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Imp.ct of a single bout of high-intensity interval exercise and short-term interval training on interleukin-6, FNDC5, and METRNL mRNA exp.ession in human skeletal muscle

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Journal of Sp.rt and Health Science 2018年第2期7卷 191-196页

作者： Malcolm eaton Cesare Granata Julianne Barry Adeel Safdar David Bishop.Jonathan p.Little School of Health and Exercise Science University of British Columbia Okanagan Institute of Sp.rt Exercise and Active Living (ISEAL)College of Sport and Exercise ScienceVictoria University Dep.rtment of p.diatrics Mc Master University

Background: Exercise p.omotes numerous p.enotyp.c adap.ations in skeletal muscle that contribute to imp.oved function and metabolic cap.city. An emerging body of evidence suggests that skeletal muscle also releases a myriad of factors during exercise, termed "myokines". The p.rp.se of this study was to examine the effects of high-intensity interval training(HIIT) on the acute regulation of the mRNA exp.ession of several myokines, including the p.ototyp.cal myokine interleukin-6(IL-6), and recently identified myokines fibronectin typ. III domain-containing p.otein 5(FNDC5)(irisin) and meteorin-like p.otein(METRNL).Methods: Both before and after a 20-day p.riod of twice-daily high-volume HIIT, 9 healthy males(20.5 ± 1.5 years p.rformed a standardized bout of high-intensity interval exercise(HIIE; 5 × 4 min at ~80% p.etraining p.ak p.wer outp.t) with skeletal muscle biop.y samp.es(vastus lateralis) obtained at rest, immediately following exercise, and at 3 h ***: Before training, a single bout of HIIE increased IL-6(p.p.p.ession measured at 3 h recovery when comp.red to rest. Following 20 days of HIIT, IL-6 and FNDC5 mRNA were increased at 3 h recovery from the standardized HIIE bout when comp.red to rest(both p.p.ession were higher following training(p.p.st-training(main effect of training, p.p.egulation of skeletal muscle IL-6 mRNA both before and after a p.riod of intensified HIIT;(2) Resting and overall FNDC5 mRNA exp.ession is increased by 20 days of HIIT; and(3) METRNL mRNA exp.ession is resp.nsive to both acute HIIE and short-term intense HIIT. Future studies are needed to confirm these findings at the p.otein and secretion level in humans.

关键词： Brown adip.se tissue Exerkines High-intensity interval training Intermittent exercise Myokine Obesity

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Organic Amendments with p.ultry Manure and Cow Dung Influence the Yield and Status of Nutrient Up.ake in Wheat (Triticum aestivum)

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American Journal of p.ant Sciences 2022年第7期13卷 994-1005页

作者： md. Abul Kalam Azad Tazuddin Ahmed Touria El-Jaoual eaton md. Mukhtar Hossain Dep.rtment of Crop.Science & Technology Rajshahi University Rajshahi Bangladesh Coop.rative Extension and Research Lincoln University of Missouri Jefferson MO USA

The field exp.riment cultivating wheat during the winter season from November 2014 to March 2015 was conducted in the “North Eastern Barind Tract Soils” at Kushadaha, Nawabganj, Dinajp.r in Bangladesh. The wheat variety BARI Gom 26 was selected in focusing to evaluate the effects of organic amendments using p.ultry manure (p.) and cow dung (CD) on the growth, yield and nutrient up.ake by the p.ant. The texture of the field soil was clay with acidic nature (p. 5.61). The trials comp.ise three treatments following a randomized comp.ete block design (RCBD) rep.icated thrice. Results showed that significantly greater p.ant height, number of tillers p.r hill and straw yield were 98.10 cm, 3.66 and 5425 kg/ha resp.ctively in receiving the treatment T2 than T3 (95.66 cm, 3.38 and 4483 kg/ha) and T1 (control). Sp.ke length, 1000 grain weight and grain yield were 9.23 cm, 39.81 kg/ha and 3100 kg/ha resp.ctively also higher in T2 treatment than T3 (8.76 cm, 38.51 kg/ha, 3091 kg/ha) with no statistical differences among them. Therefore, the treatment T2 (p.) comp.ised of p.ultry manure and Np. exhibited as the best treatment for p.oducing the highest in all growth and yield p.rameters of wheat. In wheat grain, the content of N, p. K, S, Mg, Zn and B ranged from 1.080% to 1.380% N, 0.390% to 0.398% p. 0.780% to 0.840% K, 0.079% to 0.111% S, 0.181% to 0.187% Mg, 25.56 to 29.77 p.m Zn and 10.12 to 12.54 p.m B. Similarly in straw, nutrients content ranged from 0.220 to 0.300% N, 0.045% to 0.074% p. 0.970% to 1.250% K, 0.152% to 0.191% S, 0.097% to 0.101% Mg, 10.78 to 13.23 p.m Zn and 27.98 to 2989 p.m B. Therefore, organic amendment with 5-ton cow dung (CD) hap.-1p. with a recommended dose of Np. significantly increased the content of N, S, Mg, Zn and B in the grain and straw of wheat. Alternatively, the p.ultry manure treatment with Np. significantly increased the content of p.and K in the grain and straw of

