculty of Agricultural Engineering and TechnologyBangladesh Agricultural UniversityMymensingh 2202Bangladesh Faculty of Sustainable Agriculture Universiti Malaysia Sabah(UMS)Jalan UMSKota Kinabalu 88400SabahMalaysia Department of Civil Engineering Faculty of EngineeringUniversity of MalayaKuala Lumpur 50603Malaysia

Equitable water allocation is essential in an irrigation scheme for obtaining potential crop yields from the entire scheme,especially when water supply is *** optimization model achieved this goal by coupling an optimal water allocation model with available water supply and irrigation water demand for a river-fed rice irrigation system in *** model consists of a paddy field water balance module and an optimization *** outputs from the module are daily irrigation demand and surface runoff,if there is *** optimization module consists of an objective function,which minimizes water shortage across the scheme area while maintaining equity in water *** model performs optimization subject to several system constraints,and the decision variable of the model is daily releases or supply to the tertiary *** of this model remained unaffected under different water supply conditions,and the optimization model reliably examined the effects of alternate water allocation and management rules with field *** improves efficiency and equity in water allocation with respect to crop growth stages and water shortages rather than simply cutting irrigation supply on a proportional basis to overcome water shortages.

关键词： irrigation optimization simulation equitable deliveries rice

Recent progress in engineering Clostridium autoethanogenum to synthesize the biochemicals and biocommodities

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Synthetic and Systems Biotechnology 2024年第1期9卷 19-25页

作者： sai Wan Mingchi lai Xinyu Gao Mingxin Zhou Song Yang Qiang Li Fuli Li Lin Xia Yang Tan Qingdao C1 Refinery Engineering Research Center Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao266101ShandongChina CAS Key Laboratory of Quantitative Engineering Biology Shenzhen Institute of Synthetic BiologyShenzhen Institutes of Advanced TechnologyChinese Academy of ScienceShenzhen518055China Shenzhen Powered Carbon Biotechnology Co. LtdShenzhen518055China School of Life Sciences Qingdao Agricultural UniversityQingdao266109ShandongChina School of Biological Science and Technology University of JinanJinan250022ShandongChina

Excessive mining and utilization fossil fuels has led to drastic environmental consequences,which will contribute to global warming and cause further climate change with severe consequences for the human *** magnitude of these challenges requires several approaches to develop sustainable alternatives for chemicals and fuels *** this context,biological processes,mainly microbial fermentation,have gained particular *** example,autotrophic gas-fermenting acetogenic bacteria are capable of converting CO,CO_(2) and H_(2) into biomass and multiple metabolites through Wood-Ljungdahl pathway,which can be exploited for large-scale fermentation processes to sustainably produce bulk biochemicals and biofuels(*** and ethanol)from *** autoethanogenum is one representative of these chemoautotrophic bacteria and considered as the model for the gas ***,the development of synthetic biology toolbox for this strain has enabled us to study and genetically improve their metabolic capability in gas *** this review,we will summarize the recent progress involved in the understanding of physiological mechanism and strain engineering for ***,and provide our perspectives on the future development about the basic biology and engineering biology of this strain.

关键词： Genetic engineering Clostridium autoethanogenum Gas fermentation Carbon fixation Biofuel

An investigation into the effects of particle texture,water content and parallel plates' diameters on rheological behavior of fine sediment

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International Journal of Sediment Research 2016年第2期31卷 120-130页

作者： Masoumeh Moayeri Kashani lai sai Hin Shaliza Binti Ibrahim Nik Meriam Binti Nik Sulaiman Fang Yenn Teo Department of Civil Engineering Faculty of EngineeringUniversity of Malaya Department of Chemical Engineering Faculty of EngineeringUniversity of Malaya Research Development and Innovation DivisionNational Water Services Commission

Siltation,a phenomenon resulted from the presence of fine particles in an aqueous environment,dominated by silt and clay,is a known and common environmental issue *** accumulation of fine sediments engenders murky water with low oxygen levels,which leads to the death of aquatic ***,investigating the physical and mechanical properties of fine sediment by rheological methods has *** is the science of deformation and flow of matter in *** survey investigates the rheological behavior of six samples of soil as the fine particles structure(D < 63 μm) from different regions of Malaysia by using a rotational rheometer with a parallel-plate measuring(using two sizes:25 mm and 50 mm) device to explore the flow and viscoelastic properties of fine *** samples were examined in two rheological curve and amplitude sweep test methods to investigate the effect of water content ratio,texture,and structure of patticles on rheological *** was found that the content of fine sand,clay,and silt had an effect on the stiffness,structural stability,and shear ***,the pseudoplastic and viscoelastic behaviot are respectively ***,the amount of fine sediments present in water *** concentration of these particles,has a direct effect on the rheological curve.A reduction in viscosity of samples with higher concentrations of water has been *** a consequence,a considerable quantity of fine sediments are distributed within the water body and remain suspended over the *** a result,the sedimentation rate slows *** needs to be asserted that the stotage modulus G′,loss modulus G″,and yield point can vary depending on particle *** G′ and G″were instigated for samples(70%and 45%concentrations) that demonstrated viscoelastic characteristics using the same rotational rheometer with a parallel-plate measuring device.

