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Optimised NSAIDs-loaded Biocompatible Nanoparticles

Nano-Micro Letters 2010年第4期2卷 247-255页

作者： V.Gaelle ROULLIN Maaite CALLEWAERT michael molinari Franck DELAVOIE Aurelie SECONDE Marie-Christine ANDRY Institut de Chimie Mole culaire de Reims CNRS UMR 6229UFR Pharmacie Reims Laboratoire de Microscopies et d’Etudes des Nanostructures UFR des SciencesUniversitéde Reims Champagne-Ardenne Laboratoire de Microscopie Electronique Analytique INSERM UMRS 92621 rue Clement Ader51685 Reims Cedex 2France

In this formulation study,biocompatible non steroidal anti-inflammatory(NSAIDs)-loaded nanoparticles were designed as models to be further integrated in a prosthesis surface functionalization.A modified spontaneous emulsion-solvent diffusion methodology was used to produce drug-loaded PLGA nanoparticles without any purification or solvent evaporation *** parameters,such as lactide/glycolide ratio,polymer concentration,solvent/non solvent ratio and non solvent phase,as well as the non ionic tensioactive P188 co-precipitation composition were systematically *** optimized formulation(mean size:145 nm,surface charge:-13 m V) was employed to encapsulate various amounts of NSAIDs in a simple and scalable *** drug release was characterized in vitro by a complete release for 48 *** results encourage upcoming preliminary steps for in vivo experiments of prosthesis surface functionalization.

关键词： Drug delivery systems(DDS) Biocompatible Emulsion-solvent diffusion method PLGA Glycofurol Non steroidal anti-inflammatory drugs(NSAIDs)

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3D bioprinted breast cancer model reveals stroma-mediated modulation of extracellular matrix and radiosensitivity

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Bioactive Materials 2024年第12期42卷 316-327页

作者： Theo Desigaux Leo Comperat Nathalie Dusserre Marie-Laure Stachowicz Malou Lea Jean-William Dupuy Anthony Vial michael molinari Jean-Christophe Fricain Francois Paris Hugo Oliveira Univ.Bordeaux Tissue Bioengineering INSERM U1026F-33000BordeauxFrance INSERM U1026 ART BioPrintF-33000BordeauxFrance Univ.Bordeaux Bordeaux ProteomeF-33000BordeauxFrance Univ.Bordeaux CNRSINSERMTBM-CoreUS5UAR 3427OncoProtF-33000BordeauxFrance Univ.Bordeaux CNRSBordeaux INPCBMNUMR 5248F-33600PessacFrance Services d’Odontologie et de Sante Buccale CHU BordeauxF-33000BordeauxFrance CRCINA INSERMCNRSUniv.NantesF-44000NantesFrance Institut de Cancerologie de l’Ouest F-44800Saint HerblainFrance

Deciphering breast cancer treatment resistance remains hindered by the lack of models that can successfully capture the four-dimensional dynamics of the tumor ***,we show that microextrusion bioprinting can reproducibly generate distinct cancer and stromal compartments integrating cells relevant to human *** findings unveil the functional maturation of this millimeter-sized model,showcasing the development of a hypoxic cancer core and an increased surface *** was also driven by the presence of cancer-associated fibroblasts(CAF)that induced elevated microvascular-like structures *** modulation was concomitant to extracellular matrix remodeling,with high levels of collagen and matricellular proteins deposition by CAF,simultaneously increasing tumor stiffness and recapitulating breast cancer fibrotic ***,our bioprinted model faithfully reproduced response to treatment,further modulated by ***,CAF played a protective role for cancer cells against radiotherapy,facilitating increased paracrine *** model holds promise as a platform to decipher interactions within the microenvironment and evaluate stroma-targeted drugs in a context relevant to human pathology.

关键词： Bioprinting Cancer microenvironment Extracellular matrix

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A novel approach for the prevention of ionizing radiation-induced bone loss using a designer multifunctional cerium oxide nanozyme

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Bioactive Materials 2023年第3期21卷 547-565页

作者： Fei Wei Craig J.Neal Tamil Selvan Sakthivel Yifei Fu Mahmoud Omer Amitava Adhikary Samuel Ward Khoa Minh Ta Samuel Moxon Marco molinari Jackson Asiatico michael Kinzel Sergey N.Yarmolenko Vee San Cheong Nina Orlovskaya Ranajay Ghosh Sudipta Seal Melanie Coathup Biionix Cluster Department of Internal MedicineCollege of MedicineUniversity of Central FloridaOrlandoFLUSA Advanced Materials Processing and Analysis Centre Nanoscience Technology Center(NSTC)Materials Science and EngineeringCollege of MedicineUniversity of Central FloridaOrlandoFLUSA CMC Materials 870 North CommonsDrAuroraILUSA Department of Chemistry Oakland UniversityRochesterMIMIUSA School of Applied Sciences Department of Chemical SciencesUniversity of HuddersfieldUK Department of Mechanical and Aerospace Engineering University of Central FloridaOrlandoFLUSA Engineering Research Center for Revolutionizing Biomaterials North Carolina A&T UniversityGreensboroNCUSA Department of Automatic Control and Systems Engineering Insigneo Institute for In Silico MedicineUniversity of SheffieldSheffieldS13JDUK

The disability,mortality and costs due to ionizing radiation(IR)-induced osteoporotic bone fractures are sub-stantial and no effective therapy *** radiation increases cellular oxidative damage,causing an imbalance in bone turnover that is primarily driven via heightened activity of the bone-resorbing *** demonstrate that rats exposed to sublethal levels of IR develop fragile,osteoporotic *** reactive surface sites,cerium ions have the ability to easily undergo redox cycling:drastically adjusting their electronic con-figurations and versatile catalytic *** properties make cerium oxide nanomaterials *** show that an engineered artificial nanozyme composed of cerium oxide,and designed to possess a higher fraction of trivalent(Ce^(3+))surface sites,mitigates the IR-induced loss in bone area,bone architecture,and *** investigations also demonstrate that our nanozyme furnishes several mechanistic avenues of protection and selectively targets highly damaging reactive oxygen species,protecting the rats against IR-induced DNA damage,cellular senescence,and elevated osteoclastic activity in vitro and in ***,we reveal that our nanozyme is a previously unreported key regulator of osteoclast formation derived from macrophages while also directly targeting bone progenitor cells,favoring new bone formation despite its exposure to harmful levels of IR in *** findings open a new approach for the specific prevention of IR-induced bone loss using synthesis-mediated designer multifunctional nanomaterials.

关键词： Ionizing radiation Osteoporosis Nanozyme Cerium oxide Bone strength Bone resorption

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