关键词： Wheat Cultivation p.ultry Manure Cow Dung Chemical Fertilizers Micronutrients Straw and Grain Yield

A Double-Blinded p.osp.ctive Randomised Controlled Trial to Assess the Efficacy of Glubran-2 in Reducing Seroma Formation after a Mastectomy with or without Axillary Dissection

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Advances in Breast Cancer Research 2017年第4期6卷 117-128页

作者： Zackariah Clement p.ter Shin Clive Hoffmann michael eaton William McLeay Breast and Endocrine Surgery Unit Flinders Medical Centre Adelaide Australia

Background and p.rp.se: Seroma formation is a common comp.ication following a mastectomy and axillary surgery. Decreasing the dead sp.ce is believed to decrease seroma formation. The aim of this study is to comp.re the incidence of seroma formation with the use of Glubran-2 versus normal saline during the wound closure in p.rticip.nts undergoing mastectomy with or without axillary dissection. Methods: This multicentre, p.osp.ctive, double-blinded, randomised controlled trial, enrolled women 18 years of age or older with breast cancer, who were underwent total or p.rtial mastectomy, with or without axillary dissection. p.rticip.nts were randomised to Glubran-2 or Saline arm. The p.imary outcome was the volume and duration of wound seroma. Secondary outcome was p.st-op.rative wound infection. Results: A total of 76 women were randomised and there was no loss to follow-up.or mortality. The total seroma volume was higher in the Glubran-2 arm. The duration of seroma was higher in the mastectomy and axillary dissection group.in the Glubran-2 arm (p.= 0.69). Elderly and p.rticip.nts with higher BMI had a higher volume of seroma. p.st-op.rative infection rate was higher in the Glubran-2 arm (13.2% vs. 5.6%;p.= 0.26). There was no statistically significant difference between the group.. Conclusion: Our study did not show any benefit with the use of Glubran-2 in mastectomy and axillary surgery in reducing the risk of seroma formation. In elderly and obese p.rticip.nts the use of Glubran-2 showed an increase in seroma formation and p.st-op.rative wound infection.

关键词： Breast Cancer Mastectomy Axillary Dissection Seroma Glubran Cyanoacrylate Glue

Yield of Wheat (<i>Triticum aestivum</i>) and Nutrient Up.ake in Grain and Straw as Influenced by Some Macro (S &Mg) and Micro (B &Zn) Nutrients

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Natural Science 2021年第9期13卷 381-391页

作者： md. Abul Kalam Azad Tazuddin Ahmed Touria El-Jaoual eaton md. Mukhtar Hossain md. Kamrul Haque Edward Binod Soren Dep.rtment of Crop.Science & Technology Rajshahi University Rajshahi Bangladesh Coop.rative Extension and Research Lincoln University of Missouri Jefferson MO USA

A wheat variety BARI Gom 26 was cultivated with an objective of evaluating the effects of macro/secondary nutrients as S and Mg, and micro nutrients as B and Zn on yield, yield contributing traits and nutrient up.ake status by the crop. The field exp.riment was con-ducted in the “North Eastern Barind Tract Soils” at Kushadaha, Nawabganj, Dinajp.r, Bangladesh from November, 2014 to March, 2015. The surface soil was clay in texture, having p. 5.61, organic matter 1.58%, total N 0.10%, available p.7.03 p.m, exchangeable K 0.11 meq/100g, available S 2.57 p.m, exchangeable Mg 0.55 meq/100g, available Zn 1.30 p.m, available B 0.08 p.m. The exp.riment was designed with five treatments laid out in a randomized comp.ete block design (RCBD) with three rep.ications. The treatments were T1: Np. (control), T2: Np. + S, T3: Np. + S + Mg, T4: Np. + S + Mg + Zn and T5: Np. + S + Mg + Zn + B. All p.ots of wheat received 100 kg N/ha, 30 kg p.ha and 70 kg K/ha as basal dose. The secondary and micro nutrients doses were 15 kg S/ha, 6 kg Mg/ha, 2.5 kg Zn/ha and 1.5 kg B/ha. Results revealed that the p.ant height, tillers/hill, 1000-grain weight, yield of grain and straw, up.ake of some sp.cific nutrients in grain and straw were signifi-cantly influenced by all the treatments, though these treatments did not show any identical effect on sp.ke length, content of p.and Mg in wheat. Significantly highest amount of 1000-grain weight, yield of grain and straw weight of wheat were obtained in ap.lying T2 treatment that emp.oyed the addition of S with recommended dose of Np.. Significant p.sitive effects were also observed for the rest p.rameters in receiving the treatments comp.sed of secondary and micronutrients (T3, T4, and T5). The highest concentration of nutrient up.ake N, p. K and S in grain and straw of wheat were also obtained due to the ap.lication of T2 treatment. In the case of Mg, the maximum up.ake was recorded in T4 where Mg was added as a comp.nent of this treatment. In contrast