关键词： Fine sediment Rheology Siltation Soil texture Stiffness degradation

Preoperative laser reduces silicone oil use in primary diabetic vitrectomy

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International Journal of Ophthalmology(English edition) 2022年第4期15卷 591-597页

作者： Wen-Bin Zheng Xiao-Hu Ding Kun-Bei lai Ji-Zhu Li Yu-Qing Wu Yuan Ma Zi-Ye Chen Shi-Da Chen sai-Nan Xiao Bing-Qian Liu Ying Lin Tao Li State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhou 510060Guangdong ProvinceChina

AIM: To identify the predictive factors and laser photocoagulation associated with the use of silicone oil as endotamponade during primary diabetic vitrectomy. METHODS: The medical and surgical records of 690 patients(798 eyes) who underwent primary diabetic vitrectomy at a tertiary eye hospital in China from January 2018 to December 2018 were reviewed in this retrospective cohort study. The patients’ baseline characteristics and preoperative treatments were recorded. The binary Logistic regression model was used to evaluate the risk factors for the use of silicone oil as endotamponade agent during primary vitrectomy for proliferative diabetic retinopathy(PDR)-related ***: Among 690 patients with mean age of 52.1±10.5 y(range: 18-85 y), 299/690(43.3%) were female. The 31.6% of the eyes received preoperative laser treatment, and 72.4% of the eyes received preoperative anti-VEGF adjuvant therapy. Non-clearing vitreous haemorrhage(VH) alone or combined with retinal detachment was the main surgical indication(89.5%) for primary vitrectomy. Silicone oil was used as endotamponade in 313(39.2%) eyes. Lack of preoperative laser treatment [odds ratio(OR) 0.66, 95% confidence interval(CI): 0.48-0.92;P=0.015] and older age(OR 0.96, 95%CI: 0.95-0.98;P<0.001) were predictors of silicone oil tamponade during primary vitrectomy for PDR. CONCLUSION: The lack of preoperative laser treatment is a significant predictor of silicone oil tamponade during primary vitrectomy for PDR. However, the severity of PDR relevant to silicone oil use should be further evaluated.

关键词： proliferative diabetic retinopathy vitrectomy laser photocoagulation silicone oil tamponade predictive factors

Does erroneous differentiation of tendon-derived stem cells contribute to the pathogenesis of calcifying tendinopathy？

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Chinese Medical Journal 2011年第4期124卷 606-610页

作者： RUI Yun-feng LUI Pauline Po-yee CHAN lai-shan CHAN Kai-ming FU sai-chuen LI Gang Department of Orthopaedics and Traumatology Faculty of Medicine Chinese University of Hong Kong Hong Kong SARChina The Hong Kong Jockey Club Sports Medicine and Health Sciences Centre Faculty of Medicine Chinese University of Hong KongHong Kong SAR China Department of Orthopaedics Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200011China Department of Orthopaedics and Traumatology Faculty of Medicine Chinese University of Hong Kong Hong Kong SARChina The Hong Kong Jockey Club Sports Medicine and Health Sciences Centre Faculty of Medicine Chinese University of Hong KongHong Kong SAR China Program of Stem Cell and Regeneration School of Biomedical Science Chinese University of Hong Kong Hong Kong SARChina Department of Orthopaedics and Traumatology Faculty of Medicine Chinese University of Hong Kong Hong Kong SARChina The Hong Kong Jockey Club Sports Medicine and Health Sciences Centre Faculty of Medicine Chinese University of Hong KongHong Kong SAR China Department of Orthopaedics and Traumatology Faculty of Medicine Chinese University of Hong Kong Hong Kong SARChina The Hong Kong Jockey Club Sports Medicine and Health Sciences Centre Faculty of Medicine Chinese University of Hong KongHong Kong SAR China