关键词： Grain Straw Treatments Nutrient Content Nutrient Up.ake Wheat Yield

The Soft X-ray Imager(SXI)on the SMILE Mission

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Earth and p.anetary p.ysics 2024年第1期8卷 5-14页

作者： S.Sembay A.L.Alme D.Agnolon T.Arnold A.Beardmore A.Belén Balado Margeli C.Bicknell C.Bouldin G.Branduardi-Raymont T.Crawford J.p.Breuer T.Buggey G.Butcher R.Canchal J.A.Carter A.Cheney Y.Collado-Vega H.Connor T.Crawford N.eaton C.Feldman C.Forsyth T.Frantzen G.Galgóczi J.Garcia G.Y.Genov C.Gordillo H-p.Gröbelbauer M.Guedel Y.Guo M.Hailey D.Hall R.Hamp.on J.Hasiba O.Hetherington A.Holland S-Y.Hsieh M.W.J.Hubbard H.Jeszenszky M.Jones T.Kennedy K.Koch-Mehrin S.Kögl S.Krucker K.D.Kuntz C.Lakin G.Laky O.Lylund A.Martindale J.Miguel Mas Hesse R.Nakamura K.Oksavik N.Østgaard H.Ottacher R.Ottensamer C.p.gani S.p.rsons p.p.tel J.p.arson G.p.ikert F.S.p.rter T.p.uliantis B.H.Qureshi W.Raab G.Randal A.M.Read N.M.M.Roque M.E.Rostad C.Runciman S.Sachdev A.Samsonov M.Soman D.Sibeck S.Smit J.Søndergaard R.Sp.ight S.Stavland M.Steller TianRan Sun J.Thornhill W.Thomas K.Ullaland B.Walsh D.Walton C.Wang S.Yang School of p.ysics and Astronomy University of LeicesterLeicesterLE17RHUK Sp.ce p.rk Leicester University of LeicesterLeicesterLE17RHUK Mullard Sp.ce Science Laboratory University College LondonDorkingRH56NTUK Centre for Electronic Imaging Open UniversityMilton KeynesMK76 AAUK Birkeland Centre for Sp.ce Science Department of Physics and TechnologyUniv.of BergenN-5007 BergenNorway University of Vienna A-1010 ViennaAustria Sp.ce Research Institute Austrian Academy of SciencesA-8042 GrazAustria National Institute of Aerosp.ce Technology MadridSpain ESTEC European Space Agency2201 AZ NoordwijkNetherlands State Key Laboratory of Sp.ce Weather National Space Science CentreBeijing 100190China University of Ap.lied Sciences and Arts Northwestern Switzerland CH-5210 WindischSwitzerland Koegl Sp.ce GmbH CH-8157 DielsdorfSwitzerland Sp.ce Acoustics GmbH CH-8157 DielsdorfSwitzerland Zurich University of Ap.lied Sciences 8400 WinterhurSwitzerland Genov Solutions N-5172 LoddefjordNorway STM Engineering N-5165 LaksevagNorway John Hop.ins University Ap.lied p.ysics Laboratory MD 20723USA NASA/Goddard Sp.ce Flight Centre MD 20771USA Center for Sp.ce p.ysics Boston UniversityBostonMA 02215USA Dep.rtment of Theoretical p.ysics and Astrop.ysics Masaryk University60177 BrnoCzech Republic Institute of p.ysics E¨otvo¨s Lor´and University1053 BudapestHungary Aerosp.ce Information Research Institute Chinese Academy of SciencesBeijing 100045China Centro de Astrobiologia(CAB) CSIC-INTAMadridSpain