Calcifying tendinopathy is a tendon disorder with calcium deposits in the mid-substance presented with chronic activity-related pain, tenderness, local edema and various degrees of incapacitation. Most of current treatments are neither effective nor evidence-based because its underlying pathogenesis is poorly understood and treatment is usually symptomatic. Understanding the pathogenesis of calcifying tendlinopathy is essential for its effective evidence-based management. One of the key histopathological features of calcifying tendinopathy is the presence of chondrocyte phenotype which surrounds the calcific deposits, suggesting that the formation of calcific deposits was *** the origin of cells participating in the formation of chondrocyte phenotype and ossification is still unknown, many evidences have suggested that erroneous tendon cell differentiation is involved in the process. Recent studies have shown the presence of stem cells with self-renewal and multi-differentiation potential in human,horse, mouse and rat tendon tissues. We hypothesized that the erroneous differentiation of tendon-derived stem cells （TDSCs） to chondrocytes or osteoblasts leads to chondrometaplasia and ossification and hence weaker tendon, failed healing and pain, in calcifying tendinopathy. We present a hypothetical model on the pathogenesis and evidences to support this hypothesis. Understanding the key role of TDSCs in the pathogenesis of calcifying tendinopathy and the mechanisms contributing to their erroneous differentiation would provide new opportunities for the management of calcifying tendinopathy. The re-direction of the differentiation of resident TDSCs to tenogenic or supplementation of MSCsprogrammed for tenogenic differentiation may be enticing targets for the management of calcifying tendinopathy in e future.

关键词： calcifying tendinopathy mesenchymal stem cells tendon-derived stem cells cell differentiation pathogenesis Calcifying tendinopathy is a tendon disorder with calcium deposits in the mid-substance presented with chronic activity-related pain, tenderness

An Improved Differential Evolution and Its Industrial Application

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Journal of Intelligent Learning Systems and Applications 2012年第2期4卷 81-97页

作者： Johnny Chung Yee lai Frank Hung Fat Leung sai Ho Ling Edwin Chao Shi Centre for Health Technologies Faculty of Engineering and IT University of Technology Sydney Sydney Australia. Centre for Signal Processing Department of Electronic and Information Engineering The Hong Kong Polytechnic University Hung Hom Hong Kong China

In this paper, an improved Differential Evolution (DE) that incorporates double wavelet-based operations is proposed to solve the Economic Load Dispatch (ELD) problem. The double wavelet mutations are applied in order to enhance DE in exploring the solution space more effectively for better solution quality and stability. The first stage of wavelet operation is embedded in the DE mutation operation, in which the scaling factor is governed by a wavelet function. In the second stage, a wavelet-based mutation operation is embedded in the DE crossover operation. The trial population vectors are modified by the wavelet function. A suite of benchmark test functions is employed to evaluate the performance of the proposed DE in different problems. The result shows empirically that the proposed method out-performs signifycantly the conventional methods in terms of convergence speed, solution quality and solution stability. Then the proposed method is applied to the Economic Load Dispatch with Valve-Point Loading (ELD-VPL) problem, which is a process to share the power demand among the online generators in a power system for minimum fuel cost. Two different conditions of the ELD problem have been tested in this paper. It is observed that the proposed method gives satisfactory optimal costs when compared with the other techniques in the literature.

关键词： Differential Evolution Evolutionary Algorithm Economic Load Dispatch

Publication scope and priorities of FESE in an evolving world: An editorial update and perspective

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Frontiers of Environmental Science & Engineering 2024年第1期18卷 169-171页

作者： Deng, Shubo Jin, Rencun Liang, sai Liu, Fudong Liu, Jinyong Lyu, lai Ning, Daliang Pan, Bingcai van Hullebusch, Eric Wang, Bin Wen, Xianghua Xiao, Kang Xu, Elvis Genbo Yang, Hong Ying, Qi Zhan, Xinmin Zhao, Dongye

Frontiers of Environmental Science&Engineering(FESE)is one of the flagship journals of the Chinese Academy of *** is an international peer-reviewed journal that publishes cutting-edge scientific work in all aspects of environmental *** 2007,FESE has been an important platform for communicating the cutting-edge progress of theories,methods,technologies,and policies in environmental science and *** authors and readers involve scientists,engineers,and policymakers that are important stakeholders in dealing with environmental *** authors are encouraged to review recent issues of FESE to gain a deep understanding of the topics that are of great interest to the journal’s *** the cover letter,please clearly state the relevance to the journal’s publication scope and *** particular,prospective authors are directed to the following instructions for further details on the scope,novelty and quality expectations,and minimum requirements.

关键词： journal please dealing