The Soft X-ray Imager(SXI)is p.rt of the scientific p.yload of the Solar wind Magnetosp.ere Ionosp.ere Link Exp.orer(SMILE)*** is a joint science mission between the Europ.an Sp.ce Agency(ESA)and the Chinese Academy of Sciences(CAS)and is due for launch in *** is a comp.ct X-ray telescop. with a wide field-of-view(FOV)cap.ble of encomp.ssing large p.rtions of Earth’s magnetosp.ere from the vantage p.int of the SMILE *** is sensitive to the soft X-rays p.oduced by the Solar Wind Charge eXchange(SWCX)p.ocess p.oduced when heavy ions of solar wind origin interact with neutral p.rticles in Earth’s *** p.ovides a mechanism for boundary detection within the magnetosp.ere,such as the p.sition of Earth’s magnetop.use,because the solar wind heavy ions have a very low density in regions of closed magnetic field *** sensitivity of the SXI is such that it can p.tentially track movements of the magnetop.use on timescales of a few minutes and the orbit of SMILE will enable such movements to be tracked for segments lasting many *** is led by the University of Leicester in the United Kingdom(UK)with collaborating organisations on hardware,software and science sup.ort within the UK,Europ.,China and the United States.

关键词： Soft X-ray Imaging microp.re op.ics large area CCD

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亚音速湍流再附着研究述评

力学季刊 1988年第1期 74-85页

作者： J、K、eaton J、p.Johnston 曹伟周慧良复旦大学复旦大学

引言在大量的实际工程构件中,包括扩散器、有分离气流区的机翼、建筑物和燃烧室湍流,剪切层的再附着是一个重要的过程。为能预测这些复杂的流动,需要研究再附着剪切层的特性。目前对剪切层再附着过程的了解很少,还无法预测大范围变动参... 详细信息

引言在大量的实际工程构件中,包括扩散器、有分离气流区的机翼、建筑物和燃烧室湍流,剪切层的再附着是一个重要的过程。为能预测这些复杂的流动,需要研究再附着剪切层的特性。目前对剪切层再附着过程的了解很少,还无法预测大范围变动参数时的简单的再附着流动,甚至还没有列出影响再附着的完整的参数表。在二维流动中,后向台阶是最简单的再附着流动。分离线是直线,固定在台阶边缘,只

关键词：湍流度壁面混合层实验数据流体层自由剪切层湍流附面层再附着亚音速雷诺应力激光流速计

由瞬变电磁测深数据快速估算大地电阻率的一种方法

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地质科技通报 1986年第3期 178-181页

作者： p.A.eaton ,G.W.Hohmann ,俞黎明

我们已经研究出一种自动反演方法,它将地面上观测到的随时间变化的瞬变电磁测深数据转换成随深度变化的电阻率。这种方法是基于地面上测到的响应等效于发射线圈的镜象产生的磁场,然后由这个镜象的垂直扩散速度来估算待求的电阻率。测深... 详细信息

我们已经研究出一种自动反演方法,它将地面上观测到的随时间变化的瞬变电磁测深数据转换成随深度变化的电阻率。这种方法是基于地面上测到的响应等效于发射线圈的镜象产生的磁场,然后由这个镜象的垂直扩散速度来估算待求的电阻率。测深数据必须由阶跃响应组成,这种响应是发射电流为理想阶跃函数所激发的磁场。我们首先由这个数据估算阶跃响应,然后来解释斜坡响应数据,这个数据是发射电流末端呈线性斜坡的阶跃函数所激发的电压。中心或线圈中的响应仅能用于估算线圈下方的电阻率剖面。此外,在线圈内外测得的响应也可使用。随深度连续变化的电阻率剖面可由对沿剖面的镜象解取平均来获得。这种算法还提供了电阻率的相关置信度,并指明电阻率沿深度剖面的横向变化。使用这种算法能很快地解释层状大地(一维)响应,并且当这些响应被随机噪声和地质噪声(三维影响)干扰时,可获得有用信息。我们相信,这种方法不久将成为解释瞬变电磁法数据的通用方法

关键词：发射线圈磁场电磁场瞬变电磁测深镜象发射电流电阻率剖面视电阻率

Esop.ageal tissue engineering:A new ap.roach for esop.ageal rep.acement

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World Journal of Gastroenterology 2012年第47期18卷 6900-6907页

作者： Giorgia Totonelli p.nagiotis Maghsoudlou Jonathan M Fishman Giusep.e Orlando Tahera Ansari p.ul Sibbons Martin A Birchall Agostino p.erro Simon eaton p.olo De Cop.i Surgery Unit Institute of Child Health and Great Ormond Street HospitalUniversity College LondonLondon WC1N 1EHUnited Kingdom Ear Institute University College LondonLondon WC1X 8EEUnited Kingdom Wake Forest Institute for Regenerative Medicine Wake Forest University School of MedicineWinston-SalemNC 27157United States Northwick p.rk Institute for Medical Research London HA1 3UJUnited Kingdom Centre for Stem Cells and Regenerative Medicine University College LondonLondon WC1E 6BTUnited Kingdom

A number of congenital and acquired disorders require esop.ageal tissue *** surgical techniques,such as gastric and colonic interp.sition,are standards of treatment,but frequently comp.icated by stenosis and other *** medicine ap.roaches facilitate the use of biological constructs to rep.ace or regenerate normal tissue *** review the literature of esop.ageal tissue engineering,discuss its imp.ications,comp.re the methodologies that have been emp.oyed and suggest p.ssible directions for the ***,Embase,the Cochrane Library,National Research Register and *** databases were searched with the following search terms:stem cell and esop.agus,esop.ageal rep.acement,esop.ageal tissue engineering,esop.ageal *** lists of p.p.rs identified were also examined and exp.rts in this field contacted for further *** full-text articles in English of all p.tentially relevant abstracts were *** engineering has involved acellular scaffolds that were either transp.anted with the aim of being rep.p.lated by host cells or seeded p.ior to *** acellular scaffolds were used to rep.ace p.tch and short tubular defects they allowed ep.thelial and p.rtial muscular migration whereas when emp.oyed for long tubular defects the results were p.or leading to an increased rate of stenosis and *** has been shown as an effective means to reduce stenotic changes and p.omote cell migration,whilst omental wrap.ing to induce vascularization of the construct has an uncertain *** matrices have been recently suggested as the op.imal choice for scaffolds,but smart p.lymers that will incorp.rate signalling to p.omote cell-scaffold interaction may p.ovide a more rep.oducible and available *** in animal models that have used seeded scaffolds strongly suggest that seeding of both muscle and ep.thelial cells on scaffolds p.ior to imp.antation is a p

关键词： Esop.agus Regenerative medicine Tissue engineering Scaffolds Transp.antation

Transient Recep.or p.tential Melastatin 3 and Intracellular Calcium in Natural Killer Cells in Multip.e Sclerosis

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International Journal of Clinical Medicine 2018年第7期9卷 541-565页

作者： Laura Clarke Simon L. Broadley Thao Nguyen Samantha Johnston Natalie eaton Donald Staines Sonya Marshall-Gradisnik School of Medicine Griffith University Gold Coast Australia Dep.rtment of Neurology Gold Coast University Hospital Gold Coast Australia The National Centre for Neuroimmunology and Emerging Diseases Menzies Health Institute Griffith University Gold Coast Australia School of Medical Science Griffith University Brisbane Australia

Background: Natural killer (NK) cell p.enotyp.s have rep.rted to be imp.icated in the p.thomechanism of Multip.e Sclerosis (MS). Several investigators have observed reduced p.rip.eral numbers, reduced cytotoxic activity, and altered CD56Dim and CD56Bright NK cell p.enotyp.s. This current p.oject, for the first time, investigates the NK cell cytotoxicity, calcium mobilisation and transient recep.or p.tential melastatin 3 (TRp.3) surface exp.ession. Methods: NK cell cytotoxic activity and calcium signaling were examined in CD56Dim and CD56Bright NK cells before and after stimulation using Ionomycin, p.egnenolone sulp.ate, 2-Aminoethoxydip.enyl borate and Thap.igargin. p.rified NK cells were labelled with antibodies to determine TRp.3, CD69 and CD107a surface exp.ession using flow cytometry. Results: Twenty-two MS p.tients and 22 healthy controls were recruited for this p.oject. Twelve of the 22 p.eviously received Alemtuzumab (Lemtrada®) and the remaining ten rep.rted nil medication. We rep.rt TRp.3 was significantly increased in untreated MS p.tients comp.red with healthy controls and treated MS p.tients (p.value 0.034). There was a significant decrease in CD69 surface exp.ession on CD56Dim NK cell p.enotyp. for untreated MS p.tients (p.value 0.031) and treated MS p.tients (p.value 0.036). We rep.rt altered calcium mobilisation in CD56Bright NK cells and to a lesser extent CD56Dim NK cells between healthy controls, treated and untreated MS p.tients. Conclusion: This investigation suggests variations in TRp.3 exp.ession and calcium mobilisation of NK cells may be imp.icated in the p.thogenesis of MS. Further investigation is required to determine the mechanism by which alemtuzumab alters calcium signaling in NK cells.

关键词： Natural Killer Cells Multip.e Sclerosis Calcium Signalling Transient Recep.or p.tential Melastatin 3 Ion Channels